Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Virginia Drake, Elaine Bigelow, Carole Fakhry, Melina Windon, Lisa M. Rooper, Patrick Ha, Brett Miles, Christine Gourin, Rajarsi Mandal, Wojciech Mydlarz, Nyall London, Peter S. Vosler, Siddhartha Yavvari, Tanya Troy, Tim Waterboer, David W. Eisele, Gypsyamber D'Souza
Summary: The study revealed that HPV positivity and small tumor size are significant predictors of ER alpha positivity in HNSCC. Male sex, overweight/obesity, and being married/living with a partner may also be associated with ER alpha positivity.
Review
Immunology
Habib Sadeghi Rad, Yavar Shiravand, Payar Radfar, Rahul Ladwa, Chris Perry, Xiaoyuan Han, Majid Ebrahimi Warkiani, Mark N. Adams, Brett G. M. Hughes, Ken O'Byrne, Arutha Kulasinghe
Summary: This review discusses the characteristics of Head and Neck Squamous Cell Carcinoma (HNSCC), predictive biomarkers, and factors influencing the response to immunotherapy, with a focus on the tumor microenvironment.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Samantha Tam, Mona Gajera, Xiaoning Luo, Bonnie S. Glisson, Renata Ferrarotto, Faye M. Johnson, Frank E. Mott, Maura L. Gillison, Charles Lu, Xiuning Le, George R. Blumenschein, Michael K. Wong, David I. Rosenthal, Priyadharsini Nagarajan, Adel K. El-Naggar, Michael R. Midgen, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: Patients with cutaneous squamous cell carcinoma of the head and neck treated with cytotoxic or targeted systemic therapy were divided into two groups based on the presence of distant metastasis (M1 vs. M0) at presentation. Independent predictors of improved survival included M0 status, radiotherapy for locally advanced disease, and lower ECOG score. Survival outcomes were worse for M1 patients but improved in those receiving radiotherapy. These findings can provide valuable information for future systemic therapy trials, including potential use of immunotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Farzaneh Kordbacheh, Camile S. Farah
Summary: Head and neck cancer poses a significant burden on global health systems and patients, with traditional treatments including surgery, radiation, and chemotherapy. Targeted immunotherapies have shown significant progress, but rely on understanding molecular pathways. Developing a broader range of targeted therapies is crucial for improving outcomes in head and neck oncology.
Review
Biochemistry & Molecular Biology
Ajaz A. Bhat, Parvaiz Yousuf, Nissar A. Wani, Arshi Rizwan, Shyam S. Chauhan, Mushtaq A. Siddiqi, Davide Bedognetti, Wael El-Rifai, Michael P. Frenneaux, Surinder K. Batra, Mohammad Haris, Muzafar A. Macha
Summary: HNSCC is a highly aggressive disease with a poor prognosis, and understanding the complex TME interactions is crucial for new therapeutic interventions. The different molecular and immune landscapes between HPV+ve and HPV-ve tumors present new opportunities for individualized, targeted CIT regimens.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Soma Ghosh, Pooja A. Shah, Faye M. Johnson
Summary: Head and neck squamous cell carcinomas (HNSCCs) are common cancers that often recur and metastasize. Tobacco and alcohol use are associated with HNSCCs in the oral cavity and larynx, while HPV infection, particularly HPV16, is increasingly recognized as a cause of oropharyngeal HNSCC. Current treatment approaches have similar strategies for both HPV-positive and HPV-negative HNSCCs, but carry a high risk of toxic side effects. The landscape of HNSCC therapy is changing, with ongoing clinical trials investigating novel and less toxic treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Kimberley L. Kiong, Christopher M. K. L. Yao, Fang-Yu Lin, Diana Bell, Renata Ferrarotto, Randal S. Weber, Carol M. Lewis
Summary: A study found that a longer time to surgery (≥34 days) after neoadjuvant chemotherapy in head and neck squamous cell carcinoma patients leads to significantly worse distant metastasis-free rate and disease-free survival rate, but no significant differences in overall survival and locoregional recurrence rate.
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Oncology
Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Amy Trinh, Isla Leslie, Kee Howe Wong, Alan Melcher, Kate Newbold, Chris M. Nutting, Derfel Ap Dafydd, Shreerang A. Bhide, Kevin Harrington
Summary: In patients with relapsed and/or metastatic head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, on-treatment levels of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen are significantly correlated with response and survival outcomes. An on-treatment scoring system incorporating these biomarkers shows appropriate discrimination for predicting overall survival (OS) and progression-free survival (PFS).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Markus Haas, Alexander Lein, Thorsten Fuereder, Julia Schnoell, Faris F. Brkic, Nicholas J. Campion, David T. Liu, Lorenz Kadletz-Wanke, Gregor Heiduschka, Bernhard J. Jank
Summary: Thyroid dysfunction is common in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) treated with pembrolizumab. Low fT3 is associated with worse overall survival (OS), while immune-related hyperthyroidism is correlated with longer progression-free survival (PFS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Emily Khuc, Russell Bainer, Marie Wolf, Selene M. Clay, Daniel J. Weisenberger, Jacquelyn Kemmer, Valerie M. Weaver, David G. Hwang, Matilda F. Chan
Article
Oncology
Brandon Leonard, Toni M. Brand, Rachel A. O'Keefe, Eliot D. Lee, Yan Zeng, Jacquelyn D. Kemmer, Hua Li, Jennifer R. Grandis, Neil E. Bhola
Article
Ophthalmology
David Morrison, James Shaffer, Gui-Shuang Ying, Gil Binenbaum
Article
Ophthalmology
Emily A. McCourt, Gui-Shuang Ying, Anne M. Lynch, Alan G. Palestine, Brandie D. Wagner, Erica Wymore, Lauren A. Tomlinson, Gil Binenbaum
JAMA OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Gil Binenbaum, Edward F. Bell, Pamela Donohue, Graham Quinn, James Shaffer, Lauren A. Tomlinson, Gui-Shuang Ying
JAMA OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Kornwipa Hemarat, Jacquelyn D. Kemmer, Travis C. Porco, Alexander M. Eaton, Rahul N. Khurana, Jay M. Stewart
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2018)
Article
Otorhinolaryngology
Nicholas A. Dewyer, Patpong Jiradejvong, David S. Lee, Jacquelyn D. Kemmer, Jennifer Henderson Sabes, Charles J. Limb
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2019)
Article
Medicine, Research & Experimental
Andrew R. Larson, Jacquelyn Kemmer, Eric Formeister, Ivan El-Sayed, Patrick Ha, Jonathan George, William Ryan, Emily Chan, Chase Heaton
Article
Obstetrics & Gynecology
John A. F. Zupancic, Gui-shuang Ying, Alejandra de Alba Campomanes, Lauren A. Tomlinson, Gil Binenbaum
JOURNAL OF PERINATOLOGY
(2020)
Article
Education, Scientific Disciplines
Marie Murphy, Helena Record, Jacquelyn K. Callander, Daniel Dohan, Jennifer R. Grandis
Summary: This study found that mentoring relationships may be a context in which gender inequities are acknowledged and mitigated. It also pointed out that mentoring relationships may be a context in which gender inequities, such as sexual harassment, occur. While mentoring relationships have the potential to identify and mitigate gender inequities, this study suggests that this potential remains largely unrealized.
Article
Medicine, General & Internal
Marie Murphy, Jacquelyn K. Callander, Daniel Dohan, Jennifer R. Grandis
Summary: Gender disparities in career advancement persist in academic medicine despite gender parity in medical school matriculation. Women's experiences of promotion and tenure in academic medicine reveal inconsistencies, lack of standardized processes, susceptibility to malicious behavior, and observations of different experiences of advancement between men and women. These findings suggest that promotion and tenure processes in academic medicine may contribute to gender disparities.
Article
Surgery
Jacquelyn K. Callander, Madeleine P. Strohl, Phillip Daniel Knott, Andrea Park, Rahul Seth, Chase M. Heaton
Summary: This study found that in HNC patients undergoing head and neck free tissue transfer reconstruction, HCV status was not significantly associated with flap failure, flap takeback, or total length of hospital stay.
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2022)
