Article
Dentistry, Oral Surgery & Medicine
C. Katata, J. Sasaki, A. Li, G. L. Abe, J. E. Nor, M. Hayashi, S. Imazato
Summary: Vascularized DPSC constructs, formed by inducing endothelial differentiation, showed enhanced blood supply and pulp regeneration when transplanted into human pulpless teeth, compared to DPSC constructs without prevascularization. This study demonstrates the potential of vascularized DPSC constructs as a biomaterial for novel dental pulp regeneration.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Izeia Lukin, Itsasne Erezuma, Lidia Maeso, Jon Zarate, Martin Federico Desimone, Taleb H. Al-Tel, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Tissue engineering has become a viable medical alternative in response to the increasing lifespan of society. This review focuses on gelatin, a widely used biomaterial in tissue engineering, and discusses ongoing concerns and the latest developments in this field. Advancements in technology, such as 3D bioprinting and gelatin functionalization, have allowed for better replication of native tissue in gelatin-based systems. This breakthrough has implications for both the manufacturing process, making it more practical and cost-effective, and the future use of gelatin in disease detection and diagnosis rather than treatment.
Review
Engineering, Biomedical
Daniel Salthouse, Katarina Novakovic, Catharien M. U. Hilkens, Ana Marina Ferreira
Summary: This review highlights the importance of the immune response to biomaterials and discusses challenges and opportunities in the development and standardized assessment of the immune response to biomaterials, including the importance of endotoxin levels. It also explores the properties of biomaterials that impact the host immune response and the use of immunomodulatory biomaterials in regenerative medicine. Finally, a standardized in vitro pathway for evaluating the immune response to biomaterials (hydrogels) and their regenerative potential is proposed to ensure safety, consistency, and reduce costs and animal use.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Sunena Dhania, Manju Bernela, Ruma Rani, Minakshi Parsad, Sapna Grewal, Santosh Kumari, Rajesh Thakur
Summary: Tissue engineering technology utilizes biopolymer materials like polyhydroxyalkanoates to mimic and replace damaged tissues, with excellent biocompatibility and biodegradability. This technology has vast potential applications in areas such as bone grafts, cardiovascular repair, and nerve regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Materials Science, Multidisciplinary
Shivesh Anand, Serena Danti, Lorenzo Moroni, Carlos Mota
Summary: It is estimated that by 2050 one in every ten people will be suffering from disabling hearing loss. Perforated tympanic membranes (TMs) are the most common injury to the human ear, resulting in a partial or complete hearing loss due to inept sound conduction. Tissue engineering approaches, including TM repair and reconstruction, have been developed for TM regeneration.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
David R. Maestas, Liam Chung, Jin Han, Xiaokun Wang, Sven D. Sommerfeld, Sean H. Kelly, Erika Moore, Helen Hieu Nguyen, Joscelyn C. Mejias, Alexis N. Pena, Hong Zhang, Joshua S. T. Hooks, Alexander F. Chin, James I. Andorko, Cynthia A. Berlinicke, Kavita Krishnan, Younghwan Choi, Amy E. Anderson, Ronak Mahatme, Christopher Mejia, Marie Eric, JiWon Woo, Sudipto Ganguly, Donald J. Zack, Liang Zhao, Edward J. Pearce, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff
Summary: The immune system plays an important role in tissue repair. A regenerative immunotherapy using the helminth Schistosoma mansoni soluble egg antigen (SEA) was developed, which stimulates the production of IL-4 and other type 2-associated cytokines. The application of regenerative SEA (rSEA) promotes accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells, leading to improved repair and reduced fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhance tissue repair.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Tissue engineering in regenerative medicine utilizes cells, substrates, and physiologically active biomolecules to generate advanced therapeutic methods, while nanotechnology can accelerate tissue repair by providing dynamic three-dimensional nano-environments.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biotechnology & Applied Microbiology
Karolina Lawkowska, Clemens Rosenbaum, Piotr Petrasz, Luis Kluth, Krzysztof Koper, Tomasz Drewa, Marta Pokrywczynska, Jan Adamowicz
Summary: Despite tissue engineering studies heralding the introduction of this method into clinics for over a decade, its application in reconstructive urology is still limited.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francisco Vieira dos Santos, Renato Luiz Siqueira, Lucas de Morais Ramos, Sergio Akinobu Yoshioka, Marcia Cristina Branciforti, Daniel Souza Correa
Summary: This review highlights the versatile application of silk fibroin (SF)-derived electrospun materials in tissue regeneration, disease treatment, and drug delivery systems, as well as explores potential future trends and limitations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Dentistry, Oral Surgery & Medicine
Diana G. Soares, Ester A. F. Bordini, W. Benton Swanson, Carlos A. de Souza Costa, Marco C. Bottino
Summary: This review highlights recent progress in biomaterials-mediated dental pulp tissue engineering, emphasizing critical design criteria, preclinical evaluation models, and innovative strategies. Significant contributions have been made in regenerative dentistry over the past 5 years, with a focus on studies with potential clinical translatability.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Immunology
Alok Shiomurti Tripathi, Magdi E. A. Zaki, Sami A. Al-Hussain, Bidhyut Kumar Dubey, Prabhjot Singh, Laiba Rind, Rajnish Kumar Yadav
Summary: Biomaterials are widely used in various medical applications, but their introduction into the body can cause immune responses. The immune system recognizes natural biomaterials as foreign substances, activating immune cells and leading to inflammation. The surface properties and released immunomodulatory factors of biomaterials can influence immune cell behavior, and a better understanding of this interaction can help design improved biomaterials.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Engineering, Manufacturing
Amitava Bhattacharyya, Gopinathan Janarthanan, Insup Noh
Summary: The complexity of biological architectures has led to extensive use of additive manufacturing techniques for tissue engineering scaffolding, with a current focus on cell-laden 3D bioprinting for tissue or organ regeneration. Nanocomposite bioinks have gained attention for their ability to improve structural stability, shape fidelity, and induce differentiation and cell growth through controlled use of nano-biomaterials. The review emphasizes the significant importance of bioactive nanomaterials in bioinks for 3D bioprinting processes, highlighting recent advances and future possibilities in the field.
ADDITIVE MANUFACTURING
(2021)
Review
Engineering, Biomedical
Vishnu Priya Murali, Christina A. Holmes
Summary: This review summarizes various biomaterial-based extracellular vesicle (EV) delivery systems used in preclinical tissue regeneration studies and other therapeutic applications. EV-based therapies have shown success in preclinical models for biomedical applications, but the challenge lies in prolonging EV retention at target sites for improved therapeutic efficacy through biomaterial-based systems.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Lingfei Ren, Zhiwei Jiang, Hui Zhang, Yani Chen, Danji Zhu, Jin He, Yunxuan Chen, Ying Wang, Guoli Yang
Summary: The hard palate mucosa (HPM) serves as an autologous donor area with superior biosafety and trauma healing ability, making it widely used and researched. Specific mesenchymal stem cells have been isolated from HPM, which have played an essential role in various clinical applications.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Agnese Gugliandolo, Luigia Fonticoli, Oriana Trubiani, Thangavelu S. Rajan, Guya D. Marconi, Placido Bramanti, Emanuela Mazzon, Jacopo Pizzicannella, Francesca Diomede
Summary: Tissue engineering has become a major focus of research, with the potential of biomaterials and mesenchymal stem cells (MSCs) showing promise for bone regeneration, particularly in oral bone regeneration. Combining MSCs with biomaterials enhances bone regenerative power, and utilizing the MSC secretome also presents a promising future for bone tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Jun-Ichi Sasaki, Satoshi Imazato
JOURNAL OF PROSTHODONTIC RESEARCH
(2020)
Review
Dentistry, Oral Surgery & Medicine
Tomotaro Nihei, Katsura Ohashi, Masayuki Hattori, Satoshi Imazato
DENTAL MATERIALS JOURNAL
(2020)
Letter
Dentistry, Oral Surgery & Medicine
S. Yamaguchi, C. Lee, O. Karaer, S. Ban, A. Mine, S. Imazato
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
J. I. Sasaki, Z. Zhang, M. Oh, A. M. Pobocik, S. Imazato, S. Shi, J. E. Nor
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Aifang Han, Hao Ding, James Kit Hon Tsoi, Satoshi Imazato, Jukka P. Matinlinna, Zhuofan Chen
Article
Dentistry, Oral Surgery & Medicine
Gabriela L. Abe, Jun-Ichi Sasaki, Chihiro Katata, Tomoki Kohno, Ririko Tsuboi, Haruaki Kitagawa, Satoshi Imazato
Review
Polymer Science
Shuo Yao, Tong Li, Chuanjian Zhou, Michael D. Weir, Mary Anne S. Melo, Franklin R. Tay, Christopher D. Lynch, Satoshi Imazato, Junling Wu, Hockin H. K. Xu
EUROPEAN POLYMER JOURNAL
(2020)
Article
Engineering, Biomedical
Oguzcan Karaer, Satoshi Yamaguchi, Yutaro Nakase, Chunwoo Lee, Satoshi Imazato
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Takahiko Sakai, Hefei Li, Tomohiro Abe, Satoshi Yamaguchi, Satoshi Imazato
Summary: This study aimed to investigate fracture initiation criteria of resin composites (RCs) at the micro-scale and evaluate the impact of filler shapes on RCs' flexural properties. Experimental RCs with irregular-shaped silica fillers were compared to models with sphere-shaped fillers, showing that irregular-shaped fillers led to significantly greater elastic modulus values and flexural strength. Ultimately, optimizing filler shapes can improve the mechanical strength of RCs.
Article
Dentistry, Oral Surgery & Medicine
Satoshi Yamaguchi, Oguzcan Karaer, Chunwoo Lee, Takahiko Sakai, Satoshi Imazato
Summary: The study evaluated the optical properties of supra-nano spherical fillers with different diameters and the color matching ability of resin composites. Results showed that both 150-nm and 260-nm nano fillers had uniform spherical shape and produced structural colors close to blue and yellow. The experimental RC could reflect base RC colors via the matrix resin, suggesting its ability to enhance color matching effects.
Article
Dentistry, Oral Surgery & Medicine
Tomoki Kohno, Yuhan Liu, Ririko Tsuboi, Haruaki Kitagawa, Satoshi Imazato
Summary: The study showed that the GIC containing BioUnion filler has the potential to inhibit biofilm formation in the oral cavity. Recharging with Zn2+ and F- could further enhance the effectiveness of the GIC.
Article
Dentistry, Oral Surgery & Medicine
Haruaki Kitagawa, Ranna Kitagawa, Ririko Tsuboi, Nanako Hirose, Pasiree Thongthai, Hirohiko Sakai, Mayuka Ueda, Shunka Ono, Jun-Ichi Sasaki, Tooru Ooya, Satoshi Imazato
Summary: This study successfully prepared new dental resins with long-lasting antimicrobial activity to control infection in root canals without compromising sealing abilities and physical properties of the sealers. The incorporation of CPC-loaded particles in HEMA resins yielded endodontic sealers with long-term bactericidal activity against E. faecalis in root canals.
Article
Dentistry, Oral Surgery & Medicine
Masayoshi Morita, Haruaki Kitagawa, Katsuya Nakayama, Ranna Kitagawa, Satoshi Yamaguchi, Satoshi Imazato
Summary: The study found that all four MTA cements had little antibacterial effects and did not inhibit bacterial growth after setting, with the resin-modified MTA cement exhibiting lower mineral induction ability compared to the conventional MTA cements.
DENTAL MATERIALS JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
C. Katata, J. Sasaki, A. Li, G. L. Abe, J. E. Nor, M. Hayashi, S. Imazato
Summary: Vascularized DPSC constructs, formed by inducing endothelial differentiation, showed enhanced blood supply and pulp regeneration when transplanted into human pulpless teeth, compared to DPSC constructs without prevascularization. This study demonstrates the potential of vascularized DPSC constructs as a biomaterial for novel dental pulp regeneration.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nevin Cobanoglu, Tuncay Alptekin, Haruaki Kitagawa, Markus B. Blatz, Satoshi Imazato, Fusun Ozer
Summary: This study found that direct pulp capping with Clearfil Protect Bond (CPB) self-etching adhesive containing an antibacterial monomer MDPB induced an acceptable healing response, with no severe inflammation or soft tissue disorganization observed in the CPB group compared to other control groups.
DENTAL MATERIALS JOURNAL
(2021)