Article
Agriculture, Dairy & Animal Science
R. A. N. Soares, G. Vargas, T. Duffield, F. Schenkel, E. J. Squires
Summary: This study identified genomic regions associated with clinical and subclinical ketosis in North American Holstein dairy cattle, revealing candidate genes and metabolic pathways linked to these traits. The top 20 genomic regions explained a large proportion of the genetic variance and included genes like ACAT2 and IGF1 associated with ketosis. Enrichment analysis showed involvement of fatty acid metabolism, lipid metabolism, and inflammatory response in dairy cattle with ketosis.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
H. Wen, H. Luo, M. Yang, S. M. A. Augustino, D. Wang, S. Mi, Y. Guo, Y. Zhang, W. Xiao, Y. Wang, Y. Yu
Summary: This study analyzed the incidence and genetic parameters of supernumerary teats (SNT) in Chinese Holstein cattle and detected SNT-related genes. The total frequency of SNT was 9.8% with a heritability of 0.22, and 10 genes associated with SNT were identified. Estimated correlations with SNT-related indicator traits were generally low to moderate, with genetic variance for SNT located in BTA4 and potential candidate genes identified in BTA4 and BTA5. These findings provide valuable information for breeders looking to reduce SNT in cattle.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Connor A. Emdin, Mary Haas, Veeral Ajmera, Tracey G. Simon, Julian Homburger, Cynthia Neben, Lan Jiang, Wei-Qi Wei, Qiping Feng, Alicia Zhou, Joshua Denny, Kathleen Corey, Rohit Loomba, Sekar Kathiresan, Amit Khera
Summary: This study identified 12 independent genetic variants, including 7 newly identified ones, that confer risk for cirrhosis. A polygenic score based on these variants can identify a subset of the population at substantially increased risk, particularly those susceptible to the hepatotoxic effects of excess alcohol consumption or obesity.
Article
Biochemistry & Molecular Biology
Shiyu Liao, Ju Yan, Hongkun Xing, Yuan Tu, Hu Zhao, Gongwei Wang
Summary: The study identified significant association loci for vascular bundle variations in rice, with key loci such as Ghd7 and NAL1 influencing the vascular bundles in different parts of the plant. These findings could be valuable for improving the vascular bundle system in rice breeding.
Article
Psychiatry
Zhen Zhang, Li Liu, Huijie Zhang, Chun'e Li, Yujing Chen, Jingxi Zhang, Chuyu Pan, Shiqiang Cheng, Xuena Yang, Peilin Meng, Yao Yao, Yumeng Jia, Yan Wen, Feng Zhang
Summary: This study explores the etiological mechanism of pain in depression patients from the perspective of genetics. Genome-wide association studies (GWAS), proteome-wide association study (PWAS), and transcriptome-wide association study (TWAS) were conducted to identify candidate genes associated with different pain traits in depression patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Matthew Barden, Bingjie Li, Bethany E. Griffiths, Alkiviadis Anagnostopoulos, Cherry Bedford, Androniki Psifidi, Georgios Banos, Georgios Oikonomou
Summary: The study aimed to estimate the genetic parameters of digital cushion thickness (DCT), assess the genetic correlation between DCT and claw horn lesions (CHL), and identify candidate genes associated with DCT. The results showed moderate heritability of DCT and a negative genetic correlation between DCT and sole lesions at different stages of production. Additionally, genes related to inflammation, fat metabolism, and bone development were found to be associated with DCT.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Plant Sciences
Agnieszka Deja-Muylle, Davy Opdenacker, Boris Parizot, Hans Motte, Guillaume Lobet, Veronique Storme, Pieter Clauw, Maria Njo, Tom Beeckman
Summary: Root system architecture (RSA) directly affects nutrient uptake efficiency and plant growth. Using natural variation, this study conducted a detailed in vitro analysis of 241 Arabidopsis thaliana accessions, revealing a high variability in RSA traits among different accessions and their correlation with natural habitat conditions. The study also found a high consistency in the spatial distribution of roots between in vitro and ex vitro conditions, with a larger root area in the lower zone favoring drought tolerance. Genome-wide association studies (GWAS) based on collected RSA phenotype data identified multiple known genes associated with RSA traits and potential candidate genes involved in adaptation to natural habitats.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Neurosciences
Bang-Sheng Wu, Yi-Jun Ge, Wei Zhang, Shi-Dong Chen, Shi-Tong Xiang, Ya-Ru Zhang, Ya-Nan Ou, Yu-Chao Jiang, Lan Tan, Wei Cheng, John Suckling, Jian-Feng Feng, Jin-Tai Yu, Ying Mao
Summary: In this study, a genome-wide association analysis of cerebellar white matter microstructure was conducted using diffusion tensor imaging data from 25,415 individuals from UK Biobank. The study identified 11 genetic loci and 86 genes associated with cerebellar white matter microstructure. Functional enrichment analysis revealed the involvement of GABAergic neurons and cholinergic pathways. The study also found significant genetic overlap between cerebellar white matter tracts and adjacent brain regions, as well as genetic correlations with movement, cognitive, psychiatric, and cerebrovascular traits. Overall, this study provides important insights into the genetics of cerebellar white matter microstructure and its shared genetic etiology with common brain disorders.
Article
Medicine, General & Internal
Yusuke Ebana, Lian Liu, Kensuke Ihara, Keiko Abe, Chikashi Terao, Yoichiro Kamatani, Tetsuo Sasano, Tetsushi Furukawa
Summary: This study aimed to explore novel ischemic stroke risk variants in patients with a history of atrial fibrillation (AF), and to investigate their associations with CHADS2 and CHA2DS2-VASc scores. By conducting an association study on 8181 AF cases, we identified eight genetic loci that were potentially associated with the risk of ischemic stroke. Further analysis showed that these associations were independent of CHADS2 or CHA2DS2-VASc scores.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Yin Huang, Dan Li, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang, Kun Tang, Stefan Grunewald
Summary: This study conducted a genome-wide association study on the genetic basis of facial morphology in the Han Chinese population, identifying significant associations between multiple facial features and different genomic regions. These findings contribute to a more comprehensive understanding of the genetic factors underlying variation in human facial morphology.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Agronomy
Fucheng Zhao, Nan Wang, Fei Bao, Guangwu Zhao, Liquan Jing, Guiyue Wang, Qinghui Han, Zhuanfang Hao, Bin Chen
Summary: Clarifying the genetic basis of trace element accumulation is crucial for breeding new maize varieties with high quality. This study conducted a genome-wide association study on the accumulation of iron, manganese, copper, zinc, cadmium, and arsenic in maize kernels, identifying several genes and SNPs associated with different trace elements. The findings provide insights into the molecular mechanism of trace element accumulation and offer candidate genes for breeding high nutritional quality maize varieties.
Article
Biochemistry & Molecular Biology
Da-Tian Bau, Ting-Yuan Liu, Chia-Wen Tsai, Wen-Shin Chang, Jian Gu, Jai-Sing Yang, Liang-Chun Shih, Fuu-Jen Tsai
Summary: Taiwan has the highest incidence rate of oral cancer in the world. A genome-wide association study identified several susceptibility loci for oral cancer in the Taiwanese population, highlighting the importance of both genetic and environmental factors. This study provides important insights into the etiology of oral cancer in Taiwan.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Hamdi Mbarek, Scott D. Gordon, David L. Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J. Beck, Jouke-Jan Hottenga, Rene Pool, Conor Dolan, Ky'Era Actkins, Zachary F. Gerring, Jenny Van Dongen, Erik A. Ehli, William G. Iacono, Matt Mcgue, Daniel Chasman, C. Scott Gallagher, Samantha L. P. Schilit, Cynthia C. Morton, Guillaume Pare, Gonneke Willemsen, David C. Whiteman, Catherine M. Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K. E. Magnusson, Nancy L. Pedersen, Pirro Hysi, Massimo Mangino, Timothy D. Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W. Penninnx, Adrian Campos, Ken K. Ong, John R. B. Perry, Cornelis B. Lambalk, Jaakko Kaprio, Isleifur Olafsson, Karine Duroure, Celine Revenu, Miguel E. Renteria, Loic Yengo, Lea Davis, Eske M. Derks, Sarah E. Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W. Montgomery, Dorret Boomsma, Nicholas G. Martin
Summary: This study identified four new loci associated with female propensity for giving birth to spontaneous dizygotic twins. The novel loci, GNRH1 and FSHR, have established roles in female reproduction, while ZFPM1 and IPO8 were not previously linked to female fertility. The study also found significant genetic correlations with multiple aspects of female reproduction and body size, suggesting important roles in human evolution.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Hyun-Ju An, Jae-Hwa Kim, Siyeong Yoon, Junwon Choi, Jeongmo Koo, Soonchul Lee
Summary: This study aimed to identify specific genes or genetic variants associated with rotator cuff tears through a genome-wide association study. More than 20 significantly associated SNPs were found. However, the study was limited by the small sample size and requires further validation. Nevertheless, the identification of potential genetic variants related to rotator cuff injury would aid in the early detection of individuals at risk and provide insight into future gene therapies.
Article
Genetics & Heredity
Xinye Zhang, Tao Zhu, Liang Wang, Xueze Lv, Weifang Yang, Changqing Qu, Haiying Li, Huie Wang, Zhonghua Ning, Lujiang Qu
Summary: This study conducted a genome-wide association study to identify candidate genes associated with white, black, and spotty plumage in domestic ducks. The results showed that two non-synonymous SNPs in MC1R were significantly related to black plumage, while three SNPs in MITF were associated with white plumage. The epistatic effect between MC1R and MITF genes was also observed. These findings highlight the importance of epistasis in plumage color variation in ducks.