Article
Critical Care Medicine
Edwige Peju, Jean-Francois Llitjos, Julien Charpentier, Anne Francois, Nathalie Marin, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Jerome Lambert, Matthieu Jamme, Frederic Pene
Summary: This study investigated the impact of blood product transfusions on the susceptibility to ICU-acquired infections in high-risk patients with septic shock, and found that transfusions of platelets and fresh frozen plasma were independently associated with the further occurrence of ICU-acquired infections.
CRITICAL CARE MEDICINE
(2021)
Letter
Medicine, General & Internal
Azib S. Shahid, Philip Fanapour, Raul J. Gazmuri
Summary: The CLASSIC trial found similar death rates at 90 days in patients with septic shock who received resuscitation with a restrictive-fluid strategy and a liberal-fluid approach.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Yuta Takahashi, Tomoyuki Morisawa, Hiroshi Okamoto, Nobuto Nakanishi, Noriko Matsumoto, Masakazu Saitoh, Tetsuya Takahashi, Toshiyuki Fujiwara
Summary: This study compared the incidence of diaphragm dysfunction and ICU-acquired weakness in patients with septic shock, with and without mechanical ventilation. The incidence of diaphragm dysfunction was higher than that of ICU-acquired weakness in patients with septic shock, regardless of the use of mechanical ventilation. Further studies are needed to assess the association between diaphragm dysfunction and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yaxin Xu, Wentao Xue, Hongwei Gao, Jiabo Cui, Lingzhi Zhao, Chongge You
Summary: Studies have shown that TLRs gene polymorphisms may play a significant role in HBV and HCV infections, with certain SNPs affecting disease progression and prognosis. However, the exact mechanism of action still requires further exploration.
Review
Immunology
Yingchi Zhang, Jia Liu, Changlun Wang, Junxian Liu, Wei Lu
Summary: Toll-like receptor gene polymorphisms can increase the risk of autoimmune diseases, and studying these variations can expand our understanding of the pathogenesis of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Andres F. Londono, Diana G. G. Scorpio, J. Stephen Dumler
Summary: Rickettsial agents are diverse alpha-proteobacteria that can cause human diseases. They are mainly transmitted by arthropod vectors and have evolved various mechanisms to evade the host innate immune responses. This review focuses on the mechanisms used by two common rickettsial agents, Rickettsia species and Anaplasma phagocytophilum, to survive within and propagate from host cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Shiqi Yuan, Chong Chen, Fengshuo Xu, Didi Han, Rui Yang, Shuai Zheng, Mengmeng Qiao, Xiaxuan Huang, Jun Lyu
Summary: This study explores the association between antithrombotic therapy and ICU mortality in septic patients with peripheral vascular disease. The results show that both the anticoagulant and antiplatelet-anticoagulation groups have a lower risk of ICU mortality compared to the group without antithrombotic treatment. However, antiplatelet therapy did not reduce ICU mortality. Additionally, the AC-AT group had a lower risk of bleeding complications.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Immunology
Sonal Yadav, Vivek Verma, Rakesh Singh Dhanda, Manisha Yadav
Summary: TLRs play a crucial role in the innate immune system, protecting the body from invading pathogens, but their signaling pathways can also influence infection or autoimmune disease development. Research has shown that TLR polymorphisms may make hosts more resistant or vulnerable to infections.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Pediatrics
Guo-Yun Su, Chao-Nan Fan, Bo-Liang Fang, Zheng-De Xie, Su-Yun Qian
Summary: This study explored the differences in baseline characteristics, pathogens, complications, outcomes, and risk factors between children with hospital-acquired septic shock (HASS) and community-acquired septic shock (CASS) in the pediatric intensive care unit (PICU). The results showed significant variations in underlying diseases, pathogens, complications, prognosis, and mortality rates between the HASS and CASS groups.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Felipe Perez-Garcia, Maria Angeles Jimenez-Sousa, Esther Gomez-Sanchez, Hugo Gonzalo-Benito, Amanda Fernandez-Rodriguez, Mario Lorenzo-Lopez, Maria Heredia-Rodriguez, Pedro Martinez-Paz, Estefania Gomez-Pesquera, Eduardo Tamayo, Salvador Resino
Summary: We conducted a retrospective exploratory study on patients who developed septic shock after major surgery, and found that polymorphisms in the CEACAM7 gene may influence the risk of septic shock-related death in these individuals.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Critical Care Medicine
Neveux Nathan, Jean-Paul Sculier, Lieveke Ameye, Marianne Paesmans, Grigoriu Bogdan-Dragos, Anne-Pascale Meert
Summary: Research indicates that the Sequential Organ Failure Assessment (SOFA) score is more accurate in predicting hospital mortality of infected patients than the systemic inflammatory response syndrome (SIRS) criteria, and the new definition of sepsis and septic shock demonstrates the same reliability in cancer patients as in the general population.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Immunology
Karen Sanchez-Luquez, Ines Claudia Schadock, Carla Vitola Goncalves, Michele Tornatore, Fabiana Finger-Jardim, Emiliana Claro Avila, Marcelo Alves Soares, Ana Maria Barral de Martinez, Joel Henrique Ellwanger, Jose Artur Bogo Chies, Vanusa Pousada da Hora
Summary: The study evaluated the impact of TLR7 and TLR9 SNPs on susceptibility to placental infections and pregnancy complications in Brazilian women. The TT genotype of TLR7 SNP was associated with increased susceptibility to HSV-1 infection, while the C allele of TLR9 SNP decreased the risk of HCMV infection. Specific genotypes were found to influence the risk of infections, hypertension, and hospitalization during pregnancy.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Chunlin Zhang, Zhiping Yang, Ping Luo, Mengxia Ye, Ping Gong, Quan Gong, Bing Mei
Summary: The aim of this study was to investigate the role of TLR4 and TLR9 gene polymorphisms in the risk and progression of HPV-related cervical lesions. The results revealed that mutant allele carriers of TLR4 rs10116253, rs1927911, and rs10759931 had a significantly decreased risk of cervical lesions, and the interaction between TLR4/TLR9 gene polymorphisms and HPV-16/18 infection played a role in cervical lesion risk. Therefore, TLR4 rs10116253, rs1927911, and rs10759931 may serve as potential biomarkers for cervical lesion susceptibility.
BIOMARKERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Anahita Rouze, Ignacio Martin-Loeches, Pedro Povoa, Demosthenes Makris, Antonio Artigas, Mathilde Bouchereau, Fabien Lambiotte, Matthieu Metzelard, Pierre Cuchet, Claire Boulle Geronimi, Marie Labruyere, Fabienne Tamion, Martine Nyunga, Charles-Edouard Luyt, Julien Labreuche, Olivier Pouly, Justine Bardin, Anastasia Saade, Pierre Asfar, Jean-Luc Baudel, Alexandra Beurton, Denis Garot, Iliana Ioannidou, Louis Kreitmann, Jean-Francois Llitjos, Eleni Magira, Bruno Megarbane, David Meguerditchian, Edgar Moglia, Armand Mekontso-Dessap, Jean Reignier, Matthieu Turpin, Alexandre Pierre, Gaetan Plantefeve, Christophe Vinsonneau, Pierre-Edouard Floch, Nicolas Weiss, Adrian Ceccato, Antoni Torres, Alain Duhamel, Saad Nseir
Summary: The incidence of ventilator-associated lower respiratory tract infections (VA-LRTI) is significantly higher in patients with SARS-CoV-2 infection compared to those with influenza pneumonia or no viral infection. Gram-negative bacilli, mainly Pseudomonas aeruginosa, Enterobacter spp., and Klebsiella spp., were responsible for a large proportion of VA-LRTI episodes.
INTENSIVE CARE MEDICINE
(2021)
Article
Physiology
Vlasios Skopas, Dimitrios Papadopoulos, Nikolaos Trakas, Eleni Papaefstathiou, Charalampos Koufopoulos, Demosthenes Makris, Zoe Daniil, Konstantinos Gourgoulianis
Summary: This study aimed to evaluate the differences in serum LDH isoenzymes between AECOPD patients and other LRTIs, finding significant differences in LDH1, LDH2, LDH3, and LDH4 ratios between the two groups. A sum of LDH3 and LDH4 ratios below 29% had the highest discriminative ability in classifying subjects in the AECOPD group. Aerobic metabolic adaptive mechanisms in respiratory muscles during AECOPD may explain the observed differences.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Letter
Critical Care Medicine
Ananthu Narayan, Prerna Garg, Umang Arora, Animesh Ray, Naveet Wig
LANCET RESPIRATORY MEDICINE
(2021)
Article
Health Care Sciences & Services
Triantafyllia Koukoubani, Demosthenes Makris, Zoe Daniil, Theoniki Paraforou, Vasiliki Tsolaki, Epaminondas Zakynthinos, John Papanikolaou
Summary: The study found that patients infected with ABRPs, especially XDR, in the ICU had higher mortality rates and decreased ability to recover for a prolonged period post-discharge compared to non-ABRP-infected or non-infected patients. Differences were observed between multi-drug resistant and extensively drug resistant subgroups, highlighting the need for further research.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Review
Endocrinology & Metabolism
Ioanna Papathanasiou, Lydia Anastasopoulou, Aspasia Tsezou
Summary: Cholesterol homeostasis is crucial for skeletal development, and dysregulation in cholesterol-related mechanisms can lead to cartilage diseases like osteoarthritis (OA). Studies have linked elevated serum cholesterol levels to OA, and abnormal lipid accumulation in chondrocytes due to disrupted cholesterol homeostasis has been implicated in OA development. However, the precise mechanisms linking cholesterol metabolism, particularly HDL cholesterol metabolism, to OA remain unclear, and further research is needed to uncover new therapeutic targets for OA patients.
Review
Biochemical Research Methods
Aspasia Destouni, Konstantinos C. Tsolis, Anastassios Economou, Ioanna Papathanasiou, Charalampos Balis, Evanthia Mourmoura, Aspasia Tsezou
Summary: A systems analysis approach identified modules related to extracellular matrix mechanosensing and glycolysis in the core proteome network of chondrocytes, showing strong correlation with osteoarthritis. The interconnection between cartilage ECM remodeling and metabolism indicates the significance of dynamic chondrocyte states in osteoarthritis.
EXPERT REVIEW OF PROTEOMICS
(2021)
Article
Clinical Neurology
Chiara Robba, Francesca Graziano, Paola Rebora, Francesca Elli, Carlo Giussani, Mauro Oddo, Geert Meyfroidt, Raimund Helbok, Fabio S. Taccone, Lara Prisco, Jean-Louis Vincent, Jose Suarez, Nino Stocchetti, Giuseppe Citerio
Summary: This study investigated the practice of intracranial pressure (ICP) monitoring in acute brain injury patients and its impact on patient outcomes. The results showed significant variability in ICP monitoring use across different centers, with a potential association between ICP monitoring and lower 6-month mortality and better long-term neurological outcomes in severe cases.
Article
Cell Biology
Andreas Goutas, Zozo Outskouni, Ioanna Papathanasiou, Maria Satra, George Koliakos, Varvara Trachana
Summary: Research shows that oxidative stress can lead to upregulation, phosphorylation, and nuclear translocation of Cav-1 in young stem cells, but this regulation is lost as cells age. Older cells are unable to repair DNA damage, and downregulation of Cav-1 results in persistent DNA damage and onset of senescence. Additionally, the establishment of senescence is mediated by autophagy activation.
Article
Cell Biology
Evanthia Mourmoura, Ioanna Papathanasiou, Varvara Trachana, Vasilis Konteles, Alexandra Tsoumpou, Andreas Goutas, Aliki-Alexandra Papageorgiou, Nikolaos Stefanou, Aspasia Tsezou
Summary: Our study found that leptin and ROS are involved in the regulation of inflammatory pathways, specifically the formation and activation of NLRP3 inflammasome in osteoarthritis (OA). We observed increased protein expression of inflammasome components in OA cartilage biopsies and chondrocytes, along with elevated ROS levels. Additionally, NLRP3-siRNA in OA chondrocytes led to downregulation of MMP-9/MMP-13. Treatment with ROS inhibitors or leptin-siRNA attenuated ROS levels and NLRP3 inflammasome formation/activation, while incubation with leptin enhanced ROS production and inflammasome formation/activation in normal chondrocytes. These findings suggest a leptin-NOX4-ROS-inflammasome regulatory axis in OA chondrocytes.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Medicine, Research & Experimental
Aliki-Alexandra Papageorgiou, Malamo Litsaki, Evanthia Mourmoura, Ioanna Papathanasiou, Aspasia Tsezou
Summary: In this study, the researchers investigated the role of DNA methylation in the regulation of SIRT1 expression and deacetylase activity in human osteoarthritis (OA) chondrocytes. They found that hypermethylation of specific CpG dinucleotides on the SIRT1 promoter was associated with downregulation of SIRT1 expression. Treatment with 5-AzadC restored SIRT1 expression and decreased inflammation in OA chondrocytes. These findings suggest that DNA methylation plays a role in the suppression of SIRT1 in OA chondrocytes, contributing to the development of OA.
ADVANCES IN MEDICAL SCIENCES
(2023)
Letter
Critical Care Medicine
Vasiliki Tsolaki, George E. Zakynthinos, John Papanikolaou, Nikitas Karavidas, Vasileios Vazgiourakis, Maria Eirini Papadonta, Paris Zygoulis, Ioannis Pantazopoulos, Demosthenes Makris, Epaminondas Zakynthinos
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Andreas Goutas, Zozo Outskouni, Ioanna Papathanasiou, Aphrodite Georgakopoulou, Georgios E. Karpetas, Efstathios S. Gonos, Varvara Trachana
Summary: We find that genomic instability occurs not only during senescence but also in young cells exposed to oxidative stress. This instability is caused by oxidative stress overriding the spindle assembly checkpoint. Additionally, the degradation of Bub1b/BubR1 upon aging is explained as an initial increase in levels followed by autophagy-dependent degradation.
Article
Genetics & Heredity
Ioanna Papathanasiou, Charalampos Balis, Dimitrios Destounis, Evanthia Mourmoura, Aspasia Tsezou
Summary: The role of miR-150-5p in osteoarthritic chondrocytes and the regulatory role of long non-coding RNAs (lncRNAs) in miR-150-5p expression were investigated. Bioinformatics analysis and experimental validation suggested a catabolic role of NEAT1/miR-150-5p interaction in OA progression by regulating b-catenin expression.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Cell Biology
Vasileios Konteles, Ioanna Papathanasiou, Maria Tzetis, Evgenios Goussetis, Varvara Trachana, Evanthia Mourmoura, Charalampos Balis, Konstantinos Malizos, Aspasia Tsezou
Summary: Despite the limitations posed by factors like heterogeneity, MSCs show great potential for cell therapies. To overcome these limitations, researchers are turning to iMSCs, which are derived from iPSCs. In this study, the transcriptome of MSCs, iPSCs, and iMSCs from healthy individuals and OA patients was analyzed, along with the miRNA-mRNA interactions during these transitions. The findings suggest that iMSCs derived from iPSCs exhibit enhanced properties, such as proliferation, differentiation, and migration, which make them a promising candidate for cell therapy in osteoarthritis. Additionally, the involvement of specific miRNAs in pluripotency was identified, highlighting their potential role in guiding iMSCs towards therapeutic applications.
Article
Critical Care Medicine
Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Megarbane, Anastasia Saade, Gemma Goma, Eleni Magira, Jean-Francois Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W. Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loic Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouze
Summary: This study found that VAP was significantly associated with increased 28-day mortality in SARS-CoV-2 patients, but SARS-CoV-2 pneumonia did not significantly modify the relationship between VAP and 28-day mortality compared to influenza pneumonia or no viral infection.
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)
