Journal
JOURNAL OF CONTROLLED RELEASE
Volume 284, Issue -, Pages 1-14Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2018.06.005
Keywords
Zinc phthalocyanine; Phospholipid complex; Synergetic therapy; Photoacoustic image; Fluorescence image; Photothermal treatment; Photodynamic treatment; Folate receptor-targeted
Funding
- National Natural Science Foundation of China [81772278, 21706221]
- Project of Xiamen Science and Technology Bureau [3502Z20163004]
- Natural Science Foundation of Fujian Province of China [2015Y0081]
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For the purpose of precision theranostic of tumor, multifunctional drug delivery systems are always receiving great attentions. Here, we developed a zinc phthalocyanine-soybean phospholipid (ZnPc-SPC) complex based drug delivery system with doxorubicin (Dox) as loading cargo to achieve additional chemotherapy while the carrier itself could serve as multifunctional and switchable theranostic agent. In the early phase, the ZnPc-SPC complex assembled to nanostructure displaying photothermal therapy (PTT) and photoacoustic (PA) properties while in the late phase, the prepared NPs dis-assembled into ZnPc-SPC complex again performing photodynamic therapy (PDT) and low-background fluorescence (FL) image. With the decoration of folate receptors alpha (FR alpha) targeted MTX, Dox-loaded, MTX-decorated self-assembled ZnPc-SPC complex NPs (DZSM) was formed. In vitro and in vivo evaluations both indicated that DZSM presented high selectivity for FR alpha over-expressed tumor cells, excellent switchable PA/FL image, significant multiphase PTT/PDT effect, as well as great synergetic therapy potential, leading to notable inhibition of tumor growth.
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