Article
Chemistry, Applied
Beatriz Arauzo, M. Pilar Lobera, Antonio Monzon, Jesus Santamaria
Summary: Electrospray technique was utilized to produce inhalable ciprofloxacin-loaded chitosan sub-micron particles, which had small sizes and high surface charge for enhanced mucoadhesive properties and antimicrobial activity against common respiratory pathogens. The particles showed biocompatibility with alveolar cell line (A549) and promising results in antimicrobial efficacy.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Sarah Strickler, Michael Hindle, Worth Longest
Summary: This study focused on the development of an infant air-jet dry powder inhaler (DPI) that could be actuated multiple times with minimal user interaction. The metering system, consisting of a powder delivery tube (PDT) and a powder supporting shelf, could be tuned for individual powder formulations to maintain high efficiency lung delivery. The optimized infant air-jet DPI provided efficient and consistent lung delivery of aerosols based on in vitro testing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Adam Paclawski, Stavros Politis, Evangelos Balafas, Ekaterini Mina, Paraskevi Papakyriakopoulou, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Dimitrios M. Rekkas, Georgia Valsami, Stefano Giovagnoli
Summary: This study developed a novel highly performing inhalable acetylsalicylic acid dry powder using nano spray-drying technique and leucine as an excipient. Compared with oral administration, the dry powder showed faster absorption in blood and higher retention in the lungs. The results suggest that this dry powder formulation has promising features for the treatment of inflammatory and infectious lung diseases.
Article
Chemistry, Multidisciplinary
Damiano La Zara, Feilong Sun, Fuweng Zhang, Frans Franek, Kinga Balogh Sivars, Jenny Horndahl, Stephanie Bates, Marie Brannstrom, Par Ewing, Michael J. Quayle, Gunilla Petersson, Staffan Folestad, J. Ruud van Ommen
Summary: Surface nanoengineering using atomic layer deposition (ALD) on micronized budesonide particles can effectively tailor the drug release and lung deposition characteristics, providing promising opportunities for the next generation of controlled pulmonary drug delivery systems.
Article
Pharmacology & Pharmacy
Shalaleh Zendehdel Baher, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: This study aimed to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation for the local treatment of pulmonary arterial hypertension (PAH). The results confirmed that the spray drying technique can be used to obtain inhalable simvastatin nanoparticles with suitable inhalation performance.
Article
Pharmacology & Pharmacy
Annalisa Bianchera, Esraa'a Alomari, Annalisa Michielon, Gianluca Bazzoli, Nicoletta Ronda, Giovanni Pighini, Ilaria Zanotti, Carmine Giorgio, Andrea Mozzarelli, Ruggero Bettini, Stefano Bruno
Summary: This study investigates an alternative administration strategy for augmentation therapy of alpha-1 antitrypsin (AAT) deficiency. The researchers utilized recombinant expression of AAT in bacteria and spray drying to produce a respirable powder. The study successfully formulated active and endotoxin-free recombinant AAT and suggests that the dry powder form could be a potential alternative to current treatments.
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of mouthpiece designs in carrier-based dry powder inhalation on aerosol particle characteristics. It is found that a mouthpiece with a spiral channel and mixing chamber is effective in delivering drug particles uniformly to the peripheral target regions of the respiratory system under low flow velocities.
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of adding bypass holes in a dry powder inhaler on aerosol particle characteristics. The direction, size, and position of the bypass holes in the inhaler passage were found to significantly influence the spray output. Adding bypass holes decreased the mean penetration length of drug particles by 12%, but simultaneously increased the spray angle by 35%, resulting in a significant decrease in forward particle momentum.
Article
Pharmacology & Pharmacy
Stephanie Hufnagel, Haiyue Xu, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui, Laura Q. M. Chow, Robert O. Williams
Summary: Thin-film freeze-drying (TFFD) is an effective technique for preparing inhalable dry powders of monoclonal antibodies (mAbs) for pulmonary drug delivery. This study investigated the formulation and aerosol performance of TFFD dry powders prepared with different excipients. The results showed that TFFD dry powders had desirable aerosol properties and improved stability compared to liquid formulations. The addition of polyvinylpyrrolidone K40 further enhanced the storage stability of the mAbs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Hend I. Shahin, Lipika Chablani
Summary: Dry powder inhalers (DPIs) are attractive drug delivery systems for the lungs, but designing them with suitable physicochemical properties is challenging. The development of novel DPIs requires the selection of appropriate particle engineering techniques, carriers, and excipients. Optimizing the physicochemical properties of these systems is crucial for efficient drug delivery. This review focuses on recent advances in inhalable dry powder formulations, including current particle engineering techniques, challenges in DPI development, carrier and excipient selection, and factors influencing aerosolization. It also discusses the current and emerging applications of DPIs for local and systemic drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Adriana M. Ledo, Stefan Thibodeaux, Lisa Duong, Erhan Altinoglu, Thomas Dimke, Duncan Shaw, David Rowlands, Ellena Growcott
Summary: This study introduces a new in vitro system to study epithelial absorption of inhaled dry powders in lung barrier models. The system allows for the coupling of drug dissolution and permeability assessments. The results highlight the value of this in vitro drug aerosolization setup for research and development of inhaled medicines.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hairui Zhang, Yajie Zhang, Robert O. Williams, Hugh D. C. Smyth
Summary: The study focuses on using thin-film freeze-drying (TFFD) to prepare gene editing dry powder formulations containing PEGylated chitosan/CRISPR-Cas9 nanocomplexes. Six potential DPI formulations were identified and characterized, with two formulations containing 3% mannitol found to be suitable for inhalation with desired aerodynamic performance. The flow rate and inhaler dependency of these formulations were also evaluated at different conditions, demonstrating the suitability of TFFD-processed CRISPR-Cas9 polymer nanocomplexes for dry powder inhalation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Thomas Hibbard, Hannah Mitchell, Yoonha Kim, Kenneth Shankland, Hisham Al-Obaidi
Summary: The aim of this study was to investigate inhaled formulations of progesterone through spray drying and analyze how spray drying affects the physicochemical properties of progesterone. X-ray diffraction, spectroscopy, and thermal analysis were used to characterize the formulations. The addition of HPMCAS was shown to increase the solubility of progesterone and temporarily enable a supersaturated state. Additionally, spray drying improved the inhalation performance of progesterone. Therefore, HPMCAS is suggested as a suitable excipient to improve the solubility and inhalation properties of spray-dried progesterone formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Miftakul Munir, Vicky L. Kett, Nicholas J. Dunne, Helen O. McCarthy
Summary: This study optimised the spray drying process and determined the optimal parameters for spray drying RALA/pDNA NPs into dry powder. The results showed that mannitol concentration was the most influential variable for all responses. Spray drying with the optimal parameters produced functional RALA/pDNA NPs.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rick Heida, Paul Hagedoorn, Melle C. van Meel, Jurrie E. R. Prins, Frederike S. Simonis, Renate Akkerman, Anke L. W. Huckriede, Henderik W. Frijlink, Anne H. de Boer, Wouter L. J. Hinrichs
Summary: A challenge in developing dry powder formulations for inhalation is the poor reproducibility of administration to small laboratory animals. Current devices for delivering dry powder formulations to small rodents often fail to function optimally due to the use of the same puff of air for both powder dispersion and aerosol delivery. A novel aerosol generator was introduced, allowing the administration of a pre-generated aerosol to mice lungs, with controlled powder delivery. Although the emitted aerosol showed favorable size range for lung deposition and reproducibility, in vivo fluorescent imaging revealed significant differences in dose deposition and powder distribution among mice, suggesting inevitable biological variation in lung deposition.
Article
Infectious Diseases
Aart van der Meijden, Vincent Aranzana-Climent, Heleen van der Spek, Brenda C. M. de Winter, William Couet, Joseph Meletiadis, Anouk E. Muller, Sanne van den Berg
Summary: In this study, the pharmacokinetics and pharmacodynamics of polymyxin B were determined in neutropenic infected mice. The fAUC/MIC index was found to best describe the drug’s effectiveness. However, the standard dosing regimen did not achieve the PK/PD targets for the majority of clinical isolates, suggesting that polymyxin B may be ineffective as monotherapy for serious infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Dolores R. Serrano, Aytug Kara, Ivan Yuste, Francis C. C. Luciano, Baris Ongoren, Brayan J. J. Anaya, Gracia Molina, Laura Diez, Bianca I. I. Ramirez, Irving O. O. Ramirez, Sergio A. A. Sanchez-Guirales, Raquel Fernandez-Garcia, Liliana Bautista, Helga K. K. Ruiz, Aikaterini Lalatsa
Summary: 3D printing technologies offer customization of medicine to meet individual patients' needs. Various techniques such as nozzle-based extrusion, laser-writing systems, and powder binder jetting are used to print solid dosage forms, implants, stents, medical devices, and locally applied medicines. The challenge lies in selecting the appropriate 3D printing technique and pharmaceutical ink to ensure desired physicochemical and biological performance. Integration of biopharmaceuticals, nanotechnology-based drugs, and 3D printing opens up new possibilities for personalized nanomedicines. Continuous manufacturing using 3D-printed microfluidic chips facilitates translation into clinical practice.
Article
Pharmacology & Pharmacy
Guillermo Landa, Teresa Alejo, Theo Sauzet, Julian Laroche, Victor Sebastian, Frederic Tewes, Manuel Arruebo
Summary: Compared to parenteral administration, direct pulmonary administration of colistin maximizes lung drug deposition and reduces systemic side effects. However, the current method of aerosolizing the prodrug colistin methanesulfonate (CMS) results in slow conversion to colistin, limiting its effectiveness. This study synthesized nanoparticle carriers loaded with colistin using different techniques, finding that nanoprecipitation of pure colistin showed the highest drug loading and had the potential to reach the entire lung.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
E. de Pablo, P. O'Connell, R. Fernandez-Garcia, S. Marchand, A. Chauzy, F. Tewes, M. A. Dea-Ayuela, D. Kumar, F. Bolas, M. P. Ballesteros, J. J. Torrado, A. M. Healy, D. R. Serrano
Summary: A carbohydrate-based AmB dry powder inhaler (DPI) formulation was developed to address the lack of effective antifungal pulmonary treatments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Olga Gonzalez-Gonzalez, Enrique Leal, Mercedes Martin-Martinez, Liliana Bautista, Maria Paloma Ballesteros, Juan J. Torrado, Dolores R. Serrano
Summary: The stability of commonly prescribed topical SCG formulations was evaluated. The results showed that these formulations can be stable for up to three months at room temperature. Creamgel formulations with 2% SCG significantly improved the permeation of SCG across the skin, being 4.5-fold higher than formulations prepared with Beeler's base. These findings can guide rational prescription of topical SCG formulations.
Review
Biochemistry & Molecular Biology
Eva Ramos, Emilio Gil-Martin, Cristobal de los Rios, Javier Egea, Francisco Lopez-Munoz, Rene Pita, Antonio Juberias, Juan J. J. Torrado, Dolores R. R. Serrano, Russel J. J. Reiter, Alejandro Romero
Summary: In this review, melatonin is proposed as a therapeutic option to counteract the toxicological mechanisms and pathways activated after exposure to sulfur and nitrogen mustards. Additionally, the metabolites of melatonin are predicted to have a scavenger action and neutralize the damage induced by these blister agents. The anti-inflammatory action and NLRP3 inflammasome modulation of melatonin can also provide protection against sulfur and nitrogen mustard-induced injury.
Article
Pharmacology & Pharmacy
Shizhe Shao, David Bonner, Brendan Twamley, Abhishek Singh, Anne Marie Healy
Summary: This study explored the use of fluidized bed granulation (FBG) to produce co-crystal granules of dapsone (DAP) and different molecular weight polyethylene glycols (PEGs). It was found that solvent evaporation (SE) and FBG were effective in generating co-crystals, with FBG producing co-crystals with higher purity. The co-crystals produced by FBG demonstrated superior pharmaceutical properties compared to those prepared by SE.
Review
Infectious Diseases
Ivan Yuste, Francis C. Luciano, Brayan J. Anaya, Pablo Sanz-Ruiz, Almudena Ribed-Sanchez, Elena Gonzalez-Burgos, Dolores R. Serrano
Summary: The use of additive manufacturing or 3D printing in biomedicine has grown rapidly, especially in pharmaceutical development and manufacturing. It shows promise as a tool for preventing and treating periprosthetic joint infections through the development of novel therapies using 3D-printing techniques. This review provides an in-depth understanding of different approaches and strategies for the current management and prophylaxis of PJIs using 3D printing.
Article
Chemistry, Medicinal
Aytug Kara, Dinesh Kumar, Anne Marie Healy, Aikaterini Lalatsa, Dolores R. Serrano
Summary: Using cocrystals is a promising strategy to improve the physicochemical properties of APIs. This study utilized 3D-printed microfluidic chips to control the cocrystal habit and polymorphism of SDM:4ASA cocrystals, resulting in high-purity cocrystals with improved solubility and bioavailability. The microfluidic device allowed for a more homogenous and rapid mixing process, enabling continuous manufacturing of cocrystals coated on beads in a single step.
Article
Education & Educational Research
Ana Isabel Fraguas-Sanchez, Dolores R. Serrano, M. angeles Medina Sanchez, Elena Gonzalez-Burgos
Summary: This study investigated the impact of a Ph.D. degree on students' satisfaction and career prospects among graduates from the Complutense University of Madrid. The findings suggest that the Ph.D. degree has a positive influence on the development of soft skills and the ability for continuous learning, while its impact on overall employability is minimal.
EDUCATION SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Salome S. Celi, Raquel Fernandez-Garcia, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano
Summary: In recent decades, the increasing incidence and prevalence of pulmonary fungal infections has become a global health problem due to the lack of specific antifungal therapies for pulmonary administration. This study developed microparticles and dry powder inhalers to improve the pharmacological effect of antifungal drugs, providing new options for pulmonary treatment.
Article
Pharmacology & Pharmacy
Sarah Kymberly Santos de Lima, italo Novaes Cavallone, Dolores Remedios Serrano, Brayan J. Anaya, Aikaterini Lalatsa, Marcia Dalastra Laurenti, Joao Henrique Ghilardi Lago, Dalete Christine da Silva Souza, Gabriela Pustiglione Marinsek, Beatriz Soares Lopes, Renata de Britto Mari, Luiz Felipe Domingues Passero, Bozena B. Michniak-Kohn
Summary: This study developed a topical formulation containing 8-HQ and demonstrated its efficacy in experimental cutaneous leishmaniasis. The formulation was able to reduce parasite burden and lesion size without causing significant side effects.
Article
Microbiology
Beatriz Esteban-Cartelle, Dolores R. Serrano, Covadonga Perez Menendez-Conde, Noelia Vicente-Oliveros, Ana alvarez-Diaz, Jesus Fortun Abete, Pilar Martin-Davila, Maria Guembe
Summary: This study demonstrates the suitability of using Meropenem in outpatient parenteral antimicrobial therapy with portable elastomeric infusion devices, and elucidates its physicochemical stability at different concentrations and temperatures.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Olga Gonzalez-Gonzalez, M. Paloma Ballesteros, Juan J. Torrado, Dolores R. Serrano
Summary: In this study, the Accelerated Predictive Stability (APS) approach was used to investigate the commercially available Cristalmina (CR) and extemporaneously compounded chlorhexidine (DCHX) formulations, revealing different degradation kinetics between the two formulations. By predicting and confirming through experiments, it was demonstrated that the shelf life of DCHX extemporaneously compounded formulations could be prolonged by up to 6 months.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)