Article
Chemistry, Multidisciplinary
S. Chemmalar, Abdul Razak Intan-Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, N. S. K. Gowthaman, Md Zuki Abu Bakar
Summary: Calcium carbonate nanoparticles synthesized from blood cockle shells were loaded with gefitinib and paclitaxel, showing potential as a drug delivery system against breast cancer. The nanoparticles exhibited excellent physico-chemical characteristics and slow release kinetics.
Article
Chemistry, Physical
Ali Maleki Nojehdehi, Farina Moghaddam, Bejan Hamawandi
Summary: This study aimed to improve the mechanical properties of glass ionomer cement/ diopside (GIC/DIO) nanocomposite for biomaterial applications. Diopside was synthesized using a sol-gel method and added to GIC at different weight percentages. Characterization of the synthesized diopside was performed using XRD, DTA, SEM, and FTIR analyses. The fabricated nanocomposite showed enhanced compressive strength, microhardness, and fracture toughness. The fluoride-releasing test indicated suitable options for dental restorations and orthopedic implants.
Article
Materials Science, Multidisciplinary
Chitrangda Singh, Chandan Bhogendra Jha, Navneet Kumar, Ragini Singh, Himanshu Ojha, Sreedevi Upadhyayula, Raunak Varshney, Rashi Mathur
Summary: This study synthesized ZIF-8 and conducted simulation studies to gain a comprehensive understanding of the drug's interactions with ZIF-8. Experimental and computational results revealed the adsorption mechanism and energy interactions between the drug and the MOF framework, providing guidance for the design of new metal-organic ligand drug carriers.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Polymer Science
Bogdan-Florin Craciun, Isabela-Andreea Sandu, Dragos Peptanariu, Mariana Pinteala
Summary: Nanomedicine has gained attention for its advantages in the treatment of cancer-related diseases. This study focuses on loading methotrexate and cytarabine into PEGylated squalene micelles to enhance therapeutic effectiveness and minimize drawbacks. The drug-encapsulated micelles demonstrated higher antitumoral activity compared to free drugs and provided sustained release for at least 48 hours.
Article
Food Science & Technology
Maryam Muhammad Mailafiya, Kabeer Abubakar, Samaila Musa Chiroma, Abubakar Danmaigoro, Tawfiq Y. T. Zyoud, Ezamin Bin Abdul Rahim, Mohamad Aris Mohd Moklas, Zuki Abu Bakar Zakaria
Summary: This study aimed to investigate the ameliorative effect of curcumin-loaded cockle shell-derived calcium carbonate nanoparticle (Cur-CSCaCO3NP) on lead-induced neurotoxicity. The results showed that Cur-CSCaCO3NP treatment demonstrated enhanced ameliorative effects compared to free curcumin treatment by reducing oxidative stress and improving motor function.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Melanie Donnette, Mourad Hamimed, Joseph Ciccolini, Yael Berda-Haddad, Elise Kaspi, Geoffroy Venton, Bruno Lacarelle, Regis Costello, L''Houcine Ouafik, Laure Farnault, Raphaelle Fanciullino
Summary: The pharmacokinetics of liposomal CPX-351 in treating AML patients were studied, revealing a major impact of CDA status on cytarabine PK and safety.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Abdurrahim Can Egil, Alessio Carmignani, Matteo Battaglini, Bengu Sueda Sengul, Egemen Acar, Gianni Ciofani, Gozde Ozaydin Ince
Summary: The study reported the synthesis of dual-responsive nanocarriers that can tune drug release rates by controlling pH and temperature, showing potential therapeutic effects on human colorectal adenocarcinoma cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
E. Barchiesi, T. Wareing, L. Desmond, A. N. Phan, P. Gentile, G. Pontrelli
Summary: Drug delivery carriers, specifically layer-by-layer releasing particles, are gaining interest for their ability to control the release of multiple therapeutic drugs and biomolecules. Mathematical models can provide a better understanding of the drug release process, and our model successfully evaluates the transport and release of a drug from a microparticle. Through sensitivity analysis, we found that the outer layer diffusivity is more significant than the diffusivity in the core, and increasing the dissolution parameters leads to an initial burst release of the drug.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fengqin Li, Gutian Zhao, Guizhong Tian
Summary: Currently, stent implantation is the main treatment for severe coronary artery stenosis, using sirolimus-coated stents to inhibit restenosis. In vitro release testing of sirolimus-loaded coatings is commonly done using high-performance liquid chromatography (HPLC) with phosphate buffered solution (PBS). However, this method has limitations in accurately measuring the actual release of sirolimus. In this study, a new method involving drug decay, numerical convolution, and pharmacokinetic models was developed to accurately determine the actual drug release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Min Liu, Wushan Li, Haichang Ma, Xinyu Yang, Anchang Liu, Chunyan Ji
Summary: In this study, the application of gold nanoparticles synthesized by Alhagi maurorum aqueous extract in the treatment of various types of leukemia was investigated. The nanoparticles exhibited cytotoxicity and anti-leukemia properties against leukemia cell lines.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nur Izzati Zakaria, Rosmawani Mohammad, Sharina Abu Hanifah, Khadijah Hilmun Kamarudin, Azrilawani Ahmad
Summary: In this study, 99.5% CaCO3 nanoparticles from cockle shells were successfully synthesised and functionalised with acrylic acid N-hydroxysuccinimide ester to immobilise urease. The immobilised urease showed potential for the development of urea biosensors, with approximately 85.8% of urease covalently immobilised on the nanoparticles' surface areas.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Luigi Talarico, Marco Consumi, Gemma Leone, Gabriella Tamasi, Agnese Magnani
Summary: Quercetin-loaded Solid Lipid Nanoparticles were successfully synthesized in this study, showing high encapsulation efficiency and suitable controlled release. The samples were characterized qualitatively using various techniques, and the encapsulation efficiency, drug release, and antioxidant effect were evaluated in vitro.
Article
Engineering, Mechanical
R. Vescovini, N. Fantuzzi
Summary: This article presents a formulation for studying the free vibrations of open and closed conical shells efficiently. It allows for various boundary conditions and stiffness enhancements. The resulting models have few degrees of freedom, reducing computational effort, and do not require meshing.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Katalin Kristo, Reihaneh Manteghi, Yousif H-E Y. Ibrahim, Ditta Ungor, Edit Csapo, Daniel Berkesi, Zoltan Konya, Ildiko Csoka
Summary: In this study, core-shell nanoparticles containing lysozyme were formulated using precipitation and layering self-assembly. Mathematical equations were determined to understand the effect of process parameters, with pH being identified as the most crucial factor. Findings showed that mixing time significantly influenced encapsulation efficiency and particle size, while enzyme activity correlated well with alpha-helix content.
Article
Materials Science, Ceramics
Ali Maleki Nojehdehi, Farina Moghaddam, Mohammad Taghi Hamedani
Summary: This study successfully synthesized a glass ionomer cement/forsterite nanocomposite by adding different amounts of forsterite to the cement. The nanocomposite with 2% forsterite showed the most significant enhancements in compressive strength, microhardness, and fracture toughness.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
