4.7 Article

Semi-interpenetrating network hyaluronic acid microgel delivery systems in micro-flow

Journal

JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 519, Issue -, Pages 174-185

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2018.02.049

Keywords

Microgel; Semi-interpenetrating network hydrogel particles; Micro-flow; Hyaluronic acid; Injectable hydrogel; Hemocompatibility

Funding

  1. EPSRC [EPSRC EP/L020904/1, EP/M026884/1]
  2. UCL Doctoral Training Programme in Medical Device Innovation
  3. Biotechnology and Biological Sciences Research Council [1483131] Funding Source: researchfish
  4. Engineering and Physical Sciences Research Council [GR/T17953/01] Funding Source: researchfish

Ask authors/readers for more resources

Macroscopic hydrogels are commonly used as injectable scaffolds or fillers, however they may easily obstruct blood vessels, which poses risks and limits their clinical use. In the present study, three types of hyaluronic acid (HA)-based hydrogel micro-particles with non-covalent, covalent semi-interpenetrating and conventional 3D molecular networks, have been designed, fabricated and characterized. The micro particles are spherical, biconcave or irregular in shape and their diameter ranged between 2.5 and 3.5 pm; their suspensions exhibit a tuneable viscosity, shear-thinning behaviour, dynamic stability and dispersity in microfluidic flow as a result of their specific particulate nature, providing thus a well-controlled injectable platform. Hydrogel particle suspensions also demonstrate an enhanced safety profile, in terms of the dispersity, cell safety, and hemocompatibility. In addition, Rhodamine 6G has successfully been loaded and released from the particles as a model for drug delivery. Functionalisation of hydrogel microparticles using synthetic polymers has been proven to be a cost-effective way to achieve desirable rheological properties and flow dynamic stability with improved physicochemical properties and biocompatibility in vitro, showing promise as a multifunctional biomedical material for various advanced surgical devices and therapies. Crown Copyright (C) 2018 Published by Elsevier Inc. All rights reserved.

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