Article
Biochemistry & Molecular Biology
Charlie Jennison, Janna M. Armstrong, Dorender A. Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A. Abatiyow, Myo Naung, Nana K. Minkah, Kristian E. Swearingen, Robert Moritz, Alyssa E. Barry, Stefan H. I. Kappe, Ashley M. Vaughan
Summary: Plasmodium parasites, the eukaryotic pathogens that cause malaria, have three distinct invasive forms adapted to different host environments. Micronemes, a type of secretory organelle, play crucial roles in egress, motility, adhesion, and invasion. This study demonstrates that GPI-anchored micronemal antigen (GAMA) is involved in sporozoite motility, egress, and invasion, suggesting its role as a regulator of microneme function. The findings also show conservation of GAMA's function across Plasmodium species.
MOLECULAR MICROBIOLOGY
(2023)
Article
Parasitology
Antsa Rakotonirina, Pierre-Olivier Maquart, Claude Flamand, Chea Sokha, Sebastien Boyer
Summary: This study aimed to understand the spatial and temporal distribution of sylvatic mosquito populations in Cambodia and determine the factors impacting their abundance and presence. The results revealed a diverse range of mosquito species in the forests, with meteorological and geographical factors influencing their community. Additionally, the abundance of medically important species highlights the high risk of pathogen emergence/re-emergence in the region.
PARASITES & VECTORS
(2023)
Review
Entomology
Li Gao, Wenxu Yang, Jingwen Wang
Summary: Mosquito-borne diseases cause a significant number of deaths each year, but effective vaccines and drugs are lacking. Disease prevention relies mainly on mosquito control, which is currently insufficiently eco-friendly and sustainable. Understanding the metabolic interactions between mosquitoes and pathogens can help develop strategies to reduce mosquito populations or vector competence. This review summarizes current knowledge on the effects of mosquito metabolism on pathogen transmission and highlights the need for further research in order to develop multiple biological prevention and control strategies for mosquito-borne diseases.
Article
Multidisciplinary Sciences
Zhenke Yang, Yang Shi, Huiting Cui, Shuzhen Yang, Han Gao, Jing Yuan
Summary: This study identifies the presence of a Plasmodium flippase in the midgut epithelium, which is essential for parasite survival and mosquito transmission.
Article
Multidisciplinary Sciences
Thiago Luiz Alves e Silva, Andrea Radtke, Amanda Balaban, Tales Vicari Pascini, Zarna Rajeshkumar Pala, Alison Roth, Patricia H. Alvarenga, Yeong Je Jeong, Janet Olivas, Anil K. Ghosh, Hanhvy Bui, Brandon S. Pybus, Photini Sinnis, Marcelo Jacobs-Lorena, Joel Vega-Rodriguez
Summary: The study demonstrates that Plasmodium gametes recruit human plasminogen to their surface and process it into plasmin, facilitating parasite migration in the host. Inhibition of plasminogen activation affects parasite development and is inversely correlated with mosquito infectivity.
Article
Cell Biology
Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schon, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adela Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino
Summary: By using 13 different monoclonal antibodies, researchers have revealed the mechanisms of neutralizing the malaria parasite in host tissues and found that the skin is the most vulnerable site to monoclonal antibody-mediated neutralization.
Article
Multidisciplinary Sciences
Katsuya Taniyama, Masatoshi Hori
Summary: In our previous studies, we have found that blue light with a wavelength similar to 420 nm is highly effective in controlling populations of the mosquito Culex pipiens form molestus. In this study, we investigated the lethal effects of blue light on the Asian tiger mosquito Aedes albopictus and found that the 417 nm blue light had a strong lethal effect on the larvae, pupae, and adults of this species. However, it had no lethal effect on the eggs.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Nanang Rudianto Ariefta, Baldorj Pagmadulam, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: This study evaluated the growth-inhibitory effects of the antimalarial agent sparsomycin against drug-resistant malaria parasites. The results showed that sparsomycin had inhibitory effects on both sensitive and resistant strains of the parasites. This study suggests that sparsomycin has potential as an alternative treatment for malaria.
Article
Parasitology
Nantha Kumar Jeyaprakasam, Sandthya Pramasivan, Jonathan Wee Kent Liew, Lun Van Low, Wan-Yusoff Wan-Sulaiman, Romano Ngui, Jenarun Jelip, Indra Vythilingam
Summary: The study evaluated the potential of Mosquito Magnet as a collection tool for Anopheles mosquito vectors of simian malaria and found that while it was slightly less efficient compared to human trapping methods, it showed superior performance in catching certain Anopheles species.
PARASITES & VECTORS
(2021)
Article
Microbiology
Helen R. Davison, Jessica Crozier, Stacy Pirro, Helge Kampen, Doreen Werner, Gregory D. D. Hurst
Summary: Symbiotic bacteria in Anopheles mosquitoes can alter host biology and the transmission of diseases. A study identified a symbiont called 'Ca. Tisiphia' in Anopheles plumbeus and investigated its genome and metabolic competence. This research provides valuable insights into the symbiotic relationships in Anopheles mosquitoes and their impact on host biology and disease transmission.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Laughing Bear Torrez Dulgeroff, Miranda S. Oakley, Michal C. Tal, Ying Ying Yiu, Joy Q. He, Maia Shoham, Victoria Majam, Winter A. Okoth, Pallavi Malla, Sanjai Kumar, Irving L. Weissman
Summary: CD47 is an antiphagocytic signal that inhibits programmed cell removal of self. Blocking CD47 can significantly improve the therapeutic effect against malaria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Entomology
Amira Nebbak, Lionel Almeras, Philippe Parola, Idir Bitam
Summary: The article discusses the risks of infectious diseases transmitted by mosquitoes to both humans and animals. It focuses on mosquito species and diseases in North Africa, providing an update on the literature and highlighting the need for further research and effective surveillance and control strategies.
Article
Parasitology
Carlos Mora-Rubio, Martina Ferraguti, Sergio Magallanes, Daniel Bravo-Barriga, Irene Hernandez-Caballero, Alfonso Marzal, Florentino de Lope
Summary: The incidence and distribution of vector-borne diseases have significantly increased in recent decades. Understanding the interaction and seasonal variations between vectors, parasites, and hosts can help assess disease risk and predict the impact of climate change on disease transmission.
PARASITES & VECTORS
(2023)
Article
Entomology
Lindsay P. Campbell, Nathan D. Burkett-Cadena, Evaristo Miqueli, Isik Unlu, Kristin E. Sloyer, Johana Medina, Chalmers Vasquez, William Petrie, Lawrence E. Reeves
Summary: Aedes scapularis is an important mosquito species that recently established in southern Florida, marking its first appearance on the Florida Peninsula. Model projections suggest suitable habitats for Ae. scapularis in various areas across the Americas and Caribbean Islands, indicating the need for enhanced surveillance to prevent further spread.
Article
Microbiology
Nanang R. Ariefta, Baldorj Pagmadulam, Masaki Hatano, Noriko Ikeda, Kunio Isshiki, Kazuaki Matoba, Masayuki Igarashi, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: The increasing burden and spread of resistant malaria parasites have driven the demand for a new therapeutic agent. Phebestin showed nanomolar efficacy against Plasmodium falciparum 3D7 and inhibited parasite multiplication in vitro. It exhibited no cytotoxicity against human cells and inhibited parasite stages at high concentrations. In vivo evaluation in mice infected with different malaria strains also showed promising results.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Environmental Sciences
P. Annie Vinosha, J. V. Annie Vinsla, J. Madhavan, Sandhanasamy Devanesan, Mohamad S. AlSalhi, Marcello Nicoletti, Belina Xavier
Summary: The study synthesized Rare Earth Metal dysprosium (Dy) doped Zinc Ferrite as a nano photocatalyst for degrading harmful dyes, with good structural and magnetic properties. It exhibited significant photo-Fenton activity against Methylene blue, showing high efficiency in dye removal. Additionally, it acted as a magnetic recyclable catalyst with minimal reduction in elements and activity after multiple cycles.
ENVIRONMENTAL RESEARCH
(2022)
Review
Polymer Science
Akon Higuchi, Tzu-Cheng Sung, Ting Wang, Qing-Dong Ling, S. Suresh Kumar, Shih-Tien Hsu, Akihiro Umezawa
Summary: This review discusses the current usage of biomaterials in vaccine development, focusing on new platforms and mRNA vaccines. mRNA vaccines are considered safer than traditional vaccines but require special temperature conditions for storage and transportation. Further development is needed to improve the efficacy of mRNA vaccines.
Article
Materials Science, Ceramics
Syed Khasim, Syed G. Dastager, Mohammed Issa Alahmdi, Taymour A. Hamdalla, Chellasamy Panneerselvam, Mohammad Basha Makandar
Summary: A green synthesis approach using rice husk biomass was used for the fabrication of a Pd/TiO@BC nanocomposite, which showed crystalline structure and successful biosynthesis. The nanocomposite exhibited high efficiency in the removal of Congo red dye from wastewater and showed potential for applications in various fields such as electrochemistry, catalysis sensors, and wastewater treatment.
CERAMICS INTERNATIONAL
(2023)
Article
Electrochemistry
Premnath Kumar, Malathi Arumugam, Madhavan Jagannathan, Gilberto Maia, Supareak Praserthdam, Piyasan Praserthdam
Summary: In this study, an efficiently reduced Ni-CoS/C composite was synthesized by a hydrothermal method. It exhibited higher current density, lower Tafel slope, and improved stability for hydrogen evolution reaction.
ELECTROCHIMICA ACTA
(2022)
Article
Electrochemistry
Premnath Kumar, Malathi Arumugam, Gilberto Maia, Supareak Praserthdam, Piyasan Praserthdam
Summary: This study reports the synthesis of a novel Ni-Mo2C/GA composite by hydrothermal and carbonization process, which exhibits improved morphology and hydrogen evolution reaction (HER) performance. The dual role of CTAB in the synthesis of Mo2C as a surfactant and carbon source resulted in enhanced material properties. The Ni-Mo2C/GA composite, obtained by incorporating Ni and graphene aerogel (GA), showed improved current density, low overpotential, low Tafel slope, enhanced active surface area, and excellent stability.
ELECTROCHIMICA ACTA
(2023)
Article
Environmental Sciences
Thirugnanam Bavani, Parthasarathy Sasikala, Swaminathan Arumugam, Arumugam Malathi, Piyasan Praserthdam, Jagannathan Madhavan
Summary: Constructing S-scheme heterojunction between two semiconductor materials is an effective route to increase the photocatalytic degradation efficiency. A novel S-scheme WS2/BiYWO6 heterojunction photocatalyst was prepared by wet chemical route, and its photocatalytic degradation performance was evaluated by analyzing the degradation of Rhodamine B under visible light. The 20 wt.% WS2 loaded WS2/BiYWO(6) composite exhibited enhanced photocatalytic degradation ability, with O-2(center dot)- and (OH)-O-center dot radicals playing a crucial role in the degradation process.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Biomaterials
Ting Wang, Qian Liu, Yu-Tang Chang, Jun Liu, Tao Yu, Kailibinuer Maitiruze, Lee-Kiat Ban, Tzu-Cheng Sung, Suresh Kumar Subbiah, Remya Rajan Renuka, Shih Hsi Jen, Henry Hsin-Chung Lee, Akon Higuchi
Summary: Human pluripotent stem cells (hPSCs) can differentiate into various cell types and are promising for regenerative medicine. However, they cannot be cultured in traditional flasks, but can be cultured on biomaterials with specific hPSC interaction sites. The use of hydrogels conjugated with designed peptides significantly improved the expansion of hPSCs compared to recombinant vitronectin-coated plates. Moreover, hPSCs cultured on these hydrogels can still differentiate into specific cell lineages even after long-term cultivation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Environmental Sciences
Malathi Arumugam, Ravindranadh Koutavarapu, Kamala-Kannan Seralathan, Supareak Praserthdam, Piyasan Praserthdam
Summary: This study synthesized noble metal-doped BiOBr microspheres using a solvothermal method and tested their degradation performance of phenol under visible light. The results showed that the Pd-doped BiOBr material exhibited enhanced degradation efficacy, about 4 times higher than pure BiOBr. This improvement was attributed to enhanced photon absorption, reduced recombination rate, and increased surface area facilitated by surface plasmon resonance. Additionally, the Pd-doped BiOBr sample showed good reusability and stability after 3 cycles of operation. A plausible charge transfer mechanism for phenol degradation over the Pd-doped BiOBr sample was also revealed. These findings highlight the potential application of noble metal-doped semiconductor metal oxides as visible light materials for the elimination of colorless toxins from untreated wastewater.
Article
Chemistry, Multidisciplinary
Rajaduraipandian Subramanian, Mohemedibrahim Ponnanikajamideen, Rapael Samuel Rajendran, Mohammed Ali Alshehri, Abdulrahman Alasmari, Chellasamy Panneerselvam, Selvendiran Periyasamy
Summary: The study focused on the green synthesis of titanium dioxide nanoparticles (G-TiO2 NPs) using Salacia reticulata leaf extract and evaluated their antidiabetic, anti-inflammatory, and antibacterial effects as well as toxicity in zebrafish. Zebrafish embryos were exposed to different concentrations of G-TiO2 NPs, and the results showed acute developmental toxicity, mortality, and malformation. Additionally, G-TiO2 NPs exhibited antidiabetic, anti-inflammatory, and antibacterial activities. Overall, this study provided valuable insights into the synthesis and potential applications of G-TiO2 NPs.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Entomology
Kalimuthu Loganathan, Vasugi Chellamuthu, Dhanalakshmi Karupuswami, Kannan Mohan, Udaiyan Suresh, Chellasamy Panneerselvam, Subrata Trivedi, Al Thabiani Aziz, Fuad A. Alatawi, Alaa M. Munshi, Hatem A. Al-Aoh, Hamza S. Al-Shehri, Aliyah S. Alhawiti
Summary: Mosquitoes act as reservoirs for viruses and microorganisms, posing a significant health risk to humans and livestock. Controlling disease-carrying mosquito vectors is crucial. This study analyzed the chemical composition of Parmotrema reticulatum and confirmed the synthesis of lichen-mediated AgNPs. The AgNPs exhibited significant toxicity against Aedes aegypti larvae and reduced the survival and reproductive efficiency of adults.
ENTOMOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Subramani Abilaji, Kuppusamy Sathishkumar, Jayaraman Narenkumar, Mohamad S. Alsalhi, Sandhanasamy Devanesan, Punniyakotti Parthipan, Balakrishnan Muthuraj, Aruliah Rajasekar
Summary: Textile effluent was treated through sequential electro oxidation (EO) and photo electro oxidation (PEO) using RuO2-IrO2 coated titanium electrode as an anode and cathode, followed by biodegradation. The pre-treatment of textile effluent by photo electro oxidation for 14 h resulted in 92% decolorization. Subsequent biodegradation of the pre-treated textile effluent achieved a 90% reduction in chemical oxygen demand. Metagenomics analysis revealed the involvement of Fla-vobacterium, Dietzia, Curtobacterium, Mesorhizobium, Sphingobium, Streptococcus, Enterococcus, Prevotella, and Stenotrophomonas bacterial communities in the biodegradation of textile effluent. Therefore, the integration of sequential photo electro oxidation and biodegradation offers an efficient and eco-friendly approach for treating textile effluent.
Article
Biotechnology & Applied Microbiology
Lavanya Nehru, Gayathri Devi Kandasamy, Vanaraj Sekar, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Abdulrahman Alasmari, Preethi Kathirvel
Summary: The biogenic manufacture of ZnONPs using endophytic fungus was studied, and their biological properties were evaluated. The biosynthesized ZnO-NPs were characterized using spectroscopic and microscopic methods and showed potent bioactivity, making them a promising choice for biomedical applications.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Entomology
Al Thabiani Aziz, Chellasamy Panneerselvam, Edwin Edward-Sam
Summary: Mosquitoes are a huge threat to millions of people, animals, and organisms worldwide. Vector-borne diseases such as malaria, filariasis, dengue fever, chikungunya, and Japanese encephalitis have a significant impact on humans globally. The use of botanical insecticides, including plant-derived compounds, essential oils, green synthesized nanomaterials, and microbial secondary metabolites, has shown great efficacy in controlling mosquito vectors.
ENTOMOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hoda A. Salem, Karema Abu-Elfotuh, Sharifa Alzahrani, Nermin I. Rizk, Howaida S. Ali, Nehal Elsherbiny, Alhanouf Aljohani, Ahmed M. E. Hamdan, Panneerselvam Chellasamy, Nada S. Abdou, Ayah M. H. Gowifel, Alshaymaa Darwish, Osama Mohamed Ibrahim, Zakaria Y. Abd Elmageed
Summary: This study aimed to investigate the relationship between social isolation and the progression of Parkinson's disease (PD), as well as the therapeutic effects of punicalagin. The results showed significant effects of social isolation and manganese chloride exposure on behavior, biochemistry, and histopathology in rats, with punicalagin effectively alleviating these effects.
Article
Chemistry, Multidisciplinary
Abdullah F. Shater, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Hattan Gattan, Bassam M. Al-Ahmadi, Nizar H. Saeedi, Mohammed M. Jalal, Chellasamy Panneerselvam
Summary: This study tested the effectiveness of manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and the malaria vector Anopheles stephensi. AgNPs were synthesized using plant filtrate from Madhuca longifolia and their characteristics were determined through various methods. The results showed that the biosynthesized AgNPs had promising larval and pupal toxicity against A. stephensi in laboratory settings at low dosages. Additionally, they exhibited significant in vitro antimalarial activity against P. falciparum.
GREEN PROCESSING AND SYNTHESIS
(2023)