Article
Hematology
Come Bommier, Claire Mauduit, Juliette Fontaine, Estelle Bourbon, Pierre Sujobert, Sarah Huet, Lucile Baseggio, Sandrine Hayette, Camille Laurent, Emmanuel Bachy, Herve Ghesquieres, Catherine Thieblemont, Gilles Salles, Alexandra Traverse-Glehen
Summary: The study showed that TNGS can lead to a more accurate diagnosis in challenging lymphoma cases, thus improving clinical management in routine practice.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mona El Khoury, Antonio Maietta, Alphonse Tran, Isabelle Trop, Lucie Lalonde, Benoit Mesurolle
Summary: A 25-year-old woman was referred to a breast clinic for assessment of a palpable mass in her left breast that developed quickly in 2 weeks. Clinical examination and imaging studies did not reveal any significant abnormalities.
Editorial Material
Hematology
Elaine S. Jaffe, James R. Cook
Summary: In this article, the authors present the experience of the French Lymphopath network in using core needle biopsies and excisional lymph node biopsies as a tool for the primary diagnosis of lymphoma.
Article
Oncology
Alexander Kurz, Dieter Krahl, Heinz Kutzner, Raymond Barnhill, Antonio Perasole, Maria Teresa Fernandez Figueras, Gerardo Ferrara, Stephan A. Braun, Hans Starz, Mar Llamas-Velasco, Jochen Sven Utikal, Stefan Froehling, Christof von Kalle, Jakob Nikolas Kather, Lucas Schneider, Titus J. Brinker
Summary: This study developed the first human 3D melanoma histology model with complete data and code availability. Through testing and discussion, it is found that 3D histology models have potential applications in digital pathology, but there are still limitations that need to be addressed.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Katharina Kriegsmann, Frithjof Lobers, Christiane Zgorzelski, Joerg Kriegsmann, Charlotte Janssen, Rolf Ruedinger Meliss, Thomas Muley, Ulrich Sack, Georg Steinbuss, Mark Kriegsmann
Summary: This study provides a curated dataset for training and improving deep learning models to classify skin tumors. The use of deep learning techniques enables accurate automated classification of skin tumors, aiding in tumor localization and supporting routine diagnostics.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Mariko Tsujimoto, Yasumasa Kakei, Nozomi Yamano, Takeshi Fujita, Takehiro Ueda, Ryusuke Ono, Sae Murakami, Shinichi Moriwaki, Chikako Nishigori
Summary: This study aims to evaluate the clinical efficacy of N-acetyl-5-methoxytryptamine in patients with XP. A multicentre, double-blinded placebo-controlled, two-group crossover study followed by a 52-week open study was conducted based on preclinical research. The results suggest that the drug can effectively suppress skin tumor development.
Article
Pathology
Alicia Tourneret, Melissa Alame, Valerie Rigau, Luc Bauchet, Michel Fabbro, Laura De Oliveira, Valere Cacheux, Valerie Costes, Vanessa Lacheretz-Szablewski
Summary: The study identified atypical/unbalanced gene rearrangements in 19.6% of DLBCL patients, who had poorer prognosis compared to those with simple gene rearrangements. Detection of these abnormalities through FISH analysis at diagnosis is crucial for predicting outcomes in DLBCL patients.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Dermatology
Yahya Daneshbod, Jason Kissell, Justin Kerstetter
Summary: Diagnosis of giant vascular spiradenocylindroma (GVSC) can be challenging clinically and radiologically, with differential diagnoses including angiolipoma, angiosarcoma, and glomus-tumor-like vascular lesions. Dermatologists should consider this variant of spiradenocylindroma in cases of vascular-like lesions.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Dermatology
Stephen S. Koh, Sherry M. Youssef, Mohsen Baghchechi, Crystal T. Chang, Johann Kolev, Anthony C. Shay, Sean K. Lau, David S. Cassarino
Summary: The 2022-2023 mpox outbreak is a global concern due to its previous regional localization. Cases have been observed presenting with atypical symptoms, including initial skin lesions. The histopathological changes of mpox lesions are rarely reported, but two cases presented with ulceration and viral cytopathologic changes.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Pathology
David E. Elder, Megan M. Eguchi, Raymond L. Barnhill, Kathleen F. Kerr, Stevan R. Knezevich, Michael W. Piepkorn, Lisa M. Reisch, Joann G. Elmore
Summary: Diagnostic error refers to the deviation from a gold standard diagnosis, usually defined by expert opinion or unexpected events in follow-up. In the case of melanoma, deviations from the gold standard diagnosis are more likely due to uncertainty, lack of specific criteria, and differences in opinion, rather than a lack of diagnostic skills. This article examines the concept of diagnostic error in relation to diagnostic uncertainty and discusses the concept of overdiagnosis in melanoma.
Article
Dermatology
Mike C. M. van Zon, Jose D. van der Waa, Mitko Veta, Gertruud A. M. Krekels
Summary: The study showed that deep learning models based on whole-slide images can be a feasible option to improve the clinical workflow and reduce costs in histological analysis of BCC in MMS.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Pathology
Amy S. Joehlin-Price, Thaddeus W. Mully
Summary: This study analyzed 189 consecutive vulvar biopsy cases and found squamous intraepithelial neoplasia, melanocytic neoplasia, and lichenoid dermatoses to be common diagnoses. Clinicians were most likely to include correct diagnoses in their differential for melanocytic lesions and least likely for inflammatory lesions.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Cell Biology
Farhaan Hafeez, Andrew C. Krakowski, Christine G. Lian, Rosalynn M. Nazarian, Joseph J. Maleszewski
Summary: Superficial angiomyxomas are slow-growing skin mesenchymal tumors. This study found abnormal expression of PRKAR1A in non-syndromic superficial angiomyxomas, providing evidence for its role in the pathogenesis of these tumors.
Review
Oncology
Akira Satou, Taishi Takahara, Shigeo Nakamura
Summary: Hodgkin lymphomas (HLs) consist of classic HL (CHL) and nodular lymphocyte predominant HL (NLPHL). Recent molecular research has led to significant developments in the treatment and identification of HLs. The PD-1/PD-L1 pathway, NF-kappa B, and JAK/STAT have been identified as key players in CHL development. NLPHL is characterized by preserved B cell features and shares similarities with T-cell/histiocyte-rich large B-cell lymphoma. This paper provides an overview of the morphologic, immunophenotypic, and molecular features of CHL and NLPHL.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Xuexin He, Chentao Jin, Xiao He, Shuang Wu, Rui Zhou, Xiaohui Zhang, Kai Zhang, Weizhong Gu, Jing Wang, Hong Zhang
Summary: Pathology is a medical specialty focused on studying the nature and causes of disease, and plays a crucial role in connecting basic research and clinical medicine. Challenges such as invasiveness and sample representativeness limitations exist in traditional pathology, while molecular imaging provides a noninvasive way to visualize and measure biological processes at the molecular level. A new pathophysiology visualization system based on molecular imaging is showing great potential in reforming pathological practice, driving improvements in trans-scale imaging, transparency, and translation processes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Jeremy Force, Lynn J. Howie, Sara L. Abbott, Rex Bentley, P. Kelly Marcom, Gretchen Kimmick, Kelly Westbrook, Sarah L. Sammons, Michelle Parks, Donna L. Topping, Ryan Emerson, Gloria Broadwater, Terry Hyslop, Kimberly L. Blackwell, Smita K. Nair
CLINICAL BREAST CANCER
(2018)
Article
Immunology
William S. DeWitt, Krystle K. Q. Yu, Damien B. Wilburn, Anna Sherwood, Marissa Vignali, Cheryl L. Day, Thomas J. Scriba, Harlan S. Robins, Willie J. Swanson, Ryan O. Emerson, Philip H. Bradley, Chetan Seshadri
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Ashley S. Plant, Shohei Koyama, Claire Sinai, Isaac H. Solomon, Gabriel K. Griffin, Keith L. Ligon, Pratiti Bandopadhayay, Rebecca Betensky, Ryan Emerson, Glenn Dranoff, Mark W. Kieran, Jerome Ritz
JOURNAL OF NEURO-ONCOLOGY
(2018)
Letter
Dermatology
Jie Wang, Bryan Rea, Paul Haun, Ryan Emerson, Ilan Kirsch, Adam Bagg
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Meeting Abstract
Oncology
Jeffrey L. Nordstrom, John Muth, Courtney L. Erskine, Catherine Sanders, Erik C. Yusko, Ryan O. Emerson, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Seock-Ah Im, Yung-Jue Bang, Giuseppe Giaccone, Todd Michael Bauer, Howard A. Burris, Jan E. Baughman, Edwin P. Rock, Paul A. Moore, Ezio Bonvini, Keith L. Knutson
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Immunology
Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins, Eric J. Alm
Article
Cell Biology
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Catherine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold
Article
Multidisciplinary Sciences
Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M. Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, Farrah Kheradmand, Runzhe Chen, Chi-Wan Chow, Heather Lin, Chantale Bernatchez, Ali Jalali, Xin Hu, Chang-Jiun Wu, Agda Karina Eterovic, Edwin Roger Parra, Erik Yusko, Ryan Emerson, Sharon Benzeno, Marissa Vignali, Xifeng Wu, Yuanqing Ye, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Tina Cascone, Alexandra Snyder, Jennifer A. Wargo, Roy Herbst, Stephen Swisher, Humam Kadara, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A. Vaporciyan, Boris Sepesi, Don L. Gibbons, Harlan Robins, Patrick Hwu, John V. Heymach, Padmanee Sharma, James P. Allison, Veera Baladandayuthapani, Jack J. Lee, Mark M. Davis, Ignacio I. Wistuba, P. Andrew Futreal, Jianjun Zhang
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski, Ilan R. Kirsch, Charles Sang, Harlan S. Robins, Bryan Howie, Anna Sherwood
Article
Medicine, General & Internal
Rebeca Sanz-Pamplona, Marilena Melas, Asaf Maoz, Stephanie L. Schmit, Hedy Rennert, Flavio Lejbkowicz, Joel K. Greenson, Xavier Sanjuan, Maria Lopez-Zambrano, M. Henar Alonso, Chenxu Qu, Kevin J. McDonnell, Gregory E. Idos, Marissa Vignali, Ryan Emerson, Paul Fields, Elisabet Guino, Cristina Santos, Ramon Salazar, Harlan S. Robins, Gad Rennert, Stephen B. Gruber, Victor Moreno
Article
Oncology
F. Milano, R. O. Emerson, R. Salit, K. A. Guthrie, L. A. Thur, A. Dahlberg, H. S. Robins, C. Delaney
FRONTIERS IN ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Emily Engelhart, Ryan Emerson, Leslie Shing, Chelsea Lennartz, Daniel Guion, Mary Kelley, Charles Lin, Randolph Lopez, David Younger, Matthew E. Walsh
Summary: The dataset presented here contains quantitative binding scores of scFv-format antibodies against a SARS-CoV-2 target peptide, which can be used in the development and benchmarking of machine learning models. This dataset is the largest publicly available dataset that includes antibody sequences, antigen sequence, and quantitative measurements of binding scores, providing an opportunity to evaluate antibody-specific representation models for machine learning.
Article
Pathology
Lik Wee Lee, Shahin Shafiani, Beryl Crossley, Ryan O. Emerson, David Williamson, Anna Bunin, Justin Vargas, Arnold S. Han, Ian M. Kaplan, Peter H. R. Green, Ilan Kirsch, Govind Bhagat
Summary: Research on sequencing T-cell receptor genes in the small intestine of patients with celiac disease reveals changes associated with the disease, including increased frequency of rearranged T-cell receptors and higher abundance of specific amino acid sequences.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charlotte A. James, Krystle K. Q. Yu, Martine Gilleron, Jacques Prandi, Vijayendar R. Yedulla, Zuzanna Z. Moleda, Eleonora Diamanti, Momin Khan, Varinder K. Aggarwal, Josephine F. Reijneveld, Peter Reinink, Stefanie Lenz, Ryan O. Emerson, Thomas J. Scriba, Michael N. T. Souter, Dale I. Godfrey, Daniel G. Pellicci, D. Branch Moody, Adriaan J. Minnaard, Chetan Seshadri, Ildiko Van Rhijn
CELL CHEMICAL BIOLOGY
(2018)