Journal
JOURNAL OF CLINICAL ONCOLOGY
Volume 36, Issue 2, Pages 160-+Publisher
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2017.75.3467
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Funding
- PharmaMar
- GlaxoSmithKline
- Novartis
- MSD
- AstraZeneca
- NATIONAL CANCER INSTITUTE [ZIASC010354] Funding Source: NIH RePORTER
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Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research. (c) 2017 by American Society of Clinical Oncology
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