Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 6, Pages 2197-2198Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI121080
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Funding
- [UM1CA121947]
- [P30AI094189]
- [P30CA006973]
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The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.
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