Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Endocrinology & Metabolism
Fjola Johannesdottir, Melissa S. Putman, Sherri-Ann M. Burnett-Bowie, Joel S. Finkelstein, Elaine W. Yu, Mary L. Bouxsein
Summary: The study found that postmenopausal Black women have similar rates of bone loss compared to White women, with lower weight women experiencing greater declines in bone density and microstructure at the radius. Women who lost weight during the follow-up period had higher rates of bone loss, particularly at the tibia, while higher baseline total body fat mass was protective against bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Orthopedics
Carsten Schlickewei, Conradin Schweizer, Klaus Pueschel, Benjamin Ondruschka, Holger Kleinertz, Alexej Barg, Tim Rolvien, Julian Stuerznickel
Summary: This study examines the effects of age, sex, and subregion on the bone microarchitecture and strength of the distal fibula. Results show that cortical parameters increase and trabecular parameters decrease from distal to proximal. Age is primarily associated with a cortical decrease in all subregions for women, while men also exhibit age-associated decreases in certain parameters. The stiffness and failure load are highest in the type C subregion for both genders. A critical age-related decline in bone strength parameters is observed in the type B subregion for women, providing an explanation for the increased incidence of low-traumatic type B fractures in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
E. H. S. Koy, A. Amouzougan, E. Biver, R. Chapurlat, T. Chevalley, S. L. Ferrari, A. Fouilloux, H. Locrelle, H. Marotte, M. Normand, R. Rizzoli, L. Vico, T. Thomas
Summary: This study presents reference values of HR-pQCT measurements in a Franco-Swiss female cohort at the distal radius and tibia sites, considering specific age bounds. Microarchitectural parameters start to decline before the age of 30, with the optimal bone profile observed between the ages of 22 to 27 in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Rehabilitation
Mingyang Li, Yi Zeng, Yong Nie, Yuangang Wu, Yuan Liu, Limin Wu, Bin Shen
Summary: Long kneeling is associated with increased bone volume fraction and trabecular number, while long squatting is associated with decreased trabecular separation and increased trabecular thickness. Subchondral bone microarchitecture may be a useful monitoring indicator for knee osteoarthritis patients who engage in prolonged kneeling or squatting.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Nicklas Hojgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrom Jensen, Peter Vestergaard
Summary: This study compared the bone mineral density, bone strength, and bone microarchitecture of individuals with type 1 diabetes and type 2 diabetes to those without diabetes. The results showed that individuals with type 1 diabetes had lower bone density, while those with type 2 diabetes had higher bone density. Both groups showed favorable bone microarchitecture and strength parameters at the tibia and radius.
Article
Endocrinology & Metabolism
Ko Chiba, Naoki Iwamoto, Kounosuke Watanabe, Kazuteru Shiraishi, Kengo Saito, Naoki Okubo, Atsushi Kawakami, Makoto Osaki
Summary: This study investigated the effect of denosumab on bone mineral density (BMD) and bone microarchitecture in patients with rheumatoid arthritis (RA) treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). The results suggest that denosumab can increase BMD and improve bone microarchitecture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Orthopedics
Julian Stuerznickel, Felix N. Schmidt, Conradin Schweizer, Herbert Mushumba, Matthias Krause, Klaus Pueschel, Tim Rolvien
Summary: This study analyzed the skeletal microarchitecture of the proximal fibula and its association with age. It found that age was a relevant risk factor for impaired skeletal microarchitecture in women. The regions of drill tunnels according to anatomic techniques showed superior bone microarchitecture compared to the Larson technique.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Biotechnology & Applied Microbiology
Jiazi Gao, Pengling Ren, He Gong
Summary: This study investigated the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs. The results showed that the micromechanical properties of articular cartilage were the lowest at 1 month of age, and the earliest degeneration of articular cartilage occurred at 6 months of age. No degeneration in the micro- or nanostructure of subchondral bone was observed before 9 months. These findings provide valuable insights into the formation and progression of hip osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Sophie Rapagna, Bryant C. Roberts, Lucian B. Solomon, Karen J. Reynolds, Dominic Thewlis, Egon Perilli
Summary: This study quantified the cartilage thickness, subchondral bone plate thickness, and subchondral trabecular bone microarchitecture in knees with varus- or valgus-malalignment and end-stage knee osteoarthritis. The results showed significant differences in cartilage and bone structures between varus-OA, valgus-OA, and controls, suggesting variations in load distribution and overall joint response to daily stimuli in OA patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Letter
Endocrinology & Metabolism
Chantal M. J. de Bakker, Lauren A. Burt, Leigh Gabel, David A. Hanley, Steven K. Boyd
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Sport Sciences
Leigh Gabel, Anna-Maria Liphardt, Paul A. Hulme, Martina Heer, Sara R. Zwart, Jean D. Sibonga, Scott M. Smith, Steven K. Boyd
Summary: The study revealed that long-duration spaceflight leads to significant decreases in bone density and strength in astronauts, while pre-flight markers of bone turnover and exercise history can help identify individuals at risk for bone loss. Additionally, increasing training volume can help prevent loss of bone strength and density.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Letter
Endocrinology & Metabolism
Lauren A. Burt, Emma O. Billington, Marianne S. Rose, Richard Kremer, David A. Hanley, Steven K. Boyd
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
R. M. Plett, T. D. Kemp, L. A. Burt, E. O. Billington, D. A. Hanley, S. K. Boyd
Summary: The study developed and validated a finite element approach for longitudinal HR-pQCT studies that reduced variability and improved measurement accuracy by using 3D image registration to account for misalignment. Results showed that 3D rigid-body registration improved measurement precision in ex vivo samples and minimized longitudinal in vivo reproducibility for failure load estimates, making it suitable for assessing the effects of interventions on bone strength in longitudinal studies.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
A. S. Michalski, B. A. Besler, L. A. Burt, S. K. Boyd
Summary: Opportunistic CT screening using abdominal CT scans is effective in predicting individuals with previous fracture at major osteoporotic sites. Combining bone mineral density and finite element-estimated bone strength provides the best prediction for low-energy fractures in women.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Chantal M. J. de Bakker, Nikolas K. Knowles, Richard E. A. Walker, Sarah L. Manske, Steven K. Boyd
Summary: Musculoskeletal injuries can cause local accumulation of blood and fluid in the bone marrow, which is detected as edema-like marrow signal intensities (EMSI) on medical imaging. The changes in marrow soft tissue composition after injury can affect the measurement of bone density. This can be corrected by using DECT-based density calibration or HR-pQCT microFE measurements.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Endocrinology & Metabolism
Danielle Elizabeth Whittier, Sarah L. Manske, Emma Billington, Richard E. A. Walker, Prism S. Schneider, Lauren A. Burt, David Arthur Hanley, Steven Kyle Boyd
Summary: This study used HR-pQCT scanning technology to investigate the bone microarchitecture characteristics of hip fracture patients and found that these patients had significantly reduced bone density, more pronounced osteoporosis, and larger void defects. Bone phenotyping analysis revealed a significant association between hip fractures and low density phenotype, but there were differences in bone phenotype continuum between male and female patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Audrey Bobillier, Philippe Wagner, Danielle E. Whittier, Rene Ecochard, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: The study found that poor vitamin D status and high parathyroid hormone levels are associated with the deterioration of bone microarchitecture and reduced bone strength in older men.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ifaz T. Haider, Lindsay L. Loundagin, Andrew Sawatsky, Paul J. Kostenuik, Steven K. Boyd, W. Brent Edwards
Summary: This study quantified the relationship between antiresorptive treatment and fatigue life in bone from ovariectomized cynomolgus monkeys. The results showed that the antiresorptive treatment groups had higher fatigue-life measurements and improved bone microstructure and composition compared to the control group. Therefore, antiresorptive treatment may have a protective effect against fatigue fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lauren A. Burt, Martin Kaufmann, Marianne S. Rose, Glenville Jones, Emma O. Billington, Steven K. Boyd, David A. Hanley
Summary: This randomized controlled trial investigated the effect of high-dose vitamin D-3 on total bone mineral density (TtBMD) in the radius and tibia. The study found that increasing vitamin D dose was associated with increased plasma levels of 25-(OH)D-3, 24,25-(OH)(2)D-3, and 1,24,25-(OH)(3)D-3, but not 1,25-(OH)(2)D-3. These vitamin D metabolites were associated with a decline in TtBMD. The findings suggest that vitamin D metabolites other than 1,25-(OH)(2)D-3 may play a role in bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Paige M. Wyatt, Kelly Drager, Erik M. Groves, Trent Stellingwerff, Emma O. Billington, Steven K. Boyd, Lauren A. Burt
Summary: The importance of relative energy deficiency in sports (REDs). A study investigated the differences in bone quality between low-risk and at-risk winter endurance athletes for REDs. The results showed that athletes at higher risk had lower bone quality, indicating the negative impact of REDs on athletes' health and performance.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Biology
Tannis D. Kemp, Bryce A. Besler, Leigh Gabel, Steven K. Boyd
Summary: This study uses numerical methods to estimate changes in astronaut bone health during spaceflight and recovery on Earth. The results show reasonable fit between the modeled and observed bone morphometry, Dice coefficient, and symmetric distance. However, the estimation of dynamic bone morphometry is poor.
Article
Endocrinology & Metabolism
Lauren A. Burt, Leigh Gabel, Emma O. Billington, David A. Hanley, Steven K. Boyd
Summary: High-dose vitamin D supplementation may lead to a decrease in radius and tibia bone mineral density, and the response may vary depending on the imaging modality and skeletal site.
Article
Endocrinology & Metabolism
Robert R. McLean, Elizabeth J. Samelson, Amanda L. Lorbergs, Kerry E. Broe, Marian T. Hannan, Steven K. Boyd, Mary L. Bouxsein, Douglas P. Kiel
Summary: Muscle loading plays a key role in bone health, with grip strength positively correlated with distal radius bone strength in older adults. Higher grip strength was associated with larger bone size and higher bone strength, suggesting that bone size may be a primary driver of this relationship.
Review
Endocrinology & Metabolism
Linsey U. Gani, Chanika Sritara, Robert D. Blank, Weiwen Chen, Julia Gilmour, Ruban Dhaliwal, Ranjodh Gill
Summary: Dual-energy X-ray absorptiometry (DXA) is the gold standard method for measuring bone mineral density (BMD), which is strongly associated with fracture risk. The International Society for Clinical Densitometry (ISCD) has released new official positions on follow-up DXA examinations, highlighting the importance of considering the clinical context and individualized testing intervals.
JOURNAL OF CLINICAL DENSITOMETRY
(2024)
Article
Endocrinology & Metabolism
Andia Cheneymann, Josephine Therkildsen, Simon Winther, Louise Nissen, Jesper Thygesen, Bente L. Langdahl, Ellen-Margrethe Hauge, Morten Bottcher
Summary: Osteoporosis is often overlooked, and contrast-enhanced CT scans used for other diseases may overestimate bone mineral density. Adjustments for this effect are necessary before contrast-enhanced images can be clinically utilized for BMD screening.
JOURNAL OF CLINICAL DENSITOMETRY
(2024)