EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis

EGFL7 reduces CNS inflammation in mouse

(2018) Catherine Larochelle et al.   Nature Communications

Randomized Phase II Trial of Parsatuzumab (Anti‐EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First‐Line Metastatic Colorectal Cancer

(2017) Rocío García‐Carbonero et al.   ONCOLOGIST

Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia

(2017) Dimitrios Papaioannou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel therapeutic modalities and drug delivery – erlotinib liposomes modified with galactosylated lipid: in vitro and in vivo investigations

(2017) Haoping Xu et al.   Artificial Cells Nanomedicine and Biotechnology

Epidermal growth factor-like domain 7 promotes cell invasion and angiogenesis in pancreatic carcinoma

(2016) Xiaochun Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

(2016) Eric R. Lechman et al.   CANCER CELL

A4. EGFL7 in placenta trophoblast and endothelial cells: implications in the pathogenesis of pre-eclampsia

(2016) M. Massimiani et al.   Journal of Maternal-Fetal & Neonatal Medicine

Overexpressed MALAT1 promotes invasion and metastasis of gastric cancer cells via increasing EGFL7 expression

(2016) Quan-jun Deng et al.   LIFE SCIENCES

Expression of epidermal growth factor-like domain 7 may be a predictive marker of the effect of neoadjuvant chemotherapy for locally advanced uterine cervical cancer

(2016) Makoto Yamauchi et al.   Oncology Letters

High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer

(2016) Diane Pannier et al.   Oncology Letters

MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression

(2016) Ming-Hua Hu et al.   Oncotarget

NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

(2016) Vincent Kuek et al.   Scientific Reports

Suppression of the Epidermal Growth Factor-like Domain 7 and Inhibition of Migration and Epithelial-Mesenchymal Transition in Human Pancreatic Cancer PANC-1 Cells

(2015) Yun-Liang Wang et al.   Asian Pacific Journal of Cancer Prevention

Tissue microRNA-126 expression level predicts outcome in human osteosarcoma

(2015) Wei Liu et al.   Diagnostic Pathology

Intra-tumoural vessel area estimated by expression of epidermal growth factor-like domain 7 and microRNA-126 in primary tumours and metastases of patients with colorectal cancer: a descriptive study

(2015) Torben Hansen et al.   Journal of Translational Medicine

Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia

(2015) A M Dorrance et al.   LEUKEMIA

Epidermal growth factor-like domain 7 promotes migration and invasion of human trophoblast cells through activation of MAPK, PI3K and NOTCH signaling pathways

(2015) M. Massimiani et al.   MOLECULAR HUMAN REPRODUCTION

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling

(2015) Der-I Kao et al.   Stem Cell Reports

Targeting EGFL7 Expression through RNA Interference Suppresses Renal Cell Carcinoma Growth by Inhibiting Angiogenesis

(2014) Han-Feng Xu et al.   Asian Pacific Journal of Cancer Prevention

Integrin αvβ5 in endothelial cells of rat splenic sinus: an immunohistochemical and ultrastructural study

(2014) Kiyoko Uehara et al.   CELL AND TISSUE RESEARCH

DNMT1-MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9-EGFR-AKT Signaling

(2014) R. Liu et al.   CLINICAL CANCER RESEARCH

Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer

(2014) Li Zhou et al.   Hepatobiliary & Pancreatic Diseases International

miR-126 Functions as a Tumor Suppressor in Osteosarcoma by Targeting Sox2

(2014) Chenglin Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell and matrix modulation in prenatal and postnatal equine growth cartilage, zones of Ranvier and articular cartilage

(2014) Maria Löfgren et al.   JOURNAL OF ANATOMY

EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades

(2014) Shek Man Chim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High expression of epidermal growth factor-like domain 7 is correlated with poor differentiation and poor prognosis in patients with epithelial ovarian cancer

(2014) Jinju Oh et al.   Journal of Gynecologic Oncology

Epidermal Growth Factor-like Domain 7 Predicts Response to First-Line Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer

(2014) T. F. Hansen et al.   MOLECULAR CANCER THERAPEUTICS

Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro

(2014) XIAOLUN YANG et al.   Molecular Medicine Reports

Epidermal Growth Factor-Like Domain-Containing Protein 7 (EGFL7) Enhances EGF Receptor−AKT Signaling, Epithelial−Mesenchymal Transition, and Metastasis of Gastric Cancer Cells

(2014) Bai-Hua Luo et al.   PLoS One

EGFL7 ligates  v 3 integrin to enhance vessel formation

(2013) I. Nikolic et al.   BLOOD

MicroRNA-126 and epidermal growth factor-like domain 7–an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial

(2013) T F Hansen et al.   BRITISH JOURNAL OF CANCER

Osteosarcoma treatment – Where do we stand? A state of the art review

(2013) Anja Luetke et al.   CANCER TREATMENT REVIEWS

Transcriptional regulation of blood vessel formation

(2013) Marta S Charpentier et al.   CELL CYCLE

Angiogenic factors in bone local environment

(2013) Shek Man Chim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CASZ1 Promotes Vascular Assembly and Morphogenesis through the Direct Regulation of an EGFL7/RhoA-Mediated Pathway

(2013) Marta S. Charpentier et al.   DEVELOPMENTAL CELL

Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer

(2013) GÉRALDINE PHILIPPIN-LAURIDANT et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

(2013) Leisa Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis

(2013) Yun Zhang et al.   NATURE CELL BIOLOGY

Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer

(2013) YU ZHANG et al.   ONCOLOGY REPORTS

Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer

(2012) T Sasahira et al.   BRITISH JOURNAL OF CANCER

miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development

(2012) Stefania Nicoli et al.   DEVELOPMENTAL CELL

EGFL7: a unique angiogenic signaling factor in vascular development and disease

(2011) D. Nichol et al.   BLOOD

Egfl7 Promotes Tumor Escape from Immunity by Repressing Endothelial Cell Activation

(2011) S. Delfortrie et al.   CANCER RESEARCH

EGFL6 Promotes Endothelial Cell Migration and Angiogenesis through the Activation of Extracellular Signal-regulated Kinase

(2011) Shek Man Chim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification

(2011) Xianrong Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23 27 24 clusters

(2011) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non–small cell lung cancer and surrounding tissues

(2011) Tatyana Azhikina et al.   Cancer Genetics

Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7

(2010) D. Nichol et al.   BLOOD

Potential Involvement of Twist2 and Erk in the Regulation of Osteoblastogenesis by HB-EGF-EGFR Signaling

(2010) Takashi Nakamura et al.   CELL STRUCTURE AND FUNCTION

Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

(2010) Fumihiko Takeuchi et al.   CIRCULATION

Expression and clinical significance of EGFL7 in malignant glioma

(2010) Chun-hai Huang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Down-regulation of miR-126 expression in colorectal cancer and its clinical significance

(2010) Xiang-Min Li et al.   MEDICAL ONCOLOGY

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells

(2010) Min Zeng et al.   PLoS One

miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7

(2009) Yanqin Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma

(2009) Fan Wu et al.   HEPATOLOGY

International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons

(2009) Lisa Mirabello et al.   INTERNATIONAL JOURNAL OF CANCER

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal

(2009) Mirko H.H. Schmidt et al.   NATURE CELL BIOLOGY

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

(2008) A. Trindade et al.   BLOOD

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126

(2008) F. Kuhnert et al.   DEVELOPMENT

Vertebrate CASTOR Is Required for Differentiation of Cardiac Precursor Cells at the Ventral Midline

(2008) Kathleen S. Christine et al.   DEVELOPMENTAL CELL

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling

(2008) TacGhee Yi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA