Chronic phosphodiesterase type 5 inhibition has beneficial effects on subcutaneous adipose tissue plasticity in type 2 diabetic mice

Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7

(2017) Riccardo Pofi et al.   Scientific Reports

The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

(2016) Elise Jeffery et al.   Cell Metabolism

PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial

(2016) Daniela Fiore et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

(2016) Elena Maneschi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

(2016) Daniela Fiore et al.   Stem Cell Research

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes

(2015) Elisabetta Mandosi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial

(2015) Claudia E. Ramirez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice

(2015) Mary Anna Venneri et al.   PLoS One

Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

(2014) Elisa Giannetta et al.   BMC Medicine

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Increased cGMP promotes healthy expansion and browning of white adipose tissue

(2013) Michaela M. Mitschke et al.   FASEB JOURNAL

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

(2012) Elisa Giannetta et al.   CIRCULATION

Reduced Vascular Nitric Oxide–cGMP Signaling Contributes to Adipose Tissue Inflammation During High-Fat Feeding

(2011) Priya Handa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Preferential Fat Deposition in SubcutaneousVersusVisceral Depots Is Associated with Insulin Sensitivity

(2011) Tracey McLaughlin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Sildenafil promotes adipogenesis through a PKG pathway

(2010) Xiaodong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gluteofemoral body fat as a determinant of metabolic health

(2010) K N Manolopoulos et al.   INTERNATIONAL JOURNAL OF OBESITY