Article
Chemistry, Multidisciplinary
Neeracha Sangpreecha, Saoraya Chanmuang, Kyung-Hee Park, Madhuri Sangar, Divya Sharma, Doyoung Song, Yun-Ja Park, Hea-Mi Sung, Kitipong Promyo, Kyung-Sik Ham
Summary: This study compared the effects of fresh and fermented onions on gut health in rats for the first time. The findings have potential implications for the development of healthy food products using onions. Fresh onion is high in FODMAPs, which may be problematic for inflammatory bowel disease (IBD). Fermentation of onion could help reduce FODMAP issues and increase the availability of beneficial compounds like quercetin. The study demonstrated that high doses of fermented onion improved IBD symptoms, while fresh onion consumption appeared to worsen the condition.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Food Science & Technology
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Summary: This study investigated the alleviating effects of kimchi and Leuconostoc mesenteroides DRC 1506 on ulcerative colitis (UC). Mice were orally given a dose of 1 x 10(9) CFU/day of freeze-dried kimchi suspension and DRC for 3 weeks, and UC was induced with dextran sulfate sodium (DSS). The results showed that the kimchi and DRC groups reduced colitis symptoms and improved the inflammatory response and mucosal barrier function in the colon.
Article
Food Science & Technology
Hye-Jung Moon, Youn-Soo Cha, Kyung-Ah Kim
Summary: This study investigated the protective effects of blackcurrant (BC) on ulcerative colitis (UC) in mice. BC powder relieved symptoms of colitis, reduced the production of pro-inflammatory cytokines, regulated the NF-kappa B signaling pathway and gut barrier function related genes, and modulated the gut microbiota composition.
Article
Medicine, Research & Experimental
Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng
Summary: This study demonstrates that the L.p R3 strain significantly improves symptoms and pathological damage in mice with colitis, and influences immune function by regulating the Th17/Treg cell balance in DSS-induced colitis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Hyeon-Ji Lim, Ha-Rim Kim, Su-Ji Jeong, Hee-Jong Yang, Myeong Seon Ryu, Do-Youn Jeong, Seon-Young Kim, Chan-Hun Jung
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence due to changes in dietary structure. Recent evidence suggests that gut dysbiosis is closely associated with the pathogenesis of IBD. Cheonggukjang, a traditional Korean fermented soybean paste, contains probiotics that may affect the gut microbiota composition and potentially protect against IBD. This study found that traditional and commercial Cheonggukjang samples contain various types of beneficial probiotics. Cheonggukjang reduced the progression of DSS-induced colitis symptoms and improved intestinal barrier integrity. It also suppressed the expression of proinflammatory cytokines and inflammatory mediators through the inactivation of NF-kappa B and MAPK signaling pathways. These findings suggest that Cheonggukjang has protective effects against DSS-induced colitis and may be used as a functional food for improving inflammatory diseases.
Article
Gastroenterology & Hepatology
Danfeng Dong, Tongxuan Su, Wei Chen, Daosheng Wang, YiLun Xue, Qiuya Lu, Cen Jiang, Qi Ni, Enqiang Mao, Yibing Peng
Summary: Clostridioides difficile exacerbates the severity of colitis in mice with inflammatory bowel disease by altering the gut microbiota and enhancing neutrophil recruitment. Inhibition of neutrophil migration or interleukin-1 beta production can ameliorate inflammation. This study provides insights into the complex interaction between microbiota and immune responses in C. difficile-induced inflammation.
Article
Gastroenterology & Hepatology
Seunghun Lee, Jeonghoon Heo, Eun-Kyung Ahn, Jae Hyun Kim, Young-Ho Kim, Hee-Kyung Chang, Sang-Joon Lee, Jongsik Kim, Seun-Ja Park
Summary: The study revealed that conditioned mADSCs secretome could alleviate colitis-induced damage, inhibit the synthesis of inflammatory cytokines, and exhibit a higher regenerative effect.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding, Hongwen Sun
Summary: Arbutin has protective effects in ulcerative colitis, potentially through the regulation of inflammatory factors and the maintenance of intestinal barrier function. Its mechanism of action may be associated with the MAPK/ELK1 pathway.
Article
Biochemistry & Molecular Biology
Sze Wing Ho, Hani El-Nezami, Harold Corke, Chun Sing Ho, Nagendra P. Shah
Summary: The study showed that the combination of L. helveticus and citrulline had a significant synergistic effect in protecting against injury from DSS-induced colitis. This combination therapy could be a potential treatment for IBD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Priyanka Raju Chougule, Rajendra Sangaraju, Pradeep B. B. Patil, S. S. Y. H. Qadri, Virendra V. V. Panpatil, Sudip Ghosh, Sathish Kumar Mungamuri, Manjula Bhanoori, Sukesh Narayan Sinha
Summary: This study demonstrates the protective effect of ethyl gallate (EG) and propyl gallate (PG) in various combinations on DSS-induced ulcerative colitis in mice. The results show that EG and PG significantly reduce the severity of colitis and improve clinical symptoms. This suggests that the combination of EG and PG has potential as a treatment for inflammatory bowel disease (IBD).
INFLAMMOPHARMACOLOGY
(2023)
Article
Microbiology
Siwen Qu, Lina Fan, Yadong Qi, Chaochao Xu, Yingying Hu, Shujie Chen, Wei Liu, Weili Liu, Jianmin Si
Summary: Akkermansia muciniphila has been shown to play a crucial role in the progression of colitis, with its protective effects in acute colitis depending on NLRP3 activation. This study enriches the understanding of the mechanisms underlying A. muciniphila's effects and offers a new prospect for probiotic-based treatments of colitis. The interaction between gut microbiota and host immune response plays a significant role in intestinal inflammatory diseases.
MICROBIOLOGY SPECTRUM
(2021)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Medicine, Research & Experimental
Paulo da Silva Watanabe, Andreza Manzato Cavichioli, Joana D'Arc de Lima Mendes, Rubina Aktar, Madusha Peiris, L. Ashley Blackshaw, Eduardo Jose de Almeida Araujo
Summary: This study evaluated the anatomical and functional changes in the colon during the development of acute and chronic DSS-induced UC in mice. The results showed that UC caused thickening of the colonic wall, fibrosis, and reduction in tuft cells, leading to abnormal colonic motility. Further studies may focus on stimulating tuft cell hyperplasia to reduce damage caused by UC.
Article
Plant Sciences
Renshi Li, Ce Chen, Bei Liu, Wen Shi, Kuniyoshi Shimizu, Chaofeng Zhang
Summary: BDG effectively alleviated symptoms and damage in chronic ulcerative colitis mice by suppressing inflammation in the intestines and lungs. It protected the integrity of intestinal epithelial cells, contributing to the inhibition of colitis and lung injury.
Article
Pharmacology & Pharmacy
Samira Zolfaghari, Peiman Brouki Milan, Ahmad Reza Dehpour, Motahareh Rajabi Fomeshi, Fatemeh Eskandari, Loghman Ebrahimi, Seyed Mahmoud Hashemi, Mohammad Taghi Joghataei
Summary: In this study, the effect of priming adipose-derived mesenchymal stem cells (ADMSCs) with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) on their immunomodulatory function was investigated. The results showed that priming with poly I:C significantly reduced splenocyte proliferation mediated by ADMSCs and alleviated the clinical and histopathological severity of arthritis. Furthermore, poly I:C-primed ADMSCs also decreased the secretion of inflammatory cytokines and increased the levels of anti-inflammatory cytokines. In contrast, priming with LPS reduced the therapeutic effect of ADMSCs in the arthritis model.
PHARMACOLOGICAL REPORTS
(2022)
Article
Engineering, Biomedical
Zahra Khosrowpour, Seyed Mahmoud Hashemi, Samira Mohammadi-Yeganeh, Mehdi Moghtadaei, Peiman Brouki Milan, Lorenzo Moroni, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: The decellularized placental sponge shows potential as a bone substitute and provides a platform for communication between macrophages and mesenchymal stem cells, guiding the differentiation of stem cells towards bone cells.
Article
Medicine, Research & Experimental
Nashmin Fayazi Hosseini, Razieh Amini, Mohammad Ramezani, Massoud Saidijam, Seyed Mahmoud Hashemi, Rezvan Najafi
Summary: Encapsulating chemotherapeutic molecules in nanocarriers is a justifiable solution in decreasing the risk of their side effects and boosting the efficiency of treatment. This study developed a new method for treating colorectal cancer using AS1411 aptamer-functionalized exosomes to deliver chemotherapy drugs. The results demonstrated that this method effectively suppressed tumor growth and has potential clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Neda Heidari, Hajar Abbasi-Kenarsari, Saeed Namaki, Kaveh Baghaei, Mohammad Reza Zali, Zahra Mirsanei, Seyed Mahmoud Hashemi
Summary: The study demonstrates that MSC-derived exosomes can attenuate colitis by regulating the balance of Treg/Th17 cells, increasing anti-inflammatory cytokines, and decreasing pro-inflammatory cytokines expression.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Mandana Sattari, Mina Masoudnia, Kazem Mashayekhi, Seyed Mahmoud Hashemi, Nikoo Khannazer, Sepanta Sattari, Saeed Mohammadian Haftcheshmeh, Amir Abbas Momtazi-Borojeni
Summary: The molecular mechanisms of senescence in dental pulp stem cells (hDPSCs) stimulated with lipopolysaccharide (LPS) from oral pathogenic bacteria were investigated in this study. The mRNA and protein expression of four senescence-related genes were significantly upregulated in a time-dependent manner following stimulation with different LPSs. Furthermore, the highest expression of certain genes was observed at different time points depending on the type of LPS.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Virology
Ensie Sadat Mirsharif, Maryam Rajabnia Chenary, Mahmood Bozorgmehr, Saeed Mohammadi, Seyed Mahmoud Hashemi, Susan Kabudanian Ardestani, Mohammad-Taghi Beigmohammadi, Alireza Abdollahi, Alireza Sadeghipour, Amina Kariminia, Fatemeh Tuserkani, Tooba Ghazanfari
Summary: The aim of this study was to identify biomarker(s) to predict mortality risk in COVID-19 patients. The study found that the count of CD8+ HLA-DR+ T cells was significantly associated with disease severity and mortality in COVID-19 patients. It suggests that monitoring the levels of these cells may help identify high-risk patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Neda Mokhberian, Kazem Sharifi, Ehsan Soleimaninejadian, Mohamad Eftekhary, Seyed Mahmoud Hashemi, Shohreh Farhadi, Satomi Miwa, Hossein Ghanbarian
Summary: This study demonstrates that upregulation of SIRT1 can be achieved by knocking down the natural antisense transcript SIRT1-NAT, leading to improved therapeutic potentials of human MSCs. Knockdown of SIRT1-NAT enhances the proliferation and differentiation abilities of MSCs, reduces senescence-associated activity, and reverses senescence-associated molecular changes.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Kosar Malekpour, Ali Hazrati, Sara Soudi, Seyed Mahmoud Hashemi
Summary: Mesenchymal stromal/stem cells (MSCs) exert their therapeutic effects through various mechanisms, including differentiation, production of growth factors, immunomodulatory factors, and extracellular vesicles. Recent studies have also highlighted the therapeutic potential of MSCs through mitochondrial transfer, with different methods of transfer being investigated. Pathological conditions can cause mitochondrial damage in cells, leading to decreased ATP production and cell death. Restoring mitochondrial content, function, and homeostasis through MSCs mitochondrial transfer can have significant effects on cell attributes and behavior, crucial for therapeutic purposes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Alireza Yeganeh, Anwar Fathollahi, Seyed Mahmoud Hashemi, Farshid Yeganeh
Summary: The study evaluated the effect of mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) on cytokine production and gene expression related to T helper cell subsets. The treatment with MSC-EV increased the frequency of CD4(+)CD25(+)FOXP3(+) T cells and upregulated Foxp3 mRNA level.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Immunology
Somaye Sadeghi, Fahimeh Ramezani Tehrani, Safa Tahmasebi, Abbas Shafiee, Seyed Mahmoud Hashemi
Summary: Cell-derived exosomes have great potential in modern therapy for drug delivery and therapeutic applications, thanks to their unique characteristics. However, challenges including short circulation time, weak targeting capacity, and inadequate controls hinder large-scale production and clinical application.
INFLAMMOPHARMACOLOGY
(2023)
Article
Allergy
Majdedin Ghalavand, Ruhollah Dorostkar, Hojat Borna, Samira Mohammadi-Yeganeh, Seyed Mahmoud Hashemi
Summary: The aggressiveness of metastatic cancers such as triple-negative breast cancer (TNBC) is primarily due to the epithelial-mesenchymal transition (EMT) mechanism. The Phosphoinositide 3-kinases (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating EMT in cancer microenvironments. This study investigates the effects of rapamycin and MicroRNA (miR)-122 on the aggressive behavior of TNBC.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Javad Charostad, Mohammad Rezaei Zadeh Rukerd, Shahab Mahmoudvand, Davood Bashash, Seyed Mohammad Ali Hashemi, Mohsen Nakhaie, Keivan Zandi
Summary: This paper provides a comprehensive overview of highly pathogenic avian influenza H5N1, including its origin, transmission, and virus structure. It explores topics such as immune response, pathogenesis, and diagnostic tools, offering insights for better management of potential pandemics.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Zohreh Bolandi, Seyed Mahmoud Hashemi, Mozhgan Abasi, Maryam Musavi, Shahin Aghamiri, Nastaran Miyanmahaleh, Hossein Ghanbarian
Summary: This study investigates the role of miR-29b in T cell differentiation reprogramming, and demonstrates that the delivery of miR-29b through adipose mesenchymal stem cell-derived exosomes alters the differentiation of CD4(+) T cells and holds promise for treating inflammatory disorders.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Tayebeh Fooladi, Mohammad Reza Soudi, Seyed Mahmoud Hashemi, Peyman Abdeshahian
Summary: The study reported a novel bioactive compound, Childinan SF-2, isolated from soil ascomycete fungus with significant antibacterial, antioxidant, and cytotoxic properties. The compound may lead to the development of novel, safe, and useful substances for medicinal applications.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Immunology
Hanieh Mojtahedi, Nikoo Hossein-khannazer, Seyed Mahmoud Hashemi, Mina Masoudnia, Monireh Askarzadeh, Arash Khojasteh, Mandana Sattari
Summary: This study evaluated the effects of P. gingivalis and E. coli lipopolysaccharide (LPS) on the gene expression of TLRs and inflammatory cytokines in human dental pulp stem cells. The results showed that both types of LPS stimulate inflammation through increased TLR4 expression, with P. gingivalis LPS showing stronger stimulation within the first 24 hours. However, with prolonged exposure time, both LPS appeared to have anti-inflammatory properties.
IRANIAN JOURNAL OF IMMUNOLOGY
(2022)
