Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Jiang Liu, Xin-Tong Yao, Xiao-Lei Feng, Xi-Zhuang Bai
Summary: In recent years, there has been increasing attention on bone loss related diseases, such as osteoporosis and osteonecrosis of the femoral head, which exhibit symptoms of insufficient bone mass. Mesenchymal stem cells (MSCs) hold potential as a new solution for bone disease, as they can be induced to differentiate into osteoblasts. This study investigates the mechanism by which BMP2 drives MSCs to differentiate into osteoblasts through ACKR3/p38/MAPK signaling. The findings suggest that ACKR3 could be a novel therapeutic target for bone-associated diseases and bone-tissue engineering.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Yan Deng, Ling Li, Jia-Hui Zhu, Pei-Pei Li, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Bai-Cheng He, Yuxi Su
Summary: This study demonstrates that overexpression of COX-2 enhances BMP9's osteogenic ability through upregulation of TGF-beta 1, resulting in the activation of p38 signaling pathway in MSCs.
Article
Biochemistry & Molecular Biology
Jin Wook Hwang, Won-Jong Park, Younho Han
Summary: Asarylaldehyde is proposed for osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) to prevent bone loss. It promotes osteogenic differentiation of hPDLSCs by increasing the expression of osteoblast-specific markers through regulating the p38/ERK signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Yixuan Jiang, Na Xin, Yi Xiong, Yanjun Guo, Ying Yuan, Qin Zhang, Ping Gong
Summary: α-calcitonin gene-related peptide (αCGRP) plays a crucial role in regulating osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the mitogen-activated protein kinase (MAPK) signaling pathway. Activation of αCGRP leads to increased phosphorylation of ERK1/2 and p38 MAPK, resulting in upregulated expression of osteogenic genes and enhanced formation of alkaline phosphatase and calcified nodules. Inhibition of this signaling pathway impairs BMSCs' osteogenic differentiation, proliferation, and apoptosis.
CELL TRANSPLANTATION
(2022)
Article
Cell Biology
Yuying He, Zuping Wu, Sirui Chen, Jiahe Wang, Li Zhu, Jing Xie, Chenchen Zhou, Shujuan Zou
Summary: This study revealed the expression status of NOD1 in periodontitis. Activation of NOD1 greatly decreased the osteogenic capacity of hPDLSCs, which was mediated by the phosphorylation of p38 downstream signaling.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Fen Xiao, Chen-Yi Tang, Hao-Neng Tang, Hui-Xuan Wu, Nan Hu, Long Li, Hou-De Zhou
Summary: This study revealed that Lnc-FR332443 inhibits adipogenesis by regulating the expression of Runx1, suggesting it as a potential drug target for obesity prevention and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Dongdong Fei, Yanmin Xia, Qiming Zhai, Yazheng Wang, Feng Zhou, Wanmin Zhao, Xiaoning He, Qintao Wang, Yan Jin, Bei Li
Summary: This study focuses on the clonal osteogenic heterogeneity of periodontal ligament stem cells (PDLSCs) and uncovers a mechanism where exosome-mediated PINK1/Parkin-dependent mitophagy regulates interclonal communication among SCCs with osteogenic heterogeneity, promoting osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jing Guo, Zhuochen Chen, Yue Xiao, Guiyuan Yu, Yong Li
Summary: SATB1 plays a key role in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through the regulation of the p38 MAPK and ERK MAPK signaling pathways. These findings may provide a new strategy for bone regeneration using BMSCs.
Article
Plant Sciences
Avinash Sanap, Kalpana Joshi, Tejas Shah, Girish Tillu, Ramesh Bhonde
Summary: The study showed that Piper longum L. fruit extract significantly increased proliferation of WJMSCs and enhanced Ca2+ accumulation and matrix mineralization, along with promoting alkaline phosphatase (ALP) activity and the expression of key gene mRNAs. This suggests that the fruit extract can enhance osteogenic differentiation of WJMSCs, potentially serving as an anti-osteoporotic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Changzhen Wang, Hongmei Ning, Jiao Gao, Teng Xue, Ming Zhao, Xiaoxia Jiang, Xiaoming Zhu, Ximin Guo, Hong Li, Xiaoyan Wang
Summary: This study investigated the impact of hematopoietic cells on MSCs and found that partial deletion of the Pten gene in hematopoietic cells can lead to abnormal differentiation of MSCs. There is a reciprocal relationship between hematopoietic cells and MSCs, with an important role in bone development.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Shunyi Tong, Sanhua Fang, Kangjie Ying, Weiwei Chen
Summary: Metallic implants have significant applications in clinical orthopedics but wear out over time due to mechanical loading, leading to complications such as wear debris formation and aseptic loosening. This study focuses on the influence of titanium particles, commonly used in clinical practice, on the osteogenic differentiation of mesenchymal stem cells. Results showed that titanium particles significantly inhibit osteogenic differentiation in a dose-dependent manner. Further exploration revealed that the MAPK signaling pathway, specifically the phosphorylation of ERK1/2, is involved in this inhibition.
Article
Dermatology
Jian Sun, Jie Zhou, Jianhui Zhou, Wenxin Xu, Yali Du, Zhenyu Jia, Yingjie Shen, Xiaohua Lin, Xulan Wang, Yuxuan Bao, Zhiheng Rao, Siyang Dong, Yongde Luo, Weitao Cong, Litai Jin, Xiaokun Li
Summary: Cutaneous wound healing is a complex process, and FGF4 has been identified as an important regulator of wound repair by promoting re-epithelialization through the migration and proliferation of keratinocytes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Sung-Bin Lee, Hyun-Jin Lee, Jun-Beom Park
Summary: This study investigates the effects of BMP-9 on cell survival, osteogenesis, and mineralization using spheroids derived from human gingival stem cells. The results demonstrate that BMP-9 can stimulate early osteogenic differentiation in stem cell spheroids.
MEDICINA-LITHUANIA
(2023)
Article
Biotechnology & Applied Microbiology
Rongkui Zhou, Shichang Miao, Jun Xu, Liping Sun, Yaofei Chen
Summary: The study showed that Circ_0000020 is upregulated during osteogenic differentiation and interacts with miR-142-5p to regulate BMP2 expression, promoting osteogenic differentiation of BMSCs. This positive regulation occurs through the Circ_0000020/miR-142-5p/BMP2/SMAD-dependent signaling pathway.