GANT-61 and GDC-0449 induce apoptosis of prostate cancer stem cells through a GLI-dependent mechanism

Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer

(2015) S.S. Islam et al.   MOLECULAR CARCINOGENESIS

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

(2015) Murielle Mimeault et al.   Oncotarget

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

(2015) Akwasi Agyeman et al.   Oncotarget

Hedgehog-GLI Signaling Inhibition Suppresses Tumor Growth in Squamous Lung Cancer

(2014) L. Huang et al.   CLINICAL CANCER RESEARCH

The role of theSHHgene in prostate cancer cell resistance to paclitaxel

(2014) Malgorzata Statkiewicz et al.   PROSTATE

Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication

(2013) Annelies Gonnissen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

(2012) Junsheng Fu et al.   CANCER LETTERS

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

(2012) Chad M. McKee et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b

(2012) Maria Karlou et al.   PROSTATE

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Hedgehog signaling protein expression and its association with prognostic parameters in prostate cancer: A retrospective study from the view point of new 2010 anatomic stage/prognostic groups

(2011) Tae-Jung Kim et al.   JOURNAL OF SURGICAL ONCOLOGY

Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

(2011) Brahma N. Singh et al.   PLoS One

GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor

(2010) Guangchun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

(2010) T. Mazumdar et al.   CANCER RESEARCH

Hedgehog signaling and therapeutics in pancreatic cancer

(2010) F. C. Kelleher   CARCINOGENESIS

Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells

(2010) M. Mimeault et al.   MOLECULAR CANCER THERAPEUTICS

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Sonic Hedgehog pathway activity in prostate cancer

(2010) OLGA BRAGINA et al.   Oncology Letters

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

(2009) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hedgehog signaling regulates proliferation of prostate cancer cells via stathmin1

(2009) Moon-Kee Chung et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The Hedgehog Pathway and Pancreatic Cancer

(2009) Manuel Hidalgo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies

(2008) Murielle Mimeault et al.   ENDOCRINE REVIEWS

Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression

(2008) S Azoulay et al.   JOURNAL OF PATHOLOGY

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE