Article
Food Science & Technology
Pan Chao, Feng Yongheng, Zhou Jin, Zhu Yu, Yang Shiyong, Yang Kunxing, Ma Yong
Summary: This study revealed that in gastric cancer development, HOTAIR expression increases while miRNA-206 expression decreases. Knockdown of HOTAIR suppresses cell viability, increases apoptosis, inhibits invasion and migration by regulating miRNA-206, and suppresses CCND1 and CCND2 expression. HOTAIR targeting miRNA-206 and miRNA-206 targeting CCND1 and CCND2 play crucial roles in the antitumor effects in gastric cancer.
FOOD SCIENCE & NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Niloufar Rezaei, Mandana Kazem Arki, Zohre Miri-Lavasani, Roya Solhi, Mahsa Khoramipour, Hamid Rashedi, Hamid Asadzadeh Aghdaei, Nikoo Hossein-Khannazer, Ebrahim Mostafavi, Massoud Vosough
Summary: This study aims to optimize treatment doses and overcome multidrug resistance in gastric cancer by developing an optimal niosomal formulation for doxorubicin and paclitaxel delivery. The results show that the drug-loaded niosomes have a higher release rate and can effectively inhibit tumor cell proliferation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Kui Zhao, Xiaohui Cheng, Zhenyu Ye, Yecheng Li, Wei Peng, Yongyou Wu, Chungen Xing
Summary: Exosomal circ_0000338 plays a role in promoting chemoresistance in colorectal cancer cells by interacting with miR-217 and miR-485-3p, affecting cell proliferation and apoptosis. Delivery of circ_0000338 via exosomes could serve as a potential diagnostic and therapeutic marker for 5-FU resistance in CRC patients.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fengcun Ji, Chao Lang, Pengfei Gao, Huanle Sun
Summary: Gastric cancer is a common malignancy with high incidence and mortality, facing challenges of tumor recurrence, metastasis, and non-specific treatment targets, needing better therapeutic strategies.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wencheng Kong, Guang Yin, Sixin Zheng, Xinchun Liu, Akao Zhu, Panpan Yu, Jian Zhang, Yuqiang Shan, Rongchao Ying, Huicheng Jin
Summary: Gastric cancer is one of the most common malignant tumors in the world, with many genetic and epigenetic risk factors playing a significant role in its development. HOTAIR, as an important epigenetic factor, is involved in the development of gastric cancer through various mechanisms and has prognostic value.
Article
Biochemistry & Molecular Biology
Lili Fan, Han Lei, Ying Lin, Zhengwei Zhou, Juanni Li, Anqi Wu, Guang Shu, Sebastien Roger, Gang Yin
Summary: This study found that miR-222-3p inhibits the migration and proliferation of OC cells and is negatively correlated with CDK19. Hotair, on the other hand, promotes the proliferation and migration of OC cells by inhibiting miR-222-3p and is positively correlated with CDK19 expression. These findings are important for a better understanding of the mechanism of occurrence and development of OC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Jiawen Zhao, Lei Zhang, Yingzhu Zhao, Nan Wu, Xi Zhang, Rong Guo, Huimeng Li, Chunxiang Li, Kai Zheng, Dequan Liu, Shicong Tang
Summary: This study investigated the role of lncRNA HOTAIR in breast cancer cells and its molecular mechanism. The results showed that high expression of HOTAIR was associated with cell proliferation, invasion, and migration in breast cancer, and HOTAIR regulated the expression of miR-1 and GOLPH3 genes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fuxiu Shi, Xinyue Chen, Yi Wang, Yujie Xie, Junpei Zhong, Kangtai Su, Miao Li, Yuqiu Li, Qing Lin, Youjia Zhou, Jie Wang, Lixia Xiong
Summary: This study reveals the role of the HOTAIR/miR-203/CAV1 axis in breast cancer through the use of bioinformatics tools and basic experiments, expanding the role network of HOTAIR as a ceRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jia Chen, Shu-Fen Hou, Feng-Jie Tang, Dai-Song Liu, Zi-Zi Chen, Hong-Lian Zhang, Shao-Hua Wang
Summary: HOTAIR, through up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC. Targeting HOTAIR, Sp1 or the underlying mechanisms may benefit CSCC treatment, as shown by functional assays and in vivo models.
Article
Environmental Sciences
Reza Safavi, Hossein Soltanzadeh, Zahra Hojati
Summary: This study aimed to enhance the therapeutic efficacy of Dox by co-administration of Scr in gastric cancer treatment. The results showed that Scr-Dox combination therapy exerted stronger anti-cancer effects on AGS and MKN28 cell lines, significantly reducing cell proliferation, invasion, and migration, increasing apoptosis rate, and modulating the expression of apoptosis- and metastasis-related genes. In conclusion, Scr-Dox combination therapy is more effective in the treatment of gastric cancer compared to Scr and Dox monotherapy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaohui Sun, Yuyan Shi, Nan Hua
Summary: In this study, HOTAIR was found to be highly expressed in patients with gastric cancer and OXA-resistant cells. Silencing HOTAIR significantly inhibited the proliferation, migration, and invasion ability of gastric cancer cells, increased apoptosis rate, and arrested cells in the G2 phase. Furthermore, HOTAIR silencing inhibited the PI3K/Akt signaling pathway and epithelial-mesenchymal transition process, leading to the inhibition of OXA resistance in gastric cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He
Summary: This study found that circ_0042881 is highly expressed in breast cancer and is closely associated with clinical features. The study revealed that circ_0042881 promotes breast cancer progression by sponging miR-217, which activates the RAS protein and initiates downstream signaling pathways.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shouhua Wang, Huanjun Tong, Tingting Su, Di Zhou, Weibin Shi, Zhaohui Tang, Zhiwei Quan
Summary: This study revealed that high expression of circTP63 in GBC is associated with poor prognosis, and knocking down circTP63 effectively inhibits proliferation and invasion of GBC cells, thereby suppressing tumor growth and progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Haifeng Jin, Zheng Wu, Bibo Tan, Zhen Liu, Binqian Zhang
Summary: The research suggests that circITGA7 may play a tumor-suppressive role in gastric cancer by regulating the miR-1471/MTDH signaling pathway. This provides a new potential mechanism involved in the progression of gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Nai Sun, Wei Zhang, Jiaying Liu, Xiaochen Yang, Qinjun Chu
Summary: Propofol exhibits anti-tumor effects on cervical cancer by modulating the HOTAIR/miR-129-5p/RPL14 axis, inhibiting cell viability, colony formation, invasion and migration while promoting apoptosis. Experimental evidence confirms the molecular mechanism underlying the inhibition of CC development by propofol.
ONCOTARGETS AND THERAPY
(2021)