Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

(2016) Goodwin G. Jinesh et al.   APOPTOSIS

Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment

(2016) Elisa ten Hacken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

(2016) M. A. Anderson et al.   BLOOD

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447

(2016) Tara L. Peters et al.   Oncotarget

Prognostic Factors for Chronic Lymphocytic Leukemia

(2016) Christopher Chen et al.   Current Hematologic Malignancy Reports

FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas

(2015) M. Szydlowski et al.   BLOOD

Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors

(2015) N. An et al.   CANCER RESEARCH

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia

(2015) S-S Chen et al.   LEUKEMIA

Increased expression of E3 ubiquitin ligases targeting p53 in CLL patients with wild-type TP53 exhibits associations with clinical features of the disease

(2015) Patryk Gorniak et al.   LEUKEMIA & LYMPHOMA

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

(2015) S. Kreuz et al.   Molecular Cancer

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia

(2015) Alessio Montresor et al.   Oncotarget

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival

(2015) Valentina Trimarco et al.   Oncotarget

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo

(2015) Noelia Purroy et al.   Oncotarget

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

(2014) U. Rozovski et al.   BLOOD

PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell Survival (PIM2/3) and CXCR4-Mediated Microenvironmental Interactions (PIM1)

(2014) S. Decker et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Mcl-1 Expression in Context to Bone Marrow Stromal Microenvironment in Chronic Lymphocytic Leukemia

(2014) Kumudha Balakrishnan et al.   NEOPLASIA

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

(2013) E. K. Keeton et al.   BLOOD

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

Chronic lymphocytic leukaemia - the role of the microenvironment pathogenesis and therapy

(2013) Alan D. Ramsay et al.   BRITISH JOURNAL OF HAEMATOLOGY

“Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia’’

(2013) P Oppezzo et al.   Blood Cancer Journal

Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma

(2012) Q. Yang et al.   BLOOD

The Pim Kinases: New Targets for Drug Development

(2011) Ronan Swords et al.   CURRENT DRUG TARGETS

The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

(2011) J Asano et al.   LEUKEMIA

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib

(2010) D. Messmer et al.   BLOOD

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

(2007) R. T. Woodland et al.   BLOOD