Lgr5+intestinal stem cells reside in an unlicensed G1phase

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

(2017) Max van Lessen et al.   eLife

Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer

(2016) Miroslava Juríková et al.   ACTA HISTOCHEMICA

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous measurement of passage through the restriction point and MCM loading in single cells

(2015) T. W. Håland et al.   NUCLEIC ACIDS RESEARCH

Linking the Cell Cycle to Cell Fate Decisions

(2015) Stephen Dalton   TRENDS IN CELL BIOLOGY

Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress

(2015) Xin Quan Ge et al.   Stem Cell Reports

Fucci2a:A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice

(2014) Richard Lester Mort et al.   CELL CYCLE

The contribution of dormant origins to genome stability: From cell biology to human genetics

(2014) Robert C. Alver et al.   DNA REPAIR

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

(2014) O. Basak et al.   EMBO JOURNAL

High-Energy Particle-Induced Tumorigenesis Throughout the Gastrointestinal Tract

(2014) Daniela Trani et al.   RADIATION RESEARCH

Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?

(2014) S. Champeris Tsaniras et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

(2014) Ann-Marie Baker et al.   Cell Reports

Oncogenic miRNAs and the Perils of Losing Control of a Stem Cell’s Epigenetic Identity

(2013) Piero Dalerba et al.   Cell Stem Cell

Multi-step Loading of Human Minichromosome Maintenance Proteins in Live Human Cells

(2013) Ioanna-Eleni Symeonidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

(2013) Ran Kafri et al.   NATURE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

(2013) A. Fatehullah et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

DNA Replication Timing

(2013) N. Rhind et al.   Cold Spring Harbor Perspectives in Biology

The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes

(2012) Kira S Makarova et al.   Biology Direct

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

(2012) A. Hirata et al.   DEVELOPMENT

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

(2012) Matthew L. Steinhauser et al.   NATURE

Paneth Cells in Intestinal Homeostasis and Tissue Injury

(2012) Sabrina Roth et al.   PLoS One

A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency

(2012) Diana Coronado et al.   Stem Cell Research

Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells

(2012) Ashley Calder et al.   STEM CELLS AND DEVELOPMENT

Replication licensing promotes cyclin D1 expression and G1progression in untransformed human cells

(2011) Peijun Liu et al.   CELL CYCLE

Origin licensing and p53 status regulate Cdk2 activity during G1

(2011) Kathleen R. Nevis et al.   CELL CYCLE

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

(2011) Arnout G Schepers et al.   EMBO JOURNAL

MCM2-7 Form Double Hexamers at Licensed Origins inXenopusEgg Extract

(2011) Agnieszka Gambus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural stem and progenitor cells shorten S-phase on commitment to neuron production

(2011) Yoko Arai et al.   Nature Communications

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

(2010) C. Lopez-Garcia et al.   SCIENCE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology