Article
Cardiac & Cardiovascular Systems
Louise Segan, Rodrigo Canovas, Shane Nanayakkara, David Chieng, Sandeep Prabhu, Aleksandr Voskoboinik, Hariharan Sugumar, Liang-Han Ling, Geoff Lee, Joseph Morton, Andre LaGerche, David M. Kaye, Prashanthan Sanders, Jonathan M. Kalman, Peter M. Kistler
Summary: The aim of this study was to develop and validate a lifestyle risk score for atrial fibrillation (AF) to identify individuals at risk in the general population. The study found that hypertension, age, body mass index, male sex, sleep apnoea, smoking, and alcohol were predictive factors for AF, while physical inactivity and diabetes were not significant. The newly developed risk score outperformed traditional AF risk models and could assist in population screening for AF.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Jiachen Luo, Zhiqiang Li, Xiaoming Qin, Xingxu Zhang, Xiangdong Liu, Wenming Zhang, Wei Xu, Yiwei Zhang, Yuan Fang, Baoxin Liu, Yidong Wei
Summary: The 4S-AF scheme score is associated with increased all-cause mortality in AMI patients with NOAF and improves risk stratification ability.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Joshua Rutland, Karam Ayoub, Farshid Etaee, Gbolahan Ogunbayo, Yousef Darrat, Meera Marji, Ahmad Masri, Claude S. Elayi
Summary: The study showed that the CHA2DS2-VASc risk score can identify patients without prior history of atrial fibrillation/flutter who are at risk of hospital readmissions with atrial arrhythmias or acute cerebrovascular accident within 6 months of hospitalization.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Zhitong Li, Quanbo Liu, Fei Liu, Tesfaldet H. Hidru, Yiheng Yang, Shihao Wang, Lan Bai, Jing Chen, Xiaolei Yang, Yunlong Xia
Summary: This study found that atrial cardiomyopathy markers including PTFV1, LAD, and BNP are closely associated with NOAF after AMI. The addition of these markers to the AF risk factors recommended by the 2020 ESC Guidelines significantly improves risk discrimination for NOAF.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Jan Daniel Niederdoeckl, Alexander Simon, Nina Buchtele, Nikola Schuetz, Filippo Cacioppo, Julia Oppenauer, Sophie Gupta, Sebastian Schnaubelt, Alexander Spiel, Dominik Roth, Fritz Wimbauer, Isabel Fegers-Wustrow, Katrin Esefeld, Martin Halle, Juergen Scharhag, Thomas Laschitz, Harald Herkner, Hans Domanovits, Michael Schwameis
Summary: A predictive model was developed and validated in this study to estimate the success rate of intravenous pharmacological cardioversion using different antiarrhythmic agents in patients with haemodynamically stable atrial fibrillation. The research showed good calibration and clinical usefulness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Amaar Obaid Hassan, Gregory Y. H. Lip, Arnaud Bisson, Julien Herbert, Alexandre Bodin, Laurent Fauchier, Rebecca V. Harris
Summary: This study found that patients with acute periapical abscess have a higher risk of developing atrial fibrillation (AF) compared to those without the abscess. Acute periapical abscess can act as an independent predictor for AF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Dishiwen Liu, Shaobo Shi, Xin Liu, Tianxin Ye, Linglin Wang, Chuan Qu, Bo Yang, Qingyan Zhao
Summary: In patients with acute pulmonary embolism, the occurrence of new-onset atrial fibrillation is 9.2%, with massive PE, ischaemic heart disease, and congestive heart failure being high-risk factors. New-onset persistent AF is an independent predictor for 6-month all-cause mortality in PE patients.
Article
Cardiac & Cardiovascular Systems
Lieselotte Knaepen, Michiel Delesie, Rik Theunis, Peter Gorissen, Johan Vijgen, Paul Dendale, Lien Desteghe, Hein Heidbuchel
Summary: This study demonstrated a positive attitude towards using a mobile application, with AF patients using the application for more than one-third of the available days. Patients primarily used the application to enter measured parameters and to communicate with the care team.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Wei Lian Tan, Kristyan Guppy-Coles, Robert Boots, Sandhir Prasad, John Atherton, Paul Martin
Summary: This study aimed to determine the factors associated with subsequent atrial fibrillation (AF) diagnoses and other adverse outcomes in critical illness associated new onset AF (CI-NOAF) patients. The results showed that AF burden and left atrial size were independently associated with subsequent AF. It was also found that CI-NOAF is often under-recognized and subsequent AF diagnoses are common post-discharge.
Article
Physiology
Jia-hui Li, Hai-yang Xie, Yan-qiao Chen, Zhong-jing Cao, Qing-hui Tang, Xiao-gang Guo, Qi Sun, Jian Ma
Summary: The study aimed to describe the incidence of AF in patients with typical AFL after CTI ablation and found that obstructive sleep apnea, advanced interatrial block, left atrial diameter > 42 mm, and CHA(2)DS(2)-VASc score > 2 were independent risk factors for new-onset AF.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tapio Hellman, Panu Uusalo, Mikko Johannes Jarvisalo
Summary: This study investigated the incidence of new-onset atrial fibrillation (NOAF) and its association with 1-year mortality in critically ill patients with acute kidney injury (AKI) undergoing continuous veno-venous haemodialysis (CVVHD) or intermittent haemodialysis (IHD). The results showed that NOAF emerging before renal replacement therapy (RRT) initiation was associated with increased mortality in critically ill AKI patients requiring RRT. However, NOAF during RRT was not associated with mortality.
Article
Cardiac & Cardiovascular Systems
Alexandre Gautier, Fabien Picard, Gregory Ducrocq, Yedid Elbez, Kim M. Fox, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Philippe Gabriel Steg
Summary: This study found that new-onset atrial fibrillation (NOAF) is common among patients with chronic coronary syndromes (CCS) and is associated with increased risk of cardiovascular adverse events. Age, body mass index, glomerular filtration rate, ethnicity, alcohol intake, and left ventricular ejection fraction were identified as predictors of NOAF. The study suggests that more intensive preventive measures and systematic screening for atrial fibrillation should be considered in this patient population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jeffrey M. Ashburner, Xin Wang, Xinye Li, Shaan Khurshid, Darae Ko, Ana Trisini Lipsanopoulos, Priscilla R. Lee, Taylor Carmichael, Ashby C. Turner, Corban Jackson, Patrick T. Ellinor, Emelia J. Benjamin, Steven J. Atlas, Daniel E. Singer, Ludovic Trinquart, Steven A. Lubitz, Christopher D. Anderson
Summary: In poststroke populations, accurate estimation of AF risk can be achieved by recalibrating existing AF risk models, and a fully refitted model is required to better account for varying baseline AF hazard and strength of associations between covariates and incident AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Urology & Nephrology
Tomohiro Kaneko, Eitaro Kodani, Hitomi Fujii, Risa Asai, Miyako Seki, Rei Nakazato, Hiroyuki Nakamura, Hajime Sasabe, Yutaka Tamura
Summary: Through specific annual health checkups in Tama City, risk factors for new-onset CKD over one year were identified as atrial fibrillation, anemia, and hyperuricemia, while anemia was also found to be a significant factor in the rapid deterioration of kidney function in subjects with CKD.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Stjepan Jurisic, Mathis Komminoth, Atanas Todorov, Daniela A. Bertschi, Martin Jurisic, Ivica Vranjic, Benedikt Wiggli, Hansruedi Schmid, Catherine Gebhard, Caroline E. Gebhard, Bettina Heidecker, Juerg-Hans Beer, Dimitri Patriki
Summary: In patients with COVID-19, new-onset atrial fibrillation is associated with an increased risk of invasive ventilation and transfer to the intermediate/intensive care unit (IMC/ICU), but does not affect in-hospital or long-term mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Rannapaula Lawrynhuk Urbano Ferreira, Angela Waleska Freire de Sousa, Antonio Gouveia Oliveira, Adriana Augusto de Rezende, Ricardo Ney Cobucci, Lucia Fatima Campos Pedrosa
Summary: This systematic review evaluated the effects of Se supplementation on glycaemic control in healthy rodents and found that sodium selenite supplementation significantly increased fasting blood glucose levels but did not affect glutathione peroxidase activity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Eduarda Pontes dos Santos Araujo, Severina Carla Vieira da Cunha Lima, Ony Araujo Galdino, Ricardo Fernando Arrais, Karla Simone Costa de Souza, Adriana Augusto de Rezende
Summary: This study investigated the associations between CYP2R1 and VDR gene variants and metabolic syndrome in non-diabetic Brazilian adolescents. The findings suggest that CYP2R1 rs12794714 polymorphism may serve as a potential molecular marker for predicting the risk of metabolic syndrome, while CYP2R1 rs10741657 polymorphism and VDR rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in overweight/obese adolescents.
Article
Multidisciplinary Sciences
Victor Hugo Rezende Duarte, Marina Sampaio Cruz, Adriana Bertolami, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Andre Ducati Luchessi, Vivian Nogueira Silbiger
Summary: This study evaluated the relationship between TREML4 expression and its polymorphisms in patients with subclinical atherosclerosis and heart failure post-acute myocardial infarction for the first time. The study found that TREML4 variants were associated with TREML4 expression and that TREML4 expression was linked to the progression of atherosclerosis.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Bruna Los, Glaucio Monteiro Ferreira, Jessica Bassani Borges, Thales Kronenberger, Victor Fernandes de Oliveira, Carolina Dagli-Hernandez, Raul Hernandes Bortolin, Rodrigo Marques Goncalves, Andre Arpad Faludi, Augusto Akira Mori, Thais Kristini Almendros Barbosa, Renata Caroline Costa de Freitas, Cinthia Elim Jannes, Alexandre da Costa Pereira, Gisele Medeiros Bastos, Antti Poso, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata
Summary: This study investigates the effects of PCSK9 missense variants on protein structure and interactions with LDLR. The findings suggest that these variants disrupt intra-molecular interactions essential for PCSK9 structural conformation and biological activity, potentially contributing to the development of Familial Hypercholesterolemia.
Article
Genetics & Heredity
Jessica Nayara Goes de Araujo, Victor Fernandes de Oliveira, Jessica Bassani Borges, Carolina Dagli-Hernandez, Elisangela da Silva Rodrigues Marcal, Renata Caroline Costa de Freitas, Gisele Medeiros Bastos, Rodrigo Marques Goncalves, Andre Arpad Faludi, Cinthia Elim Jannes, Alexandre da Costa Pereira, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata, Andre Ducati Luchessi, Vivian Nogueira Silbiger
Summary: The study identified potentially regulatory variants in the upstream regions of LDLR, APOB, and PCSK9 in patients with familial hypercholesterolemia (FH). This highlights the importance of screening variants outside of coding regions in identifying pathogenic variants associated with FH.
Article
Genetics & Heredity
Thais Kristini Almendros Barbosa, Rosario Dominguez Crespo Hirata, Glaucio Monteiro Ferreira, Jessica Bassani Borges, Victor Fernandes de Oliveira, Renata Gorjao, Elisangela Rodrigues da Silva Marcal, Rodrigo Marques Goncalves, Andre Arpad Faludi, Renata Caroline Costa de Freitas, Carolina Dagli-Hernandez, Raul Hernandes Bortolin, Gisele Medeiros Bastos, Tania Cristina Pithon-Curi, Helena Bonciani Nader, Mario Hiroyuki Hirata
Summary: Familial hypercholesterolemia (FH) is caused by harmful mutations in the LDLR gene, resulting in significantly increased low-density lipoprotein (LDL) cholesterol and premature atherosclerotic cardiovascular disease. In this study, the functional effects of LDLR variants in Brazilian FH patients were assessed. It was found that LDLR null and defective variants reduce LDL binding and uptake in activated T-lymphocytes, while LDLR missense variants affect LDLR conformational stability and the dissociation of the LDLR-ApoB complex.
Article
Virology
Caroline Aliane de Souza Prado, Dennyson Leandro M. Fonseca, Youvika Singh, Igor Salerno Filgueiras, Gabriela Crispim Baiocchi, Desiree Rodrigues Placa, Alexandre H. C. Marques, Raquel Costa Silva Dantas-Komatsu, Julia N. Usuda, Paula Paccielli Freire, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleao, Rodrigo Nalio Ramos, Vanderson Rocha, Guangyan Zhou, Rusan Catar, Guido Moll, Niels Olsen Saraiva Camara, Gustavo Cabral de Miranda, Vera Lucia Garcia Calich, Lasse M. Giil, Neha Mishra, Florian Tran, Andre Ducati Luchessi, Helder I. Nakaya, Hans D. Ochs, Igor Jurisica, Lena F. Schimke, Otavio Cabral-Marques
Summary: In this study, the authors analyzed proteome and transcriptome data to investigate the alterations in cell cycle-associated molecules in COVID-19 patients. They found that the expression of cell cycle-associated genes and proteins was changed and correlated with disease severity and trajectories. These findings provide a comprehensive understanding of the distinct alterations in cell cycle regulation in COVID-19 patients and suggest potential therapeutic pathways.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ananilia Medeiros Gomes da Silva, Marina Sampaio Cruz, Karla Simone Costa de Souza, Vivian Nogueira Silbiger
Summary: Many studies have shown that atrial fibrillation (AF) is associated with endogenous genetic regulatory mechanisms, particularly long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which play a role in AF development and related diseases. This review examines studies that have analyzed the expression of lncRNAs and circRNAs in AF, revealing their importance in the pathophysiological process and suggesting their involvement in miRNA or mRNA regulation. The lack of overlap among the studies may be attributed to variations in sample types, methods, species, and patient classification.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Vitor Galvao Lopes, Victor Fernandes de Oliveira, Livia Mendonca Munhoz Dati, Michel Satya Naslavsky, Glaucio Monteiro Ferreira, Mario Hiroyuki Hirata
Summary: The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) plays a role in lipid metabolism and can lead to coronary artery disease. Large-scale genomic studies have been conducted worldwide to support precision medicine, but non-European populations are underrepresented in public genomic data banks. However, two high-frequency variants were found in the ABraOM databank from a study conducted in Sao Paulo, Brazil. Molecular dynamics study revealed the structural and dynamical features of these variants and highlight the importance of the prodomain in PCSK9 dynamics.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klaric, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D. Russell, Tomas Malinauskas, Ryan Thwaites, Kirstie Morrice, Sean Keating, David Maslove, Alistair Nichol, Malcolm G. Semple, Julian Knight, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Colin Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, Jose A. Riancho, Augusto Rojas-Martinez, Pablo Lapunzina, Jian Yang, Chris P. Ponting, James F. Wilson, Veronique Vitart, Malak Abedalthagafi, Andre D. Luchessi, Esteban J. Parra, Raquel Cruz, Angel Carracedo, Angie Fawkes, Lee Murphy, Kathy Rowan, Alexandre C. Pereira, Andy Law, Benjamin Fairfax, Sara Clohisey Hendry, J. Kenneth Baillie
Summary: This study analyzed genetic data from 24,202 severe COVID-19 cases and identified potentially druggable targets, including inflammatory signaling, monocyte-macrophage activation and endothelial permeability, immunometabolism, and host factors required for viral entry and replication.
Article
Chemistry, Multidisciplinary
Daniel J. da Silva, Guilherme B. Gramcianinov, Pamela Z. Jorge, Vanessa B. Malaquias, Augusto A. Mori, Mario H. Hirata, Sergio A. M. Lopes, Luciano A. Bueno, Mathilde Champeau, Danilo J. Carastan
Summary: In order to prevent biofouling and combat the COVID-19 virus, PVC nanocomposites with silver nanoparticles (AgNPs) were prepared. The PVC/AgNP nanocomposites exhibit virucidal activity against SARS-CoV-2 when the AgNP content is at least 0.3 wt%, making them suitable for manufacturing furniture and medical equipment with self-disinfectant capacity to prevent secondary routes of COVID-19 transmission.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bruna C. C. Bertol, Juliana D. D. Massaro, Guilherme Debortoli, Andre L. P. Santos, Jessica N. G. de Araujo, Tatiana M. V. Giorgenon, Matheus Silva, Nathalie L. de Figueiredo-Feitosa, Cristhianna V. A. Collares, Luiz Carlos C. de Freitas, Edson G. G. Soares, Luciano Neder, Vivian N. N. Silbiger, Rodrigo T. T. Calado, Lea M. Z. Maciel, Eduardo A. A. Donadi
Summary: This study investigated the individual and collaborative role of BRAF, TERT, HLA-G, and microRNAs in papillary thyroid carcinoma (PTC). It was found that HLA-G and BRAF were strongly expressed in PTC specimens, and BRAF overexpression was associated with poor response to therapy. BRAF(V600E) and TERTC228T mutations were associated with extrathyroidal extension, advanced age, and advanced-stage cancer. Nine modulated microRNAs targeting BRAF, TERT, and/or HLA-G genes were observed in PTC, indicating their involvement in cancer-related signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marilia Cristina Santos de Medeiros, Karla Simone Costa de Souza, Ony Araujo Galdino, Ricardo Ney Cobucci, Adriana Augusto de Rezende
Summary: This article aims to summarize the impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus (SLE). Observational studies including adult SLE patients who were overweight and obese or not will be searched and analyzed. The results will help clinicians manage disease activity and remission in SLE patients to optimize disease outcomes and patient quality of life.
Article
Nutrition & Dietetics
Maria Clara da Cruz Carvalho, Julia Kaline Carvalho Pereira Araujo, Ana Gabriella Costa Lemos da Silva, Nayara Sousa da Silva, Nathalia Kelly de Araujo, Andre Ducati Luchessi, Karla Danielly da Silva Ribeiro, Vivian Nogueira Silbiger
Summary: This study aimed to evaluate the association between vitamin A levels and COVID-19 prognosis. The results showed that COVID-19 patients had lower levels of retinol compared to healthy individuals, and milder cases were associated with more severe symptoms and prolonged symptoms after infection.