Article
Oncology
Jeong Eun Kim, Song Ee Park, Hee Jun Kim, In Gyu Hwang
Summary: This study aimed to investigate the relationship between DNA damage response (DDR)-related protein expression and the clinical outcomes of patients with gastric cancer stage IV and recurrent advanced gastric cancer patients after gastrectomy treated with palliative first-line chemotherapy. The study found that patients with deficient DNA mismatch repair (dMMR) had a significantly longer overall survival and progression-free survival compared to patients with proficient DNA mismatch repair (pMMR).
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Chaelin You, Young Joon Byun, Ho Won Kang, Junho Noh, Jaehyun Lee, Hee Youn Lee, Kyeong Kim, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Kyuho Kang, Yong-June Kim
Summary: NMIBC is a common disease with high recurrence rate, which may progress to the lethal form MIBC. BUB1, a mitotic checkpoint kinase, has been identified as a potential prognostic biomarker for NMIBC by promoting cell proliferation through regulating the G2/M transition of the cell cycle. Further validation in internal and external cohorts showed its correlation with NMIBC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Seung-Woo Baek, Jeong-Yeon Mun, In-Hwan Jang, Gi-Eun Yang, Mi-So Jeong, Seon-Kyu Kim, Jong-Kil Nam, In-Sun Chu, Sun-Hee Leem
Summary: This study identifies the activation of Yes-associated protein 1 (YAP1) as a significant prognostic factor for bladder cancer progression and suggests its potential as a tool for immunotherapy selection.
Article
Oncology
Stefania Pianetti, Kathy D. Miller, Hannah H. H. Chen, Sandra Althouse, Sha Cao, Steven J. Michael, Gail E. Sonenshein, Nora D. Mineva
Summary: Breast malignancies are the leading cause of cancer-related death in women. ADAM8 has been identified as a marker of poor survival and a driver of Triple-Negative Breast Cancer growth. A highly specific IHC assay for detecting ADAM8-positive breast tumors has been developed.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Seon-Kyu Kim, Seong-Hwan Park, Yeong Uk Kim, Young Joon Byun, Xuan-Mei Piao, Pildu Jeong, Kyeong Kim, Hee Youn Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Sung-Kwon Moon, Yung Hyun Choi, Wun-Jae Kim, Seon-Young Kim, Seok Joong Yun
Summary: A molecular signature, MSP888, has been identified for Non-muscle-invasive bladder cancer (NMIBC) that can predict heterogeneity and responses to Bacillus Calmette-Guerin (BCG) therapy. This signature includes three distinct molecular subtypes, with DP.BCG+ related to progression and response to BCG treatment, and REC.BCG+ related to recurrence and response to BCG treatment. These findings enhance understanding of NMIBC prognosis and the effectiveness of BCG therapy, potentially improving clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Camilla De Carlo, Marina Valeri, Devin Nicole Corbitt, Miriam Cieri, Piergiuseppe Colombo
Summary: This review summarizes the recent evidence on prognostic and predictive tissue biomarkers in non-muscle invasive bladder cancer (NMIBC), highlighting the importance of histological features and molecular events in predicting recurrence and progression. The review also emphasizes the potential of immunohistochemical evaluation as a cost-effective tool for clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Tim Muilwijk, Murat Akand, Frank Van der Aa, Vincent De Coninck, Marc Claessens, Robert Hente, Markus Eckstein, Yves Allory, Louis Libbrecht, Steven Joniau, Thomas Gevaert
Summary: Cytokeratin 5 (CK5) is a marker of basal molecular subtypes in muscle-invasive bladder cancer (MIBC) and is associated with worse overall survival compared to luminal subtypes. However, in Ta non-muscle-invasive bladder cancer (NMIBC), CK5 expression was not confirmed as a marker of high-grade (HG) disease. Further analysis showed an inverse correlation between HG disease and CK5 expression, as well as a positive correlation between HG disease and CK20 expression. This study suggests a potential role for CK5 and CK20 in distinguishing between low-grade (LG) and HG disease in Ta NMIBC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Urology & Nephrology
Wei Shen Tan, Roberto Contieri, Nicolo Maria Buffi, Giovanni Lughezzani, Valentina Grajales, Mark Soloway, Paolo Casale, Rodolfo Hurle, Ashish M. Kamat
Summary: The purpose of this study was to determine whether the International Bladder Cancer Group IR-NMIBC scoring system can predict the need for delayed transurethral resection of bladder tumor in low-grade nonmuscle-invasive bladder cancer patients managed by active surveillance. The study found that the scoring system can predict the risk of subsequent transurethral resection of bladder tumor in patients on active surveillance.
JOURNAL OF UROLOGY
(2023)
Article
Immunology
Weizhuo Wang, Xi Zhang, Silin Jiang, Peng Xu, Kang Chen, Kai Li, Fei Wang, Xiang Le, Ke Zhang
Summary: This study aimed to construct a prognostic model based on differential gene expression between muscular and non-muscular invasive bladder cancer (BCa), and to investigate the prognosis of BCa patients. BCa patient data from GEO and TCGA databases were analyzed, and single-cell sequencing and microarray data were used to validate the differential gene expression. The prognostic model showed accuracy and validity, and S100A9 may be a better prognostic marker and therapeutic target for BCa.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Won Sik Ham, Jee Soo Park, Won Sik Jang, Young Deuk Choi, Jongchan Kim
Summary: The study suggests a correlation between larger prostate volume and worse recurrence and progression-free survival in non-muscle invasive bladder cancer.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Hannah Slovacek, Jerry Zhuo, Jennifer M. Taylor
Summary: NMIBC is a heterogeneous malignancy with high recurrence and progression rates, necessitating uniform recommendations for diagnosis and management. Guidelines worldwide have adopted risk-stratification at diagnosis to provide evidence-based treatment and surveillance recommendations. Improved endoscopic technologies enhance NMIBC detection and decrease recurrence.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Oncology
Zachary P. Schwartz, Andrew J. Li, Christine S. Walsh, B. J. Rimel, Monica M. Alvarado, Scott E. Lentz, Ilana Cass
Summary: This study aimed to investigate the practice patterns and frequency of occult gynecologic cancers in women with pathogenic variants of non-BRCA and Lynch syndrome-associated ovarian cancer susceptibility genes who underwent risk-reducing bilateral salpingo-oophorectomy (RRSO). The results showed no cases of occult ovarian or fallopian tube cancer in both groups, but 2 patients (3%) in the Lynch group had occult endometrial cancer. The use of hormone replacement therapy (HRT) was rare despite reported menopausal symptoms.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Genetics & Heredity
Kan Jiang, Lingyun Wu, Xin Yin, Qiuying Tang, Jie Yin, Ziyang Zhou, Hao Yu, Senxiang Yan
Summary: In bladder cancer, a signature based on seven NLRs was established to predict prognosis, immune microenvironment, and drug resistance.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Kiran Tripathi, Niharika Maurya, Apul Goel, Atin Singhai, Minal Garg
Summary: The study identifies the diagnostic relevance of immunohistochemical expressions of pan-RAS-pERK1/2/EMT-associated markers in stratifying NMIBC and MIBC patients. Follow-up studies support the role of altered EMT phenotype in pan-RAS-pERK1/2-activated positive tumors with disease aggressiveness, impacting short survival outcomes of muscle invasive bladder cancer patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Xiangpeng Zhan, Ju Guo, Luyao Chen, Wen Deng, Xiaoqiang Liu, Ke Zhu, Weipeng Liu, Bin Fu
Summary: The study found that bladder neck involvement (BNI) patients had a higher proportion of higher grade cancer, bigger tumor size, and more T1 and Tis stage patients compared to other sites. In survival analysis, the BNI group had lower survival probability in both overall survival (OS) and cancer-specific survival (CSS) analyses in non-muscle-invasive bladder cancer (NMIBC) patients. BNI was identified as an independent risk factor for overall mortality (OM) and cancer-specific mortality (CSM) in NMIBC patients, particularly in those with Ta or T1 stage.
Article
Environmental Sciences
Fiorella Pia Salvatore, Alessia Spada, Francesca Fortunato, Demetris Vrontis, Mariantonietta Fiore
Summary: This study examines the factors influencing the costs of cardiovascular disease in Italy's Apulia region, with findings showing an increase in health costs in 2016, lower spending for women, and a significant increase in health expenditure with age. Day-hospital has the lowest cost, surgery increases costs, with acute myocardial infarction being the most expensive pathology compared to atrial fibrillation. The inclusion of real data in estimating the economic burden of CVD from a regional health service perspective is significant for health management and planning.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Ophthalmology
Anna Bux, Francesca Fortunato, Antonio Barone, Vincenzo Russo, Nicola Delle Noci, Cristiana Iaculli
Summary: In this study, dexamethasone 0.7 mg implants (DEX-I) were found to improve visual acuity and reduce macular edema mainly in treatment-naive patients with diabetic macular edema (DME). Treatment-refractory patients also showed significant reductions in central macular thickness (CMT) after DEX-I injections, but no changes were observed in best-corrected visual acuity (BCVA). These findings suggest that DEX-I may be a promising first-line treatment option for DME.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Infectious Diseases
Francesca Fortunato, Domenico Martinelli, Giuseppina Iannelli, Marica Milazzo, Umberto Farina, Gabriella Di Matteo, Rosella De Nittis, Leonardo Ascatigno, Michele Cassano, Pier Luigi Lopalco, Rosa Prato
Summary: This study found that approximately one third of patients with mild COVID-19 symptoms still experienced olfactory and gustatory dysfunctions up to 12 months after the onset of the disease. Further investigations are needed to understand the implications of these long-term effects on patients' quality of life and pathophysiology.
BMC INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Francesca Fortunato, Domenico Martinelli, Pier Luigi Lopalco, Rosa Prato
Summary: The DTaP5-IPV-Hib-HepB vaccine has shown good safety profile in infants and toddlers, similar to other approved pentavalent and hexavalent vaccines. Limited post-marketing data are available, but there have been no relevant interferences with other co-administered pediatric vaccines or safety issues in premature infants shown so far.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Mathematics, Interdisciplinary Applications
Laura Anderlucci, Francesca Fortunato, Angela Montanari
Summary: This method addresses unsupervised classification for high-dimensional data using a Random Projection Ensemble approach. By generating low-dimensional independent random projections and conducting model-based clustering on each, the approach identifies top projections with the best grouping structures. The final partition is obtained by aggregating clusters found in these projections. Results suggest potential for high-dimensional clustering.
JOURNAL OF CLASSIFICATION
(2022)
Article
Environmental Sciences
Vito Carlo Alberto Caponio, Maria Rosaria Lipsi, Francesca Fortunato, Fabio Arena, Lorenzo Lo Muzio
Summary: Despite being fully vaccinated, some individuals may still experience symptomatic SARS-CoV-2 infection. A case report of a young dental practitioner showed symptomatic infection 55 days after receiving the Pfizer vaccine, with ageusia as a notable symptom. The use of personal protective equipment helped prevent the spread of infection to patients and colleagues. While vaccines have proven high efficacy, it is important to adopt new guidelines and markers to identify individuals who may not achieve full immunization.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Domenico Martinelli, Francesca Fortunato, Sara Mazzilli, Lucia Bisceglia, Pier Luigi Lopalco, Rosa Prato
Summary: This retrospective epidemiological study analyzed asymptomatic COVID-19 cases in the Apulia region, Italy, during the first wave of the pandemic. The study found that the proportion of asymptomatic infections was 19.9%, which decreased with increasing age, the presence of underlying comorbidities, and in males. The study also revealed that the median duration of asymptomatic SARS-CoV-2 RNA positivity was 19 days, and 74% of cases resolved within 14 days after the first positive PCR test.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Cristina Genovese, Claudio Costantino, Anna Odone, Giuseppe Trimarchi, Vincenza La Fauci, Francesco Mazzitelli, Smeralda D'Amato, Raffaele Squeri, Alessandra Casuccio, Maria Pia Fantini, Antonio Azara, Silvana Castaldi, Elena Righi, Aida Bianco, Sofia Cosentino, Antonio Mistretta, Giovanni Gabutti, Rosa Prato, Giancarlo Icardi, Leila Fabiani, Roberta Siliquini, Guglielmo Bonaccorsi, Ida Torre, Maria Pavia, Paolo Villari, Gabriele Messina, Silvia Majori, Vincenzo Restivo, Davide Gori, Giovanna Deiana, Lucia Palandri, Giovanni Panciroli, Francesca Licata, Marina Marranzano, Armando Stefanati, Francesca Fortunato, Domenico Martinelli, Donatella Panatto, Daniela Amicizia, Annalucia Moretti, Damiana Di Risio, Gianluca Voglino, Fabrizio Bert, Chiara Lorini, Francesca Pennino, Gabriella Di Giuseppe, Andrea, Carolina Marzuillo, Cesare Rivieri, Nicola Nante, Stefano Tardivo, Francesca Moretti, Rosalia Ragusa, Carlo Signorelli
Summary: This study evaluated the knowledge, attitudes, and opinions of the general population in Italy regarding COVID-19 and influenza immunization. The findings showed that 17.5% of respondents were unlikely to accept a future COVID-19 vaccine, mainly due to a lack of trust, fear of side effects, or a lack of perceived susceptibility to the disease. While over 50% of participants were willing to receive flu vaccinations, only 28.2% had received it in the previous five seasons. Higher knowledge about COVID-19 and previous flu vaccination were significantly associated with the intention to be vaccinated against COVID-19 and influenza.
Article
Infectious Diseases
Tobias Homan, Francesca Fortunato, Gaetano Corso, Pier Luigi Lopalco, Rosa Prato, Domenico Martinelli
Summary: Our study investigated the humoral immunity after a single Pfizer BNT162b2 mRNA vaccine dose in healthcare workers with a history of SARS-CoV-2 infection. Results showed higher antibody titres in previously infected individuals post-vaccination, supporting the feasibility of a single-dose vaccine regimen in this group.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Tobias Homan, Sara Mazzilli, Antonio Chieti, Alessandra Musa, Adam Roth, Francesca Fortunato, Lucia Bisceglia, Rosa Prato, Pier Luigi Lopalco, Domenico Martinelli
Summary: This study assessed the effectiveness of the COVID-19 vaccination program in the Apulia region of Italy and found that it provided strong protection against COVID-19 infection, hospitalization, and death caused by both the alpha and delta variants. However, the effectiveness of the vaccines decreased over time.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Giorgio Fedele, Filippo Trentini, Ilaria Schiavoni, Sergio Abrignani, Guido Antonelli, Vincenzo Baldo, Tatjana Baldovin, Alessandra Bandera, Filippa Bonura, Pierangelo Clerici, Massimo De Paschale, Francesca Fortunato, Andrea Gori, Renata Grifantini, Giancarlo Icardi, Tiziana Lazzarotto, Vittorio Lodi, Claudio Maria Mastroianni, Andrea Orsi, Rosa Prato, Vincenzo Restivo, Rita Carsetti, Eva Piano Mortari, Pasqualina Leone, Eleonora Olivetta, Stefano Fiore, Angela Di Martino, Silvio Brusaferro, Stefano Merler, Anna Teresa Palamara, Paola Stefanelli
Summary: This study aimed to evaluate immune responses to different COVID-19 vaccines and found that mRNA vaccines were stronger inducers of antibody responses and B-memory cell responses. Humoral immune responses were lower in frail elderly individuals. Neutralization of Delta AY.4 and Omicron BA.1 variants was severely impaired in older individuals. Most vaccinees retained vaccine-specific T-cell memory six months after vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Miriam Dellino, Eliano Cascardi, Claudia Leoni, Francesca Fortunato, Annarita Fusco, Raffaele Tinelli, Gerardo Cazzato, Salvatore Scacco, Antonio Gnoni, Antonio Scilimati, Vera Loizzi, Antonio Malvasi, Anna Sapino, Vincenzo Pinto, Ettore Cicinelli, Giovanni Di Vagno, Gennaro Cormio, Vito Chiantera, Antonio Simone Lagana
Summary: Improvements in lymphoma treatment have led to increased patient survival, and international oncology societies recommend fertility programs for long-term survivors. A study found that supplementation with Myo-Inositol and D-Chiro-Inositol could potentially restore ovarian function in female lymphoma survivors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Microbiology
Andrea Orsi, Alexander Domnich, Stefano Mosca, Matilde Ogliastro, Laura Sticchi, Rosa Prato, Francesca Fortunato, Domenico Martinelli, Fabio Tramuto, Claudio Costantino, Vincenzo Restivo, Vincenzo Baldo, Tatjana Baldovin, Elizabeth Begier, Christian Theilacker, Eva Agostina Montuori, Rohini Beavon, Bradford Gessner, Giancarlo Icardi
Summary: This study aimed to assess the serotype-specific epidemiology of pneumococci among hospitalized older adults in Italy. The prevalence of pneumococcal infection among hospitalized CAP cases was 13.1%, with serotypes 3, 8, 22F, and 11A being the most common. PCV20, which includes these serotypes, plays an important role in preventing pneumonia in older adults.
Article
Infectious Diseases
Domenico Martinelli, Filippo Quattrone, Francesca Fortunato, Elisa Di Maggio, Antonietta Filia, Maria Cristina Rota, Pier Luigi Lopalco, Rosa Prato
Summary: In Europe, the implementation of National Immunisation Technical Advisory Groups (NITAGs) has not been optimal, despite their establishment in most countries. A survey conducted within the European Joint Action on Vaccination (EU-JAV) collected information on decision-making processes regarding the introduction of new vaccines or changes to recommendations. Disease burden and availability of financial resources were identified as the most relevant criteria. Collaboration between NITAGs could lead to better workload optimization and resource utilization.
Article
Environmental Sciences
Roberto Zefferino, Francesca Fortunato, Addolorata Arsa, Sante Di Gioia, Gianfranco Tomei, Massimo Conese
Summary: Due to work-related stress, work has become a daily challenge for many occupations. The scientific community is now studying the disorder in various professions to evaluate and assess it. This paper proposes a comprehensive assessment approach by studying three biological salivary markers. The research on fishermen in the Apulia region of Italy reveals that sleep disturbances and work conflicts significantly affect the levels and rhythms of salivary markers. The results provide potential opportunities for using this approach in health surveillance to prevent mental and/or physical disorders and suggest further research directions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
