Review
Cell Biology
Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Summary: Spinal cord injury is a devastating disease causing loss of sensory and motor functions, with a pathological process involving mechanical primary injury and secondary injury. Macrophages play a crucial role in the pathology of SCI, and can be divided into different types. Hematogenous macrophages may have various roles in SCI but their specific function remains controversial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Bin Yuan, Xiao-jie Lu, Qi Wu
Summary: Research on the role of gut microbiota in acute central nervous system injuries has shown that altered gut microbiota composition can worsen secondary brain injury, cognitive impairments, and motor dysfunctions by triggering pro-inflammatory responses. Modulating gut microbiota with fecal microbiota transplantation, probiotics, and prebiotics may offer effective therapeutic interventions to alleviate secondary brain injury and improve functional outcomes after acute CNS injuries. This area of research represents an exciting frontier in both clinical and experimental medicine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Alexandre Coelho, Pablo Feito, Laura Corominas, Juan Francisco Sanchez-Soler, Daniel Perez-Prieto, Santos Martinez-Diaz, Albert Alier, Joan Carles Monllau
Summary: The study investigated the demographics injury patterns of electric scooter accidents, and found that most injuries occurred in young men, fractures were the main type of injury, and a significant proportion of fractures required surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Xin-Yue Bai, Xiao-Long Liu, Zhi-Zhong Deng, Dong-Min Wei, Die Zhang, Hui-Lin Xi, Qing-Yan Wang, Meng-Ze He, Yan-Ling Yang
Summary: Spinal cord injury is a serious traumatic disease, and recent studies have shown that Ferroptosis is closely related to its pathophysiological processes. Iron overload, reactive oxygen species accumulation, lipid peroxidation, and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, indicating the involvement of Ferroptosis in the secondary pathological processes. This article highlights the relationship between Ferroptosis and spinal cord injury, presents substances that improve spinal cord injury by inhibiting Ferroptosis, and discusses the potential challenges in the clinical translation of Ferroptosis inhibitors.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Sport Sciences
Geordie McLeod, Myles Murphy, Simon Gianotti, John W. Orchard, Lauren Fortington
Summary: This study quantified injury claims in organised community cricket in New Zealand from July 1, 2008 to June 30, 2018. The findings revealed that lumbosacral, shoulder, and knee injuries were common among all playing positions and should be given preventive attention. Strategies targeting the prevention of these injuries may reduce the injury claim rates.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Review
Medicine, General & Internal
Rama Abdin, Yusheng Zhang, Joaquin J. Jimenez
Summary: Androgenetic alopecia is a common type of progressive hair loss with limited treatment options. The pathogenesis involves hair follicle miniaturization process leading to premature termination of hair growth. Platelet-rich plasma (PRP) has been a focus for potential AGA treatment, but its clinical effectiveness is variable due to differences in preparation and administration protocols.
FRONTIERS IN MEDICINE
(2022)
Review
Cell Biology
Yun-Chang Wang, Yu-Bao Lu, Xiao-Lan Huang, Yong-Feng Lao, Lu Zhang, Jun Yang, Mei Shi, Hai-Long Ma, Ya-Wen Pan, Yi-Nian Zhang
Summary: Myeloperoxidase plays an important role in the occurrence and development of stroke. It can be used for the evaluation and prognosis of stroke, and inhibiting myeloperoxidase has positive impacts on stroke prognosis.
NEURAL REGENERATION RESEARCH
(2022)
Article
Genetics & Heredity
Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David JNikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart
Summary: Aminoglycoside antibiotics can cause toxic effects on the sensory hair cells in the inner ear, leading to permanent hearing loss and vestibular impairment. This study investigates the potential of ASK1 inhibition as a novel strategy to prevent aminoglycoside ototoxicity, providing significant pre-clinical evidence.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Communication
Kay Siebler
Summary: This article analyzes the representation of Black women's hair in contemporary films and TV shows, arguing that these hairstyles have a empowering effect on Black women audience members, representing power and pride, and showcasing the beauty, connection, and love among Black women.
FEMINIST MEDIA STUDIES
(2022)
Review
Food Science & Technology
Stoycho D. Stoev
Summary: This review examines the carcinogenic effects of ochratoxin A (OTA) on various tissues and internal organs in laboratory and farm animals. It explores ways to differentiate between common spontaneous neoplastic changes in advanced age and characteristic neoplasia caused by OTA exposure in laboratory animals and poultry. The synergistic effects of OTA and penicillic acid, as well as the malignancy and target location of OTA-induced neoplasia, are also investigated. The review also explores the time of appearance of the first neoplasia in long-term OTA-treated animals and the potential for using feed additives or herbs to counteract OTA's toxic and carcinogenic effects. Suggestions are made for prophylaxis and prevention of OTA contamination in feedstuffs, foods, and animal production. The suitability of various laboratory animals as experimental models for OTA-induced tumorigenesis in humans is also explored.
Review
Medicine, General & Internal
Stefan Sammito, Vedran Hadzic, Thomas Karakolis, Karen R. Kelly, Susan P. Proctor, Ainars Stepens, Graham White, Wes O. Zimmermann
Summary: This qualitative systematic review identified 57 different potential risk factors for MSkIs in the military and developed a new prioritizing injury model. This model may help in understanding which risk factors can be addressed and in what order they should be prioritized for intervention strategies within military groups.
MILITARY MEDICAL RESEARCH
(2021)
Article
Critical Care Medicine
Helen Harcombe, Dave Barson, Ari Samaranayaka, Gabrielle Davie, Emma Wyeth, Sarah Derrett, Paul McBride
Summary: Understanding predictors of hospital readmission following major trauma is important for reducing costs and avoidable readmissions. This study examines the incidence and factors influencing readmission rates in New Zealand for all-causes, index trauma injury, and subsequent injury events in the 30 days and 12 months following discharge. Factors such as self-inflicted trauma, intensive care unit admission, comorbidities, and older age are found to increase the likelihood of readmission. These findings can inform interventions to reduce preventable readmissions. Further research on planned and unplanned readmissions is needed. (c) 2023 Elsevier Ltd. All rights reserved.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Editorial Material
Biochemistry & Molecular Biology
G. Paolo Dotto, Caterina Missero
Summary: Flash forward genetics is a genetic approach that focuses on the functional interactions of factors to identify shared targets across different species. The study by Li et al demonstrates that AFF4 plays a specific role in hair follicle and thymus development in mice, overlapping with the function of FOXN1.
Article
Ergonomics
Mohammad-Reza Malekpour, Seyyed-Hadi Ghamari, Erfan Ghasemi, Seyedamirhossein Hejaziyeganeh, Mohsen Abbasi-Kangevari, Kavi Bhalla, Nazila Rezaei, Saeid Shahraz, Arezou Dilmaghani-Marand, Seyed Taghi Heydari, Negar Rezaei, Kamran B. Lankarani, Farshad Farzadfar
Summary: This study evaluated the effectiveness of telematics-based feedback and financial incentives in reducing speeding behaviors through a randomized controlled field trial. The results showed that the use of telematics-based feedback and financial incentives can effectively reduce speeding behaviors.
ACCIDENT ANALYSIS AND PREVENTION
(2023)
Review
Cell Biology
Conghui Zhou, Jinfeng Zheng, Yunpeng Fan, Junsong Wu
Summary: This review summarizes the role and underlying mechanism of NLRP3 inflammasome in CNS trauma and discusses the therapeutic applications of NLRP3 inflammasome activation inhibitors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)