Article
Endocrinology & Metabolism
Fjola Johannesdottir, Melissa S. Putman, Sherri-Ann M. Burnett-Bowie, Joel S. Finkelstein, Elaine W. Yu, Mary L. Bouxsein
Summary: The study found that postmenopausal Black women have similar rates of bone loss compared to White women, with lower weight women experiencing greater declines in bone density and microstructure at the radius. Women who lost weight during the follow-up period had higher rates of bone loss, particularly at the tibia, while higher baseline total body fat mass was protective against bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
E. H. S. Koy, A. Amouzougan, E. Biver, R. Chapurlat, T. Chevalley, S. L. Ferrari, A. Fouilloux, H. Locrelle, H. Marotte, M. Normand, R. Rizzoli, L. Vico, T. Thomas
Summary: This study presents reference values of HR-pQCT measurements in a Franco-Swiss female cohort at the distal radius and tibia sites, considering specific age bounds. Microarchitectural parameters start to decline before the age of 30, with the optimal bone profile observed between the ages of 22 to 27 in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Orthopedics
Carsten Schlickewei, Conradin Schweizer, Klaus Pueschel, Benjamin Ondruschka, Holger Kleinertz, Alexej Barg, Tim Rolvien, Julian Stuerznickel
Summary: This study examines the effects of age, sex, and subregion on the bone microarchitecture and strength of the distal fibula. Results show that cortical parameters increase and trabecular parameters decrease from distal to proximal. Age is primarily associated with a cortical decrease in all subregions for women, while men also exhibit age-associated decreases in certain parameters. The stiffness and failure load are highest in the type C subregion for both genders. A critical age-related decline in bone strength parameters is observed in the type B subregion for women, providing an explanation for the increased incidence of low-traumatic type B fractures in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nicklas Hojgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrom Jensen, Peter Vestergaard
Summary: This study compared the bone mineral density, bone strength, and bone microarchitecture of individuals with type 1 diabetes and type 2 diabetes to those without diabetes. The results showed that individuals with type 1 diabetes had lower bone density, while those with type 2 diabetes had higher bone density. Both groups showed favorable bone microarchitecture and strength parameters at the tibia and radius.
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Orthopedics
Camille P. Figueiredo, Mariana O. Perez, Lucas Peixoto Sales, Ana Cristina Medeiros, Valeria F. Caparbo, Rosa M. R. Pereira
Summary: This study found that BMD of MCP head was independently associated with the volume of bone erosion, suggesting it can be used to analyze and monitor bone destruction, as well as to evaluate treatment response in RA patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ko Chiba, Naoki Iwamoto, Kounosuke Watanabe, Kazuteru Shiraishi, Kengo Saito, Naoki Okubo, Atsushi Kawakami, Makoto Osaki
Summary: This study investigated the effect of denosumab on bone mineral density (BMD) and bone microarchitecture in patients with rheumatoid arthritis (RA) treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). The results suggest that denosumab can increase BMD and improve bone microarchitecture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Orthopedics
Constantin Schmidt, Christoph Riedel, Julian Stuerznickel, Herbert Mushumba, Maximilian M. Delsmann, Christian Ries, Sebastian Kleiss, Peter Bannas, Frank Timo Beil, Michael Amling, Klaus Pueschel, Tim Rolvien, Jan Hubert
Summary: This study investigates the association between demographic characteristics and microarchitectural parameters in distal femur fractures. The findings suggest that female sex, advanced age, and low bone mineral density (BMD) are major risk factors for impaired microarchitecture and fracture in this skeletal site.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Matthias Walle, Denis Schenk, Penny R. Atkins, Caitlyn J. Collins, Philippe Zysset, Kurt Lippuner, Ralph Mueller
Summary: The study established a multi-stack registration protocol for evaluating longitudinal HR-pQCT images and assessing the accuracy and precision error. Results showed that most scans improved or maintained stack alignment when multi-stack registration was implemented, with significant decrease in false discovery rate of bone remodelling events after multi-stack registration. The precision error was significantly reduced or remained unchanged in most bone morphology and micro-finite element analysis parameters.
Article
Endocrinology & Metabolism
Danielle Alves Brandao Mendes, Maria Caroline Alves Coelho, Barbara Gehrke, Leandro Kasuki, Luis Felipe Cardoso Lima, Francisco Paranhos-Neto, Laura Maria Carvalho de Mendonca, Maria Lucia Fleiuss Farias, Miguel Madeira
Summary: In this study of TIO patients, lower areal and volumetric BMD were identified using DXA and HR-pQCT evaluation, as well as severely impaired microarchitecture at cortical and trabecular bones, potentially contributing to bone fragility and fractures.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hanting Liang, Wenting Qi, Chenxi Jin, Qianqian Pang, Wei Liu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Hui Pan, Weibo Xia
Summary: This study evaluated bone density, microarchitecture, and strength in patients with achondroplasia and found higher bone density and better bone strength in these patients, although their trabecular microarchitecture was poorer.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Courtney L. Millar, Alyssa B. Dufour, James R. Hebert, Nitin Shivappa, Olivia Okereke, Douglas P. Kiel, Marian T. Hannan, Shivani Sahni, Roger Fielding
Summary: There is a correlation between a proinflammatory diet and increased risk of frailty, particularly among those with depressive symptoms. Further investigation is needed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Anna C. Siefkas, Courtney L. Millar, Alyssa B. Dufour, Douglas P. Kiel, Paul F. Jacques, Marian T. Hannan, Shivani Sahni
Summary: This study found that consuming yogurt was associated with a lower risk of frailty, while intake of high-fat dairy may increase the odds of frailty. However, no significant association was found between the consumption of other dairy foods and frailty in this study.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Endocrinology & Metabolism
Ching-Ti Liu, Timothy Tsai, Brett T. Allaire, Mary L. Bouxsein, Marian T. Hannan, Thomas G. Travison, Douglas P. Kiel
Summary: This study examines the association between changes in visceral adipose tissue (VAT) over 6 years and paraspinal muscle density, finding that greater accumulation of VAT is associated with lower muscle density.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Chloe Sarnowski, Matthew P. Conomos, Ramachandran S. Vasan, James B. Meigs, Josee Dupuis, Ching-Ti Liu, Aaron Leong
Summary: The effects of genetic burden on obesity risk and cardiovascular disease differ based on birth year, with individuals born after 1960 being more strongly affected. This suggests that the impact of genetics on obesity and cardiovascular risks may be amplified in the increasingly obesogenic environment.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Nutrition & Dietetics
Steven Oei, Courtney L. Millar, Thuy Nga Nguyen Lily, Kenneth J. Mukamal, Douglas P. Kiel, Lewis A. Lipsitz, Marian T. Hannan, Shivani Sahni
Summary: This study found that total flavonoid intake was not associated with frailty onset in adults, but higher intake of flavonols, particularly quercetin, was associated with lower odds of frailty onset. These results highlight the importance of assessing specific subclasses of flavonoids and the potential of dietary flavonols and quercetin as a strategy to prevent frailty development.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Shivani Sahni, Alyssa B. Dufour, Na Wang, Douglas P. Kiel, Marian T. Hannan, Paul F. Jacques, Emelia J. Benjamin, Ramachandran S. Vasan, Joanne M. Murabito, Anne B. Newman, Roger A. Fielding, Gary F. Mitchell, Naomi M. Hamburg
Summary: This study examined the association between vascular health measures and grip strength and gait speed. The cross-sectional analysis showed a positive association between resting brachial artery diameter and grip strength, as well as between mean arterial pressure (MAP) and grip strength. The longitudinal analysis revealed a significant association between brachial pulse pressure and slower gait speed, but no association with grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Mathematical & Computational Biology
Loraine Liping Seng, Ching-Ti Liu, Jingli Wang, Jialiang Li
Summary: Mendelian randomization is a technique that uses genetic variants to examine the causal effect of a modifiable exposure on a trait. A model average estimator is proposed to overcome the difficulty of high-dimensionality, which involves using different subsets of instruments to predict the exposure and weighting the submodels' predictions using penalization. The estimator's practical performance is examined in numerical studies and applied to a real genetic dataset investigating the relationship between stature and blood pressure.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Peitao Wu, Josee Dupuis, Ching-Ti Liu
Summary: We propose a nonparametric additive quantile regression method with network regularization to incorporate known network information, aiming to identify genomic risk factors of higher BMI.
STATISTICS IN MEDICINE
(2023)
Article
Cell Biology
Fabrice J. F. Laroche, Sheng Li, Ning Shen, Soo Kyung Hwang, Gina Nguyen, Wenling Yu, Chen Khuan Wong, Ryan J. J. Quinton, Jason N. N. Berman, Ching-Ti Liu, Anurag Singh, Neil J. J. Ganem, Sam Thiagalingam, Hui Feng
Summary: Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with poor prognosis of triple-negative breast cancer (TNBC). The phosphorylation of S1P receptor 1 (S1P1) at threonine 236 (T236) plays a critical role in TNBC dissemination and invasion. Inhibiting the phosphorylation of S1P1 T236 using AKT inhibitors or an S1P1 functional antagonist suppresses TNBC cell migration and tumor invasion.
Article
Endocrinology & Metabolism
Lauren A. Burt, Martin Kaufmann, Marianne S. Rose, Glenville Jones, Emma O. Billington, Steven K. Boyd, David A. Hanley
Summary: This randomized controlled trial investigated the effect of high-dose vitamin D-3 on total bone mineral density (TtBMD) in the radius and tibia. The study found that increasing vitamin D dose was associated with increased plasma levels of 25-(OH)D-3, 24,25-(OH)(2)D-3, and 1,24,25-(OH)(3)D-3, but not 1,25-(OH)(2)D-3. These vitamin D metabolites were associated with a decline in TtBMD. The findings suggest that vitamin D metabolites other than 1,25-(OH)(2)D-3 may play a role in bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemical Research Methods
Xiaoyu Zhang, Ching-Ti Liu
Summary: This article introduces an information-incorporated clustering method that utilizes existing information from previous studies to improve disease subtyping and biomarker identification. The method is validated through simulation studies and real data analysis, and demonstrates better performance compared to other clustering methods.
Article
Endocrinology & Metabolism
Paige M. Wyatt, Kelly Drager, Erik M. Groves, Trent Stellingwerff, Emma O. Billington, Steven K. Boyd, Lauren A. Burt
Summary: The importance of relative energy deficiency in sports (REDs). A study investigated the differences in bone quality between low-risk and at-risk winter endurance athletes for REDs. The results showed that athletes at higher risk had lower bone quality, indicating the negative impact of REDs on athletes' health and performance.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Rachana Raghupathy, Robert R. McLean, Douglas P. Kiel, Marian T. Hannan, Shivani Sahni
Summary: The objective of this cross-sectional study was to determine the relationship between abdominal fat and muscle health. The study found that higher abdominal fat was associated with lower muscle quality, particularly in obese women.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Biology
Tannis D. Kemp, Bryce A. Besler, Leigh Gabel, Steven K. Boyd
Summary: This study uses numerical methods to estimate changes in astronaut bone health during spaceflight and recovery on Earth. The results show reasonable fit between the modeled and observed bone morphometry, Dice coefficient, and symmetric distance. However, the estimation of dynamic bone morphometry is poor.