Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Kento Ikegawa, Yukihiro Hasegawa
Summary: Turner syndrome patients are at high risk of osteoporosis and fractures, with hypogonadism as a major contributing factor. Estrogen deficiency leads to low bone mineral density and increased fracture prevalence. Estrogen replacement therapy improves bone density, but other factors may also contribute to low bone density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Thaqif El Khassawna, Gero Knapp, Nadja Scheibler, Deeksha Malhan, Nike Walter, Christoph Biehl, Volker Alt, Christian Heiss, Markus Rupp
Summary: Delayed surgery after 48 hours does not negatively affect mortality in patients with PFF; The Charlson Comorbidity Index (CCI) appears to be a suitable tool for assessing mortality risk in PFF patients, while the commonly used ASA score does not provide relevant risk assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yufeng Ge, Yimin Chen, Gang Liu, Shiwen Zhu, Bo Li, Maoyi Tian, Jing Zhang, Xinbao Wu, Minghui Yang
Summary: This study aimed to investigate the association of hip bone mineral density with mortality risk after hip fracture. The results showed that all hip bone densities were significantly associated with mortality risks, and hip trochanter bone mineral density showed the strongest correlation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Kristine E. Ensrud, John T. Schousboe, Allyson M. Kats, Tien N. Vo, Brent C. Taylor, Peggy M. Cawthon, Jane A. Cauley, Nancy E. Lane, Andrew R. Hoffman, Lisa Langsetmo
Summary: The study found that height loss in elderly men is associated with a higher risk of subsequent clinical fractures, especially hip fractures. The greater the height loss, the higher the risk of fractures, even after accounting for competing mortality risk and traditional skeletal and non-skeletal risk factors.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Hossein Mokhtarzadeh, Dennis E. Anderson, Brett T. Allaire, Mary L. Bouxsein
Summary: Vertebral fractures (VFx) are common in older adults, especially at the mid-thoracic and thoracolumbar regions of the spine. This study aimed to determine activities that cause the largest vertebral load-to-strength ratios (LSRs) and examine patterns of LSRs along the spine for high-load activities in a sample of adult men and women. The results highlight the importance of considering a variety of activities when evaluating vertebral LSRs and provide guidance for future studies on the biomechanics of VFx.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Hematology
Pawel Szulc, Catherine Planckaert, Dominique Foesser, Janina Patsch, Roland Chapurlat
Summary: The study showed that severe peripheral arterial calcification is associated with a higher risk of acute coronary syndrome and major adverse cardiovascular events in older men. Even in men without cardiovascular risk factors, severe PAC was found to increase the risk of ACS.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jung Eun Yoo, Ji Won Yoon, Hyo Eun Park, Kyungdo Han, Dong Wook Shin
Summary: A positive association was found between higher blood pressure variability (BPV) and incidence of fractures in this retrospective cohort study involving over 3 million participants. BPV was identified as an independent predictor for developing fractures, with consistent results noted for vertebral fractures and hip fractures in various subgroup analyses.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: There is limited evidence on which fracture types carry the highest risk for subsequent fractures. Recent fractures, including major osteoporotic fractures and non-major osteoporotic fractures, as well as older fractures, increase the risk of subsequent fracture. Therefore, it is recommended to include all recent fractures in fracture liaison services and consider case-finding strategies for those with older fractures to prevent further fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
D. R. Duerksen, L. M. Lix, H. Johansson, E. McCloskey, N. C. Harvey, J. A. Kanis, W. D. Leslie
Summary: Celiac disease is associated with an increased risk of major osteoporotic fractures, but when considered as a secondary osteoporosis risk factor or when bone mineral density is included in FRAX assessment, FRAX accurately predicts fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Kyoung Min Kim, Li-Yung Lui, Steven R. Cummings
Summary: This study aimed to investigate the association between falls occurring within four months and the risk of fractures in the following year. The results showed that falls within four months indicated a high risk of non-spine and hip fractures in both men and women, regardless of previous fracture occurrence. Falls increased the risk of fractures, and urgent evaluation and consideration of treatment are necessary to reduce the imminent risk of fractures in older individuals.
Article
Health Care Sciences & Services
Dongyeop Kim, Jee Hyun Kim, Tae-Jin Song
Summary: This study found that variability in serum total cholesterol (TC) is associated with the risk of osteoporotic fractures. Higher TC variability was significantly associated with an increased risk of overall osteoporotic fractures, as well as vertebral and hip fractures. Maintaining stable TC levels may help reduce the risk of osteoporotic fractures in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Maria-Jose Montoya-Garcia, Merce Giner, Rodrigo Marcos, David Garcia-Romero, Francisco-Jesus Olmo-Montes, Ma Jose Miranda, Blanca Hernandez-Cruz, Miguel-Angel Colmenero, Ma Angeles Vazquez-Gamez
Summary: Fragility fractures are a significant public health issue globally, with hip fractures being most prevalent in women aged 80 and above. Older age and recent fractures were identified as independent risk factors for further fracture events. There was a significant excess mortality rate in individuals aged 80 and above with a previous hip fracture.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yingke Xu, Yueyang Bao, Megan Wang, Qing Wu
Summary: Past research suggests that men are more likely to smoke and have a higher risk of smoking-related conditions than women. A meta-analysis was conducted to assess the association between smoking and fracture risk in men. The analysis found a significant increase in fracture risk associated with smoking in men. This highlights the importance of smoking cessation in reducing the risk of fractures in male smokers.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Kristine E. Ensrud, Li-Yung Lui, Carolyn J. Crandall, Eric S. Orwoll, Lisa Langsetmo, John T. Schousboe, Howard A. Fink, Nancy E. Lane, Deborah M. Kado, Jane A. Cauley, Marcia L. Stefanick, Peggy M. Cawthon
Summary: This study evaluated the impact of a second bone mineral density (BMD) screening 7 years after the initial screening on fracture prediction in older men. The results showed that repeating the BMD screening did not significantly improve fracture prediction in community-dwelling older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Philippe Paul Wagner, Jean-Paul Roux, Quentin Chuzel, Pawel Szulc, Francois Bermond, Francois Duboeuf, Roland Chapurlat, Helene Follet, Jean-Baptiste Pialat
Summary: The study compared the differences in bone mineral content and bone density measurements between (SIM)60KeV-QCT, SEQCT, and DXA, and found that the use of different reconstruction kernels had a certain impact on the results.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
L. Vandenput, H. Johansson, E. V. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -C. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -P. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, B. Schei, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, N. C. Harvey, M. Lorentzon, W. D. Leslie, J. A. Kanis
Summary: This study describes the collection of cohorts and the analysis plan for updating the fracture risk prediction tool FRAX. The aim is to optimize the current algorithms with respect to current and novel risk factors. The resource includes over 2 million participants and documented incident major osteoporotic fractures. The assembled cohorts and models will provide an updated FRAX tool for enhanced assessment of fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Audrey Bobillier, Philippe Wagner, Danielle E. Whittier, Rene Ecochard, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: The study found that poor vitamin D status and high parathyroid hormone levels are associated with the deterioration of bone microarchitecture and reduced bone strength in older men.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Francesca Bartoli-Leonard, Mandy E. Turner, Jonas Zimmer, Roland Chapurlat, Tan Pham, Masanori Aikawa, Aruna D. Pradhan, Pawel Szulc, Elena Aikawa
Summary: This study followed a group of elderly individuals for 8 years and found that elevated Lp(a) levels were associated with an increased risk of acute coronary syndrome. The study supports the recommendation of measuring Lp(a) levels in cardiovascular risk assessment.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Endocrinology & Metabolism
P. Chotiyarnwong, E. V. McCloskey, N. C. Harvey, M. Lorentzon, D. Prieto-Alhambra, B. Abrahamsen, J. D. Adachi, F. Borgstrom, O. Bruyere, J. J. Carey, P. Clark, C. Cooper, E. M. Curtis, E. Dennison, M. Diaz-Curiel, H. P. Dimai, D. Grigorie, M. Hiligsmann, P. Khashayar, E. M. Lewiecki, P. Lips, R. S. Lorenc, S. Ortolani, A. Papaioannou, S. Silverman, M. Sosa, P. Szulc, K. A. Ward, N. Yoshimura, J. A. Kanis
Summary: The IOF Epidemiology and Quality of Life Working Group report suggests that population screening for high hip fracture risk should be strongly considered in many healthcare systems to reduce the burden of fractures.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Dylan Girard, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In older men, higher hsCRP concentrations are associated with faster endocortical expansion and slightly higher cortical bone loss, but not with fracture risk. High hsCRP levels have limited impact on bone decline in older men.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexandre Mercier-Guery, Marjorie Millet, Blandine Merle, Corinne Collet, Flora Bagouet, Olivier Borel, Elisabeth Sornay-Rendu, Pawel Szulc, Emmanuelle Vignot, Deborah Gensburger, Elisabeth Fontanges, Martine Croset, Roland Chapurlat
Summary: miRNAs are potential prognostic markers in bone diseases, regulating gene expression as epigenetic factors. This study aims to identify circulating miRNAs associated with the severity of osteogenesis imperfecta (OI) and found a miRNA signature in OI patients. The study validates the expression of specific miRNAs in OI patients and explores the relationship between miRNA expression and clinical characteristics of OI. The findings suggest a potential role of miRNAs in regulating the physiopathology of OI.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Blandine Merle, Marie Cottard, Elisabeth Sornay-Rendu, Pawel Szulc, Roland Chapurlat
Summary: The study evaluates the prevalence of sarcopenia in spondyloarthritis (SpA) patients and its association with inflammation, disease activity, muscle performance, and quality of life. The results show that probable sarcopenia is significantly higher in SpA patients compared to controls. Probable sarcopenic SpA patients had higher inflammation and disease activity, impaired muscle performance, and lower quality of life. These findings suggest that muscle strength is an important aspect of SpA.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Meeting Abstract
Geriatrics & Gerontology
A. Mercier, M. Millet, B. Merle, O. Borel, E. Sornay-Rendu, P. Szulc, E. Vignot, D. Gensburger, E. Fontanges, M. Croset, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
P. Szulc, D. Whittier, K. Boyd, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
F. Benzema, B. Merle, E. Sornay-Rendu, A. Mercier, E. Vignot, P. Szulc, E. Lespessailles, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)