Journal
JOURNAL OF BIOTECHNOLOGY
Volume 266, Issue -, Pages 84-88Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2017.12.006
Keywords
Lactobacillus plantarum LPL-1; Complete genome sequence; Class IIa bacteriocin; Biosynthetic mechanism; Antibacterial activity
Categories
Funding
- National Natural Science Foundation of China [31671831]
- Beijing Innovation Team Project of Sturgeon and Trout [SCGWZJ201711]
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Bacteriocins are antibacterial proteins or peptides synthesized by ribosomes to inhibit or kill both closely related and non-related bacterium. Class IIa bacteriocins possess high activity against foodborne pathogen Listeria monocytogenes. A novel strain Lactobacillus plantarum LPL-1 was isolated from fermented fish and considered as a bacteriocin producing probiotic with great antibacterial activity against Listeria monocytogenes 54002. The complete genome of L. plantarum LPL-1 contains one circular chromosome and plasmid. According to the genome, biosynthetic genes of bacteriocin including precursor, immunity protein, accessory protein and transporter protein were identified; and biosynthetic mechanism of class IIa bacteriocin was also further analyzed. The antibacterial activity of purified bacteriocin against L. monocytogenes54002 was determined and the diameter of inhibition zone was about 16.6mm by vernier caliper. This work provided the complete genome information of L. plantarum LPL-1 that could benefit for understanding the biosynthetic mechanism of class IIa bacteriocin as well as the potential application of L. plantarum LPL-1 in nutraceutical and pharmaceutical.
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