Article
Infectious Diseases
Roberto Rodriguez-Rivas, Ana Flisser, Luiz Fernando Norcia, Pedro Tadao Hamamoto Filho, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales, Arturo Carpio, Matthew L. Romo, Agnes Fleury
Summary: The study assessed the trends in hospitalization rates and mortality of neurocysticercosis in Brazil, Ecuador, Colombia, and Mexico. It found a decrease in hospitalization rates in Brazil, Ecuador, and Mexico, an increase in the age of patients with recent infections in Mexico, and an increase in hospitalization rates in Colombia.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Veronique Dermauw, Ellen Van De Vijver, Pierre Dorny, Emanuele Giorgi, Rasmane Ganaba, Athanase Millogo, Zekiba Tarnagda, Assana Kone Cisse, Helene Carabin
Summary: This study conducted a geostatistical analysis of active human cysticercosis in Burkina Faso, using data from a large-scale study. It found that the prevalence of the disease is influenced by environmental factors such as precipitation, distance to the nearest river, and night land temperature.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Parasitology
Md. Shahadat Hossain, Shafqat Shabir, Philip Toye, Lian F. Thomas, Franco H. Falcone
Summary: Taenia solium taeniasis/cysticercosis is a foodborne tropical disease that primarily affects low- and middle-income countries. The lack of specific diagnostic tests and human vaccines highlights the importance of treating infected pigs and tapeworm carriers, as well as preventing disease transmission, in order to control and eradicate T. solium.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Siju Susan Jacob, Pinaki Prasad Sengupta, Atru Gnana Surya Chandu, Samer Shamshad, Revanaiah Yogisharadhya, Subramanium Sudhagar, Palakurthi Ramesh
Summary: Taenia solium cysticercosis is an important neglected zoonotic disease with potential to be eradicated. Research in southern India has revealed the presence of distinct Asian and African/American mitochondrial lineages of T. solium in pigs, contributing to a better understanding of the genetic diversity of the parasite in India.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Dejia Zhang, Yu Qi, Yaxuan Cui, Weiyi Song, Xinrui Wang, Mingyuan Liu, Xuepeng Cai, Xuenong Luo, Xiaolei Liu, Shumin Sun
Summary: A UPT-LF assay for the detection of Cysticercus cellulosae was established in this study, showing higher sensitivity and specificity compared to traditional ELISA methods. With its rapidness, small volume, high sensitivity and specificity, good stability and reproducibility, this method could be used effectively in the diagnosis of cysticercosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Javier A. Bustos, Gianfranco Arroyo, Robert H. Gilman, Percy Soto-Becerra, Isidro Gonzales, Herbert Saavedra, E. Javier Pretell, Theodore E. Nash, Seth E. O'Neal, Oscar H. Del Brutto, Armando E. Gonzalez, Hector H. Garcia
Summary: This study found that approximately 38% of parenchymal cysts in patients with neurocysticercosis calcify after antiparasitic treatment, with factors such as cyst size, baseline edema, and duration of seizures associated with calcification. Some factors associated with calcification are modifiable and may help reduce the risk of seizure relapses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Francesco Pizzitutti, Gabrielle Bonnet, Eloy Gonzales-Gustavson, Sarah Gabriel, William K. Pan, Ian W. Pray, Armando E. Gonzalez, Hector H. Garcia, Seth E. O'Neal
Summary: The paper presents a new agent-based model and calibration approach for the transmission of pork tapeworm. The calibrated model accurately reproduces observed prevalences and can be transferred within an endemic region. This finding expands the potential applications of the model and informs future control interventions.
Article
Veterinary Sciences
Nicholas Ngwili, Lian Thomas, Samuel Githigia, Nancy Johnson, Raphael Wahome, Kristina Roesel
Summary: This study assessed the knowledge, attitudes, and perceptions of stakeholders regarding the six control strategies for T. solium infections in Kamuli and Hoima districts, Uganda. The results showed differential, limited, and fragmented knowledge on T. solium infections among stakeholders. Cultural, socio-economic, and physical/environmental factors also influence the adoption of control strategies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Parasitology
Jie Hou, Weilin Chen, Rong Chen, Chunlei He, Ying Ma, Junyan Qu
Summary: This case study highlights the potential of Taenia saginata infection to cause human cysticercosis, challenging the current understanding that T. saginata exclusively causes taeniasis. Accurate genome-wide analysis in patients with T. saginata taeniasis associated with cysts is needed to confirm this conclusion.
Article
Microbiology
L. Toribio, C. Guzman, S. Noazin, A. Zimic-Sheen, M. Zimic, I. Gonzales, H. Saavedra, E. J. Pretell, J. A. Bustos, S. Handali, H. H. Garcia
Summary: Neurocysticercosis is a common helminthic infection of the human central nervous system. We report a new immunoprint assay (MAPIA) that simplifies the detection process, reduces cost, and shows comparable accuracy and specificity to traditional methods.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Lucrecia Acosta Soto, Lucy Anne Parker, Maria Jose Irisarri-Gutierrez, Javier Arturo Bustos, Yesenia Castillo, Erika Perez, Carla Munoz-Antoli, Jose Guillermo Esteban, Hector Hugo Garcia, Fernando Jorge Bornay-Llinares
Summary: Cysticercosis, caused by the larval stage of Taenia solium, is a significant public health issue worldwide, especially in low-income countries where poor hygiene conditions and pig management practices facilitate transmission. A study conducted in Rwanda found a high prevalence of cysticercosis in children, highlighting the need for systematic investigations and health education to control T. solium infections in the region.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Yesenia Castillo, Luz M. M. Toribio, Carolina Guzman, Gianfranco Arroyo, Cindy Espinoza, Herbert Saavedra, Javier A. A. Bustos, Pierre Dorny, Seth E. E. O'Neal, Hector H. H. Garcia
Summary: This study compared the performance of two antigen enzyme-linked immunosorbent assay (ELISA) techniques for the detection of neurocysticercosis (NCC). The results showed that both ELISA techniques were able to detect antigen levels across different types of NCC and demonstrated high concordance. The B158/B60 antigen ELISA performed better in parenchymal and calcified NCC, while the TsW8/TsW5 antigen ELISA showed better detection in subarachnoid NCC.
Review
Infectious Diseases
Liz P. Z. Noguera, Duriya Charypkhan, Sonja Hartnack, Paul R. Torgerson, Simon R. Rueegg
Summary: This study aims to quantify the dual burden of zoonoses. The results show that rabies and echinococcosis are the most frequently reported zoonoses, and the animal burden exceeds the human burden.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Clinical Neurology
Ryan Ta, Benjamin N. Blond
Summary: Neurocysticercosis is a common cause of acquired epilepsy worldwide and is often associated with pigs as an intermediate host. This review explores its epidemiology and common risk factors in endemic regions across Africa, Asia, and Latin America. Inadequate regulation of pig farms, poor sanitation, water contamination, and limited resources contribute to the prevalence of the disease. Effective limitation of neurocysticercosis can be achieved by addressing these common risk factors.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rimanpreet Kaur, Naina Arora, Suraj S. Rawat, Anand K. Keshri, Gagandeep Singh, Rajiv Kumar, Amit Prasad
Summary: By utilizing proteomics and immunoinformatics, a vaccine candidate based on B-cell linear epitopes for the larva of Taenia solium, the causative agent of neurocysticercosis, was developed. The vaccine showed stable interactions with immune receptors and is expected to show promising results in in vivo and in vitro assays.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Clinical Neurology
S. Garfias, B. Tamaya Dominguez, A. Toledo Rojas, M. Arroyo, U. Rodriguez, C. Boll, A. L. Sosa, E. Sciutto, L. Adalid-Peralta, Y. Martinez Lopez, G. Fragoso, A. Fleury
Summary: This study evaluated the characteristics of peripheral blood lymphocytes in patients with AD and PD, and their association with the diseases and their progression. The findings indicate that the phenotypes of lymphocytes in AD and PD patients change and are associated with the severity of the diseases.
Article
Environmental Sciences
Eyden S. Hernandez-Padilla, Ana Zarate-Guzman, Omar Gonzalez-Ortega, Erika Padilla-Ortega, Azael Gomez-Duran, Pablo Delgado-Sanchez, Angelica Aguilar-Aguilar, Farid B. Cortes, Raul Ocampo-Perez
Summary: The study revealed the potential of activated carbon to remove caffeic and chlorogenic acids in aqueous solution, with adsorption equilibrium being influenced by pH values and the adsorption mechanisms involving different interactions. The binary adsorption experiment showed antagonistic behavior between caffeic acid and chlorogenic acid, with overall adsorption rate governed by internal diffusion.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Elizabeth Monreal-Escalante, Abel Ramos-Vega, Carlos Angulo, Bernardo Banuelos-Hernandez
Summary: This review article describes the use of plants as biofactories for vaccine production. Only a few plant-produced vaccines have been evaluated in clinical trials, with COVID-19 vaccines being the most recent ones approved by the FDA. The article also discusses the main strategies for antigen design and high antigen production levels, along with providing perspectives.
Article
Pharmacology & Pharmacy
Manuel F. Giraldo-Velasquez, Ivan N. Perez-Osorio, Alejandro Espinosa-Ceron, Brandon M. Barcena, Arturo Calderon-Gallegos, Gladis Fragoso, Monica Torres-Ramos, Nayeli Paez-Martinez, Edda Sciutto
Summary: Inhalants, including toluene, can induce neuroinflammation and histological damages, but intranasally administered methylprednisolone treatment can reverse these damages.
Article
Biotechnology & Applied Microbiology
Danae Samara Sanchez-Sandoval, Omar Gonzalez-Ortega, Juan Vazquez-Martinez, Ramon Fernando Garcia de la Cruz, Ruth Elena Soria-Guerra
Summary: In this study, different microalgae were evaluated for their efficiency in removing diclofenac. The results showed that S. obliquus was the best alternative for bioremediation of diclofenac.
Article
Medicine, General & Internal
Dolores Adriana Ayon-Nunez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutierrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raul J. Bobes, Julio Cesar Carrero, Rene Segura-Velazquez, Nora Alma Fierro, Marisela Hernandez, Joaquin Zuniga-Ramos, Gerardo Gamba, Graciela Cardenas, Emmanuel Frias-Jimenez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suarez-Guemes, Juan Pedro Laclette
Summary: COVID-19 pandemic is still ongoing and evolving worldwide, and monitoring population immunity is crucial for decision-making on returning to normality. This article describes the development of an RBD-based ELISA method for detecting specific antibodies, which can provide an indication of protective immunity against SARS-CoV-2.
Article
Immunology
Karla Solis-Andrade, Omar Gonzalez-Ortega, Dania O. Govea-Alonso, Mauricio Comas-Garcia, Sergio Rosales-Mendoza
Summary: Most current SARS-CoV-2 vaccines target the S protein through parenteral immunization, but there is potential for optimization by inducing immune responses on mucosal surfaces. Researchers have developed a recombinant chimeric antigen called LTB-RBD, which can be used to design mucosal vaccines for oral or intranasal administration. In experiments, this antigen was produced in E. coli and purified, and it induced immune responses in mice when administered subcutaneously or nasally. The expression and purification protocols for LTB-RBD provide a robust system for producing vaccine candidates against SARS-CoV-2 and its variants at a low cost and with ease of adaptation to new variants.
Review
Immunology
Dania O. Govea-Alonso, Mariano J. Garcia-Soto, Lourdes Betancourt-Mendiola, Erika Padilla-Ortega, Sergio Rosales-Mendoza, Omar Gonzalez-Ortega
Summary: Nanoclays have gained popularity in vaccinology as carriers, allowing for the creation of nanovaccines through physisorption or covalent attachment of antigens, adjuvants, and ligands. The safety and potential of nanoclays as vaccine candidates in humans are key factors, with ongoing evaluations and future prospects in this field.
Article
Economics
Michael Blankenburg, Mostafa Elhamamy, Diana Zhang, Naoto Fujikawa, Alice Corbin, Guanyi Jin, James Harris, Gesine Knobloch
Summary: Comparing the diagnostic and treatment pathways for colorectal cancer liver metastases (CRCLM) in the US, Japan, and China, the use of gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI) resulted in cost offsets and shorter waiting times compared to other imaging modalities, such as multidetector computed tomography (MDCT), extracellular contrast media enhanced-MRI (ECCM-MRI), and contrast-enhanced ultrasound (CEUS).
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Biochemistry & Molecular Biology
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Omar Emiliano Aparicio-Trejo, Omar Noel Medina-Campos, Edda Sciutto, Gladis Fragoso, Jose Pedraza-Chaverri
Summary: Breast cancer is the second most common cancer in women worldwide. The mortality rate has decreased due to early diagnosis and more effective treatments, but HER2 and TNBC still have poor prognoses. The immunomodulatory peptide GK-1 is being proposed as a new alternative for immunotherapy of these aggressive tumors. GK-1 has shown promising results in reducing tumor growth and lung metastasis in experimental models.
Article
Engineering, Environmental
Maria Fernanda Blanco-Orta, Ramon Fernando Garcia-de la Cruz, Luz Maria Teresita Paz-Maldonado, Diana Alejandra Pedraza-Gonzalez, Mariana Montserrat Morales-Avila, Victor Emmanuel Balderas-Hernandez, Omar Gonzalez-Ortega, Ana Silvia Perez-Martinez
Summary: This study aimed to remove diclofenac using different fungal species, with Pleurotus ostreatus showing the highest removal capacity. The addition of NaCl did not significantly affect the biosorption of diclofenac, suggesting that polar interactions play a negligible role in the removal process. The findings also highlighted the importance of stressful environments in enhancing the metabolic tools of fungi and increasing their removal efficiency.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Selene Velazquez-Moreno, Ana Maria Gonzalez-Amaro, Antonio Aragon-Pina, Lluvia Itzel Lopez-Lopez, Roberto Sanchez-Sanchez, Mario Alberto Perez-Diaz, Ricardo Oliva Rodriguez, Ana C. Lorenzo-Leal, Omar Gonzalez-Ortega, Fidel Martinez-Gutierrez, Horacio Bach
Summary: Apical periodontitis is an inflammatory condition that causes damage to the tissues surrounding the tooth root. This study evaluated the effectiveness of a fungal hydrolase (CEL) combined with amoxicillin/clavulanic acid as a treatment against a clinical strain of Enterococcus faecalis. The results showed that the treatment had excellent antibiofilm activity, significantly reducing the number of bacteria in apical biofilms. These findings could contribute to the development of a treatment for persistent E. faecalis infections in apical periodontitis.
Article
Biotechnology & Applied Microbiology
Christian Carreno-Campos, Dania O. Govea-Alonso, Maria Luisa Villarreal, Anabel O. Caltempa, Omar Gonzalez-Ortega, Sergio Rosales-Mendoza
Summary: The aggregation and spread of alpha-synuclein is associated with neurodegeneration and the development of synucleinopathies. A vaccine design focused on specific epitopes could induce a desired immune response to clear alpha-synuclein aggregates. In this study, a rapid system for evaluating a vaccine candidate was established, and a purified soluble form of the candidate was obtained. The results suggest that this vaccine candidate could be useful in designing novel vaccine formulations for synucleinopathies.
BIOTECHNOLOGY PROGRESS
(2023)
Article
Chemistry, Physical
Dania O. Govea-Alonso, Mariano J. Garcia-Soto, Emilio Sebastian Mendoza-Perez, Susan Farfan-Castro, Diana Fuente, Omar Gonzalez-Ortega, Sergio Rosales-Mendoza
Summary: The use of nanosized materials is a promising approach to diversify the properties of vaccine adjuvants. This study explores the potential adjuvanticity of layered double hydroxide (LDH) nanoparticles and shows that LDHs are non-toxic and can enhance the immune response. LDH-BSA conjugates induce a higher and longer-lasting humoral response compared to free BSA and BSA co-administered with alum. The study highlights the importance of further research on nanoclays in vaccinology and justifies studies with pathogen-specific antigens.
Article
Dentistry, Oral Surgery & Medicine
Selene Velazquez-Moreno, Norma V. Zavala-Alonso, Ricardo Oliva Rodriguez, Mildred Quintana, Hiram Joazet Ojeda-Galvan, Omar Gonzalez-Ortega, Fidel Martinez-Guiterrez
Summary: The study aimed to develop a standardized biofilm model that mimics the characteristics of infected root canal teeth and identifies treatment targets. A multispecies biofilm was cultured using continuous laminar flow reactors under anaerobic conditions, and the microbiological and chemical compositions were determined. The results showed that E. faecalis was the main microorganism in the mature biofilm, and its presence was related to the detection of beta-galactosidase.
ARCHIVES OF ORAL BIOLOGY
(2023)
