Article
Biochemistry & Molecular Biology
Xiaoli Zhao, Yifan Yang, Xuerong Su, Ying Xie, Yiyao Liang, Tong Zhou, Yangqian Wu, Liuqing Di
Summary: In this study, a transferrin-modified Triptolide (TP) liposome was developed for the treatment of hepatocellular carcinoma. The results showed that the liposome had good physicochemical properties and drug loading, and effectively inhibited tumor growth in vitro and in vivo. The modification with transferrin enhanced the drug targeting to the tumor tissues and reduced its toxic effects in normal tissues.
Letter
Oncology
Yunxin Zeng, Xinyu Zhang, Dongjun Lin, Xiaohui Feng, Yuye Liu, Zhengwen Fang, Weijian Zhang, Yu Chen, Meng Zhao, Jun Wu, Linjia Jiang
Summary: This study revealed that hypoxia environment increases lysosomes in leukemia cells, which in turn reduces the effectiveness of chemotherapy drugs. By developing a novel nanomedicine targeting lysosomes, the researchers were able to enhance the chemotherapy outcome in leukemia. This new approach shows promising results in overcoming chemoresistance in myeloid leukemia.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Muhammed H. Elnaggar, Abdelrahman I. Abushouk, Ahmed H. E. Hassan, Hadeer M. Lamloum, Amira Benmelouka, Shurouk A. Moatamed, Hossam Abd-Elmegeed, Somia Attia, Aya Samir, Nouran Amr, Dina Johar, Samy Zaky
Summary: The use of nanoparticles as targeted carriers for chemotherapy in hepatocellular carcinoma has shown promising results, with active targeting being the most commonly researched method. However, clinical research still faces challenges such as batch variations, production limitations, and lack of toxicity data.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Benjian Gao, Jia Luo, Ying Liu, Song Su, Shaozhi Fu, Xiaoli Yang, Bo Li
Summary: An in situ drug-loaded injectable thermosensitive hydrogel system was designed for the simultaneous delivery of norcantharidin-loaded nanoparticles and doxorubicin to HCC tumors. The drug-loaded hydrogel exhibited excellent thermal-sensitive properties and sustained drug release, showing remarkable antiproliferative activity in vitro and significant antitumor efficacy in vivo, suggesting it as a promising strategy for HCC treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Qiyang Zhou, Jingliang Wu, Bo Lian, Bo Zhang, Pingping Zhang, Ruiyan Pan
Summary: This study demonstrated the potential of glycyrrhetinic acid-modified sulfated hyaluronic acid nanoparticles for co-delivery of doxorubicin and magnolol. The nanoparticles showed effective anti-proliferation and anti-migration effects on cancer-associated fibroblasts (CAFs) and tumor cells. Furthermore, in vivo studies confirmed that the nanoparticles reduced the side effects of doxorubicin and inhibited CAFs activation, tumor angiogenesis, proliferation, and lung metastasis, leading to enhanced antitumor effects.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Sotoudeh Mohammadi, Zahra Heidar, Masoumeh Mirzamoradi, Zatollah Asemi
Summary: Combination chemotherapy is a beneficial option for cancer patients, but its effectiveness varies. Doxorubicin, a commonly used chemotherapy drug, has serious side effects. Studies suggest that melatonin may serve as an adjuvant to enhance the antitumor effects of Doxorubicin and mitigate its adverse reactions.
Article
Biochemistry & Molecular Biology
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Sotoudeh Mohammadi, Zahra Heidar, Masoumeh Mirzamoradi, Zatollah Asemi
Summary: Combination chemotherapy can be beneficial for some cancer patients, but not always effective. Doxorubicin is a commonly used chemotherapy drug with serious side effects. Melatonin, a potential anticancer agent, may enhance the antitumor effects of doxorubicin and reduce its side effects.
Article
Pharmacology & Pharmacy
Liang Kong, Guo-yuan Sui, Rui-bo Guo, Hui-min Cao, Yang Yu, Yang Liu, Yuan Cao, Xing Ju, Yu-hui Yan, Yu-han Ao, Xue-tao Li, Lian-qun Jia
Summary: In this study, targeting liposomes for hepatocellular carcinoma (HCC) were prepared, which showed improved targeting ability and specific recognition of tumor cells and tumor-like stem cells. These liposomes exhibited promising anti-tumor activity and have great potential for the treatment of HCC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Abdulsalam Alhalmi, Sarwar Beg, Kanchan Kohli, Md Waris, Tanuja Singh
Summary: Nanotechnology-based drug delivery approaches show promise in improving site-specific targeting and therapeutic efficiency for hepatocellular carcinoma treatment.
CURRENT DRUG TARGETS
(2021)
Article
Materials Science, Biomaterials
Runze Zhao, Xiaoyue Ning, Mengqi Wang, Ao Yu, Yongjian Wang
Summary: A new nano-delivery system combining a P-glycoprotein inhibitor with chemotherapy and phototherapy has been developed to overcome drug efflux in multidrug-resistant (MDR) tumors, achieving a synergistic therapeutic effect.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Cell Biology
Xuejiao Yuan, Yanfeng Zhou, Jinli Sun, Shanshan Wang, Xingjie Hu, Jiyu Li, Jing Huang, Nan Chen
Summary: Acute liver injury (ALI) is a severe liver disease characterized by sudden hepatocyte necrosis and liver function deterioration. This study develops hepatocyte-targeting self-assembling nanoparticles encapsulating an organic Selenium compound, which effectively removes reactive oxygen species (ROS) and protects hepatocyte viability. The nanoparticles, functionalized with a liver-targeting ligand, exhibit enhanced hepatocyte uptake and successfully reduce liver damage in mouse models of ALI induced by acetaminophen or carbon tetrachloride.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC. The platform, made of biocompatible materials, allows autonomous motion and increases the diffusion of chemotherapy drugs, leading to improved drug distribution within cells. Moreover, the hydrogen produced during the motion helps eliminate reactive oxygen species in cells. Compared to inert groups, the absorption of drugs from the active micromotors is significantly higher. At a concentration of 1 mg/mL, the micromotors also exhibit enhanced anti-tumor activity, reducing cell proliferation by almost 30%.
Review
Chemistry, Medicinal
Yusha Luo, Tingting Zhou
Summary: The gut microbiota plays a significant role in modulating drug toxicity, with its bidirectional interaction with drugs potentially leading to altered toxicity. Current research often focuses on how xenobiotics disrupt intestinal microbial composition and function, but the impact of gut microbiota on drugs, especially in terms of reducing their toxicity, should not be overlooked.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Xiujun Gao, Jiawei Zhang, Zhuanxia He, Luchen Chang, Zhihan Jian, Liyan Liu, Ying Li, Chunhong Hu, Xi Wei
Summary: This study developed multi-functional nanoparticles (MFNPs) as a therapeutic strategy for anti-tumor treatment. The MFNPs, modified with pH-responsive elastic PEG-GPC3MAb, demonstrated sensitive drug release in the acidic tumor microenvironment. In vitro and in vivo experiments showed that the MFNPs had good biocompatibility, high specificity to tumor cells, and improved therapeutic efficacy by increasing nuclear drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Engineering, Chemical
Fakhara Sabir, Maimoona Qindeel, Mahira Zeeshan, Qurrat Ul Ain, Abbas Randar, Mahmood Barani, Edurne Gonzalez, M. Ali Aboudzadeh
Summary: Lung cancer is a major global cause of death, primarily due to late diagnosis and chemotherapeutic agents affecting healthy cells. The complex pathophysiology of lung cancer offers various treatment pathways, including targeting tumor receptors and immune markers. To overcome issues with conventional methods, researchers are exploring new targeted delivery approaches, such as nanoparticles, for diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Chao Zhang, Tingting Zheng, Qian Ma, Linlin Yang, Mingzhi Zhang, Junyan Wang, Xiaoyan Teng, Yanyan Miao, Hsiao-chu Lin, Yang Yang, Da Han
Summary: Analyzing SNP combinations is crucial for research and clinical applications. DNA-based molecular computing has shown promise in sensing and analyzing molecular information. This study presents a DNA computational scheme that can sense multiple SNPs and perform logical analysis for clinical outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Cell Biology
Xianan Fu, Shoupeng Wei, Tao Wang, Hengxin Fan, Ying Zhang, Clive Da Costa, Sebastian Brandner, Guang Yang, Yihang Pan, Yulong He, Ningning Li
Summary: This article clarifies the origin of the evolution of GPR158 in different species, summarizes the relationship between GPR158 and different diseases for potential drug target identification, discusses recent studies on unraveling the features and principles of GPR158, and provides future perspectives.
Article
Oncology
Chengcheng Shi, Faming Zhao, Tingting Zhang, Denghui Xu, Zhuangyu Hao, Fengzhen Cui, Ji-Hua Shi, Yang Jin, Ningning Li, Caihong Yang, Yi Zhang, Xia Sheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li
Summary: This study found that GREM1 protein promotes invasion and metastasis of colorectal cancer cells by regulating the expression of ATF6 and ATF4, possibly through the modulation of PI3K/AKT/mTOR and BMP2 signaling pathways.
Article
Immunology
Fang Tan, Yuling Cao, Lei Zheng, Tao Wang, Shuhua Zhao, Jiong Chen, Changji Pang, Weiyi Xia, Zhengyuan Xia, Ningning Li, Xinjin Chi
Summary: The study demonstrated that diabetes exacerbates sepsis-induced intestinal injury by promoting M1 macrophage polarization. The miR-3061/Snail1 axis may be a potential target for regulating macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qian Ma, Mingzhi Zhang, Chao Zhang, Xiaoyan Teng, Linlin Yang, Yuan Tian, Junyan Wang, Da Han, Weihong Tan
Summary: Rapid and accurate classification of the etiology for acute respiratory illness is crucial for effective treatment and avoiding unnecessary antibiotic use. Researchers have developed an automated DNA computing-based platform that can accurately diagnose the cause of acute respiratory infection in just 4 hours, providing a low-cost and automated solution for emergency departments and point-of-care clinics.
Article
Multidisciplinary Sciences
Zhiwei Li, Yuan Cheng, Xiangyun Jin, Shenghe Liu, Chao Zhang
Summary: This study revealed the inhibitory function of ZDHHC16 in osteogenesis and identified ZDHHC16 as a potential target palmitoyl acyltransferase. The researchers showed that ZDHHC16 inhibited osteogenesis of hBMSCs by enhancing the palmitoylation of CREB. In a mouse femur fracture model, a general inhibitor of ZDHHCs, 2-BP, was found to promote fracture healing.
Article
Substance Abuse
Shoupeng Wei, Lei Zheng, Jinlong Chang, Jian Jiang, Zhiyu Zhou, Huanquan Liao, Kun Song, Xiaoma Liu, Xinjin Chi, Huiliang Li, Xin Kuang, Ningning Li
Summary: This study investigates the role of GPR158 in modulating sensitivity to the sedative-hypnotic effect of ethanol. The results show that Gpr158 deficiency prolongs the duration of loss of righting reflex induced by ethanol, indicating the key role of neuronal GPR158 in shaping sensitivity to ethanol's sedative-hypnotic effect.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cell Biology
Juanjuan Luo, Chunjiao Lu, Yang Chen, Xuewei Wu, Chenchen Zhu, Wei Cui, Shicang Yu, Ningning Li, Yihang Pan, Weijiang Zhao, Qingkai Yang, Xiaojun Yang
Summary: In this study, researchers found that nuclear cGAS regulates VEGF-A-mediated angiogenesis through the miR-212-5p-ARPC3 cascade, and the deficiency of cGAS impairs this process. The expression of nuclear cGAS is closely associated with VEGF-A expression, malignancy, and prognosis in malignant glioma, suggesting its potential as a therapeutic target for angiogenesis-related diseases.
Article
Neurosciences
Wenhui Zhu, Weifen Li, Jian Jiang, Dilong Wang, Xinliang Mao, Jin Zhang, Xunzhi Zhang, Jinlong Chang, Peijia Yao, Xiuyan Yang, Clive Da Costa, Ying Zhang, Jiezhong Yu, Huiliang Li, Shupeng Li, Xinjin Chi, Ningning Li
Summary: Depression is a prevalent mental disorder that has a high suicide rate. Current medications for depression have limitations, thus there is a need for more efficient and safe drugs. This study investigated the potential of salmon calcitonin (sCT) as an antidepressant and identified the molecular mechanism behind its effects. Results showed that sCT downregulated the phosphorylation of p38/JNK kinases in the hippocampus of mice exposed to chronic stress, suggesting its potential as a treatment for depression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, Xiaoran Guo, Kastytis Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Yonggao Mou, Ningning Li
Summary: This study demonstrates that IDH mutation induces metabolic reprogramming in gliomas and influences the phenotypes of glioma-associated microglia/macrophages (GAMs). Gliomas expressing mutant IDH promote M1-like polarization of GAMs, while typical IDH induces M2-like polarization. Furthermore, the study reveals the involvement of the PERK/miR-19a/LDLR signaling pathway in regulating gliomal cholesterol transport and GAM phenotypes, suggesting it as a potential target pathway for glioma therapy.
Article
Chemistry, Multidisciplinary
Junlan Liu, Chao Zhang, Jinxing Song, Qing Zhang, Rongjun Zhang, Mingzhi Zhang, Da Han, Weihong Tan
Summary: Human genetic architecture provides insights into disease risk prediction and personalized medication. A DNA-based intelligent decoder has been engineered to automate clinical analyses and interpretations, converting complex genetic profiles into actionable healthcare decisions. The decoder performs intended computations on genetic profiles and outputs corresponding answers within hours. It is validated to achieve desirable performance in interpreting genetic profiles for drug responses and can be reprogrammed for other pharmacogenetics genes and risk assessments for personalized healthcare.
Article
Biochemistry & Molecular Biology
Jinlong Chang, Ze Song, Shoupeng Wei, Yunxia Zhou, Jun Ju, Peijia Yao, Youheng Jiang, Hui Jin, Xinjin Chi, Ningning Li
Summary: Aberrant expression of GPR158 is linked to various central nervous system diseases, but the underlying mechanism is unclear. Researchers generated a GPR158 tagged mouse model and found that it is mainly expressed in neurons. Protein interaction analysis and RNA sequencing revealed potential interacting proteins and their involvement in chloride channel complex and synaptic vesicle membrane composition. This model will be valuable for future studies related to GPR158.
Article
Chemistry, Analytical
Xiaoyan Teng, Yu Wang, Liuxia You, Lirong Wei, Chao Zhang, Yuzhen Du
Summary: Due to its key roles in malignant tumor progression and reprogramming of the tumor microenvironment, integrin β3 has attracted great attention as a new target for tumor therapy. This study used a purified extracellular domain of integrin β3 and integrin β3-positive cells to screen aptamers specifically targeting integrin β3 in its native conformation on live cells. The optimized aptamer S10yh2 showed high binding affinity and selectivity, low equilibrium dissociation constant, and the ability to downregulate integrin αvβ3 levels and partially inhibit cell migration behavior.
ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Weifen Li, Tahir Ali, Shengnan Mou, Qichao Gong, Ningning Li, Liangliang Hao, Zhi-Jian Yu, Shupeng Li
Summary: Dopamine and serotonin signaling are associated with major depressive disorder, and targeting their signaling pathway is crucial for improving depression treatment. A study found that serotonin receptor 2A (5-HT2AR) abundantly forms a protein complex with dopamine receptor 1 (D1R), which regulates synaptic regulation through CREB/ERK/AKT modulation and affects depressive symptoms.
