Review
Biochemistry & Molecular Biology
Jonathan Golledge, Shivshankar Thanigaimani, James Phie
Summary: The research aimed to investigate the effect of pentagalloyl glucose (PGG) on aortic expansion in animal models of abdominal aortic aneurysm (AAA). The findings suggest that PGG significantly reduced aortic expansion in certain forms, but the studies had a high risk of bias.
Article
Engineering, Biomedical
Christie L. Crandall, Bryant Caballero, Mariana E. Viso, Naren R. Vyavahare, Jessica E. Wagenseil
Summary: This study found that pentagalloyl glucose (PGG) may be a pharmaceutical option to stabilize elastic fibers in thoracic aortic aneurysm (TAA). The results suggest that PGG treatment can prevent and restore the mechanical and structural changes caused by elastic fiber degradation in TAA.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Saphala Dhital, Charles D. Rice, Naren R. Vyavahare
Summary: The study confirmed the hypothesis of using PGG-NPs therapy to reverse abdominal aortic aneurysm, showing that the treatment can suppress inflammation and restore arterial homeostasis, potentially offering an effective option for advanced stage aneurysms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Anqi Xue, Zuming Mao, Xiaoyu Zhu, Qiang Yang, Peichen Wang, Zimu Mao, Mingze Du, Xu Ma, Dong Jiang, Yubo Fan, Feng Zhao
Summary: This study aimed to investigate the biomechanical effects of horizontal meniscal tears and different resection strategies on a rabbit knee joint using finite element analysis. The results showed that the horizontal meniscal tears had little biomechanical impact on the rabbit knee joint, and some of the partial meniscectomy strategies also had minimal effect on joint stress. It is recommended to preserve the posterior root and the remaining peripheral edge of the meniscus during surgery for a horizontal meniscal tear.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Yuchen Liu, Ming Fang, Ruifeng Zhao, Hengyan Liu, Min Tian, Sheng Zhong, Shizhu Bai
Summary: This study evaluated the effect of periodontal splints made from different materials on stress distributions in compromised periodontal tissues and cement layers. Using a computer simulation of mastication, it was found that the use of splints effectively distributed loads and reduced stress. Splinting materials with low elastic moduli reduced stress concentration at the connectors, but increased tensile stress in the cement layer.
Article
Polymer Science
Larissa Mendes Campaner, Marcos Paulo Motta Silveira, Guilherme Schmitt de Andrade, Alexandre Luiz Souto Borges, Marco Antonio Bottino, Amanda Maria de Oliveira Dal Piva, Roberto Lo Giudice, Pietro Ausiello, Joao Paulo Mendes Tribst
Summary: This study evaluated the biomechanical behavior of different interim restorative materials for posterior fixed partial dentures, with resin composite attenuating stress on the cement layer and acrylic resin attenuating stress on the connector region.
Article
Dentistry, Oral Surgery & Medicine
H. Lambert, S. Corn, R. Leger, P. Ienny, P. Slangen, M. Fages
Summary: The aim of this study was to visualize and characterize failure phenomena at the resin-ceramic bonding interface of LiSi2 samples bonded with MB and MEP using UHSI. Unprecedented frame rate, image resolution, and recording time were achieved with the advanced UHSI camera. FEA confirmed that the sample design allowed for testing the bonding interface under combined shear and compression stress close to physiological conditions. UHSI recorded that debonding occurred prior to fracture, highlighting the mixed failure mode.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Computer Science, Interdisciplinary Applications
Wenqing Wei, Tianyuan Zhang, Zifang Huang, Junlin Yang
Summary: This article reviews the use of finite element analysis (FEA) in assisting brace treatment for adolescent idiopathic scoliosis (AIS). It discusses the technical choices encountered during the construction of the finite element model (FEM) and explores the different fields and limitations of FEA. The article also collects observation items based on FEA and provides guidance and directions to improve brace treatment.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Computer Science, Interdisciplinary Applications
Farah Alkhatib, Adam Wittek, Benjamin F. Zwick, George C. Bourantas, Karol Miller
Summary: Aortic wall stress is an important factor in assessing the risk of abdominal aortic aneurysm (AAA) rupture. Finite element analysis is commonly used for its computation, but the impact of finite element formulation, element quality, and mesh construction methods on the accuracy and efficiency of the computation has been largely overlooked. This study compares the results of aortic wall stress calculation for ten AAA patients using tetrahedral and hexahedral meshes under varying finite element formulations, shape functions, spatial integration schemes, and number of elements across the wall thickness.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Mechanical
Fuhao Mo, Yuandong Li, Junjie Li, Shuangyuan Zhou, Zurong Yang
Summary: This study established a three-dimensional foot-ankle model and investigated its suitability for analyzing foot-ankle biomechanical responses. Two personalization methods were compared, using magnetic resonance imaging (MRI) and fast optical scan data, respectively, to analyze the dynamic gait responses. The results showed good correlation with subject-specific experimental results, indicating the effectiveness of the model in analyzing subject-specific foot deformation behavior during dynamic gait loading.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Frances Arnold, Nicolas Muzzio, Sourav S. Patnaik, Ender A. Finol, Gabriela Romero
Summary: Currently, nonsurgical therapy for abdominal aortic aneurysm (AAA) growth is not available, and AAA is considered an irreversible destructive disease. However, research suggests that pentagalloyl glucose (PGG) or its encapsulated form may help stabilize the aortic extracellular matrix, potentially offering a novel therapeutic option for preventing and reducing AAA progression.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Luca Salvadori Ferre, Felipe Goncalves Di Nisio, Celso Junio Aguiar Mendonca, Ivan Moura Belo
Summary: This study presents a comparative finite element analysis of two different fixation methods for treating high-energy tibial plateau fractures, LC-DCP and LCP, and finds that osteosynthesis with LCP achieves better results with reduced independent motion of bone fragments at the fracture site, as predicted in literature.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Ruofan Wang, Zenghui Wu
Summary: Finite element analysis (FEA) is a widely used tool that has contributed to a better understanding of the spine and its behavior, as well as assisting in the design and application of spinal interbody cages (ICs). FEA allows for thorough testing of new designs before manufacturing, examining biomechanical responses and spinal fusion processes that cannot easily be experimented upon in vivo. This paper reviews the recent progress of FEA in spinal ICs over the last six years and discusses its limitations and future advancements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph Leach, Dimitrios Mitsouras, David A. Saloner, Julius M. Guccione, Liang Ge, Elaine E. Tseng
Summary: This study evaluated the association between aortic area/height and peak aneurysm wall stresses, valve morphology, and 3-year all-cause mortality. The results showed that the aortic area/height ratio was more predictive of high circumferential stresses in bicuspid valve aneurysms, while peak longitudinal stress independently predicted all-cause mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Francois Zot, Estelle Ben-Brahim, Mathieu Severyns, Yann Ledoux, Michel Mesnard, Laetitia Caille, Cecile Swennen, Simon Teyssedou, Abdollah-Yassine Moufid, Arnaud Germaneau, Tanguy Vendeuvre
Summary: Lumbar disc arthroplasty is a surgical procedure used to treat degenerative disc disease. This study compared the mechanical response of ball-and-socket and elastic prostheses using finite element models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alycia G. Berman, Daniel J. Romary, Katherine E. Kerr, Natalyn E. Gorazd, Morgan M. Wigand, Sourav S. Patnaik, Ender A. Finol, Abigail D. Cox, Craig J. Goergen
Summary: The study investigates the influence of elastase concentration and BAPN on the growth rate and severity of aneurysms in a mouse model, revealing their significant impact on aneurysm formation and expansion. Results highlight the potential of elastase concentration and BAPN to modulate aneurysm growth rate and severity.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Mirunalini Thirugnanasambandam, Sabrina Frey, Yannick Roesch, Alberto Mantegazza, Francesco Clavica, Robert S. Schwartz, Nikola Cesarovic, Dominik Obrist
Summary: Cardiac microvascular obstruction (MVO) is the partial or complete loss of blood perfusion in the myocardial microcirculation caused by acute myocardial infarction. A new catheter-based method called CoFI has been developed to accurately diagnose MVO during acute therapy. Experiments on a porcine MVO model and a benchtop microcirculation model showed that CoFI could identify the increased hydraulic resistance in the affected microvascular bed. Different levels of collateral flow were studied and concepts to differentiate collateral flow from MVO were formulated.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Physiology
Katherine Leyba, Nitchawat Paiyabhroma, John P. Salvas, Frederick W. Damen, Alicia Janvier, Emma Zub, Corinne Bernis, Richard Rouland, Christophe J. Dubois, Jerome Badaut, Sylvain Richard, Nicola Marchi, Craig J. Goergen, Pierre Sicard
Summary: Retrospective studies have shown that mild traumatic brain injury (mTBI) in pediatric patients may increase the risk of cardiac events, but the precise functional and temporal dynamics and associations between heart and brain pathophysiological trajectories are not well understood. In this study, a single impact was performed on the left somatosensory cortical area of juvenile mice, and various imaging techniques were used to measure the changes in brain and heart function over time. The results showed that mTBI caused a transient decrease in brain oxygen saturation and long-term cardiac dysfunction, which was correlated with behavioral changes. These imaging biomarkers could potentially be used to improve the management of pediatric mTBI.
Article
Cardiac & Cardiovascular Systems
Frederick W. W. Damen, Daniel P. P. Gramling, Dorothy A. Ahlf Wheatcraft, Robert Y. Y. Wilpan, Mauro W. W. Costa, Craig J. J. Goergen
Summary: In this study, a multimodal analysis approach combining high-frequency four-dimensional ultrasound (4DUS) imaging and proteomics was used to comprehensively characterize cardiac structure and function in a murine model of metabolic cardiomyopathy. The presented 4DUS analysis provided a novel method for mapping circumferential and longitudinal strain profiles, enabling spatiotemporal comparisons of cardiac function and improved localization of regional dysfunction. The results of targeted Ingenuity Pathway Analysis (IPA) and combined 4DUS-proteomics analysis highlighted metabolic dysregulation and potential pathways associated with regional cardiac dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dongsheng Gu, Arvin H. H. Soepriatna, Wenjun Zhang, Jun Li, Jenny Zhao, Xiaoli Zhang, Xianhong Shu, Yongshi Wang, Benjamin J. J. Landis, Craig J. J. Goergen, Jingwu Xie
Summary: This study provides direct evidence that activation of hedgehog signaling through expression of activated smoothened can induce fibrosis in the vasculature and aortic valves, leading to abnormal function of aortic valves and heart. The relevance of this mouse model to human health is reflected in the findings that elevated GLI expression is detected in fibrotic aortic valves from patients.
CELL AND BIOSCIENCE
(2023)
Article
Physiology
J. C. Muskat, C. F. Babbs, C. J. Goergen, V. L. Rayz
Summary: Wall shear stress (WSS) is a crucial factor in regulating endothelial function. Current estimation models based on Poiseuille's flow underestimate WSS in large arteries due to the assumption of simplified velocity distribution. This study proposes a method based on the Womersley solution, which accurately captures the time-varying blood flow and WSS in conduit arteries. Validation and application of the method reveal significant underestimation of peak WSS and neglect of retrograde WSS compared to the Poiseuille solution.
PHYSIOLOGICAL REPORTS
(2023)
Article
Biophysics
Achim Hegner, Hannah L. Cebull, Antonio J. Gamez, Christopher Blase, Craig J. Goergen, Andreas Wittek
Summary: Researchers have successfully computed in vivo 3D Green-Lagrange strain in a murine model of angiotensin II-induced dissecting aortic aneurysms using a combination of 4D ultrasound and direct deformation estimation. The study revealed that the highest strain was found in areas with intact elastin without thrombus attachment, while areas with intact elastin and thrombus attachment as well as areas with disrupted elastin showed significantly lower strain. This research helps to better understand the relationship between vessel strain and structural changes, ultimately improving patient outcomes.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Engineering, Biomedical
Orlando S. Hoilett, Jason D. Ummel, Luke E. Schepers, Arvin H. Soepriatna, Jessica L. Ma, Akio K. Fujita, Alyson S. Pickering, Benjamin D. Walters, Craig J. Goergen, Jacqueline C. Linnes
Summary: The study aimed to develop a novel device using photoplethysmography technology to monitor respiratory rate in real-time, successfully demonstrated in a murine model for detecting opioid-induced respiratory depression. This device shows potential for early detection and intervention in opioid overdose events.
Article
Biophysics
Hai -Chao Han, Sarah Sultan, Michael Xiang
Summary: Artery buckling can be caused by hypertensive lumen pressure, reduced axial tension, and other pathological conditions. This study aimed to investigate how axial twisting and nonsymmetric collagen fiber distribution affect the critical pressure for arterial bent buckling. The analysis and experimental tests demonstrated that axial twisting and nonsymmetric fiber alignment can reduce the critical pressure for arterial buckling. These findings contribute to the understanding of artery buckling and vessel tortuosity.
JOURNAL OF BIOMECHANICS
(2023)
Article
Medicine, Research & Experimental
Samuel L. Kaefer, Lujuan Zhang, Rachel A. Morrison, Sarah Brookes, Oluwaseyi Awonusi, Elizabeth Shay, Orlando S. Hoilett, Jennifer L. Anderson, Craig J. Goergen, Sherry Voytik-Harbin, Stacey Halum
Summary: This study explores the early implications of muscle-derived motor-endplate expressing cells (MEEs) for injectable vocal fold medialization after recurrent laryngeal nerve (RLN) injury. Autologous muscle progenitor cells were isolated, cultured, differentiated, and induced to form MEEs. MEE injections showed positive effects on laryngeal function and regeneration.
Meeting Abstract
Obstetrics & Gynecology
Joanna Izewski, Jennifer Anderson, Kaitlyn Enderle, Samantha Tilmon, David M. Haas, David Reuter, Brandon Brown, Anthony L. Shanks, Craig Goergen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Conner C. Earl, Victoria I. Pyle, Sydney Q. Clark, Karthik Annamalai, Paula A. Torres, Alejandro Quintero, Frederick W. Damen, Kan N. Hor, Larry W. Markham, Jonathan H. Soslow, Craig J. Goergen
Summary: This study used a novel 4D strain analysis method to characterize DMD cardiomyopathy. The results showed that DMD patients had significantly decreased myocardial strain, which correlated with cardiac function and extracellular volume.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Conner C. Earl, Jonathan H. Soslow, Larry W. Markham, Craig J. Goergen
Meeting Abstract
Cardiac & Cardiovascular Systems
Francisco Gonzalez, Srikanth Perike, Frederick W. Damen, Andrielle Capote, Katherina M. Alsina, Benjamin Levin, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph Akar, Chad M. Warren, R. John Solaro, Dawood Darbar, Craig J. Goergen, Beata M. Wolska, Xander H. Wehrens, Mark McCauley
Proceedings Paper
Computer Science, Interdisciplinary Applications
Anish Salvi, Ender Finol, Prahlad G. Menon
Summary: The study focuses on automating the classification of AAA rupture risk using neural networks, showcasing the accuracy achieved with latent embeddings and U-Net training on CTA images. By training and classifying different types of U-Nets, mixed class 3D ResNets were found to have 90% accuracy in rupture risk stratification.
MEDICAL IMAGING 2022: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2022)