Mechanistic insights into transferable polymyxin resistance among gut bacteria

Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance

(2018) Pengcheng Wei et al.   FASEB JOURNAL

Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016

(2017) Alessandra Carattoli et al.   Eurosurveillance

Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014

(2017) Louise Roer et al.   Eurosurveillance

MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium

(2017) Laurent Poirel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B

(2017) Maria Borowiak et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

(2017) Anandhi Anandan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli

(2017) Wenjuan Yin et al.   mBio

Deciphering MCR-2 Colistin Resistance

(2017) Jian Sun et al.   mBio

Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs

(2017) Qingjing Wang et al.   Microbiome

Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada

(2017) Nathalie Tijet et al.   PLoS One

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

(2017) Philip Hinchliffe et al.   Scientific Reports

Increasing Trends inmcr-1Prevalence among Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates from French Calves despite Decreasing Exposure to Colistin

(2016) Marisa Haenni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Coexistence ofmcr-1andblaNDM-1in Escherichia coli from Venezuela

(2016) Jose F. Delgado-Blas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

mcr-1.2, a NewmcrVariant Carried on a Transferable Plasmid from a Colistin-Resistant KPC Carbapenemase-Producing Klebsiella pneumoniae Strain of Sequence Type 512

(2016) Vincenzo Di Pilato et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure of the catalytic domain of the colistin resistance enzyme MCR-1

(2016) Vlatko Stojanoski et al.   BMC BIOLOGY

Identification of a novel plasmid-mediated colistin-resistance gene,mcr-2, inEscherichia coli, Belgium, June 2016

(2016) Basil Britto Xavier et al.   Eurosurveillance

Molecular mechanisms of polymyxin resistance: knowns and unknowns

(2016) Sophie Baron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Genetic characterization of mcr-1 -bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant

(2016) Ruichao Li et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transferable resistance to colistin: a new but old threat: Table 1.

(2016) Stefan Schwarz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

UN High-Level Meeting on antimicrobials—what do we need?

(2016) Ramanan Laxminarayan et al.   LANCET

Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae

(2016) Hong Du et al.   LANCET INFECTIOUS DISEASES

Colistin resistance: a major breach in our last line of defence

(2016) David L Paterson et al.   LANCET INFECTIOUS DISEASES

Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1

(2016) Xu Yao et al.   LANCET INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation

(2016) V. I. Petrou et al.   SCIENCE

Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota

(2016) Zhencui Li et al.   Science China-Life Sciences

Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli

(2016) Rongsui Gao et al.   Science China-Life Sciences

Diversified mcr-1 -Harbouring Plasmid Reservoirs Confer Resistance to Colistin in Human Gut Microbiota

(2016) Huiyan Ye et al.   mBio

Dissemination and Mechanism for the MCR-1 Colistin Resistance

(2016) Rongsui Gao et al.   PLoS Pathogens

Genomic insights into the ESBL and MCR-1-producing ST648 Escherichia coli with multi-drug resistance

(2016) Huimin Zhang et al.   Science Bulletin

Co-transfer of blaNDM-5 and mcr-1 by an IncX3–X4 hybrid plasmid in Escherichia coli

(2016) Jian Sun et al.   Nature Microbiology

High resolution crystal structure of the catalytic domain of MCR-1

(2016) Guixing Ma et al.   Scientific Reports

Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance

(2016) Menglong Hu et al.   Scientific Reports

Feasibility of asymmetric flow field-flow fractionation coupled to ICP-MS for the characterization of wear metal particles and metalloproteins in biofluids from hip replacement patients

(2015) Katrin Loeschner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Detection ofmcr-1encoding plasmid-mediated colistin-resistantEscherichia coliisolates from human bloodstream infection and imported chicken meat, Denmark 2015

(2015) Henrik Hasman et al.   Eurosurveillance

DOCK 6: Impact of new features and current docking performance

(2015) William J. Allen et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Paracoccus denitrificanspossesses two BioR homologs having a role in regulation of biotin metabolism

(2015) Youjun Feng et al.   MicrobiologyOpen

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Brucella BioR Regulator Defines a Complex Regulatory Mechanism for Bacterial Biotin Metabolism

(2013) Y. Feng et al.   JOURNAL OF BACTERIOLOGY

Rapid analysis of multiclass antibiotic residues and some of their metabolites in hospital, urban wastewater and river water by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry

(2013) Meritxell Gros et al.   JOURNAL OF CHROMATOGRAPHY A

The Structure of the Neisserial Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) Required for Resistance to Polymyxin

(2013) Christopher Wanty et al.   JOURNAL OF MOLECULAR BIOLOGY

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in Gram-positive and Gram-negative bacteria

(2012) J. V. Hankins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters

(2011) Youjun Feng et al.   MOLECULAR MICROBIOLOGY

Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly

(2010) A. M. Powl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

QMEAN server for protein model quality estimation

(2009) Pascal Benkert et al.   NUCLEIC ACIDS RESEARCH

A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

(2008) Duangjit Kanistanon et al.   PLoS Pathogens