Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

(2017) Aruna Bitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)

(2017) M. Sznol et al.   JOURNAL OF CLINICAL ONCOLOGY

Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy

(2016) Alfonso R. Sanchez-Paulete et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD137-CRDI is not necessary in the role of contacting its natural ligand

(2016) Ling Yi et al.   IMMUNOLOGY AND CELL BIOLOGY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity

(2012) Timothy S. Fisher et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin

(2012) X. Luan et al.   JOURNAL OF IMMUNOLOGY

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy

(2011) Laura M. Snell et al.   IMMUNOLOGICAL REVIEWS

Crystallographic and Mutational Analysis of the CD40-CD154 Complex and Its Implications for Receptor Activation

(2011) Hyun-Jung An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoy Strategies: The Structure of TL1A:DcR3 Complex

(2011) Chenyang Zhan et al.   STRUCTURE

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and Functional Insights of RANKL-RANK Interaction and Signaling

(2010) C. Liu et al.   JOURNAL OF IMMUNOLOGY

Solution of the Structure of the TNF-TNFR2 Complex

(2010) Y. Mukai et al.   Science Signaling

Sequence, structure, function, immunity: structural genomics of costimulation

(2009) Kausik Chattopadhyay et al.   IMMUNOLOGICAL REVIEWS

The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily

(2009) Eun-Young Won et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

(2008) Takanori So et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

(2008) K. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA