High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

(2016) Xiaokai Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back

(2016) Federica Chiappori et al.   Scientific Reports

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

(2015) Xuetian Yue et al.   eLife

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

(2014) Yanlong Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of Difficult Protein–Protein Interactions Identified by High-Throughput Screening of Multiprotein Complexes

(2013) Laura C. Cesa et al.   ACS Chemical Biology

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

(2013) Xiaokai Li et al.   ACS Medicinal Chemistry Letters

Fine-Tuning Multiprotein Complexes Using Small Molecules

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70

(2012) Yoshinari Miyata et al.   CHEMISTRY & BIOLOGY

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

2-Aminothiazoles as Therapeutic Leads for Prion Diseases

(2011) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface

(2011) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparing the functional properties of the Hsp70 chaperones, DnaK and BiP

(2010) Jeanne Bonomo et al.   BIOPHYSICAL CHEMISTRY

Mutagenesis Reveals the Complex Relationships between ATPase Rate and the Chaperone Activities ofEscherichia coliHeat Shock Protein 70 (Hsp70/DnaK)

(2010) Lyra Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of small molecules that modify the protein folding activity of heat shock protein 70

(2008) Susanne Wisén et al.   ANALYTICAL BIOCHEMISTRY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity

(2008) C. Andreasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY