Article
Ophthalmology
Nicholas P. Boyer, Debra A. Thompson, Yiannis Koutalos
Summary: The study investigated the contribution of all-trans retinal to the formation and stability of RPE lipofuscin in Rdh8(-/-) mice reared under cyclic-light conditions. Results showed that the levels of A2E and RPE lipofuscin accumulated faster in cyclic-light-reared mice compared to dark-reared mice, but the impact of increased all-trans retinal was modest. Additionally, moving cyclic-light-reared mice to darkness led to unexpected decreases in A2E levels, suggesting a potential therapeutic target for controlling A2E cytotoxicity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Amanda D'Espessailles, Valeria Campos, Nevenka Juretic, Gladys S. Tapia, Paulina Pettinelli
Summary: The dietary supplementation of alpha- and gamma-tocopherols was found to modulate the expression of hepatic retinaldehyde dehydrogenases and lipogenic factors, reducing the presence of lipid vesicles and total lipid content in an animal model of diet-induced nonalcoholic fatty liver disease (NAFLD).
Article
Nutrition & Dietetics
Richard C. Baybutt, Joseph T. Standard, Daniel Dim, Tim Quinn, Hana Hamdan, Dingbo Lin, Kyle Kunz, Zachary S. Bomstein, Benjamin J. Estorge, Betty Herndon, Hamid Zia, Ahmad Mansour, Manesha Lankachandra, Agostino Molteni
Summary: The study aimed to evaluate the impact of replenishing vitamin A on bone thickness in vitamin A-deficient rats, with results showing that cod liver oil (COD) supplementation more effectively restored abnormal bone thickness in the rats compared to retinoic acid (RA) treatment.
Review
Food Science & Technology
Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim
Summary: Retinoic acid is essential for cell growth, differentiation, and embryogenesis, and inhibition of RALDH activity can lead to reproductive and developmental toxicity. The AOP(297) was discussed to support the evidence for RALDH inhibition-related developmental toxicity.
Article
Biochemistry & Molecular Biology
Mark K. Adams, Olga Belyaeva, Lizhi Wu, Ivis F. Chaple, Katelyn Dunigan-Russell, Kirill M. Popov, Natalia Y. Kedishvili
Summary: The hetero-oligomeric retinoid oxidoreductase complex (ROC) consists of two distinct components, RDH10 and DHRS3, whose interaction and activation are crucial for maintaining the steady-state output of retinaldehyde. Studies suggest that the cofactor binding to one subunit is critical for the activation of the other subunit, and specific C-terminal residues play essential roles in the activity of each subunit within the ROC complex.
BIOCHEMICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Noriko Takahashi, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, Masahiko Imai
Summary: This paper introduces the circulation of vitamin A in the body, the actions and mechanisms of retinal and RA, retinoylation as an RA mechanism independent of RA receptors, the relationship between cancer and the actions of retinol or beta-carotene, and the anti-cancer actions of vitamin A derivatives derived from fenretinide. The study suggests that nutritional management of vitamin A is effective in cancer prevention.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Microbiology
Minjae Han, Pyung Cheon Lee
Summary: Microbial production of bioactive retinoids has been reported, with successful redesign of two genes leading to increased retinoic acid production in Escherichia coli through engineering and culture optimization. Further refinements in gene expression levels and protein engineering may continue to enhance retinoic acid production.
Article
Biochemistry & Molecular Biology
Wenting Hong, Dongke Xu, Xiaowei Song, Baolin Niu, Ziyan Zhuang, Yiteng Lu, Xiaohong Lei, Runjun Ma, Chao Lu, Ning Sun, Yimin Mao, Xiaobo Li
Summary: The study revealed that there is a significant difference in the small intestine between the fasted and refed state, with long-term high-fat diet (HFD) feeding attenuating this difference. Vitamin A (VA) and retinoic acid (RA) play important roles in this process.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Fabiana M. de O. Hernandez, Marilene O. Santos, Gabriela L. Venturin, Jaqueline P. Bragato, Gabriela T. Rebech, Larissa M. Melo, Sidnei F. Costa, Jessica H. de Freitas, Carlos Eduardo Siqueira, Deborah A. Morais, Wellington T. de S. Junior, Fernando B. Junior, Flavia L. Lopes, Valeria M. F. de Lima
Summary: Canine leishmaniasis is a chronic disease caused by Leishmania infantum, and the limitations of current treatments have led to the exploration of new alternatives, such as the use of immunomodulatory nutrients. This study aimed to determine the levels of vitamin A, vitamin D, and zinc in dogs with CanL and the effects of supplementation with these nutrients on spleen leukocyte cultures. The results suggest that the tested nutrients may play a role in the leishmanicidal mechanism and warrant further investigation in future studies.
Article
Endocrinology & Metabolism
Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual
Summary: The over-expression of BCO1 through delivery of an AT-AAV-BCO1 leads to the conversion of f3-carotene to vitamin A in adipocytes, which subsequently results in the reduction of adiposity.
MOLECULAR METABOLISM
(2022)
Article
Nutrition & Dietetics
Phil-Robin Tepasse, Richard Vollenberg, Manfred Fobker, Iyad Kabar, Hartmut Schmidt, Jorn Arne Meier, Tobias Nowacki, Anna Husing-Kabar
Summary: This study found that in COVID-19 patients, plasma levels of vitamin A decrease during acute inflammation, and significantly reduced plasma levels of vitamin A are associated with ARDS and mortality.
Article
Microbiology
Xuan Wang, Xianhao Xu, Jiaheng Liu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu
Summary: Researchers developed a high retinol-producing strain of Saccharomyces cerevisiae through pathway construction, network optimization, transporter engineering, and enzyme modification. This study lays the foundation for industrial production of retinol.
Review
Neurosciences
Sajjad Farashi, Siamak Shahidi, Abdolrahman Sarihi, Mohammad Zarei
Summary: The main purpose of this systematic review was to evaluate the association between stroke and vitamin A, its organic compounds, and its provitamins. The results showed an inverse association between vitamin A and its organic compounds with the risk of stroke and mortality due to stroke, with retinol and beta-carotene being the most effective compounds. However, more studies are needed to evaluate the clinical significance of these findings due to heterogeneity between studies.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maryam Honarbakhsh, Aaron Ericsson, Guo Zhong, Nina Isoherranen, Chengsheng Zhu, Yana Bromberg, Charlene Van Buiten, Kiana Malta, Laurie Joseph, Harini Sampath, Atreju Lackey, Judith Storch, Costantino Vetriani, Michael L. Chikindas, Paul Breslin, Loredana Quadro
Summary: The deficiency of lecithin:retinol acyltransferase and retinol-binding protein in mice leads to intestinal vitamin A deficiency, compromising gut morphology, barrier function, and microbial composition.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Dermatology
Jemin Kim, Jihee Kim, Tunyaporn Jongudomsombat, B. S. Eunbin Kim, M. S. Jangmi Suk, Dongwon Lee, Ju Hee Lee
Summary: The study demonstrated that MLV-RAL 0.05%/0.1% cream effectively improved photoaged skin, including wrinkle depth and facial contour. Compared to retinol, it showed superior efficacy and good safety profile.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Josep Marti-Solans, Olga V. Belyaeva, Nuria P. Torres-Aguila, Natalia Y. Kedishvili, Ricard Albalat, Cristian Canestro
MOLECULAR BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Olga V. Belyaeva, Mark K. Adams, Lizhi Wu, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Gastroenterology & Hepatology
Yanling Ma, Olga V. Belyaeva, Philip M. Brown, Koji Fujita, Katherine Valles, Suman Karki, Ynto S. de Boer, Christopher Koh, Yanhua Chen, Xiaomeng Du, Samuel K. Handelman, Vincent Chen, Elizabeth K. Speliotes, Cara Nestlerode, Emmanuel Thomas, David E. Kleiner, Joseph M. Zmuda, Arun J. Sanyal, Natalia Y. Kedishvili, T. Jake Liang, Yaron Rotman
Article
Biochemistry & Molecular Biology
Lizhi Wu, Natalia Y. Kedishvili, Olga V. Belyaeva
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Lizhi Wu, Olga Belyaeva, Mark K. Adams, Alla Klyuyeva, Seung-Ah Lee, Kelli R. Goggans, Robert A. Kesterson, Kirill M. Popov, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Olga V. Belyaeva, Mark K. Adams, Kirill M. Popov, Natalia Y. Kedishvili
Article
Gastroenterology & Hepatology
Yanling Ma, Philip M. Brown, Dennis D. Lin, Jing Ma, Dechun Feng, Olga V. Belyaeva, Maren C. Podszun, Jason Roszik, Joselyn N. Allen, Regina Umarova, David E. Kleiner, Natalia Y. Kedishvili, Oksana Gavrilova, Bin Gao, Yaron Rotman
Summary: Extensive evaluation of Hsd17b13 deficiency in mice under several fatty liver-inducing dietary conditions did not reproduce the protective role of HSD17B13 loss-of-function mutants in human NAFLD. Moreover, mouse Hsd17b13 deficiency induces weight gain under regular chow. It is crucial to understand interspecies differences prior to leveraging HSD17B13 therapies.
Article
Biochemistry & Molecular Biology
Yanling Ma, Suman Karki, Philip M. Brown, Dennis D. Lin, Maren C. Podszun, Wenchang Zhou, Olga V. Belyaeva, Natalia Y. Kedishvili, Yaron Rotman
JOURNAL OF LIPID RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Alla Klyuyeva, Olga Belyaeva, Kelli R. Goggans, Wojciech Krezel, Kirill M. Popov, Natalia Y. Kedishvili
Summary: Liver, as the central metabolic hub, plays a crucial role in coordinating carbohydrate and lipid metabolism, with retinoic acid (RA) regulating major metabolic genes. Adaptation to fasting or type 1 diabetes (T1D) involves changes in hepatic RA levels and signaling, including alterations in RDH10 protein abundance without changes in transcript levels. These findings suggest that hepatic RA biosynthesis, through RDH10, is essential for adaptation to fasting, while upregulation of RA biosynthesis and signaling in T1D may contribute to metabolic inflexibility.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Olga Belyaeva, Samuel E. Wirth, William E. Boeglin, Suman Karki, Kelli R. Goggans, Stacy G. Wendell, Kirill M. Popov, Alan R. Brash, Natalia Y. Kedishvili
Summary: Bioactive oxylipins are involved in inflammation and immune response, and their actions are terminated by dehydrogenases. The study reveals that DHRS9, a member of the SDR superfamily, exhibits oxidative activity towards various oxylipins. The results suggest that DHRS9 plays an important role in the metabolism of bioactive oxylipins.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biology
Jianfeng Li, Silvia Garavaglia, Zhaofeng Ye, Andrea Moretti, Olga Belyaeva, Alison Beiser, Md Ibrahim, Anna Wilk, Steve McClellan, Alla Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili, E. Alan Salter, Andrzej Wierzbicki, Marie E. Migaud, Steven J. Mullett, Nathan A. Yates, Carlos J. Camacho, Menico Rizzi, Robert W. Sobol
Summary: In silico modeling was used to identify a selective inhibitor for ALDH1A3, a potential drug target highly expressed in mesenchymal glioma stem cells. The identified inhibitor, MCI-INI-3, showed efficient inhibition of retinoic acid biosynthesis comparable to ALDH1A3 depletion. Further research is needed to understand the role of ALDH1A3 and retinoic acid biosynthesis in glioma stem cell growth and differentiation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathalia Melo, Olga V. Belyaeva, Wilhelm K. Berger, Laszlo Halasz, Jianshi Yu, Nagesh Pilli, Zhengrong Yang, Alla V. Klyuyeva, Craig A. Elmets, Venkatram Atigadda, Donald D. Muccio, Maureen A. Kane, Laszlo Nagy, Natalia Y. Kedishvili, Matthew B. Renfrow
Summary: This study investigated the mechanism of action of two next-generation rexinoids, UAB110 and UAB111. The results showed that UAB110 and UAB111 were more potent in enhancing ATRA signaling compared to UAB30 and Targretin. These rexinoids achieved activation through different molecular responses to ligand binding.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Venkatram R. Atigadda, Mahendra P. Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V. Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y. Kedishvili, Clinton J. Grubbs, Matthew B. Renfrow, Donald D. Muccio, Craig A. Elmets, Mohammad Athar
Summary: Some rexinoids have anticancer activity and can prevent nonmelanoma skin cancer effectively, without causing overt toxicities. These rexinoids show high efficacy in upregulating genes responsible for the biosynthesis of all-trans retinoic acid and in diminishing inflammation.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mark K. Adams, Seung-Ah Lee, Olga V. Belyaeva, Lizhi Wu, Natalia Y. Kedishvili
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)