Article
Biochemistry & Molecular Biology
Kunihiro Sonoda, Yuka Kono, Kazuya Kitamori, Kazuo Ohtake, Sachiko Shiba, Keizo Kasono, Jun Kobayashi
Summary: This study evaluated the effects of dietary nitrite on a rat NASH model and found that nitrite can suppress liver fibrosis by reducing oxidative stress, lower blood pressure in hypertensive NASH rats, and suppress left ventricular chamber enlargement. Similar therapeutic effects were observed with captopril, suggesting a common signaling pathway for nitrite and captopril in improving NASH pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoru Tamura, Minoru Ueda, Satoshi Hirohata, Shogo Watanabe
Summary: The study found that OBG, as a specific agonist of LXR,8, does not exacerbate hepatic steatosis and has a suppressive effect on the development of nonalcoholic steatohepatitis (NASH) and atherosclerosis.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Shusei Yamamoto, Koki Honma, Moe Fujii, Mai Kakimoto, Sora Kirihara, Hinako Nakayama, Kazuya Kitamori, Ikumi Sato, Satoshi Hirohata, Shogo Watanabe
Summary: This study aimed to investigate whether stroke-prone spontaneously hypertensive rat 5 (SHRSP5/Dmcr) could serve as a useful model for studying secondary sarcopenia associated with nonalcoholic steatohepatitis. The results showed that SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet developed nonalcoholic steatohepatitis and exhibited muscle atrophy, especially in fast muscles. In contrast, the control rats did not show sarcopenia. These findings suggest that SHRSP5/Dmcr rats could be a valuable model for investigating the mechanisms of secondary sarcopenia disorder associated with nonalcoholic steatohepatitis.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2023)
Article
Food Science & Technology
Xiaozhuan Lin, Xuan Zhu, Yan Xin, Peiwen Zhang, Yunjun Xiao, Taiping He, Honghui Guo
Summary: Intermittent fasting shows potential in alleviating NASH by regulating gut microbiota and bile acids metabolism. It can reduce body weight, insulin resistance, hepatic steatosis, and inflammation, while reshaping gut microbiota and promoting bile acid excretion.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mai Kakimoto, Moe Fujii, Ikumi Sato, Koki Honma, Hinako Nakayama, Sora Kirihara, Taketo Fukuoka, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Shusei Yamamoto, Shogo Watanabe
Summary: In this study, the XO inhibitor febuxostat was found to effectively treat NASH and atherosclerosis by reducing uric acid production and suppressing oxidative stress. The results showed that febuxostat reduced uric acid levels, improved antioxidant capacity, and ameliorated liver lesions, arterial lipid deposition, and vascular endothelial function.
JOURNAL OF APPLIED BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yuanli Chen, Jiamin Su, Yali Yan, Qian Zhao, Jialing Ma, Mengmeng Zhu, Xiaoyu He, Baotong Zhang, Hongmei Xu, Xiaoxiao Yang, Yajun Duan, Jihong Han
Summary: Intermittent fasting (IF) has a protective effect against atherosclerosis in LDLR-/- mice by reducing lesions and increasing plaque stability. The mechanisms involve inhibition of cholesterol synthesis in the liver and reduction of monocyte inflammation. Therefore, IF shows potential for application in atherosclerosis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jiazhen Wu, Mengyao Li, Ning Huang, Fengkun Guan, Huijuan Luo, Liping Chen, Guilan Wei, Muxia Li, Zhixiu Lin, Ziren Su, Jiannan Chen, Yuhong Liu
Summary: This study investigated the effects and mechanisms of curcumin (Cur) and its bioconversion on hepatic endothelial function against high-fat diet-induced nonalcoholic steatohepatitis (NASH) in rats. The results showed that Cur improved hepatic lipid accumulation, inflammation, and endothelial dysfunction by inhibiting NF-κB and PI3K/Akt/HIF-1α pathways. However, these effects were weakened by antibiotic addition, which was associated with reduced production of tetrahydrocurcumin (THC) in the liver and intestinal content. Moreover, THC demonstrated a better effect than Cur in restoring liver sinusoidal endothelial cells function and attenuating steatosis and injury in L02 cells. These findings suggest that the effect of Cur on NASH is closely related to improvement of hepatic endothelial function through intestinal microbial biotransformation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Haixia Du, Chang Li, Zhixiong Wang, Yu He, Yu Wang, Huifen Zhou, Haitong Wan, Jiehong Yang
Summary: The study demonstrated that Danhong injection (DHI) significantly improved hyperlipidemia in high-fat diet-fed rats by reducing lipid levels, decreasing hepatic lipid accumulation, improving liver function, and reducing oxidative stress. The potential mechanism may involve the promotion of bile acid synthesis through the activation of the PPAR alpha-LXR alpha-CYP7A1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Hongshan Li, Yingfei Xi, Hongliang Liu, Xin Xin
Summary: The study found that gypenosides can attenuate high-fat diet-induced non-alcoholic steatohepatitis (NASH) by activating the farnesoid X receptor (FXR) and modulating fatty acid metabolism.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Wen-Cong Li, Su-Xian Zhao, Wei-Guang Ren, Yu-Guo Zhang, Rong-Qi Wang, Ling-Bo Kong, Qing-Shan Zhang, Yue-Min Nan
Summary: The combination of obeticholic acid (OCA) and simvastatin (SIM) showed promising therapeutic effects in a high-fat diet-induced model of non-alcoholic steatohepatitis (NASH), reducing liver inflammation and steatosis, preventing weight gain and fat accumulation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Pathology
Pauline Verhaegh, Eddie Wisse, Toon de Munck, Jan Willem Greve, Joanne Verheij, Robert Riedl, Hans Duimel, Ad Masclee, Daisy Jonkers, Ger Koek
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease in Western society, with multifactorial pathogenesis. Ultrastructural analysis in this study revealed less defenestration in patients with nonalcoholic steatohepatitis (NASH) compared to those without NASH, suggesting that defenestration may play a protective role in simple steatosis but not in NASH. New structures, like single cell steatonecrosis and inflammatory fat follicles, were also found in both groups.
Article
Biochemistry & Molecular Biology
Xuebin Gao, Xiaozhuan Lin, Yan Xin, Xuan Zhu, Xiang Li, Ming Chen, Zhigang Huang, Honghui Guo
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder globally. A study found that high dietary cholesterol intake accelerates the progression of NAFLD and induces liver inflammation in mice. Additionally, certain bacterial species in the gut microbiota were found to be positively correlated with the content of unconjugated bile acids in the liver. High dietary cholesterol alters gut microbiota composition and bile acid metabolism, promoting the development of NASH.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
B. Haridevamuthu, Boopathi Seenivasan, P. Snega Priya, Subramani Muthuraman, Rajendran Saravana Kumar, K. Manikandan, Bader O. Almutairi, Mikhlid H. Almutairi, Selvaraj Arokiyaraj, Pushparathinam Gopinath, Jesu Arockiaraj
Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common liver diseases caused by a western diet high in fats, which induce inflammation and impair hepatocyte function. Currently, there is a lack of pharmacological drugs for treating NAFLD/NASH. However, long pepper contains a bioactive compound called Piperlongumine (PL) that has potential antioxidant properties. In this study, demethylated dihydroxy piperlongumine (DHPL) was shown to have high antioxidant activity and was effective in reducing lipid accumulation and gene expression associated with NAFLD in a zebrafish model. DHPL may have therapeutic potential for halting the progression of NAFLD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Heng Li, Xiao-Hua Yu, Xiang Ou, Xin-Ping Ouyang, Chao-Ke Tang
Summary: NAFLD is a common chronic liver disease globally, with atherosclerotic cardiovascular disease being the leading cause of mortality in NAFLD patients. The liver plays a crucial role in cholesterol metabolism, and abnormal hepatic cholesterol metabolism can lead to NAFLD and drive the development of atherosclerosis.
PROGRESS IN LIPID RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Kazumasa Nosaka, Toru Miyoshi, Mutsumi Iwamoto, Masahito Kajiya, Keisuke Okawa, Saori Tsukuda, Fumi Yokohama, Masahiro Sogo, Tomoyuki Nishibe, Naoaki Matsuo, Satoshi Hirohata, Hiroshi Ito, Masayuki Doi
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
N. Matsuo, K. Hayashi, Y. Katou, M. Hasegawa, M. Tanimoto, T. Fujiwara, K. Kagawa, Y. Nakano, N. Oonishi, A. Takaishi, S. Hirohata, M. Ueeda
Meeting Abstract
Cardiac & Cardiovascular Systems
N. Matsuo, K. Hayashi, Y. Katou, M. Hasegawa, M. Tanimoto, T. Fujiwara, K. Kagawa, Y. Nakano, N. Oonishi, A. Takaishi, S. Hirohata, M. Ueeda
Article
Medical Laboratory Technology
Ryoko Shinohata, Yuhei Shiga, Shin-ichiro Miura, Satoshi Hirohata, Misako Shibakura, Tomoe Ueno-Iio, Shogo Watanabe, Yujiro Arao, Shinichi Usui
CLINICA CHIMICA ACTA
(2020)
Article
Biochemistry & Molecular Biology
Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui
Summary: A high-fat/high-cholesterol diet increases serum levels of apoE-rich HDL, while a high-cholesterol diet does not. This study investigates the effects of dietary fat and cholesterol on gene expression and HDL production. The results suggest that increased apoE-rich HDL induced by fat and cholesterol may be mediated by increased ABCA1-mediated cholesterol efflux from the liver.
Article
Pharmacology & Pharmacy
Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Shinichi Usui, Ryoko Shinohata, Kazuya Kitamori, Satoshi Hirohata, Shogo Watanabe
Summary: NOS inhibition exacerbates the development of NASH and CVD by promoting hepatic lipid synthesis, cholesterol absorption, and secretion, as well as increasing oxidative stress and lipid deposition in the arteries.
PHARMACOLOGICAL REPORTS
(2022)
Article
Medicine, Research & Experimental
Keiichi Asano, Midori Edamatsu, Omer F. Hatipoglu, Junko Inagaki, Mitsuaki Ono, Takashi Ohtsuki, Toshitaka Oohashi, Satoshi Hirohata
ACTA MEDICA OKAYAMA
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
Naoaki Matsuo, Atsushi Takaishi, Nobuhiko Oonishi, Yukari Nakano, Kenzou Kagawa, Tatsuya Yamaji, Yuuichi Katou, Kazuna Hayashi, Masayuki Ueeda, Satoshi Hirohata
Article
Medical Laboratory Technology
Toru Ikeda, Ryoko Shinohata, Masaaki Murakami, Kazuyoshi Hina, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi, Arisa Tamura, Shinichi Usui
CLINICA CHIMICA ACTA
(2017)