Article
Endocrinology & Metabolism
Bing Song, Yujie Chen, Chao Wang, Guanjian Li, Zhaolian Wei, Xiaojin He, Yunxia Cao
Summary: This study suggests that abnormal DNA methylation of certain CpG sites of imprinted genes is associated with poor sperm quality and severe sperm DNA damage.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Immunology
Emilia Morawiec, Michal Czerwinski, Anna Bednarska-Czerwinska, Andrzej Wiczkowski
Summary: Seminal microflora plays a crucial role in male fertility, and dysbiosis can lead to infertility and other reproductive problems. Inflammation negatively affects sperm quality and may cause partner infection. A comprehensive examination of seminal microflora can clarify the causes of infertility or prevent pathological conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Dolores J. Lamb, Jessica A. Marinaro
Summary: Semen analysis plays an important role in the evaluation and management of infertility in men. Conventional semen analysis cannot reliably predict the chance of pregnancy or differentiate fertile vs. infertile men, and further research is needed to determine how to incorporate advanced, nonstandard sperm functional tests into clinical practice. Therefore, the primary applications of semen analysis are to assess the severity of infertility, estimate the effects of future therapy, and measure the response to current therapy.
FERTILITY AND STERILITY
(2023)
Article
Urology & Nephrology
Ozge Senem Yucel Cicek, Gozde Kaya, Begum Alyuruk, Emek Doger, Tugba Girisen, Serdar Filiz
Summary: Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters revealed a significant decrease in total sperm count, sperm concentration, and total motile sperm count in samples with sORP values >1.36mV/10(6)sperm/mL. This study suggests that seminal oxidative stress, as indicated by sORP cutoff, is associated with oligozoospermia, reduced progressive motility, and low total motile sperm count in semen analysis.
INTERNATIONAL BRAZ J UROL
(2021)
Article
Pharmacology & Pharmacy
M. B. Can Balci, N. Can Cilesiz
Summary: Recent studies have found that sperm parameters may deteriorate in patients who have recovered from COVID-19. This study aimed to investigate the relationship between COVID-19 and semen parameters in male infertility patients. The results showed that COVID-19 can significantly lower sperm concentration in idiopathic infertility patients, especially within the first 6 months after recovery.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Trimble L. Spitzer, J. C. Trussell, R. Matthew Coward, Karl R. Hansen, Kurt T. Barnhart, Marcelle Cedars, Michael P. Diamond, Stephen A. Krawetz, Fangbai Sun, Heping Zhang, Nanette Santoro, Anne Z. Steiner
Summary: This study aimed to investigate whether stress, as measured by salivary alpha-amylase and cortisol levels, has a negative impact on male fertility, as measured by semen parameters, pregnancy, and live birth rates. The results showed that high levels of stress markers were not associated with DNA fragmentation or abnormal semen parameters. In fact, an increase in salivary cortisol was associated with an increase in total sperm count and total motile sperm count. Moreover, there was no difference in pregnancy and live birth rates between men with high levels of stress markers and those with lower levels.
REPRODUCTIVE SCIENCES
(2022)
Article
Urology & Nephrology
Michael B. Tradewell, Jesse Ory, Daniel E. Nassau, Andrew H. Rezk, Emad Ibrahim, Ranjith Ramasamy
Summary: Men with a solitary testis have higher serum follicle-stimulating hormone levels and a higher prevalence of compensated hypogonadism compared to men with bilateral testes, indicating a pituitary strain. Further followup is needed to assess potential detrimental consequences of this compensated state on testicular function.
JOURNAL OF UROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eliana Pintus, Jose Luis Ros-Santaella
Summary: Oxidative stress in the male reproductive system can impair sperm fertility, compromise offspring health, and induce oxidative damage to lipids, proteins, and nucleic acids. While a clear link has been shown in humans and laboratory rodents, limited information is available on the impact of impaired redox homeostasis in male fertility of domestic and wild animals. Strategies to mitigate the detrimental effects of oxidative stress on male fertility are reviewed, along with their potential economic and ecological implications in the livestock industry and biodiversity conservation.
Review
Endocrinology & Metabolism
Tarique Hussain, Mahmoud Kandeel, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Yulong Yin, Bie Tan, Muhammad Ismail Chughtai, Anjaleena Yaseen, Ali Afzal, Muhammad Saleem Kalhoro
Summary: Male infertility is a global issue with oxidative stress being the main contributing factor, affecting sperm quality and quantity. Dysfunction of mitochondria and inflammation also play important roles in compromised fertility. The interaction between oxidative stress and seminal plasma proteomes further influences male infertility. Understanding these factors can help improve strategies to prevent male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Shubhadeep Roychoudhury, Anandan Das, Manesh Kumar Panner Selvam, Saptaparna Chakraborty, Petr Slama, Suresh C. Sikka, Kavindra Kumar Kesari
Summary: This study analyzed the research trend in radiotherapy associated with male infertility over the past 20 years. The results showed a positive growth in research on the impact of radiotherapy on male infertility, primarily focusing on its effects on semen parameters and fertility preservation techniques. However, there is limited research on the influence of radiotherapy on male reproductive hormones and omics-related research in male reproductive organs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Feng Tang, Zhaoqiang Jiang, Mingying Jin, Huiqiang Sheng, Lingfang Feng, Junfei Chen, Yongxin Li, Jing Huang, Ling Xu, Jianlin Lou
Summary: This study examined the association between occupational factors and semen quality in semen donors in eastern China. The results showed that sedentary work style and intensive sports in certain professions might be associated with decreased semen quality. Evidence of the negative impact of unemployment on semen quality was also reported. Therefore, a healthy work style is advocated to improve semen quality in eastern China.
Article
Environmental Sciences
Saira Amir, Manolis Tzatzarakis, Charalampos Mamoulakis, Jaafar Haris Bello, Syed Ali Musstjab Akber Shah Eqani, Elena Vakonaki, Markos Karavitakis, Sikandar Sultan, Faheem Tahir, Syed Tahir Abbas Shah, Aristidis Tsatsakis
Summary: Male infertility is a major issue with various pathological factors such as endocrine disruption due to environmental pollution. Organochlorine pollutants can disrupt the male reproductive system, with PCBs, DDTs, and HCB being major concerns. Serum samples are the best for assessing health outcomes related to exposure levels.
ENVIRONMENTAL RESEARCH
(2021)
Review
Andrology
Ashok Agarwal, Rossella Cannarella, Ramadan Saleh, Florence Boitrelle, Murat Gul, Tuncay Toprak, Gianmaria Salvio, Mohamed Arafa, Giorgio I. Russo, Ahmed M. Harraz, Rajender Singh, Nicolas Garrido, Taha Abo-Almagd Abdel-Meguid Hamoda, Amarnath Rambhatla, Parviz Kavoussi, Shinnosuke Kuroda, Gokhan Calik, Pallavi Saini, Erman Ceyhan, Fotios Dimitriadis, Ralf Henkel, Andrea Crafa, Ayad Palani, Mesut Berkan Duran, Evangelos Maziotis, Emine Sais, Marion Bendayan, Mahsa Darbandi, Tan V. Le, Sezgin Gunes, Petroula Tsioulou, Pallav Sengupta, Berk Hazir, Gokhan Ceker, Sara Darbandi, Damayanthi Durairajanayagam, Azin Aghamajidi, Noora Alkhalidi, Emrullah Sogutdelen, Kristian Leisegang, Abdullah Alarbid, Christopher C. K. Ho, Vineet Malhotra, Federica Finocchi, Luis Crisostomo, Raghavender Kosgi, Haitham ElBardisi, Armand Zini, Ponco Birowo, Giovanni Colpi, Hyun Jun Park, Ege Can Serefoglu, Quang Nguyen, Edmund Ko, Jean de la Rosette, Germar M. Pinggera, Ho Vinh Phuoc Nguyen, Hussein Kandil, Rupin Shah
Summary: This study provides evidence for the positive effect of varicocele repair on conventional semen parameters in infertile men with clinical varicocele. There is significant improvement in sperm concentration, total motility, progressive motility, total sperm motility, and normal sperm morphology after varicocele repair. However, there is high inter-study heterogeneity.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Biology
Mona S. Almujaydil
Summary: Male infertility is a significant health issue that affects economy, psychology, and medicine. Dietary nutrients play a crucial role in male reproductive potential. This review focuses on examining the impact of omega-3 fatty acids, vitamins, minerals, and phytochemicals on semen attributes, sperm bioenergetics, and sperm functionality in male infertility.
Review
Environmental Sciences
Naina Kumar, Amit Kant Singh
Summary: Adverse environmental factors have a significant impact on semen quality and can cause male infertility. These factors include air pollution, chemicals, heat exposure, and heavy metals. By changing lifestyle, these risk factors can be avoided.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Urology & Nephrology
Ross E. Anderson, Sorena Keihani, Rupam Das, Heidi A. Hanson, Marta L. McCrum, James M. Hotaling, Jeremy B. Myers
Summary: This study found that nephrectomy in high grade renal trauma patients is significantly associated with increased risk of mortality. Other factors associated with death included age, race, mechanism of injury, shock, blood transfusion, Glasgow Coma Scale, Revised Trauma Score, and Injury Severity Score.
JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Karen C. Schliep, Marcia L. Feldkamp, Heidi A. Hanson, Michael Hollingshaus, Alison Fraser, Ken R. Smith, Katherine A. Panushka, Michael W. Varner
Summary: The study found that there was no significant association between grandmaternal age and trisomy 21, while young paternal age was positively associated with an increased risk of trisomy 21 after adjusting for other factors.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2021)
Article
Peripheral Vascular Disease
Sadeer G. Al-Kindi, Robert D. Brook, Udayan Bhatt, Michael Brauer, William C. Cushman, Heidi A. Hanson, John Kostis, James P. Lash, Robert Paine, Kalani L. Raphael, Stephen Rapp, Leonardo Tamariz, Jackson T. Wright, Sanjay Rajagopalan
Summary: This study examined the impact of fine particulate matter (PM2.5) exposure on cardiovascular events in the context of intensive blood pressure lowering intervention. The results showed that the benefits of intensive blood pressure lowering on cardiovascular events were greater in patients exposed to higher levels of PM2.5.
Article
Genetics & Heredity
Darshan P. Patel, Huong T. Meeks, Heidi A. Hanson, Alexander W. Pastuszak, James M. Hotaling, Ken R. Smith
Summary: This study found an association between contemporary total motile count (TMC) in men and intergenerational family size, with lower TMC associated with smaller family size. Men with lower TMC tended to have fewer offspring in their ancestral pedigree, while men with higher intergenerational family size had higher TMC levels.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Multidisciplinary Sciences
David S. Curtis, Tessa Washburn, Hedwig Lee, Ken R. Smith, Jaewhan Kim, Connor D. Martz, Michael R. Kramer, David H. Chae
Summary: The highly public anti-Black violence in the United States has a significant impact on the mental health of Black Americans, as indicated by national search interest and survey data. Reducing such violence may benefit the mental health of Black Americans nationally.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Urology & Nephrology
Benjamin J. McCormick, Joshua J. Horns, Rupam Das, Niraj Paudel, Heidi A. Hanson, Marta McCrum, Raminder Nirula, Jeremy B. Myers
Summary: The study found that after controlling for blood transfusions, nephrectomy after HGRT was not associated with increased mortality or AKI. Trauma nephrectomy should be avoided whenever possible as a clinical principle.
JOURNAL OF UROLOGY
(2022)
Article
Psychology, Clinical
Amanda Bakian, Danli Chen, Chong Zhang, Heidi A. Hanson, Anna R. Docherty, Brooks Keeshin, Douglas Gray, Ken R. Smith, James A. VanDerslice, David Z. Yu, Yue Zhang, Hilary Coon
Summary: This study examines the familial risk of suicide in Utah and explores whether the risk varies based on the characteristics of the suicides and their relatives. The findings suggest that there is a significantly elevated risk of suicide in family members of female and younger suicide probands. This highlights the importance of targeting prevention efforts towards specific risk groups, such as suicidal young adults and women with a strong family history of suicide.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Andrology
Darshan P. Patel, Huong T. Meeks, Alexander W. Pastuszak, Heidi A. Hanson, Ken R. Smith, Joseph M. Letourneau, James M. Hotaling
Summary: The study found that female partners of male cancer survivors have a lower chance of giving birth after the cancer diagnosis, especially for men aged 18-30. These results are crucial for patient counseling on fertility preservation at the time of cancer diagnosis.
Article
Demography
Kieron Barclay, Ken R. Smith
Summary: The study finds that shorter birth intervals may lead to poor perinatal outcomes, but this disadvantage disappears over the extended life course.
Article
Public, Environmental & Occupational Health
David S. Curtis, Ken R. Smith, David H. Chae, Tessa Washburn, Hedwig Lee, Jaewhan Kim, Michael R. Kramer
Summary: Highly public anti-Black violence may increase the risk of preterm birth for pregnant women, especially for Black women exposed to such violence during early pregnancy. A study showed that Black mothers had higher odds of preterm birth when exposed to any highly publicized racial incidents during their first trimester, and there was also an increase in preterm birth odds with an increase in national interest in racial violence. However, additional analysis indicated differences in these associations.
SSM-POPULATION HEALTH
(2022)
Article
Andrology
Darshan P. Patel, Philip J. Cheng, Heidi A. Hanson, Ken R. Smith, Kenneth I. Aston, Alexander W. Pastuszak, James M. Hotaling
Summary: This study examined seasonal variation in semen quality in men and its impact on subsequent live birth rates. The findings showed that semen quality was highest in spring and winter, but there was no significant association between seasonal variability in semen quality and subsequent births.
Article
Surgery
Brian T. Bucher, Meng Yang, Rebecca Richards Steed, Alison Fraser, Samuel R. G. Finlayson, Heidi A. Hanson
Summary: The geographic proximity of family members is significantly associated with decreased healthcare utilization after complex cardiovascular and oncologic surgical procedures.
Article
Oncology
Rosalie Griffin, Heidi A. Hanson, Brian J. Avery, Michael J. Madsen, Douglas W. Sborov, Nicola J. Camp
Summary: This study presents an approach called SPECTRA, which uses transcriptome data to predict clinical outcomes in multiple myeloma patients. The derived quantitative variables can provide insights into tumor differences and are associated with clinical and expression risk factors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Judy Y. Ou, Natalie Bennion, Kellee Parker, Douglas Fair, Heidi A. Hanson, Deanna Kepka, Echo L. Warner, Joemy M. Ramsay, Heydon K. Kaddas, Anne C. Kirchhoff
Summary: Subsequent malignant neoplasms (SMN) after an original cancer diagnosis contribute to premature mortality among young cancer survivors. This study identifies demographic and clinical risk factors for HPV-associated SMNs (HPV-SMN) among adolescent and young adult (AYA) cancer survivors. The results show that AYA survivors have increased risk for any HPV-SMN and oropharyngeal-SMN, while the risk for cervical-SMN is generally lower but higher among Hispanic AYA survivors. The use of chemotherapy and radiation is associated with HPV-SMN among survivors with first HPV-related cancers.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Evolutionary Biology
Amy M. Boddy, Shawn Rupp, Zhe Yu, Heidi Hanson, Athena Aktipis, Ken Smith
Summary: The study found that early life adversity accelerates the timing of first birth and death, while being unrelated to breast cancer risk. Early age at first birth and high parity were associated with decreased breast cancer risk.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2022)