Article
Biochemistry & Molecular Biology
Alexander K. Murashov, Elena S. Pak, Jordan Mar, Kevin O'Brien, Kelsey Fisher-Wellman, Krishna M. Bhat
Summary: Multiple lines of evidence suggest that ancestral diet plays a crucial role in determining the metabolic traits of offspring. However, its impact on offspring's food choices and feeding behavior remains unclear. Using a Drosophila model system, this study demonstrates that a paternal Western diet (WD) increases food consumption in offspring up to the fourth generation and induces alterations in brain proteome. Further analysis reveals that the upregulated proteins are associated with translation and translation factors, while the downregulated proteins are related to small molecule metabolic processes, TCA cycles, and electron transport chain (ETC). The identification of miR-10 as a potential factor in programming feeding behavior suggests that ancestral nutrition may influence offspring's feeding behavior through alterations in miRNAs.
Article
Nutrition & Dietetics
Edward Archer, Carl J. Lavie
Summary: The etiology of obesity is complex, with various factors influencing its development. Current management strategies tend to be one-size-fits-all, failing to consider the different responses based on the etiologic status of each individual. Research suggests that there are two broad etiologic subtypes: acquired and inherited obesity, each requiring personalized management.
Article
Nutrition & Dietetics
Blanca Gavilan-Carrera, Alba Ruiz-Cobo, Francisco Jose Amaro-Gahete, Alberto Soriano-Maldonado, Jose Antonio Vargas-Hitos
Summary: This study found that a 12-week aerobic training intervention did not improve anthropometry, body composition, or adherence to the Mediterranean diet in women with SLE.
Review
Agriculture, Multidisciplinary
Xu Deng, Li Niu, Jing Xiao, Qianqian Guo, Jiayi Liang, Jiayu Tang, Xuebo Liu, Chunxia Xiao
Summary: This review explores the mechanisms behind the effects of coarse grains on type 2 diabetes, including their ability to combat inflammation and oxidative stress, repair insulin signaling and beta-cell dysfunction, and regulate intestinal flora disorders and miRNA expression. It provides new insights into the potential of coarse grains for prevention and treatment of diabetes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Pediatrics
Yue Cheng, Zhenjia Sun, Xudong Ya, Linlin Zhou, Mingxia Wang, Xingqi Wang, Yujia Liu
Summary: The aim of this study was to investigate the effect of exercise training on arterial stiffness in obese and overweight children. The results showed that exercise training improved vascular endothelial function and vascular sclerosis in overweight and obese children, especially in those with a BMI < 30 and younger than 14 years. AE had a more favorable effect on arterial stiffness.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Engineering, Environmental
Long Zhang, Min Wang, Mi Chen, Wen Niu, Wenguang Liu, Tongtong Leng, Wenchen Ji, Bo Lei
Summary: This study developed a safe and efficient biomaterials-based anti-obesity nanosystem, which could deliver miR33 agonist into adipocytes and reduce obesity-related inflammatory factors expression. In obese rat models, the nanosystem effectively reduced body weight without suppressing appetite and inhibited the growth of adipocytes. The system may serve as an ideal platform for RNA drug delivery in anti-obesity therapy for individuals unable to control their diet.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Nutrition & Dietetics
Muhammed Mustafa Atakan, Sukran Nazan Kosar, Yasemin Guzel, Hiu Tung Tin, Xu Yan
Summary: Calorie restriction, regular exercise, or a combination of the two are accepted as effective strategies in preventing or treating obesity. The benefits of exercise in combating obesity are not only attributed to reducing adiposity but also to releasing proteins, peptides, enzymes, and metabolites that are beneficial for overall health.
Article
Peripheral Vascular Disease
Patrick J. Smith, Andrew Sherwood, Alan L. Hinderliter, Stephanie Mabe, Lana L. Watkins, Linda Craighead, Krista Ingle, Crystal Tyson, Forgive Avorgbedor, Pao-Hwa Lin, William E. Kraus, Lawrence Liao, James A. Blumenthal
Summary: Lifestyle modification in patients with resistant hypertension can improve cognitive function, which may be associated with reduced ambulatory blood pressure changes through weight loss.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Tina E. Brinkley, Iris Leng, Margie J. Bailey, Denise K. Houston, Christina E. Hugenschmidt, Barbara J. Nicklas, W. Gregory Hundley
Summary: Combining aerobic exercise with moderate caloric restriction leads to greater improvements in proximal aortic stiffness in older adults with obesity than exercise alone.
Article
Nutrition & Dietetics
Jiabao Yan, Cuiru Ren, Yunlong Dong, Jibran A. A. Wali, Hongjie Song, Ying Zhang, Hengrui Zhang, Guangning Kou, David Raubenheimer, Zhenwei Cui
Summary: Ketogenic diet combined with moderate aerobic exercise effectively reduces body weight and fat mass, with no significant adverse effects except for an increase in circulating triglyceride level. Aerobic exercise further improves blood parameters and hepatic condition in mice fed with ketogenic diet.
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Article
Oncology
Suryun Kim, Dong Hoon Lee, Edward L. Giovannucci, NaNa Keum
Summary: Weight cycling refers to repeated intentional weight loss followed by unintentional weight gain. A study found that moderate weight cycling is associated with a reduced risk of colorectal cancer independent of BMI. Further research is needed to validate these findings and explore potential biological mechanisms.
BRITISH JOURNAL OF CANCER
(2023)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Article
Biochemistry & Molecular Biology
Diego A. A. Rodriguez-Chiaradia, Karys Khilzi, Isabel Blanco, Anna Rodo-Pin, Clara Martin-Ontiyuelo, Anna Herranz Blasco, Jessica Garcia-Lucio, Lluis Molina, Ester Marco, Esther Barreiro, Lucilla Piccari, Victor I. I. Peinado, Agustin R. Garcia, Olga Tura-Ceide, Joan Albert Barbera
Summary: In stable patients with pulmonary arterial hypertension, pulmonary rehabilitation is an effective non-pharmacological treatment. This study aimed to explore the effects of endurance exercise training on vascular function in these patients. The results showed that training promoted mechanisms of damage/repair in favor of repair, leading to potential improvements in hemodynamics and clinical response.
Review
Biochemistry & Molecular Biology
Masato Kajikawa, Yukihito Higashi
Summary: Obesity is closely related to cardiovascular diseases. It affects endothelial function through complications such as oxidative stress, insulin resistance, and inflammation. Various measures and methods have shown an association between obesity and endothelial function. Understanding the mechanisms of obesity-induced endothelial dysfunction is crucial for preventing and treating cardiovascular events.
Article
Developmental Biology
Dong-Dong Gao, Jun-Hao Huang, Yi-Lin Zhang, Lei Peng, Wei-Ji Deng, You-Nian Mai, Jia-Rui Wu, Pei-Lun Li, Nan Ding, Zi-Yang Huang, Yun-Xin Zhu, Wen-Liang Zhou, Min Hu
Summary: The study reveals the crucial role of TRPV4 in promoting transepithelial K+ secretion via BK activation in rat epididymis, leading to the formation of high K+ concentration in epididymal intraluminal fluid.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Cell Biology
Dong-Dong Gao, Jun-Hao Huang, Nan Ding, Wei-Ji Deng, Pei-Lun Li, You-Nian Mai, Jia-Rui Wu, Min Hu
Summary: The present study revealed the expression and function of Piezo1 channel in rat epididymal epithelium. Activation of Piezo1 channel promoted BK-mediated transepithelial K+ secretion, suggesting its important physiological role in the male reproductive tract.
Article
Sport Sciences
Yuxin Zhu, Fenghua Sun, Chunxiao Li, Junhao Huang, Min Hu, Kangle Wang, Shan He, Jiarui Wu
Summary: This study found that a brief mindfulness-based intervention (MBI) during sports competition can improve athletes' working memory performance and reduce mental fatigue and cortisol levels. It is recommended to use MBI during halftime of a soccer game.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2022)
Article
Psychiatry
Ming-Qiang Xiang, Long-Lin, Yun-Ting Song, Min Hu, Xiao-Hui Hou
Summary: This study used functional near-infrared spectroscopy (fNIRS) to examine the differences in inhibitory control in individuals with problematic smartphone use (PSPU). The results showed that college students with PSPU exhibited greater Stroop interference and longer reaction times compared to the control group. Furthermore, the PSPU group had lower cortical activation in the left dorsolateral prefrontal cortex (DLPFC) during Stroop interference.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Reproductive Biology
Dong-Dong Gao, Nan Ding, Wei-Ji Deng, Pei-Lun Li, Yi-Lin Chen, Lian-Meng Guo, Wen-Hao Liang, Jia-Hui Zhong, Jing-Wen Liao, Jun-Hao Huang, Min Hu
Summary: Aerobic exercises can improve the sperm motility of obese individuals, and this study investigated the potential involvement of the epididymis in this improvement. The results showed that aerobic exercises reversed the downregulation of TRPA1, improving the epididymal luminal milieu and sperm fertilizing capacity. Further experiments demonstrated that the activation of TRPA1 stimulated anion secretion via CFTR and CaCC, essential for sperm maturation.
BIOLOGY OF REPRODUCTION
(2023)
Review
Neurosciences
Jiayi Wen, Lu Leng, Min Hu, Xiaohui Hou, Junhao Huang
Summary: Whole-body vibration (WBV) training is a novel training method that stimulates the human neuromuscular system and induces adaptive changes in the body. This systematic review evaluated the effects of WBV on cognitive function and found both positive and ineffective impacts. The majority of studies suggest that WBV may be a useful strategy for managing cognitive impairment, but further research is needed.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Fenghua Sun, Junhao Huang, Min Hu, Gaoxia Wei, Tifei Yuan, Simon B. Cooper
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Liuqing Chen, Meiting Chen, Mupeng Luo, Yong Li, Bagen Liao, Min Hu, Qiuliyang Yu
Summary: Mapping NAD+ dynamics in live cells and human is crucial for effective therapies. We introduce multicolor NAD+ sensors for clinical measurement and subcellular visualization, enabling screenings for NAD+ modulators and identification of cognition-related metabolite alpha-GPC.
Article
Medicine, General & Internal
Linyu Peng, Lidan Chen, Shen Wang, Lianmeng Guo, Wenhao Liang, Jie Zhou, Niujin Shi, Junhao Huang, Min Hu, Jingwen Liao
Summary: This study aimed to analyze the association between lifestyle habits and cardiovascular risk among sedentary adults. The findings showed significant associations between prolonged sitting and circulating biomarkers, sleep habits and cardiovascular risk, and eating habits and arterial stiffness and flow mediated dilation.
Article
Allergy
Jun-Hao Huang, Hui-Wen Gao, Dong-Dong Gao, Wei-Yue Yang, Meng-Ke Zhao, Bing Shen, Min Hu
Summary: Aerobic exercise can improve airway smooth muscle contractile function in asthmatic rats by inhibiting IL-4 secretion and down-regulating the expression of STIM1, Orai1, and Orai2, thus decreasing excessive SOCE-mediated ASM contraction.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Peripheral Vascular Disease
Chaoge Wang, Jie Zhou, Dongdong Gao, Yarong Wang, Lianmeng Guo, Wenhao Liang, Niujin Shi, Ran Cheng, Han Wang, Junhao Huang, Jingwen Liao, Min Hu
Summary: This study evaluated the effect of long-term aerobic exercise on the function of perivascular adipose tissue (PVAT) in obese rats and the potential regulatory factors involved. The results showed that long-term aerobic exercise restored abnormalities in circulating biomarkers, systemic inflammation, and circulating adipokines in obese rats (P < 0.05). Furthermore, exercise significantly increased the production of NO and promoted the phosphorylation levels of Akt (Ser473) and eNOS (Ser1177) in PVAT (P < 0.05).
Article
Microbiology
Honggang Yin, Junhao Huang, Xiaozheng Guo, Jingbo Xia, Min Hu
Summary: Our previous study found that moderate-intensity exercise improved endothelial function and decreased Romboutsia in rats on a high-fat diet. However, the influence of Romboutsia on endothelial function remains unclear. This study aimed to investigate the effects of Romboutsia lituseburensis JCM1404 on rat vascular endothelium under a standard diet or high-fat diet.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Clinical Neurology
Genghong Tu, Youli Guo, Ruoshi Xiao, Lianying Tang, Min Hu, Bagen Liao
Summary: The study found that exercise therapy can improve behavioral deficits in individuals with autism spectrum disorder (ASD), and this improvement may be related to the structural and molecular plasticity of synapses in the medial prefrontal cortex (mPFC).
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Public, Environmental & Occupational Health
Xueji Wu, Xiongfei Chen, Bingying Pan, Lan Liu, Xiaomei Dong, Wanwen Yu, David L. Parker, Bagen Liao, Min Hu
Summary: This study aimed to design and evaluate a social worker-led self-management program for low-income Cantonese women aged 60 years and older with multiple non-communicable diseases. The results showed that the intervention group had significant improvements in weight, NCD-related knowledge, and self-reported exercise compared to the control group. Furthermore, the intervention had significant effects on fasting plasma glucose and total cholesterol.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Biochemistry & Molecular Biology
Niujin Shi, Jingbo Xia, Chaoge Wang, Jie Zhou, Junhao Huang, Min Hu, Jingwen Liao
Summary: This study aimed to investigate the efficacy of exercise in preventing arterial stiffness and the potential role of sympathetic nerves in perivascular adipose tissue (PVAT) in pressure-overload-induced heart failure. The results showed that regular aerobic exercise can effectively prevent arterial stiffness and extracellular matrix remodeling in the developmental course of heart failure, with a potential involvement of sympathetic innervation and adiponectin within PVAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
