Article
Biotechnology & Applied Microbiology
Phillipe Huber, Brandon J. J. Ausk, K. Lionel Tukei, Steven D. D. Bain, Ted S. S. Gross, Sundar Srinivasan
Summary: The study developed a convolutional neural network model to accurately assess the running frequency of aged mice. The model achieved a 94% accuracy rate. This research method provides a higher resolution of information for studying the physiological effects of voluntary wheel running activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Biological
Sadahiko Nakajima
Summary: Previous studies have shown that laboratory mice can learn food avoidance based on wheel running, where consumption of a snack paired with running in an activity wheel is suppressed. This Pavlovian conditioning effect was replicated in the present study without pretraining on closed wheels, emphasizing the intrinsic capacity of running to establish food avoidance.
BEHAVIOURAL PROCESSES
(2021)
Article
Biochemistry & Molecular Biology
Rebecca K. Dirkes, Nathan C. Winn, Thomas J. Jurrissen, Dennis B. Lubahn, Victoria J. Vieira-Potter, Jaume Padilla, Pamela S. Hinton
Summary: The study found that in male mice, ERKO has a positive impact on bone density, with exercise having little effect. ERKO has a negative impact on cortical geometry, but exercise can partially reverse this effect. Neither ERKO nor exercise have an effect on sclerostin expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yan Gao, Zhaoyun Yang, Kang He, Zeyu Wang, Tingyu Zhang, Jiang Yi, Lijing Zhao
Summary: This study found that exercise has anti-inflammatory and antioxidant effects on pulmonary fibrosis induced by paraquat, reducing the infiltration of inflammatory cells and fibrotic lesions. Furthermore, exercise also increased the expression of antioxidative distress proteins, improved the degree of epithelial-mesenchymal transition in alveolar epithelial cells, and ultimately alleviated paraquat-induced pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Annesofie Thorup Olesen, Lasse Alchow-Moller, Rune Duus Bendixen, Michael Kjaer, Rene Bruggebusch Svensson, Jesper Lovind Andersen, S. Peter Magnusson
Summary: The study showed that ten weeks of high intensity training could attenuate age-related loss of muscle mass and function, with greater effects observed in old mice in the HR group. The HR running increased fiber CSA and shifted fiber types in the older mice, suggesting its effectiveness in counteracting sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Anesthesiology
Isabella M. Fuentes, Brittni M. Jones, Aaron D. Brake, Angela N. Pierce, Olivia C. Eller, Rachel M. Supple, Douglas E. Wright, Julie A. Christianson
Summary: Studies suggest that voluntary exercise can alleviate the negative impact of a history of early life stress exposure on patients with chronic pain and mood disorders, with evidence showing that voluntary wheel running may improve outcomes related to urologic chronic pelvic pain syndrome.
Article
Neurosciences
Kyeong Jin Yoon, Suhong Park, Seung Hee Kwak, Hyo Youl Moon
Summary: Anxiety disorders are commonly diagnosed psychological conditions that are often treated with drugs, but these medications can have side effects. Exercise is an effective treatment for anxiety, and it has been found to release extracellular vesicles (EVs) that may help reduce anxiety. Research suggests that exercise-derived EVs may have anti-anxiety effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Kiersten S. Scott, Brandon Chelette, Chinenye Chidomere, A. Phillip West, Robert Dantzer
Summary: Cisplatin decreases energy-consuming activities but not energy-procuring activities unless they require a choice between options differing in their cost-benefit ratio. The physical dimension of fatigue is more likely to develop in cisplatin-treated individuals than the motivational dimension of fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Behavioral Sciences
Kyle A. Sullivan, Corena V. Grant, Kelley R. Jordan, Selina S. Vickery, Leah M. Pyter
Summary: The study found that exercise helps faster recovery from paclitaxel-induced weight loss and deficits in melanocortin signaling, but did not alleviate fatigue or inflammation. Body mass recovery was associated with the wheel running-induced recovery of body composition and associated peripheral circulating hormones.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Ahmad Mohammad, Michael S. Finch, Jacob Sweezey-Munroe, Rebecca E. K. MacPherson
Summary: This study found that voluntary exercise can prevent the increase in BACE1 activity and maintain memory recall in ovariectomized female mice. This may provide a method of slowing the progression of Alzheimer's disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka
Summary: Recent clinical studies suggest a close association between dry eye and psychiatric disorders. This study investigates the depressive-like behavior in two mouse models of dry eye and the potential benefits of voluntary wheel-running in alleviating depressive states induced by dry eye.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Immunology
Kiersten Scott, Thien Trong Phan, Nabila Boukelmoune, Cobi J. Heijnen, Robert Dantzer
Summary: Chronic restraint stress affects the behavior of mice, specifically their voluntary wheel running but not working for food. This indicates a dissociation between energy demanding and energy procuring activities, possibly due to adaptive response to mitochondrial dysfunction caused by chronic restraint stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Anatomy & Morphology
Alberto A. Castro, Fotios Alexandros Karakostis, Lynn E. Copes, Holland E. McClendon, Aayushi P. Trivedi, Nicole E. Schwartz, Theodore Garland
Summary: The study found that chronic exercise can affect muscle attachment site morphology, but there is not always evolutionary coadaptation of muscle attachments with voluntary exercise behavior.
JOURNAL OF ANATOMY
(2022)
Review
Biochemistry & Molecular Biology
Ismael Galvan, Tonia S. Schwartz, Theodore Garland
Summary: Evolutionary physiology, born out of the interaction between evolutionary biology and physiology, has not reached its full potential yet. By exploring new avenues and studying the potential of wild animal physiological adaptations for biomedical purposes, as well as the role of epigenetic modifications in regulating physiological traits, there is a possibility of enhancing the understanding of physiological evolution.
Article
Psychology, Biological
Monica P. McNamara, Marcell D. Cadney, Alberto A. Castro, David A. Hillis, Kelly M. Kallini, John C. Macbeth, Margaret P. Schmill, Nicole E. Schwartz, Ansel Hsiao, Theodore Garland Jr
Summary: This study found that the gut microbiome can affect the exercise ability of mice. After antibiotic treatment, the daily wheel-running distance significantly decreased in high runner mice, while there was no apparent change in the control group. This suggests that the microbiome is an important component of the high-running phenotype in these mice.
BEHAVIOURAL PROCESSES
(2022)
Article
Biology
Jessica L. Tingle, Brian M. Sherman, Theodore Garland
Summary: This study examines the locomotor kinematics and morphology of sidewinder rattlesnakes. It finds that the movement of sidewinders differs significantly from limbed animals and that larger individuals are not necessarily faster. Sidewinders lift sections of their body while others maintain ground contact during locomotion. The frequency, wavelength, and amplitude of the body wave impact speed. The study suggests that increasing frequency may be the best way to increase speed for sidewinding snakes.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Sarah E. Latchney, Marcell D. Cadney, Austin Hopkins, Theodore Garland
Summary: High runner mice (HR) have altered DNA methylation patterns of imprinted genes in the brain compared to non-selected control (C) mice. Maternal upbringing and sex also modify the DNA methylation profiles of these imprinted genes.
Article
Public, Environmental & Occupational Health
Marcell D. Cadney, Ralph L. Albuquerque, Nicole E. Schwartz, Monica P. McNamara, Alberto A. Castro, Margaret P. Schmill, David A. Hillis, Theodore Garland Jr
Summary: This study investigated the long-lasting effects of early-life fructose consumption in mice and found that it increased total caloric intake, body mass, and body fat during juvenile exposure. However, it had no significant effects on adult physical activity or body weight/composition. Interestingly, mice that had early-life fructose and wheel access had reduced maximal aerobic capacity in adulthood. Overall, early-life exercise had positive long-term effects, while the effects of early-life fructose were minimal.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Genetics & Heredity
David A. Hillis, Theodore Garland Jr
Summary: Replicate lines under uniform selection evolve in different ways, and each line responds differently to selection, with HR3 being the most distinct. These results suggest that multiple solutions and private alleles can obscure general signatures of selection involving public alleles.
Article
Biology
Monica P. McNamara, Emily M. Venable, Marcell D. Cadney, Alberto A. Castro, Margaret P. Schmill, Lawrence Kazzazi, Rachel N. Carmody, Theodore Garland
Summary: In this study, the fecal microbial community composition and diversity were compared between a group of mice selectively bred for high wheel-running activity and a control group. The results showed that the high wheel-running mice had a higher relative abundance of the bacterial family Clostridiaceae, which differed from a previous study on rats. Additionally, the replicate lines within the high wheel-running and control groups had unique microbiomes, indicating potential random genetic drift and/or multiple adaptive responses to selection.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biology
Alberto A. Castro, Theodore Garland, Saad Ahmed, Natalie C. Holt
Summary: There is a trade-off between locomotor speed and endurance, which is likely to be caused by changes in muscle physiology. However, the muscle-level trade-off contradicts the organismal-level trade-off previously reported.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
Ralph L. Albuquerque, Peter A. Zani, Theodore Garland
Summary: This study found that individual behavior is related to morphology and physiological function, which in turn indirectly affect behavior. On the other hand, parasite load has no direct effect on individual performance ability. Due to the low repeatability of field behaviors, the relationship between behavior and performance may be stronger than indicated by the results.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biology
Nicole E. Schwartz, Monica P. McNamara, Jocelyn M. Orozco, Jaanam O. Rashid, Angie P. Thai, Theodore Garland
Summary: Selective breeding for behavioral traits can result in significant behavioral changes without proportional modifications to underlying morphological or physiological traits.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biology
Jessica L. Tingle, Brian M. Sherman, Theodore Garland Jr
Summary: Physical characteristics of the substrate have a significant impact on terrestrial locomotion of animals and machines. Snakes' gait is more influenced by the environment rather than their speed. Testing sidewinder rattlesnakes on different surfaces revealed that the body's waveform had longer wavelength on vinyl flooring and snakes lifted their bodies higher on sand.