Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 62, Issue 2, Pages 571-578Publisher
IOS PRESS
DOI: 10.3233/JAD-171058
Keywords
C57Bl/6; CRISPR; gene knockout; mouse; tau
Categories
Funding
- National Health & Medical Research Council (NHMRC) [1037746, 1081916]
- Australian Research Council (ARC) [DP150104321, DP170100781]
- University of New South Wales
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Alzheimer's disease and other dementias present with tau pathology. Several mouse lines with knockout of the tau-encoding Mapt gene have been reported, yet findings often differed between lines and sites. Here, we report a new tau knockout strain (tau(Delta ex1)), generated by CRISPR/Cas9-mediated genome editing of intron - 1/exon 1 of Mapt in C57Bl/6J mice. Tau(Delta ex1) mice had no overt phenotype, but, in line with previous models, they showed a significantly reduced susceptibility to excitotoxic seizures, with normal memory formation in young mice. This new in vivo resource will be made freely available to the research community.
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