Review
Biology
Khulood M. Al-Khater, Sarah Almofty, Vijaya Ravinayagam, Noor Alrushaid, Suriya Rehman
Summary: Breast cancer is the most common cancer in females globally and metastasis, resistance to current drugs, and the role of metastatic suppressors like KAI1 are key challenges in managing the disease. Understanding the molecular events of genes like KAI1 is crucial for developing prognostic biomarkers and specific therapies for breast cancer patients.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hiba-Tun-Noor Afshan Mahmood, Elena Tomas Bort, Anthony J. Walker, Richard P. Grose, Athina-Myrto Chioni
Summary: This study investigates the role of FGFR signaling in cervical cancer through bioinformatic analysis and experimental validation. The results demonstrate that FGFR activation can facilitate the progression of cervical cancer and may serve as a potential therapeutic target for this disease.
Article
Multidisciplinary Sciences
Saba Iordanishvili, Tornike Metreveli, Elene Lipartia, Konstantine Gachechiladze, Irakli Khuntsaria, Tamar Qobulashvili, Mariam Jorbenadze, Tamaz Revazishvili, Ekaterina Kldiashvili, Andreas Martin Kaufmann
Summary: The study reveals a significant connection between HR-HPV infection, TP53 polymorphism, and MALAT1 expression in cervical cancer. MALAT1 overexpression is correlated with HR-HPV positivity, especially in cases with the TP53 Pro72Pro polymorphism. HPV-negative invasive cervical carcinoma samples do not show any notable changes in MALAT1 expression.
Article
Cell Biology
Qiaosi Tang, Gizem Efe, Anna M. Chiarella, Jessica Leung, Maoting Chen, Taiji Yamazoe, Zhenyi Su, Jason R. Pitarresi, Jinyang Li, Mirazul Islam, Tatiana Karakasheva, Andres J. Klein-Szanto, Samuel Pan, Jianhua Hu, Shoji Natsugoe, Wei Gu, Ben Z. Stanger, Kwok-K Wong, J. Alan Diehl, Adam J. Bass, Hiroshi Nakagawa, Maureen E. Murphy, Anil K. Rustgi
Summary: Esophageal squamous cell carcinoma (ESCC) is a deadly cancer that often metastasizes to the lungs. The study investigated how the p53R175H mutation regulates metastasis in ESCC. Depletion of Trp53R172H in primary tumor cell lines led to reduced invasion and lung metastasis, with the YAP-BIRC5 axis identified as a potential mediator. Survivin, a protein encoded by BIRC5, was found to be upregulated by Trp53R172H and associated with increased metastasis in GI cancers. These findings provide new insights into mutant p53-mediated metastasis.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Min-Chieh Hsin, Yi-Hsuan Hsiao, Pei-Ni Chen, Chiao-Wen Lin, Po-Hui Wang, Shun-Fa Yang, Chung-Yuan Lee
Summary: DHM inhibits cell migration in human cervical cancer cell lines by reducing S100A4 expression and regulating the ERK1/2/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Jiaming Zhang, Baofang Zhang, Congli Pu, Jiarui Cui, Kexin Huang, Hongbo Wang, Yingchao Zhao
Summary: A novel nanoliposomal DT2216 (DT@NPs) was developed for targeting Bcl-xL, which exhibited enhanced ability to degrade Bcl-xL and induce apoptosis in cervical and breast cancer cells compared to DT2216. In a mouse model, DT@NPs showed stronger inhibition of tumor growth. DT@NPs also had notable cytocompatibility in normal cells and good biodistribution in vivo.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Oncology
Qian Chen, Lu Li, Xian Liu, Qian Feng, Yanru Zhang, Pengsheng Zheng, Nan Cui
Summary: This study demonstrates that HK2 can enhance cell motility and tumor metastasis in cervical cancer cells by activating Akt1 and inducing FN1, MMP2, and MMP9 expression. There is likely an interactive regulatory mechanism between HK2 and Akt1 during the malignant progression of cervical cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Ayumu Arakawa, Hitoshi Ichikawa, Takashi Kubo, Noriko Motoi, Tadashi Kumamoto, Miho Nakajima, Kan Yonemori, Emi Noguchi, Kuniko Sunami, Kouya Shiraishi, Hiroki Kakishima, Hiroshi Yoshida, Tomoro Hishiki, Naonori Kawakubo, Takafumi Kuroda, Takako Kiyokawa, Kyosuke Yamada, Nozomu Yanaihara, Kazuaki Takahashi, Aikou Okamoto, Shinsuke Hirabayashi, Daisuke Hasegawa, Atsushi Manabe, Kentaro Ono, Masaki Matsuoka, Yasuhito Arai, Yosuke Togashi, Tatsuhiro Shibata, Hiroyoshi Nishikawa, Kazunori Aoki, Noboru Yamamoto, Takashi Kohno, Chitose Ogawa
Summary: Two cases of pediatric lung cancer resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses. Treatment with immune checkpoint inhibitor therapy led to a strong regression of all remaining tumors in the first child.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Yun Lin, Zhi Li, Mubiao Liu, Haiyan Ye, Jianhui He, Jianguo Chen
Summary: This study indicates that positive CD34 expression before NACT may serve as a predictive biomarker for NACT in cervical cancer patients, while the pre-NACT expression of Bcl-2 is not an independent predictor. The down-regulation of these two indicators after NACT may suggest the effectiveness of NACT.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Materials Science, Biomaterials
Kangkang Li, Xiaohua Cai, Yong Fan, Meng Jin, Yi Xie, Zhenghui Jing, Xinlong Zang, Yantao Han
Summary: Multifunctional nanocomplexes (Que/siBCL2@BioMICs) were developed to deliver quercetin (Que) and BCL-2 siRNA (siBCL2) simultaneously, resulting in synergistic inhibition of tumor growth and enhanced chemotherapy efficacy. The nanocomplexes facilitated cellular uptake and cytosolic release of cargos through active targeting and proton sponge effect. In vitro experiments demonstrated enhanced cytotoxicity and anti-metastasis activity, while in vivo studies showed significant reduction in primary tumor burden and lung metastatic nodules with no apparent side effects on major organs. These biotin-targeted nanocomplexes with chemotherapeutic and nucleotide agent entrapment provide a promising strategy for efficient triple-negative breast cancer (TNBC) therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Guanglei Zhong, Qian Zhao, Zhiliao Chen, Tingting Yao
Summary: This study found that the TGF-ss pathway promotes cervical cancer metastasis through upregulation of CDR1as, which facilitates the stabilization of SLUG mRNA by regulating IGF2BP1. Additionally, CDR1as activates TGF-ss signaling factors known to promote EMT. These findings highlight the significance of the TGF-ss pathway in cervical cancer metastasis.
Article
Biochemistry & Molecular Biology
Jiazhan Mei, Guiju Liu, Ruijun Li, Peng Xiao, Dan Yang, Hua Bai, Yibin Hao
Summary: The study revealed that lncRNA SNHG6 has inhibitory effects on DDP resistance and progression of GC by sponging miR-1297 and regulating BCL-2 expression.
BIOSCIENCE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Deeksha Kaloni, Sarah T. Diepstraten, Andreas Strasser, Gemma L. Kelly
Summary: Acquired resistance to cell death is a key characteristic of cancer. The BCL-2 protein family members have important roles in regulating apoptotic cell death. Abnormal expression of pro-survival BCL-2 family proteins or reduction in pro-apoptotic BCL-2 family proteins, both leading to inhibition of apoptosis, are commonly observed in various types of cancer. The critical role of pro-survival and pro-apoptotic BCL-2 family proteins in apoptosis regulation makes them attractive targets for cancer treatment. This review discusses the roles of different pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal function, as well as how defects in apoptosis control contribute to cancer development and therapy resistance. Lastly, the development of inhibitors targeting pro-survival BCL-2 proteins, known as BH3-mimetic drugs, as novel agents for cancer therapy is discussed.
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Oncology
Divya Adiga, Sangavi Eswaran, Deeksha Pandey, Krishna Sharan, Shama Prasada Kabekkodu
Summary: Cervical cancer recurrence poses a significant challenge due to poor prognosis and limited treatment options. Both genetic and epigenetic modifications impacting cell signaling pathways have been identified as key factors in CC recurrence. Research is ongoing to better understand the molecular pathways and improve disease management.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)