Article
Endocrinology & Metabolism
Qing Han, Xuede Yan, Yufei Ye, Linhui Han, Xianhua Ma, Ting Wang, Dongmei Cao, Weiping J. Zhang
Summary: ZBTB20 is a critical cell-autonomous regulator that controls PRL expression and lactotrope function in mature lactotropes during adulthood.
Review
Immunology
Shengbo Zhang, Cindy Audiger, Michael Chopin, Stephen L. Nutt
Summary: This review summarizes recent advances in understanding the transcriptional networks that regulate the development of different subsets of dendritic cells (DCs). It discusses the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC subset, DC3. The review also examines critical transcription factors such as IRF8, PU.1, and E2-2, and highlights their regulatory mechanisms and downstream targets. The complex interplay between these transcription factors shapes the DC transcriptome and influences their function in response to environmental stimuli. The information presented in this review provides essential insights into the regulation of DC development and function, with potential implications for developing novel therapeutic strategies for immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Nassif, G. Lignon, A. Asselin, C. C. Zadikian, S. Petit, H. W. Sun, C. Klein, F. C. Ferre, M. I. Morasso, A. Berdal, B. P. J. Fournier, J. Isaac
Summary: This study investigated the transcription factor gene expression in jaw and tibia osteoblasts, revealing site-specific genes associated with skeletal development and disorders. These findings contribute to our understanding of the pathophysiology of craniofacial and appendicular skeletal disorders.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Neurosciences
Hoi Yan Gladys Lau, Alex Fornito, Ben D. Fulcher
Summary: The study of spatial embedding of transcription patterns in mouse brain development reveals that transcriptional similarity decreases exponentially with separation distance, following a power-law relationship with brain size. This indicates a balance between local molecular similarity and longer-range diversity in the developing mouse brain. Extrapolating this relationship to the human cortex yields a prediction consistent with actual data.
Article
Biochemistry & Molecular Biology
Jian Sun, Yijun Lin, Nayoung Ha, Jianfei Zhang, Weiqi Wang, Xudong Wang, Qian Bian
Summary: In this study, researchers used single-cell RNA-Seq to investigate the transcriptional dynamics during mouse maxillary development. They identified distinct mesenchymal cell populations and their developmental trajectory, as well as key transcription factors associated with mesenchymal fate transitions. This study provides important insights for understanding craniofacial morphogenesis and abnormalities at a systems-level.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Multidisciplinary Sciences
Joshua E. Burda, Timothy M. O'Shea, Yan Ao, Keshav B. Suresh, Shinong Wang, Alexander M. Bernstein, Ashu Chandra, Sandeep Deverasetty, Riki Kawaguchi, Jae H. Kim, Sarah McCallum, Alexandra Rogers, Shalaka Wahane, Michael Sofroniew
Summary: This study reveals the regulatory mechanism of genes associated with astrocyte reactivity through biological and informatic analyses. These genes show heterogeneity across different central nervous system disorders and are regulated by transcriptional regulators. By modulating reactivity, these transcriptional regulators can alter the outcome of the disorders and may serve as therapeutic targets.
Article
Multidisciplinary Sciences
Sara Ballouz, Risa Karakida Kawaguchi, Maria T. Pena, Stephan Fischer, Megan Crow, Leon French, Frank M. Knight, Linda B. Adams, Jesse Gillis
Summary: This study explores the stochastic variation in allele-specific expression during organism development. The research on nine-banded armadillos reveals the enduring signal of autosomal allelic variability and its influence on phenotype. The findings shed light on the non-genetic factors shaping organismal diversity and provide insights into the inconsistent penetrance associated with stochastic allelic expressions.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ruiqi Liao, Abiola Babatunde, Stephanie Qiu, Hamsini Harikumar, Joshua J. Coon, Katherine A. Overmyer, Yusuf A. Hannun, Chiara Luberto, Emery H. Bresnick
Summary: This study reveals that the hematopoietic transcription factor GATA1 regulates ceramide homeostasis during erythroid differentiation. Disruption of ceramide homeostasis affects erythroid activity but not myeloid activity. The study demonstrates the importance of ceramide homeostasis in vital cytokine signaling for erythropoiesis through rewiring of the regulatory circuitry.
NATURE COMMUNICATIONS
(2023)
Article
Andrology
Laura O'Hara, Helen C. Christian, Paul Le Tissier, Lee B. Smith
Summary: The research identified the cell type on which androgens act to repress prolactin release. Castrated PARKO male mice showed significantly reduced circulating prolactin, indicating that removal of both estrogen and androgen reduces pituitary prolactin release stimulation.
Review
Cell Biology
Hyeonwoo La, Hyunjin Yoo, Young Bin Park, Nguyen Xuan Thang, Chanhyeok Park, Seonho Yoo, Hyeonji Lee, Youngsok Choi, Hyuk Song, Jeong Tae Do, Kwonho Hong
Summary: The lymphatic system is crucial for maintaining lipid and interstitial fluid homeostasis, as well as regulating immune cell development and functions. Recent studies have shown that epigenetic regulation plays a critical role in embryonic lymphatic endothelial cell (LEC) development and function. Understanding the epigenetic mechanisms involved in lymphatic development and function is important for managing lymphatic disorders.
Review
Biotechnology & Applied Microbiology
Georgette Femerling, Socorro Gama-Castro, Paloma Lara, Daniela Ledezma-Tejeida, Victor H. Tierrafria, Luis Muniz-Rascado, Cesar Bonavides-Martinez, Julio Collado-Vides
Summary: The ability to regulate gene expression is crucial for bacteria to adapt and interact with the environment. This article provides an overview of the transcriptional regulatory knowledge for Escherichia coli K-12, focusing on the sensing mechanisms and regulation of gene expression. It discusses the signal transduction pathways and the role of allosteric effectors in the sensing process. The article also introduces the concept of genetic sensory-response units and their functional heterogeneity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pierluigi Scalia, Stephen J. Williams, Yoko Fujita-Yamaguchi
Summary: The regulation of the human IGF2 gene is controlled by multiple mechanisms at the genetic and epigenetic levels, ultimately affecting gene expression. Deregulation of these mechanisms can lead to overexpression of IGF2, resulting in abnormal fetal growth and increased cell proliferation observed in overgrowth syndromes and cancer. Our review sheds new light on the extended regulation of IGF2 gene activation, emphasizing the integration between epigenetic and genetic machinery. It also suggests potential targets for therapeutic strategies aimed at degrading the IGF2 gene and regulatory proteins.
Article
Biochemistry & Molecular Biology
Seung-Jun Lee, Jinah Park, Dong-Joon Lee, Keishi Otsu, Pyunggang Kim, Seiya Mizuno, Min-Jung Lee, Hyun-Yi Kim, Hidemitsu Harada, Satoru Takahashi, Seong-Jin Kim, Han-Sung Jung
Summary: This study investigated the role of MAST4 in spermatogenesis in mice, revealing its importance in the localization to Sertoli cells, phosphorylation of ERM, and maintenance of SSC self-renewal.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Jiejie Zhang, Chen C. Li, Xin Li, Yaxi Liu, Qianhao Wang, Guangyu Zhang, Haiqing Xiong, Aibin He, Shanshan Ai
Summary: Distinct enhancer elements can regulate the cell type-specific expression of the developmental gene. We comprehensively studied enhancers U1 and U2 in controlling Nkx2-5 transcription during heart development. Our findings suggest that U1 and U2 have redundant functions at early stages, but U2 instead of U1 supports Nkx2-5 expression at later stages. Deletions of both enhancers result in reduced Nkx2-5 dosage and disturbed enhancer landscape in mouse hearts.
Review
Neurosciences
Erick Sousa, Nuria Flames
Summary: Neuronal diversity is an intrinsic feature of the nervous system, with transcription factors playing key roles in establishing different neuronal identities. Common features in transcription factor categories can be identified in both mammals and nematodes, highlighting their pleiotropic functions. Transcriptional repression is crucial in controlling neuronal diversity, and the acquisition of neuronal identities is considered a metastable process.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)