Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Allergy
Niek B. Achten, Annemarie M. C. van Rossum, Leonard B. Bacharier, Anne M. Fitzpatrick, Tina Hartert
Summary: This article examines the impact of early-life viral infections on the lung and immune systems and focuses on the causal relationship between early-life viral infections and asthma. The article calls for a shift in research focus towards improving patient outcomes in the spectrum of respiratory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Chemistry, Multidisciplinary
Jae-Hong Lee, Seong-Nyum Jeong
Summary: The study found an association between chronic periodontitis and acute respiratory infections, particularly with acute upper and lower respiratory infections.
APPLIED SCIENCES-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Sue Smith, Roger Morbey, Simon de Lusignan, Richard G. Pebody, Gillian E. Smith, Alex J. Elliot
Summary: There are significant differences in GP consultation rates for respiratory conditions across English regions, with higher rates in the North and Midlands compared to London and the South. Upper and lower respiratory tract infections, as well as asthma, tend to be higher in more deprived and urban areas, while influenza-like illness is highest in less deprived and rural areas. This study improves understanding of regional GP surveillance data and will help in providing more accurate public health messages.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Virology
Kenichiro Takahashi, Tsuguto Fujimoto, Nozomu Hanaoka, Mariko Tamura, Yoko Suzuki, Shigetaka Sugihara
Summary: This study aims to investigate the usefulness of clinical manifestations in deciding the use of adenovirus IC kits for children with upper respiratory infections (URI). The study found that when patients lack the clinical manifestations of fever, rhinorrhea, and tonsillar exudate, the results of adenovirus IC kits are often negative.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Christian Tanislav, Karel Kostev
Summary: Research found that during the COVID-19 pandemic, there was a significant decrease in non-COVID-19 related respiratory tract and gastrointestinal infections, especially influenza and bacterial infections. Conversely, relatively rare viral pneumonia showed a significant increase in diagnoses.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Abate Bekele Belachew, Aino K. Rantala, Maritta S. Jaakkola, Timo T. Hugg, Jouni J. K. Jaakkola
Summary: Using data from a population-based prospective study, we found that individuals with asthma are more susceptible to respiratory tract infections (RTIs). This susceptibility is evident from childhood to young adulthood, with increased risks of both upper and lower RTIs. Women with asthma are at a particularly high risk.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Juliana Ochoa-Grullon, Celina Benavente Cuesta, Ataulfo Gonzalez Fernandez, Gustavo Cordero Torres, Cristina Perez Lopez, Ascension Pena Cortijo, Laura Conejero Hall, Marta Mateo Morales, Antonia Rodriguez de la Pena, Carmen M. Diez-Rivero, Edgard Rodriguez de Frias, Kissy Guevara-Hoyer, Miguel Fernandez-Arquero, Silvia Sanchez-Ramon
Summary: The study demonstrates that MV130 can reduce infection rate and enhance humoral immune responses in vulnerable patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Nicklas Brustad, Alessandra Olarini, Min Kim, Liang Chen, Mina Ali, Tingting Wang, Arieh S. Cohen, Madeleine Ernst, David Hougaard, Ann-Marie Schoos, Jakob Stokholm, Klaus Bonnelykke, Jessica Lasky-Su, Morten A. Rasmussen, Bo Chawes
Summary: This study aimed to investigate the influence of vertically transferred metabolites on the risk of atopic diseases and infections in preschool-age children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Sucheta Sharma, Nishat Tasnim, Kuchalambal Agadi, Ummul Asfeen, Jatin Kanda
Summary: Asthma is a non-communicable and long-term condition that affects both children and adults. It is often underdiagnosed and under-treated in many regions, particularly in developing countries. This study aims to determine the predisposition of asthmatics to develop various viral infections and susceptibility toward certain viruses that cause upper respiratory tract infections.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Difficult-to-treat pulmonary infections caused by multidrug-resistant pathogens are a major concern and nebulized antibiotics are increasingly being used to treat these infections. Nebulized antibiotics have the advantage of delivering high drug concentrations to the site of infection while minimizing systemic adverse effects. However, there is still a lack of clinical studies confirming their efficacy and safety.
Article
Infectious Diseases
Nicole Maison, Jimmy Omony, Sophia Rinderknecht, Laura Kolberg, Melanie Meyer-Buehn, Erika von Mutius, Johannes Huebner, Ulrich von Both
Summary: Following COVID-19 lockdown measures, respiratory tract infections increased worldwide, specifically affecting children's hospitals. Changes in the epidemiological pattern of respiratory viral infections were observed, with a higher number of virus detections and a shift in the pattern of infections.
Article
Nutrition & Dietetics
Jose Antonio Pico-Monllor, Beatriz Ruzafa-Costas, Eva Nunez-Delegido, Pedro Sanchez-Pellicer, Javier Peris-Berraco, Vicente Navarro-Lopez
Summary: Studies have shown that certain probiotic strains can be used to prevent and improve respiratory tract infections. A combination of various probiotics can effectively strengthen the immune system of the healthy working population and reduce symptoms of upper respiratory tract infections.
Article
Infectious Diseases
Benjamin Davido, Benoit Lemarie, Elyanne Gault, Marion Pepin, Karim Jaffal, Sebastien Beaune, Lotfi Dahmane, Jennifer Dumoulin, Segolene Greffe, Djillali Annane, Pierre De Truchis
Summary: This study analyzed the predictors of outcomes in patients with viral respiratory tract infections (VRTIs) and found a significant correlation between superinfection and outcomes. The species of the virus also affects mortality rates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Manuel E. Machado-Duque, Diego Arturo Garcia, Melissa Hiromi Emura-Velez, Andres Gaviria-Mendoza, Claudia Giraldo-Giraldo, Jorge E. Machado-Alba
Summary: This study assessed the frequency of antibiotic prescriptions for patients with viral upper respiratory tract infections (URTIs) and identified variables associated with the use of antibiotics for viral infections. The study found that antibiotics were frequently prescribed inappropriately for URTIs, highlighting the need for interventions to improve their use.
Article
Obstetrics & Gynecology
Patrick Sloan, Cynthia Rodriguez, Bruce A. Bedell, Jeffrey C. Murray, John M. Dagle, Kelli Ryckman, Lori R. Holtz
Summary: This study aimed to determine the prevalence of virus in a preterm cohort and explore its association with histologic chorioamnionitis, spontaneous preterm labor, and pre-eclampsia. The results showed a higher detection rate of virus in maternal samples compared to cord blood from infants. However, there was no significant correlation between the presence or quantity of virus in maternal blood and the aforementioned conditions in this well-defined cohort.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sonia T. Anand, Elizabeth A. Chrischilles, Rebecca J. Baer, Mary E. Charlton, Patrick J. Breheny, William W. Terry, Monica R. McLemore, Deborah A. Karasek, Laura L. Jelliffe-Pawlowski, Kelli K. Ryckman
Summary: In both California and Iowa, women with a history of leukemia or lymphoma are at increased risk for preterm birth. This highlights the importance of counseling and monitoring for women with a history of leukemia or lymphoma before and during pregnancy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Molly E. McCarthy, Scott P. Oltman, Elizabeth E. Rogers, Kelli Ryckman, Laura L. Jelliffe-Pawlowski, Valery A. Danilack
Summary: The study analyzed data from 736,435 California infants born between 2005-2011 to determine the effects of SES and SGA on infant metabolite levels. Findings showed that SGA was significantly associated with 36 metabolites, while SES was significantly associated with 41 out of 42 metabolites. The study also revealed a dose-response relationship between SGA and metabolite levels as SES worsened, and significant interaction between SES and SGA on 14 metabolites.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sonia T. Anand, Kelli K. Ryckman, Rebecca J. Baer, Mary E. Charlton, Patrick J. Breheny, William W. Terry, Kord Kober, Scott Oltman, Elizabeth E. Rogers, Laura L. Jelliffe-Pawlowski, Elizabeth A. Chrischilles
Summary: The study found significant metabolic changes in newborns born to mothers with a history of leukemia or lymphoma, with higher levels of certain acylcarnitines and lower levels of citrulline. These findings suggest potential metabolic implications for offspring, which could impact future metabolic consequences.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Kelli K. Ryckman, Abhismitha Ramesh, Hyunkeun Cho, Scott P. Oltman, Elizabeth E. Rogers, John M. Dagle, Laura L. Jelliffe-Pawlowski
Summary: Newborn metabolic screening is a promising method for predicting neonatal morbidity and mortality. However, the type of syringe used for blood collection, specifically in this study the electrolyte-balanced dry lithium heparin syringe, may have an impact on the levels of targeted metabolites and biomarkers. While the median levels did not differ significantly by syringe type, there was considerable variability for certain metabolites, suggesting the need to consider sample collection methods when utilizing these markers in prediction models for neonatal outcomes.
CLINICAL BIOCHEMISTRY
(2022)
Article
Health Care Sciences & Services
Margaret Carrel, Barbara C. Keino, Kelli K. Ryckman, Stephanie Radke
Summary: The closure of rural hospitals and labor & delivery units has impacted access to timely care. In the past decade, Iowa has lost over a quarter of its labor & delivery units. The study found that certain areas in the state consistently have travel times exceeding 30 minutes.
JOURNAL OF RURAL HEALTH
(2023)
Article
Cell Biology
Matthew Wessendarp, Miki Watanabe-Chailland, Serena Liu, Traci Stankiewicz, Yan Ma, Rajesh K. Kasam, Kenjiro Shima, Claudia Chalk, Brenna Carey, Lindsey-Romick Rosendale, Marie Dominique Filippi, Paritha Arumugam
Summary: GM-CSF plays a critical role in maintaining mitochondrial turnover, function, and integrity in macrophages, impacting fatty acid beta-oxidation and other metabolic pathways. Additionally, GM-CSF regulates cytosolic pathways in macrophages.
Review
Oncology
Tafadzwa Chihanga, Sara Vicente-Munoz, Sonya Ruiz-Torres, Bidisha Pal, Mathieu Sertorio, Paul R. Andreassen, Ruby Khoury, Parinda Mehta, Stella M. Davies, Andrew N. Lane, Lindsey E. Romick-Rosendale, Susanne I. Wells
Summary: Germline loss-of-function mutations in Fanconi anemia (FA) genes can cause FA, which is associated with increased susceptibility to squamous cell carcinomas (SCCs) and higher prevalence of human papilloma virus (HPV). However, there is limited information on metabolic deregulation in FA deficient systems. Understanding the metabolic architecture of FA may help in understanding SCC development and identifying diagnostic biomarkers and therapeutic targets. This review discusses the metabolic consequences of FA pathway loss and its impact on SCC development.
Article
Obstetrics & Gynecology
Martina A. Steurer, Kelli K. Ryckman, Rebecca J. Baer, Jean Costello, Scott P. Oltman, Charles E. McCulloch, Laura L. Jelliffe-Pawlowski, Elizabeth E. Rogers
Summary: A resiliency score has been developed and validated to predict survival and survival without neonatal morbidity in preterm neonates.
JOURNAL OF PERINATOLOGY
(2023)
Editorial Material
Nursing
Margaret Carrel, Barbara C. Keino, Nicole L. Novak, Kelli K. Ryckman, Stephanie Radke
Summary: Patient decisions to bypass the closest labor & delivery facility can lead to changes in the provision of healthcare in rural areas. In Iowa, more than half of the deliveries occurred in facilities further away from the parents' residences than the closest L&D facility. Bypassing behavior is more common among White, non-Hispanic individuals with private insurance, and it is increasing among micropolitan birth parents who already have a greater travel burden.
BIRTH-ISSUES IN PERINATAL CARE
(2023)
Article
Obstetrics & Gynecology
Kelli K. Ryckman, Paul J. Holdefer, Eva Sileo, Claire Carlson, Nancy Weathers, Elizabeth A. Jasper, Hyunkeun Cho, Scott P. Oltman, John M. Dagle, Laura L. Jelliffe-Pawlowski, Elizabeth E. Rogers
Summary: This study found that diagnostic hospital billing codes are a reliable metric to evaluate complications and surgeries in preterm neonates, except for more ambiguous diagnoses such as necrotizing enterocolitis and its surgery.
JOURNAL OF PERINATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kedir N. Turi, Cole R. Michel, Jonathan Manke, Katrina A. Doenges, Nichole Reisdorph, Alison K. Bauer
Summary: Allergy and asthma pathogenesis are linked to dysregulation of metabolic pathways. This study used a multi-omics approach to investigate the effects of allergen sensitization on metabolic pathways in mice. The results showed that glycerophospholipid and sphingolipid metabolism were affected, with increased levels of certain oxylipins. Gene pathways related to calcium channel, G protein-signaling, and mTORC1 signaling were also upregulated. These findings suggest a role for bioactive lipids in the development of allergy and asthma.
Article
Multidisciplinary Sciences
Lin Ammar, Hilary A. Tindle, Angela M. Miller, Margaret A. Adgent, Hui Nian, Kelli K. Ryckman, Mulubrhan Mogos, Mariann R. Piano, Ethan Xie, Brittney M. Snyder, Abhismitha Ramesh, Chang Yu, Tina V. Hartert, Pingsheng Wu
Summary: The use of electronic cigarettes (ECs) during pregnancy, either alone or in combination with combustible cigarettes (CCs), is associated with increased risks of preterm birth and low birth weight. Quitting EC use can reduce these risks. ECs should not be considered a safe alternative or a viable strategy for smoking cessation during pregnancy.
Article
Obstetrics & Gynecology
Samhita Jain, Scott Oltman, Elizabeth Rogers, Kelli Ryckman, Mark Petersen, Rebecca J. Baer, Larry Rand, Xianhua Piao, Laura Jelliffe-Pawlowski
Summary: This retrospective cohort study examined the relationship between maternal immune activation (MIA) and neurologic morbidity in offspring. The study found that maternal inflammatory environment, combined with pre-existing risk factors such as obesity, poverty, and prematurity, increases the susceptibility of offspring to neurologic morbidities.
JOURNAL OF PERINATOLOGY
(2023)
Article
Physiology
Denise C. Hasson, Miki Watanabe-Chailland, Lindsey Romick-Rosendale, Adeleine Koterba, Dashiell S. Miner, Patrick Lahni, Qing Ma, Stuart L. Goldstein, Prasad Devarajan, Stephen W. Standage
Summary: This study found that altered choline metabolism is involved in sepsis-associated acute kidney injury (SA-AKI) in both humans and mice, and choline administration improved renal function in experimental SA-AKI. These findings suggest that mouse models can help in investigating clinically relevant mechanisms and that choline supplementation may ameliorate SA-AKI in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)