Article
Environmental Sciences
Hui Guo, Zhi Liang, Peihua Zheng, Ling Li, Jian'an Xian, Xiaowen Zhu
Summary: Exposure to nonylphenol caused significant histological changes and apoptosis in Pacific white shrimp, resulting in the generation of numerous differentially expressed genes. The study demonstrated that nonylphenol exposure impairs the immune, antioxidant, DNA repair, and anti-apoptosis abilities of shrimp, leading to severe histopathological changes and eventual apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Fisheries
Pei-Hua Zheng, Yao-Peng Lu, Xiu-Xia Zhang, Ke-Er Luan, Ze-Long Zhang, Jia-Jun Li, Tong Xu, Jun-Tao Li, Jian-An Xian, Hui Guo, An-Li Wang
Summary: This study investigated the molecular mechanisms of 4-NP toxicity in the hepatopancreas of Pacific white shrimp (Litopenaeus vannamei) through transcriptomic analysis. The results revealed that 4-NP exposure induced the expression of genes in L. vannamei to resist adverse environments, while prolonged exposure to 4-NP resulted in more inhibited genes. Furthermore, specific pathways related to hormonal effects and endocrine function were significantly enriched after 4-NP stress. These findings provide novel insights into the molecular mechanisms underlying 4-NP toxicity effects in prawns and enrich the understanding of the toxicity mechanism of crustaceans in response to endocrine-disrupting chemical exposure.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Bong Jung Kang, Zakea Sultana, Marcy N. Wilder
Summary: Vitellogenesis-inhibiting hormone (VIH) negatively regulates reproduction in shrimp, and transcriptional silencing of Liv-SGP-G was successfully achieved with dsRNA injections. Although the treatment did not promote ovarian maturation, it was the first report of co-transcriptional repression of Liv-SGP-G using dsRNAs for homologous genes. This study indicates that subadult shrimp can respond to transcriptional silencing techniques.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Fisheries
Wei Li, Pingping He, Xingzhi Zhang, Junliang Guan, Yongxian Chen, Li Zhang, Bin Zhang, Yusi Zheng, Xin Li, Qingsong He, Longcheng Liu, Chang Yuan, Pinyuan Wei, Jinxia Peng
Summary: This study performed high-throughput sequencing to reveal the miRNA expression profile in the gonads of white Pacific shrimp and identified sex-related differentially expressed miRNAs and KEGG pathways. The results of this study are of great significance for understanding the regulatory mechanism of gonadal differentiation in white Pacific shrimp.
Article
Engineering, Marine
Kangxuan Chen, Shihao Li, Jianhai Xiang, Amir Sagi, Fuhua Li
Summary: A comparative transcriptome analysis of the androgenic gland in L. vannamei revealed that 20-hydroxyecdysone could dose-dependently inhibit the expression of Lv-IAG at different molting stages, providing new insights into the regulatory mechanism of ecdysteroids on Lv-IAG expression and the endocrine axis between eyestalk and AG in male crustaceans.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Toshiya Yamaguchi, Takeshi Kitano
Summary: Japanese flounder is a teleost fish with an XX/XY sex determination system and temperature-dependent sex determination. The up-regulation of Amh expression during the sex differentiation period leads to masculinization. In this study, researchers found that the loss of Amhr2 function caused male-to-female sex reversal, confirming the role of Amh/Amhr2 signaling in inhibiting estrogen synthesis for masculinization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Jakkapong Kluebsoongnoen, Apisara Saensuwanna, Maryam Jozghorbani, Teerapong Ho, Ewa Szolajska, Tomasz J. Sarnowski, Apinunt Udomkit
Summary: The aim of this study was to investigate the transcriptional regulation of the GIH gene in the black tiger prawn. A potential hormone response element (HRE) was found in the 5' upstream DNA fragment of the GIH gene. Deletion of the HRE increased the promoter activity, while the addition of 20-hydroxyecdysone (20E) reduced the promoter activity. The Ecr, a candidate HRE-binding nuclear receptor, was expressed ubiquitously in female prawns and inhibited GIH expression.
Review
Critical Care Medicine
Eric Lang, Hossam Abdou, Joseph Edwards, Neerav Patel, Jonathan J. Morrison
Summary: Trauma-hemorrhage is a major cause of death both before and early in hospitalization, and it also contributes to the development of organ dysfunction/failure and sepsis. Sex hormone therapy, including estradiol and its derivatives, has shown beneficial effects in animal models. Gender-based differences in mortality following trauma-hemorrhage have been observed, suggesting a role for estrogens.
Article
Medicine, Research & Experimental
Haidong Wang, Zhaohui Li, Yachong Huo, Tao Tian, Dalong Yang, Lei Ma, Sidong Yang, Wenyuan Ding
Summary: The study discovered that 17 beta-Estradiol (E2) can ameliorate intervertebral disc degeneration (IVDD) by inhibiting nucleus pulposus cell apoptosis, and this effect is mediated through regulation of the NF-kappa B signal pathway.
Article
Public, Environmental & Occupational Health
Margot Guth, Tyler Pollock, Mandy Fisher, Tye E. Arbuckle, Maryse F. Bouchard
Summary: A study found a negative correlation between urinary paraben concentrations and serum hormone levels in girls, particularly estradiol, LH, and FSH. This suggests that parabens may impact the development and function of the endocrine system in females.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Immunology
Kaikai Shen, Lixin Bao, Muxin Liu, Wen Lei, Qin Zhou, Jiali Ding, Peng Fang, Baoqing Hu, Chungen Wen, Vikas Kumar, Mo Peng, Gang Yang
Summary: This study found that adding beta-1,3-glucan to the diet of white shrimp increased microbial diversity and changed their composition, reducing the abundance of pathogenic and gram-negative bacteria. Beta-1,3-glucan improved intestinal health in white shrimp by modulating the balance of intestinal microbiota, suppressing intestinal inflammatory response, and enhancing immune and antioxidant capacity, ultimately promoting shrimp growth.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zoe B. Mills, Richard L. M. Faull, Andrea Kwakowsky
Summary: Alzheimer's disease disproportionately affects women, with two thirds of all cases being female. The decline in estrogen levels during menopause is believed to be a contributing factor to the higher risk of developing AD in women. This review evaluates the impact of estrogen and hormone replacement therapy on cognition in women, and discusses the conflicting findings regarding the use of HRT as a preventive or therapeutic option for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Elizabeth Doll, Ian Gunsolus, Abigail Thorgerson, Vin Tangpricha, Nathan Lamberton, Jenna L. Sarvaideo
Summary: Sublingual administration of E2 resulted in higher peak serum E2 levels and AUC (0-8 hours) compared to oral administration. Sublingual E2 peaked at 1 hour, while oral E2 peaked at 8 hours. The E2-to-estrone ratio was higher for sublingual E2, but the clinical significance of this is unclear.
ENDOCRINE PRACTICE
(2022)
Article
Geriatrics & Gerontology
Wei-Chuan Chang, Jen-Hung Wang, Dah-Ching Ding
Summary: This study found that menopausal hormone therapy (MHT) with conjugated equine estrogen (CEE) was associated with an increased risk of hemorrhagic stroke (HS) in postmenopausal Taiwanese women. Women using CEE should discuss this risk with their clinicians in comparison to those using estradiol (E2) MHT.
Review
Cardiac & Cardiovascular Systems
Zahra Hajializadeh, Mohammad Khaksari
Summary: Cardiac hypertrophy (CH) is a major cause of morbidity and mortality worldwide, leading to heart failure. Sex differences in CH may be caused by sex hormones or their receptors, with the incidence increasing in postmenopausal women due to the decrease in female sex hormone 17-beta estradiol (E2). E2 and its receptors inhibit CH, while Silent information regulator 1 (SIRT1) plays a crucial role in biological processes and has a protective effect against CH.
HEART FAILURE REVIEWS
(2022)