Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 7, Pages 1629-1637Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b05833
Keywords
persimmon tannin; blood glucose levels; starch digestibility; alpha-amylase; alpha-glucosidase; glucose uptake and transport
Funding
- Natural Science Foundation of China [81403160, 31701712]
- Hubei Provincial Natural Science Foundation of China [2017CFB197]
- Fundamental Research Funds for the Central Universities [2662016QD035]
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Regulation of postprandial blood glucose levels is an effective therapeutic proposal for type 2 diabetes treatment. In this study, the effect of persimmon tannin on starch digestion with different amylose levels was investigated both in vitro and in vivo. Oral administration of persimmon tannin starch complexes significantly suppressed the increase of blood glucose levels and the area under the curve (AUC) in a dose-dependent manner compared with starch treatment alone in an in vivo rat model. Further study proved that persimmon tannin could not only interact with starch directly but also inhibit alpha-amylase and alpha-glucosidase strongly, with IC50 values of 0.35 and 0.24 mg/mL, separately. In addition, 20 mu g/mL of persimmon tannin significantly decreased glucose uptake and transport in Caco-2 cells model. Overall, our data suggested that persimmon tannin may alleviate postprandial hyperglycemia through limiting the digestion of starch as well as inhibiting the uptake and transport of glucose.
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