Article
Chemistry, Applied
Dan Yuan, Feibai Zhou, Penghui Shen, Yuanhong Zhang, Lianzhu Lin, Mouming Zhao
Summary: Controlled partial enzymatic hydrolysis can effectively lead to the formation of multifunctional soy protein nanoparticles, which can serve as nanocarriers for active cargo delivery. The encapsulated curcumin in SPNPs showed enhanced solubility, stability, bioaccessibility, and antioxidant effects, providing potential for applications in targeted drug delivery and cellular antioxidant activity.
FOOD HYDROCOLLOIDS
(2021)
Article
Multidisciplinary Sciences
Danni Zhong, Dongxiao Zhang, Wei Chen, Jian He, Chaojie Ren, Xingcai Zhang, Na Kong, Wei Tao, Min Zhou
Summary: The innovative strategy of oral drug delivery using a formulation based on Spirulina platensis loaded with curcumin shows promise for treating intestinal diseases. The formulation not only improves drug bioavailability but also demonstrates excellent antitumor and anti-inflammatory efficacy.
Article
Biochemistry & Molecular Biology
Ying Liu, Meng Zhou, Shuo Wang, Jiankang Feng, Chichong Lu, Guofan Jin
Summary: Curcumin was modified and four kinds of nanoparticles with regular morphology were prepared using non-toxic and non-irritating acrylic resin as coating material to improve the stability and bioavailability of the compounds. The results showed that these composites had good stability and potential for slow and controlled release, and could enter and be absorbed by cells, demonstrating good imaging performance. MTT experiments showed that the complexes had certain anti-tumor activity and low cytotoxicity.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao
Summary: A new microfluidic nanoprecipitation approach has been developed for making polymer NPs with tunable drug loading up to 50%. The synthesized NPs remain very stable under acidic conditions but release the drug in a sustained manner at neutral pH.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Elias A. Halabi, Ralph Weissleder
Summary: Highly multiplexed, cyclic fluorescence imaging has improved our understanding of human diseases. However, current cyclic methods have limitations such as long quenching times and extensive wash steps. This study presents a new series of fluorochromes that can be efficiently inactivated by a single light pulse, allowing for fast and controllable quenching without the need for washing or additional chemicals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Food Science & Technology
Ozi Adi Saputra, Wahyu Nur Safitriono, Dyah Ellyawati Kusumaningtyas Maharani, Amalia Febiana, Fajar Rakhman Wibowo
Summary: This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion (CE) and encapsulating it within chitosan-assembled mesoporous silica nanoparticles (Chi@SiO2@CE). The CE exhibited strong antioxidant activity compared to curcumin alone, and the Chi@SiO2@CE showed pH-controlled release behavior, indicating potential as a pH-responsive drug delivery material.
Article
Chemistry, Multidisciplinary
Jing Yan, Ya-Ling Tan, Min-jie Lin, Hang Xing, Jian-Hui Jiang
Summary: The crosslinking strategy improved the delivery efficiency and intracellular sensor performance of ProSNA, with X-SNA showing significantly enhanced sensor performance with a 4 times higher signal-to-noise ratio when detecting intracellular lactate.
Article
Chemistry, Multidisciplinary
Roya Karimi Alavijeh, Kamran Akhbari, Jonathan M. White
Summary: A new nano bio-coordination polymer was synthesized using ultrasonic irradiation in water, which exhibited reversible structure changes under wet conditions. This polymer, named bio-CP 2, was thermodynamically stable and capable of improving the solubility of curcumin. Experimental results showed that loading curcumin onto bio-CP 2 enhanced its cytotoxicity, leading to increased apoptosis in cancer cells.
Review
Pharmacology & Pharmacy
Rita Tabanelli, Simone Brogi, Vincenzo Calderone
Summary: This article discusses the issue of low bioavailability of curcumin and introduces strategies to improve its bioavailability, including the use of adjuvants, complexed/encapsulated curcumin, specific curcumin formulations, and curcumin nanoparticles. Clinical trial results show that improved bioavailability leads to increased therapeutic efficacy, and advancements in nanoparticle technology hold great promise for developing curcumin-based therapeutic agents.
Review
Chemistry, Multidisciplinary
Upendar Reddy Gandra, Santhosh Kumar Podiyanachari, Hassan S. Bazzi, Mohammed Al-Hashimi
Summary: This mini-review presents recent advances in the synthesis of functional materials using ring-opening metathesis polymerization (ROMP)-derived poly(olefins) for drug release, sensing, and cellular uptake in the past seven years (2015-2022). The review highlights the highly promising potential of ROMP-derived well-defined functional poly(olefins) for medical and biological studies. It provides valuable insights for the design and development of new smart and flexible-functionality ROMP-based polymeric materials for various biological applications.
Article
Nanoscience & Nanotechnology
Kiara Bruggeman, Meng Zhang, Nicolo Malagutti, Shiva Soltani Dehnavi, Richard Williams, Antonio Tricoli, David Nisbet
Summary: Nanoparticles are commonly used as delivery vehicles for drugs, but their diffusion often leads to inconsistent drug release. In this study, brain-derived neurotrophic factor (BDNF) is attached to photoactive titanium dioxide nanoparticles and loaded into a nanofibrous self-assembling peptide (SAP) hydrogel. By manipulating UV exposure conditions, the researchers were able to achieve a more constant and flattened drug release profile. The adsorption of the growth factor onto the hydrogel nanofibers and the interaction between the released growth factor and the hydrogel were found to affect the drug release. This study demonstrates the potential for precise control of drug release by manipulating the amount of bound growth factor on the nanoparticles and provides insights into the diffusion and release behavior of nanoparticles in hydrogels.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Lele Zhou, Lu Wang, Ning Ma, Yizhen Wan, Yu Zhang, Hao Liu, Weiping Qian
Summary: This study developed a novel and effective strategy to monitor the real-time release of hydrophobic cargo curcumin using a lipid-curcumin-loaded silica colloidal crystal film controlled by lipase. The degradation of a digestible lipid complex triggered by lipase resulted in the real-time release of curcumin, which was tracked by changes in optical thickness. The study also found that the addition of soluble dietary fiber delayed the release rate of curcumin.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lan Wang, Jin Mao, Qi Zhou, Qianchun Deng, Lei Zheng, Jie Shi
Summary: In this study, sodium caseinate and carboxymethylpachymaran nanoparticles loaded with curcumin were created. The main drivers behind the creation of the nanoparticles were identified as hydrogen bonding, hydrophobic interaction, and electrostatic interaction. The composite nanoparticles exhibited smaller particle size, better dispersion, and higher encapsulation rate at a mass ratio of sodium caseinate to CMP of 3:5. The nanoparticles showed good performance in preventing the early release of curcumin and sustained release in the intestinal tract.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yuanhong Zhang, Dan Yuan, Penghui Shen, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao
Summary: Novel soy peptide-based nanoparticles were successfully fabricated from insoluble soy peptide aggregates, showing potential for sustainable utilization and improved antioxidant activity.
Article
Engineering, Biomedical
Joao P. Martins, Patricia Figueiredo, Shiqi Wang, Erika Espo, Elena Celi, Beatriz Martins, Marianna Kemell, Karina Moslova, Ermei Makila, Jarno Salonen, Mauri A. Kostiainen, Christian Celia, Vincenzo Cerullo, Tapani Viitala, Bruno Sarmento, Jouni Hirvonen, Helder A. Santos
Summary: Oral insulin delivery has the potential to be an effective alternative to insulin injections for diabetic patients. A multistage nanoparticle system was designed to overcome the barriers to oral drug absorption and bioavailability. The nanoparticles were able to release insulin at the appropriate pH conditions and demonstrated increased interaction and internalization by target cells. These nanoparticles showed potential for oral delivery of anti-diabetic drugs.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Applied
Yuanhong Zhang, Feibai Zhou, Penghui Shen, Qiangzhong Zhao, Mouming Zhao
FOOD HYDROCOLLOIDS
(2020)
Article
Chemistry, Applied
Yuanhong Zhang, Dan Yuan, Penghui Shen, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao
Summary: Novel soy peptide-based nanoparticles were successfully fabricated from insoluble soy peptide aggregates, showing potential for sustainable utilization and improved antioxidant activity.
