Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 6, Pages 1369-1376Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b04383
Keywords
hydrothermal vents; deep-sea; marine microorganism; natural products; food allergy
Funding
- Xiamen Ocean Economic Innovation and Development Demonstration Project [16PZPOO1SF16]
- China Postdoctoral Science Foundation [2016M602056]
- National Natural Science Foundation of China [41606185, 41676130, 21372233]
Ask authors/readers for more resources
To discover antifood allergic components from deep-sea-derived microorganisms, we performed a systematic chemical investigation of the Atlantic hydrothermal fungus Graphostroma sp. MCCC 3A00421. Consequently, nine new (1-9) and 19 known (10-28) polyketides were isolated. The planar structures of the new compounds were elucidated mainly by detailed analysis of their nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data, while the absolute configurations were established using the modified Mosher's method in association with electronic circular dichroism spectra. Graphostrin A (1) is a novel chlorinated polyketide derivate bearing an oxazole moiety. All isolates were tested for antifood allergic bioactivities in immunoglobulin E-mediated rat basophilic leukemia-2H3 cells. Reticulol (10) significantly decreased the rates of degranulation and histamine release with IC50 values of 13.5 and 13.7 mu M respectively, suggesting reticulol could be a potential antifood allergic medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available