Article
Multidisciplinary Sciences
Xue Xu, Ali Naseri, Jos Houbraken, Farzaneh Akbari, Xiaodong Wang, Rongfen Zhao, Hong Zhang, Mohammad Javad Najafzadeh, Shuwen Deng
Summary: In Mashhad, Iran, A. flavus is the most common Aspergillus species causing onychomycosis. MALDI-TOF MS shows promise as a rapid and accurate identification tool, particularly for common Aspergillus species. Terbinafine, posaconazole, and echinocandins were the most effective antifungal drugs against the Aspergillus isolates studied, suggesting terbinafine as a preferred treatment option.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Paulo H. F. Carmo, Gustavo J. C. Freitas, Joao C. M. Dornelas, Bruna C. T. Almeida, Ludmila M. Baltazar, Gabriella F. Ferreira, Nalu T. A. Peres, Daniel A. Santos
Summary: Amorolfine and ciclopirox olamine exhibit antifungal activity in onychomycosis through the production of oxidative and nitrosative radicals, leading to cell damage and fungal death.
Article
Immunology
Samaneh Halvaee, Roshanak Daie-Ghazvini, Seyed Jamal Hashemi, Sadegh Khodavaisy, Abbas Rahimi-Foroushani, Heidar Bakhshi, Zahra Rafat, Pegah Ardi, Mahdi Abastabar, Mahdi Zareei, Zeinab Borjian-Boroujeni, Hasti Kamali Sarvestani
Summary: The study conducted in Iran found a relatively high prevalence of onychomycosis in patients, with dermatophytes, yeasts, and saprophytic fungi being the main causative agents. Additionally, luliconazole showed potent antifungal activity against a broad spectrum of fungi, suggesting its potential as a first-line therapy for onychomycosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Laura Trovato, Maria Domina, Maddalena Calvo, Rocco De Pasquale, Guido Scalia, Salvatore Oliveri
Summary: This study evaluated the DermaGenius (DG) multiplex kit for detecting and identifying dermatophytes from nail samples of untreated and treated patients with a clinical suspicion of onychomycosis. The results showed that DG had a high sensitivity and specificity in diagnosing onychomycosis, especially in patients who had undergone antifungal treatments without clinical improvement. The positive results of cultural exams were significantly lower in treated patients compared to untreated patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Microbiology
Marta Elisabetta Eleonora Temporiti, Marta Guerini, Rebecca Michela Baiguera, Simone Buratti, Anthea Desiderio, Lorenzo Goppa, Paola Perugini, Elena Savino
Summary: Different Trichophyton species had varying effects on the mechanical properties of bovine membranes, with potential for a new diagnostic test for onychomycosis. Mechanical analysis of membranes can evaluate changes in thickness and structural integrity following fungal colonization.
Article
Microbiology
Laura Trovato, Maddalena Calvo, Rocco De Pasquale, Guido Scalia, Salvatore Oliveri
Summary: This study aimed to evaluate the incidence of toenail onychomycosis in diabetic patients and healthy individuals. The results showed that diabetic patients are more susceptible to nail fungal infections. Therefore, dermatological follow-ups should be conducted for diabetic patients, and all skin and nail disorders should be carefully monitored.
Article
Dermatology
Alicia Moreno-Sabater, Nacera Ouali, Francois Chasset, Camille Frances, Patricia Senet, Caroline Faucon, Christophe Hennequin, Claude Bachmeyer
Summary: The study investigated the management of severe onychomycosis in kidney transplant recipients (KTR) and assessed the tolerance profile of systemic terbinafine in this population. Results indicated that oral terbinafine can be used to treat severe onychomycosis with acceptable tolerance in KTR receiving different antirejection treatments, such as tacrolimus. Further multicentric studies are needed to establish guidelines for onychomycosis treatment in KTR.
Article
Biotechnology & Applied Microbiology
Behnaz Ghaemi, Seyed Jamal Hashemi, Sharmin Kharrazi, Arfa Moshiri, Hossein Kargar Jahromi, Amir Amani
Summary: This study aimed to investigate the therapeutic effects of photodynamic therapy with Ag@ZnO nanoparticles on resistant onychomycosis and its ability to prevent the recurrence of fungal infection. The results showed that 40μg/mL of UVB-activated Ag@ZnO nanoparticles exhibited 100% antifungal activity against dermatophytosis in both in vitro and in vivo experiments. After 180 days, complete growth prevention of fungi was observed. Additionally, the nanoparticles demonstrated good biocompatibility.
Article
Infectious Diseases
Anne Landreau, Loic Simon, Pascal Delaunay, Christelle Pomares, Lilia Hasseine
Summary: We conducted an epidemiological assessment of superficial fungal infections in the Laboratory of Parasitology-Mycology of the Hospital of Nice over a 2-year period. Dermatophytes, particularly Trichophyton rubrum, remain the predominant fungal species. Our study also revealed an increasing number of non-dermatophytic mould infections. This research provides important insights into the epidemiological profile of superficial fungal infections in our patient population.
Review
Mycology
Bassey E. Ekeng, Winnie Kibone, Asa E. Itam-Eyo, Felix Bongomin
Summary: Despite a significant number of diabetes mellitus (DM) patients in Africa, there is a lack of research on onychomycosis in this population. Our review highlights a high prevalence of onychomycosis, with males being more affected. Risk factors identified include duration of diabetes, increasing age, occupation, subclinical atherosclerosis, metabolic syndrome, obesity, triglyceride levels, and glycosylated haemoglobin. Diagnosis is primarily done through microscopy and culture.
Article
Mycology
Ge Song, Meijie Zhang, Weida Liu, Guanzhao Liang
Summary: Onychomycosis is a common nail disease caused by dermatophytes, yeasts, or molds. This study investigated the epidemiology of onychomycosis in Chinese mainland over the past 30 years and found that fungi, especially Trichophyton rubrum, were the most common pathogens. The study revealed differences in gender, clinical types, infection sites, and geographical distribution of fungal pathogens.
Article
Infectious Diseases
Cyril Debuysschere, Laurent Blairon, Roberto Cupaiolo, Ingrid Beukinga, Marie Tre-Hardy
Summary: The aim of this study was to evaluate the clinical performance of a multiplex PCR in the identification of the causative agent of onychomycosis on nail samples, and its impact on the turnaround time, compared to traditional laboratory methods. The new method is rapid, reliable, robust, and inexpensive. Onychomycosis is a growing public health problem and current diagnostic methods have drawbacks.
Article
Dermatology
Gergana Vazheva, Liliya Zisova, Tsonka Miteva-Katrandzhieva, Valentin Dichev, Veselin Chonov
Summary: This study evaluates the application of real-time PCR in diagnosing fungal infections, and finds that it has higher sensitivity, specificity, and efficacy compared to conventional methods.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Charussri Leeyaphan, Chatree Chai-Adisaksopha, Napatra Tovanabutra, Phichayut Phinyo, Sumanas Bunyaratavej
Summary: This retrospective cohort study investigated the mycological cure and prognostic factors in Neoscytalidium onychomycosis patients. The study found that advanced age, thick nails, and peripheral vascular disease were poor prognostic factors, while combination therapy was associated with achieving a mycological cure.
Article
Medicine, General & Internal
Ebrahim Taghian, Sayed Hamidreza Abtahi, Abdolrasoul Mohammadi, Seyed Mostafa Hashemi, Kazem Ahmadikia, Somayeh Dolatabadi, Rasoul Mohammadi
Summary: In this study, fungal rhinosinusitis (FRS) among immunocompetent and immunosuppressed patients was categorized and the etiologic agents of the disease were identified using molecular methods. The results showed a high prevalence of FRS, with common predisposing factors being antibiotic consumption, corticosteroid therapy, and diabetes mellitus. Common clinical manifestations among patients included eyesore, proptosis, and headache. Rhizopus oryzae and Aspergillus flavus were identified as the most prevalent fungal species. It is crucial to accurately diagnose and classify FRS, as a delay in diagnosis can lead to delays in treatment. Accurate identification of etiologic agents should be based on phenotypic and molecular methods.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2023)
Article
Medical Laboratory Technology
Shima Ahmadpour Kermani, Samira Salari, Pooya Ghasemi Nejad Almani
Summary: The study showed that TiO2-NPs and ZnO-NPs have antifungal effects against Candida species, but are less effective than AmB. AmB exhibited higher cytotoxicity compared to ZnO-NPs and TiO2-NPs.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Medical Laboratory Technology
Monireh Sezavar, Iraj Sharifi, Pooya Ghasemi Nejad Almani, Bahram Kazemi, Noushin Davoudi, Samira Salari, Ehsan Salarkia, Ahmad Khosravi, Mehdi Bamorovat
Summary: The study compared the effect of MA on non-healing Leishmania tropica isolates and MA transfected non-healing isolates expressing PTR1. Results showed that PTR1 gene reduced drug efficacy, and inhibiting it with antisense could improve treatment for non-healing cases. These findings have implications for future prophylactic and therapeutic approaches for non-healing Leishmania isolates.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Dermatology
Saman Ahmad Nasrollahi, Azam Fattahi, Atefeh Naeimifar, Ensieh Lotfali, Alireza Firooz, Ali Khamesipoor, Seyed Ebrahim Skandari, Akram Miramin Mohammadi
Summary: The study aimed to investigate the antifungal activity of amphotericin B-loaded nanoliposomes against Trichophyton interdigitale and Trichophyton rubrum, as well as assessing resistance in vitro. The nanoliposomes showed lower MIC compared to amphotericin B and liposomes separately, without inducing drug resistance in tested strains. Amphotericin B-loaded nanoliposomes could be a potent antifungal treatment for onychomycosis with low probability of inducing drug resistance in dermatophyte species.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Samira Salari, Ahmad Taghdiri, Mehdi Bamorovat, Iraj Sharifi, Pooya Ghasemi Nejad Almani
Summary: Leishmaniasis is a neglected parasitic disease that requires rapid diagnosis. This study introduces a modified LAMP technique for the rapid and cost-effective diagnosis of leishmaniasis, with higher sensitivity and specificity compared to other methods.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Mahsa Fattahi, Reza Ghasemi, Olga Pinegina, Mohammad Mahdi Bahrami, Mahdi Hosseini, Ensieh Lotfali
Summary: In this study, the antifungal patterns of biofilms of filamentous species keratitis isolates were investigated using scanning electron microscopy. Itraconazole, posaconazole, and natamycin showed the highest activity against biofilms of all tested filamentous strains.
ARCHIVES OF CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medical Laboratory Technology
Samira Salari, Mehdi Bamorovat, Iraj Sharifi, Pooya Ghasemi Nejad Almani
Summary: Through reviewing recent original studies, we have identified molecular biomarkers associated with drug resistance in leishmaniasis and thoroughly investigated their geographical distribution in each country. Selection of appropriate treatment modalities is crucial due to the emergence of resistant genes mainly in anthroponotic Leishmania species.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Microbiology
Mohsen Nosratabadi, Javad Akhtari, Leila Faeli, Iman Haghani, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Hossein Zarrinfar, Rasoul Mohammadi, Mohammad Javad Najafzadeh, Sadegh Khodavaisy, Ahmed Al-Harrasi, Mohammad Javan-Nikkhah, Reza Kachuei, Maryam Salimi, Mahsa Fattahi, Hamid Badali, Abdullah M. S. Al Hatmi, Mahdi Abastabar
Summary: Fusarium species are a group of filamentous fungi that cause various infections in humans and are commonly resistant to many antifungal drugs. This study found that miltefosine showed the most effective antifungal activity against Fusarium isolates, suggesting its potential as a novel treatment option.
Review
Microbiology
Reza Ghasemi, Ensieh Lotfali, Kamran Rezaei, Seyed Ataollah Madinehzad, Mahdi Falah Tafti, Nikta Aliabadi, Ebrahim Kouhsari, Mahsa Fattahi
Summary: Meyerozyma guilliermondii is a microorganism that can cause serious infections and its incidence has increased in recent years. Reduced sensitivity to conventional antifungals and drug resistance have raised concerns among researchers.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Infectious Diseases
Mahzad Erami, Seyed Jamal Hashemi, Omid Raiesi, Mahsa Fattahi, Muhammad Ibrahim Getso, Mansooreh Momen-Heravi, Roshanak Daie Ghazvini, Sadegh Khodavaisy, Shohre Parviz, Narges Mehri, Mohsen Babaei
Summary: This study aims to investigate fungal infections in patients with COVID-19. The study found that 14.3% of the severe COVID-19 pneumonia patients were probable cases of pulmonary aspergillosis. Male patients had a higher incidence rate, and voriconazole and amphotericin B showed greater antifungal activity against Aspergillus species.
Article
Dermatology
Azin Ayatollahi, Nima Aramipour, Arash Sadri, Alireza Firooz, Reza M. Robati, Mahsa Fattahi, Masoud Ayazi, Mohammad Saber
Summary: This study evaluated the efficacy and safety of a date palm leaf-based ointment for the treatment of warts. The results showed that the ointment was effective in treating warts and did not cause any adverse effects.
DERMATOLOGIC THERAPY
(2022)
Review
Infectious Diseases
Mehdi Bamorovat, Iraj Sharifi, Setareh Agha Kuchak Afshari, Pooya Ghasemi Nejad Almani
Summary: Leishmaniasis, a neglected and old emerging/reemerging disease, has significantly increased and expanded in various geographical areas. Cutaneous leishmaniasis (CL) is a global public health concern, particularly in the Eastern Mediterranean Region, Africa, Latin America, and the Indian subcontinent. The disease poses challenges in its management and control due to its epidemiological and clinical characteristics. The study reviews the interactive role of patients and healthcare management in controlling CL and emphasizes the importance of improving socioeconomic conditions, strengthening healthcare systems, and implementing appropriate control programs. However, there are still major challenges and gaps in controlling the disease. Overall, the article highlights the need for sustained efforts and collaboration across different sectors. Rating: 7/10.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Review
Medicine, General & Internal
Zeynab Yassin, Shokoufeh Hajsadeghi, Mohsen Taghavi Shavazi, Mahsa Fattahi, Koohyar Ahmadzadeh, Armita Farid, Yeganeh Karimi, Farnoosh Seirafianpour, Pegah Babaheidarian, Azadeh Goodarzi
Summary: Patients with a history of COVID-19 may develop Aspergillus endocarditis complicated by multiple thromboembolisms. Early initiation of antifungal therapy and surgical removal of infected valves and emboli can improve the prognosis in patients.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Infectious Diseases
Ensieh Lotfali, Reza Ghasemi, Niloofar Masoumi, Danial Molavizadeh, Sara Sadeghi, Zahra Rahmani, Fatemeh Yazdani Hamid, Mahsa Fattahi
Summary: This study investigated patients with suspicious symptoms of otomycosis and examined the etiological agents and antifungal susceptibility. The results showed that otomycosis has a high occurrence in Iran due to climatic conditions. Caspofungin was found to be the most effective drug against Aspergillus and Candida isolates.
ARCHIVES OF CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Zeynab Yassin, Zahra Salehi, Mohammad Soleimani, Ensieh Lotfali, Mahsa Fattahi, Somayeh Sharifynia
Summary: In this study, Fusarium species causing keratitis were identified and their genetic diversity was investigated using gene sequences. Seventeen isolates were identified as FSSC, four as FFSC, and three as Fusarium oxysporum. A novel set of primers was designed to differentiate the 24 isolates.
IRANIAN JOURNAL OF MICROBIOLOGY
(2022)
