Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Stijn P. Andeweg, Rutger M. Schepp, Jan van de Kassteele, Liesbeth Mollema, Guy A. M. Berbers, Michiel van Boven
Summary: RSV infection is a common occurrence in children, with the majority experiencing it before the age of 2. Age and birthdate are significant predictors of RSV infection probability, with children born in summer having a higher likelihood of infection.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Na Li, Tianyun Shi, Meng Zhang, Yanchao He, Jingjing Feng, Zhoufang Mei, Xiao Su, Zhijun Jie
Summary: Clarifying the pathogenesis of asthma and identifying the specific pathway underlying oral asthma tolerance (OT) is important. This study explores the effects of promyelocytic leukemia zinc finger (PLZF) on memory phenotypes in asthma and OT mouse models. The results suggest that PLZF may reduce memory cells and promote the establishment of OT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Health Care Sciences & Services
Nora Suleiman-Martos, Alberto Caballero-Vazquez, Jose Luis Gomez-Urquiza, Luis Albendin-Garcia, Jose Luis Romero-Bejar, Guillermo A. Canadas-De la Fuente
Summary: This study systematically reviewed the prevalence and factors associated with RSV in children under 5 years in the European region. The main risk factors identified were age, gender, season, and environmental factors such as cold temperatures, humidity, benzene concentrations, tobacco exposure, and urban living.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kentaro Tamura, Kenta Matsumura, Akiko Tsuchida, Taketoshi Yoshida, Hidekuni Inadera
Summary: This study examines the risk of common childhood infections in preterm infants compared to full-term infants and suggests that Palivizumab prophylaxis can reduce the frequencies of lower respiratory tract infection in preterm infants to the same level as in full-term infants.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Deidre Wilkins, Yuan Yuan, Yue Chang, Anastasia A. Aksyuk, Beatriz Seoane Nunez, Ulrika Wahlby-Hamren, Tianhui Zhang, Michael E. Abram, Amanda Leach, Tonya Villafana, Mark T. Esser
Summary: Nirsevimab is an extended half-life monoclonal antibody that provides sustained, high levels of neutralizing antibodies (NAbs) against the respiratory syncytial virus (RSV) while allowing the development of an immune response. It effectively protects infants from RSV disease throughout their first RSV season and has similar seroresponse rates compared with placebo recipients. It is likely due to the prolonged persistence of nirsevimab at elevated levels that leads to this observed protection.
Article
Environmental Sciences
Stephane Jouneau, Anthony Chapron, Cecile Ropars, Solenne Marette, Ange-Marie Robert, Thomas Gouyet, Chantal Belleguic, Cecile Rochefort-Morel, Stephanie Guillot, Carole Mailloux, Benoit Desrues, Jean-Francois Viel, AIRBAg Res Grp
Summary: This study aimed to identify the prevalence and risk factors for asthma in dairy farmers. Results showed associations between asthma and family history of allergy, personal history of eczema, hay manipulation, farm area, and handling treated seeds.
ENVIRONMENTAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Farah Elawar, Ahmed K. Oraby, Quinten Kieser, Lionel D. Jensen, Tyce Culp, Frederick G. West, David J. Marchant
Summary: RSV infection is a major cause of pediatric hospitalizations and deaths, with limited treatment options. The development of effective antivirals and vaccines is crucial in combating RSV, despite challenges in therapeutics so far. This review provides insight into current research progress and future considerations in RSV treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Genta Ito, Takahiro Takazono, Naoki Hosogaya, Naoki Iwanaga, Shogo Miyazawa, Satoki Fujita, Hideaki Watanabe, Hiroshi Mukae
Summary: This retrospective observational study evaluated the factors influencing the start date of the influenza epidemic season and the total number of infected persons per 1,000,000 population in 47 prefectures of Japan. Using a Japanese health insurance claims database, single and multiple regression analyses were conducted to assess the relationship between the start time of the epidemic and various factors such as absolute humidity, total visitors, and total population. The study found that the earlier the climate became suitable for virus transmission and the higher the human mobility, the earlier the epidemic season tended to begin.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Moria Be'er, Shai Bushmitz, Michal Cahal, Efraim Sadot, Sivan Yochpaz, Omri Besor, Israel Amirav, Moran Lavie
Summary: This case-control study aimed to evaluate the association between hospitalization in the PICU due to RSV bronchiolitis and future asthma in early life. The results showed that children admitted to the PICU for RSV bronchiolitis are at higher risk for asthma in subsequent pre-school years and will require close respiratory follow-up.
PEDIATRIC PULMONOLOGY
(2022)
Article
Immunology
Katherine M. Begley, Arnold S. Monto, Lois E. Lamerato, Anurag N. Malani, Adam S. Lauring, H. Keipp Talbot, Manjusha Gaglani, Tresa McNeal, Fernanda P. Silveira, Richard K. Zimmerman, Donald B. Middleton, Shekhar Ghamande, Kempapura Murthy, Lindsay Kim, Jill M. Ferdinands, Manish M. Patel, Emily T. Martin
Summary: In this study, adults hospitalized with respiratory syncytial virus (RSV) were found to have worse outcomes compared with influenza. They were more likely to have cardiopulmonary comorbidities, experience a longer stay, and require mechanical ventilation. This study highlights the importance of RSV surveillance and informs future vaccination strategies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Seon Jin Lee, Jeong Min Kim, Ha Rim Keum, Sang Won Kim, Hee Sun Baek, Jun Chul Byun, Yu Kyung Kim, Saeyoon Kim, Jae Min Lee
Summary: This study investigated the relationship between the incidence of encephalitis and viral infections in all age groups from 2015 to 2019. The results showed that respiratory syncytial virus (HRSV), coronavirus (HCoV), influenza virus (IFV), and norovirus tended to precede encephalitis by 1 month. Further research is needed to confirm the association between these viruses and encephalitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Sherri A. Powledge, Taylor B. McAtee, Amelia R. Woolums, T. Robin Falkner, John T. Groves, Merilee Thoresen, Robert Valeris-Chacin, John T. Richeson
Summary: Vaccination with modified-live virus (MLV) did not have a clear impact on the health or growth of high-risk calves, but intranasal MLV vaccination was associated with increased carriage of Histophilus somni (Hs) in the naris and reduced culture of Mannheimia haemolytica (Mh) from lung tissue samples. This suggests that intranasal MLV vaccination can alter the microbial community in the respiratory tract of cattle.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Allergy
Natasha Yumi Matsunaga, Livea Gianfrancesco, Tais Nitsch Mazzola, Marina Simoes Oliveira, Andre Moreno Morcillo, Maria Angela Goncalves Oliveira Ribeiro, Jose Dirceu Ribeiro, Simone Hashimoto, Adyleia Aparecida Dalbo Contrera Toro
Summary: This study assessed the clinical, functional, and inflammatory patterns of children and adolescents with severe uncontrolled asthma. It found that after participating in a structured outpatient clinic for six months, patients showed notable improvement in asthma control and quality of life.
Article
Pediatrics
Juliana Cristina Santiago Bastos, Paulo Vitor Marques Simas, Leonardo Cardia Caserta, Alfonso Eduardo Alvarez Bragunde, Fernando Augusto de Lima Marson, Matheus Cavalheiro Martini, Marina Aiello Padilla, Jose Dirceu Ribeiro, Marcia Merces Aparecida Bianchi dos Santos, Clarice Weis Arns
Summary: RSV and rhinoviruses are the most commonly detected viruses in severe bronchiolitis cases in infants. However, a significant portion of cases do not show RSV presence, indicating the presence of other viral agents like rhinoviruses.
JORNAL DE PEDIATRIA
(2022)
Article
Developmental Biology
Leticia R. de Oliveira, Carlos A. Longui, Guilherme Guaragna-Filho, Jose L. da Costa, Rafael Lanaro, Maria I. Chiamolera, Maricilda P. de Mello, Andre M. Morcillo, Andrea T. Maciel-Guerra, Gil Guerra-Junior
Summary: This study aimed to determine a testosterone (T) cutoff level using LC-MS/MS after stimulation with recombinant human chorionic gonadotropin (rhCG) in the evaluation of gonadal steroidogenesis in patients with 46,XY disorders of sex development (DSD).
SEXUAL DEVELOPMENT
(2023)
Article
Genetics & Heredity
Mariana Dalbo Contrera Toro, Jose Dirceu Ribeiro, Fernando Augusto Lima Marson, Erica Ortiz, Adyleia Aparecida Dalbo Contrera Toro, Carmen Silvia Bertuzzo, Marcus Herbert Jones, Eulalia Sakano
Summary: This study investigated the clinical, genetic, and ultrastructural characteristics of individuals with clinical suspicion of PCD in a Brazilian tertiary hospital. The results showed that the diagnosis of PCD is still challenging for individuals with clinical suspicion, but transmission electron microscopy and genetic screening are still valuable for determining the PCD diagnosis.
Article
Pediatrics
Emilia da Silva Goncalves, Jose Dirceu Ribeiro, Fernando Augusto Lima Marson, Ciro Garcia Montes, Antonio Fernando Ribeiro, Jochen Georg Mainz, Adyleia Aparecida Dalbo Contrera Toro, Juliana Helena Zamariola, Daniela Souza Paiva Borgli, Elizete Aparecida Lomazi, Maria de Fatima Correa Pimenta Servidoni
Summary: The prevalence of GERD in children with CF was assessed using multichannel intraluminal impedanciometry associated with pH monitoring (MIIpH) and compared with respiratory symptoms. It was found that MIIpH detected 30% more GERD patients than pHmetry.
JORNAL DE PEDIATRIA
(2023)
Article
Endocrinology & Metabolism
Carolina Trombeta Reis, Marina Cruvinel Macedo, Andre Moreno Morcillo, Gil Guerra-Junior, Sofia Helena Valente de Lemos-Marini
Summary: This study aimed to analyze the association between anthropometric factors, physical appearance, and quality of life in Turner syndrome (TS) women. The results showed that dissatisfaction with height and physical appearance was related to lower scores in mental health and role emotional domains. Participants who desired to change their physical appearance had higher scores in the mental component, social function, and mental health domains. Therefore, there is a need to develop and validate an official questionnaire to assess how specific characteristics of TS interfere with the quality of life in more detail.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Respiratory System
Ana Paula G. Malheiro, Livea Gianfrancesco, Roberto Jose N. Nogueira, Milena B. Grotta, Andre M. Morcillo, Jose Dirceu Ribeiro, Adyleia A. D. C. Toro
Summary: This study assessed the association between serum vitamin D levels and asthma control and severity in children and adolescents in different seasons. The results showed that sunlight exposure did not influence serum vitamin D levels, and there was no significant association between asthma control and serum vitamin D levels. However, there was a positive correlation between vitamin D and lung function, and the group with vitamin D insufficiency had a higher prevalence of severe asthma.
Article
Medicine, General & Internal
Mariana Dalbo Contrera Toro, Erica Ortiz, Fernando Augusto Lima Marson, Laiza Mohana Pinheiro, Adyleia Aparecida Dalbo Contrera Toro, Jose Dirceu Ribeiro, Eulalia Sakano
Summary: The study aimed to compare changes in electron microscopy findings, clinical variables, and saccharin tests in individuals diagnosed with clinical PCD and a control group. The results showed that the saccharin transit time test is associated with clinical alterations related to PCD and can assist in screening PCD patients.
SAO PAULO MEDICAL JOURNAL
(2023)
Article
Pediatrics
Camila Isabel Santos Schivinski, Renata Maba Goncalves Wamosy, Paloma Lopes Francisco Parazzi, Andre Moreno Morcillo
Summary: This study establishes normal curves and percentiles for maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) values of healthy schoolchildren, providing reference values for clinical follow-up and therapeutic monitoring.
REVISTA PAULISTA DE PEDIATRIA
(2022)