Article
Surgery
Jason B. Doppenberg, Marjolein Leemkuil, Marten A. Engelse, Christina Krikke, Eelco J. P. de Koning, Henri G. D. Leuvenink
Summary: The study suggested that using hypothermic machine perfusion (HMP) could safely extend cold ischemia time, leading to better preservation of discarded donor pancreases and successful isolation of islets.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Michal Grat, Marcin Morawski, Andriy Zhylko, Pawel Rykowski, Maciej Krasnodebski, Anya Wyporski, Jan Borkowski, Zbigniew Lewandowski, Konrad Kobryn, Rafal Stankiewicz, Jan Stypulkowski, Waclaw Holowko, Waldemar Patkowski, Magdalena Mielczarek-Puta, Marta Struga, Benedykt Szczepankiewicz, Barbara Gornicka, Marek Krawczyk
Summary: This study suggests that routine use of end-ischemic hypothermic oxygenated machine perfusion (HOPE) in liver transplantations from donors after brain death (DBD) is not justified, as the clinical benefits are limited to high-risk donors.
Article
Medicine, General & Internal
Rebecca Panconesi, Mauricio Flores Carvalho, Janina Eden, Marilena Fazi, Fariha Ansari, Leandro Mancina, Nadia Navari, Richard Xavier Sousa Da Silva, Daniele Dondossola, Lucia Bautista Borrego, Matthias Pietzke, Adriano Peris, David Meierhofer, Paolo Muiesan, Alexander Galkin, Fabio Marra, Philipp Dutkowski, Andrea Schlegel
Summary: This study investigated the effects of NRP and HOPE on DCD liver transplantation using an animal model. The results showed that HOPE can reduce mitochondrial injury and inflammation, and improve post-transplant survival.
Article
Gastroenterology & Hepatology
Wei Kelly Wu, Rei Ukita, Yatrik J. Patel, Michael Cortelli, Vincent Q. Trinh, Ioannis A. Ziogas, Sean A. Francois, Meredith Mentz, Nancy L. Cardwell, Jennifer R. Talackine, William M. Grogan, John W. Stokes, Youngmin A. A. Lee, Jinho Kim, Sophoclis P. Alexopoulos, Matthew Bacchetta
Summary: Xenogeneic cross-circulation technique has been successfully used to support and rehabilitate declined donor livers, resulting in preservation of organ structure and function, improved viability markers, and potential for further research in organ recovery and rehabilitation.
Article
Medicine, General & Internal
Sodai Sakamoto, Hiroki Bochimoto, Kengo Shibata, Nur Khatijah Mohd Zin, Moto Fukai, Kosei Nakamura, Takahisa Ishikawa, Masato Fujiyoshi, Tsuyoshi Shimamura, Akinobu Taketomi
Summary: This study aimed to verify the optimal pH of hypothermic machine perfusion (HMP) for donation after circulatory death (DCD) livers. The results showed that the HMP group with pH 7.8 displayed significant graft protection, as evidenced by lower enzyme levels, bile production, diminished tissue injury, and well-preserved mitochondrial structure. Therefore, HMP with a pH of 7.8 enhances protective effects by preserving mitochondrial structure and function, reducing reperfusion injury in DCD livers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wayne J. Hawthorne, Sussan Davies, Hee-chang Mun, Yi Vee Chew, Lindy Williams, Patricia Anderson, Natasha Rogers, Philip J. O'Connell
Summary: This study compared the isolation and transplant outcomes of donor pancreata according to the distance from the islet isolation facility. The results showed that the distance of donors did not significantly impact the isolation and transplant outcomes.
Article
Medicine, General & Internal
R. Van Rijn, I. J. Schurink, Y. de Vries, A. P. van den Berg, M. Cortes Cerisuelo, S. Darwish Murad, J. I. Erdmann, N. Gilbo, R. J. de Haas, N. Heaton, B. van Hoek, V. A. L. Huurman, I. Jochmans, O. B. van Leeuwen, V. E. de Meijer, D. Monbaliu, W. G. Polak, J. J. G. Slangen, R. I. Troisi, A. Vanlander, J. de Jonge, R. J. Porte
Summary: This study demonstrated that hypothermic oxygenated machine perfusion can reduce the risk of nonanastomotic biliary strictures following liver transplantation from donors after circulatory death, with lower rates of complications compared to conventional static cold storage.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Surgery
Zoltan Czigany, Johann Pratschke, Jiri Fronek, Markus Guba, Wenzel Schoening, Dimitri Aristotle Raptis, Joachim Andrassy, Matthijs Kramer, Pavel Strnad, Rene Hany Tolba, Wenjia Liu, Theresa Keller, Hannah Miller, Sandra Pavicevic, Deniz Uluk, Matej Kocik, Isabella Lurje, Christian Trautwein, Arianeb Mehrabi, Irinel Popescu, Florian Wolfgang Rudolf Vondran, Cynthia Ju, Frank Tacke, Ulf Peter Neumann, Georg Lurje
Summary: This study demonstrates that HOPE significantly reduces early allograft injury and improves post-transplant outcomes in ECD-DBD liver transplantation compared to SCS.
Article
Endocrinology & Metabolism
Marluce da Cunha Mantovani, Ilana Gabanyi, Carlos Andres Pantanali, Vinicius Rocha Santos, Maria Lucia Cardillo Correa-Giannella, Mari Cleide Sogayar
Summary: Background: Type 1 diabetes mellitus (T1D) is a condition caused by autoimmune destruction of pancreatic beta cells. Transplantation of isolated pancreatic islets from donors is a potential treatment for T1D, but the limited availability of suitable pancreas donors is a major challenge. Methods: A retrospective study was conducted to analyze the profile of brain-dead human pancreas donors and the reasons for organ refusal. Results: The main reasons for refusal were hyperglycemia, technical issues, age, positive serology, and hyperamylasemia. Conclusions: This study provides insights to improve the availability of suitable pancreas donors and enhance the outcome of islet isolation and transplantation.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cardiac & Cardiovascular Systems
Qiudong Chen, Dominic Emerson, Dominick Megna, Asishana Osho, Amy Roach, Joshua Chan, Georgina Rowe, George Gill, Fardad Esmailian, Joanna Chikwe, Natalia Egorova, James K. Kirklin, Jon Kobashigawa, Pedro Catarino
Summary: Heart transplantation with donation after circulatory death donors has comparable short-term survival to donation after brain death transplants, and broader implementation could increase donor organ availability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Tom Darius, Jay Nath, Michel Mourad
Summary: The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes and decrease organ discard rate. Oxygenation during hypothermic machine preservation is proposed as a resuscitative measure, providing a critical overview of the fundamentals and suggesting different strategies for clinical implementation.
Article
Surgery
Otto B. van Leeuwen, Silke B. Bodewes, Veerle A. Lantinga, Martijn P. D. Haring, Adam M. Thorne, Isabel M. A. Bruggenwirth, Aad P. van den Berg, Marieke T. de Boer, Iris E. M. de Jong, Ruben H. J. de Kleine, Bianca Lascaris, Maarten W. N. Nijsten, Koen M. E. M. Reyntjens, Vincent E. de Meijer, Robert J. Porte
Summary: Ex situ machine perfusion using sequential DHOPE-NMP for resuscitation and viability assessment of high-risk donor livers results in excellent transplant outcomes, irrespective of the oxygen carrier used.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Louise E. See, Gianluigi Li Bassi, Karin Wildi, Margaret R. Passmore, Mahe Bouquet, Kei Sato, Silver Heinsar, Carmen Ainola, Nicole Bartnikowski, Emily S. Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G. Obonyo, Tristan Shuker, Lucy Bradbury, Chiara Palmieri, Sanne Engkilde-Pedersen, Charles McDonald, Sebastiano M. Colombo, Matthew A. Wells, Janice D. Reid, Hollier O'Neill, Samantha Livingstone, Gabriella Abbate, Andrew Haymet, Jae-Seung Jung, Noriko Sato, Lynnette James, Ting He, Nicole White, Meredith A. Redd, Jonathan E. Millar, Maximillian Malfertheiner, Peter Molenaar, David Platts, Jonathan Chan, Jacky Y. Suen, David C. McGiffin, John F. Fraser
Summary: There is a shortage of donor hearts for transplantation, but using hypothermic machine perfusion (HMP) can safely extend the ischemic time of donor hearts and improve transplantation outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Niels Moeslund, Imran A. Ertugrul, Michiel A. Hu, Frederik Flyvholm Dalsgaard, Lars Bo Ilkjaer, Pia Ryhammer, Michael Pedersen, Michiel E. Erasmus, Hans Eiskjaer
Summary: In this study, a novel oxygenated hypothermic machine perfusion (HMP) system was compared to static cold storage (SCS) in heart transplantation (HTX). The results showed that hearts preserved with HMP exhibited increased biventricular contractility post-HTX and required less dobutamine for maintaining cardiac output. Additionally, HMP groups had lower levels of myocardial damage. Therefore, DCD HTX can be successfully performed using DPP followed by preservation with HMP.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
Isabel M. A. Brueggenwirth, Matteo Mueller, Veerle A. Lantinga, Stefania Camagni, Riccardo De Carlis, Luciano De Carlis, Michele Colledan, Daniele Dondossola, Moritz Drefs, Janina Eden, Davide Ghinolfi, Dionysios Koliogiannis, Georg Lurje, Tommaso M. Manzia, Diethard Monbaliu, Paolo Muiesan, Damiano Patrono, Johann Pratschke, Renato Romagnoli, Michel Rayar, Federico Roma, Andrea Schlegel, Philipp Dutkowski, Robert J. Porte, Vincent E. de Meijer
Summary: Prolonged hypothermic oxygenated machine perfusion (HOPE) preservation of donor livers is safe and can lead to good outcomes in liver transplantation, with low incidence of complications and high survival rates. It can also reduce ischemia-reperfusion injury-related complications.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)