A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours
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Title
A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours
Authors
Keywords
BMS-986115, Oral NOTCH inhibitor, Gamma-secretase inhibitor, Phase I trial
Journal
INVESTIGATIONAL NEW DRUGS
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-04-10
DOI
10.1007/s10637-018-0597-6
References
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Note: Only part of the references are listed.- Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)
- (2017) Shivaani Kummar et al. JOURNAL OF CLINICAL ONCOLOGY
- A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer
- (2016) Shubham Pant et al. EUROPEAN JOURNAL OF CANCER
- Results of a phase 1 trial combining ridaforolimus and MK-0752 in patients with advanced solid tumours
- (2015) S.A. Piha-Paul et al. EUROPEAN JOURNAL OF CANCER
- A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours
- (2014) I Brana et al. BRITISH JOURNAL OF CANCER
- A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral -Secretase Inhibitor PF-03084014
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- Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma
- (2014) A. Stoeck et al. Cancer Discovery
- A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors
- (2013) Ivan Diaz-Padilla et al. INVESTIGATIONAL NEW DRUGS
- Notch inhibitors for cancer treatment
- (2013) Ingrid Espinoza et al. PHARMACOLOGY & THERAPEUTICS
- Targeting Notch signaling pathway in cancer: Clinical development advances and challenges
- (2013) Naoko Takebe et al. PHARMACOLOGY & THERAPEUTICS
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
- (2012) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
- (2011) N. J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Notch to Target Cancer Stem Cells
- (2010) A. Pannuti et al. CLINICAL CANCER RESEARCH
- The Notch signaling pathway: Transcriptional regulation at Notch target genes
- (2009) T. Borggrefe et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Notch signalling in cancer stem cells
- (2009) Victoria Bolós et al. Clinical & Translational Oncology
- HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil
- (2009) H. Korkaya et al. CLINICAL CANCER RESEARCH
- Angiogenesis: A Team Effort Coordinated by Notch
- (2009) L.-K. Phng et al. DEVELOPMENTAL CELL
- Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
- (2008) E. Rosati et al. BLOOD
- Notch Signaling in Leukemias and Lymphomas
- (2008) Franziska Jundt et al. CURRENT MOLECULAR MEDICINE
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